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Search results for: antifungal targets
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Anticancer imidazoacridinone C-1311 inhibits hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and angiogenesis
PublicationAntitumor imidazoacridinone C-1311 is a DNA-reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor. Here, we demonstrate the mechanism of C-1311 inhibitory action on novel targets: hypoxia-inducible factor-1α (HIF-1α), vascular-endothelial growth factor (VEGF), and angiogenesis. In a cell-free system, C-1311 prevented HIF-1α binding to an oligonucleotide encompassing a canonical hypoxia-responsive element (HRE),...
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The Chitosan-Based System with Scutellariae baicalensis radix Extract for the Local Treatment of Vaginal Infections
PublicationScutellarie baicalensis radix, as a flavone-rich source, exhibits antibacterial, antifungal, an-tioxidant, and anti-inflammatory activity. It may be used as a therapeutic agent to treat various
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Comparative Study of Self-Organizing Maps vs. Subjective Evaluation of Quality of Allophone Pronunciation for Nonnative English Speakers
PublicationThe purpose of this study was to apply Self-Organizing Maps to differentiate between the correct and the incorrect allophone pronunciations and to compare the results with subjective evaluation. Recordings of a list of target words, containing selected allophones of English plosive consonants, the velar nasal and the lateral consonant, were made twice. First, the target words were read from the list by 9 non-native speakers and...
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Study of structural and optical properties of tio2:tb thin films prepared by high energy reactive magnetron sputtering method
Publicationw pracy zaprezentowano wyniki badań optycznych i strukturalnych cienkich warstw na bazie domieszkowanego tlenku tytanu. warstwy tlenkowe wytworzono zmodyfikowaną metodą rozpylania magnetronowego z targetu mozaikowego w atmosferze tlenu. badania strukturalne wykazały nanokrystaliczność badanych warstw.
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Empirical investigation on labour market interactions in an enlarged Europe
PublicationThis paper proposes an empirical assessment of economic interactions between the labour markets ofthe integrating EU over the period of time 1995-2005. Drawing on recently made available industrystatistics, we provide a sector level study (13 tradable sectors, including manufacturing and services),analysing the contemporary evolution of domestic and trade partners' employment levels. Given theintensification of trade relations...
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The share of investments in gold and oil using the example of selected European stock exchanges– A comparative analysis
PublicationIn this article, optimal investment portfolios with minimal risk and maximum efficiency were calculated. The portfolios were designated for ten selected European stock exchanges, based on the listings of the twenty largest companies in each of those markets. All calculations were made based on company shares only, company shares and investments in gold, shares of companies and investments in crude oil as well as shares of companies...
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Approximation Strategies for Generalized Binary Search in Weighted Trees
PublicationWe consider the following generalization of the binary search problem. A search strategy is required to locate an unknown target node t in a given tree T. Upon querying a node v of the tree, the strategy receives as a reply an indication of the connected component of T\{v} containing the target t. The cost of querying each node is given by a known non-negative weight function, and the considered objective is to minimize the total...
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Stiffness of cold-recycled mixtures under variable deformation conditions in the IT-CY test
PublicationStiffness modulus belongs to the most important properties describing the cold-recycled mixtures (CRM) in terms of their usability in road pavement structures. Previous research proved that this property is strongly dependent on the scheme and conditions of the test (temperature and time of loading) and the time that has passed since the compaction of the specimen or pavement layer. It is a result of the influence of two different...
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The effects of the IM1-12Br ionic liquid and the oxytetracycline mixture on selected marine and brackish microorganisms
PublicationThe number of applications and commercialized processes utilizing ionic liquids has been increasing, and it is anticipated that this trend will persist and even intensify in the future. Ionic liquids possess desirable characteristics, such as low vapor pressure, good water solubility, amphiphilicity, and stability. Nevertheless, these properties can influence their environmental behavior, resulting in resistance to biotic and abiotic...
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Online Volatile Compound Emissions Analysis Using a Microchamber/Thermal Extractor Coupled to Proton Transfer Reaction-Mass Spectrometry
PublicationIndoor air is a complex and dynamic mixture comprising manifold volatile organic compounds (VOCs) that may cause physiological and/or psychological discomfort, depending on the nature of exposure. This technical note presents a novel approach to analyze VOC emissions by coupling a microchamber/thermal extractor (μ-CTE) system to a proton transfer reaction-mass spectrometer (PTR-MS). This configuration provides an alternative to...
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Security Mechanisms in the Comcute System
PublicationThe aim of this paper is pointing out the basic security problems and mechanisms in the Comcute system - maintenance system of large computing power in the face of critical crisis. Moreover security mechanism and tools useful to apply in laboratory model as well as target version of the Comcute system are presented.
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The accuracy of a new approach to order determination for the Modified Prony method in swath mapping application
PublicationThis article presents the performance of a new approach to determine the model order for the modified Prony method applied to swath acoustic mapping. Key requirements for any mapping application are depth determination accuracy and angular resolution. Depth determination accuracy is strictly related to angular accuracy and geometrical relations between receiver and sources of the backscattered signal. Angular resolution determines...
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Modified DNA polymerases for PCR troubleshooting
PublicationPCR has become an essential tool in biological science. However, researchers often encounter problems with difficult targets, inhibitors accompanying the samples, or PCR trouble related to DNA polymerase. Therefore, PCR optimization is necessary to obtain better results. One solution is using modified DNA polymerases with desirable properties for the experiments. In this article, PCR troubleshooting, depending on the DNA polymerase...
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"Born Poland, Gone Global". The case of successful Polish ICT company - Aiton Caldwell
PublicationThis work examines the pathway to global markets of Polish ICT company Aiton Caldwell
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The estimation of fish lenght distribution from its acoustical measures
PublicationThe paper concerns the problem of estimating fish length PDF from its target strength PDF obtained from acoustic surveys. It has been shown that the target strength of single fish can be treated in the first approximation as a finction of two variables: one, which depends on fish size and the other, which depends on its angular orientation (aspect). Extending this simplified relationship to the case of fish populations allows to...
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Ligand-Modified Boron-Doped Diamond Surface: DFT Insights into the Electronic Properties of Biofunctionalization
PublicationWith the increasing power of computation systems, theoretical calculations provide a means for quick determination of material properties, laying out a research plan, and lowering material development costs. One of the most common is Density Functional Theory (DFT), which allows us to simulate the structure of chemical molecules or crystals and their interaction. In developing a new generation of biosensors, understanding the nature...
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Koncepcja systemu wspomagania decyzji nawigatora statku opartego na ewolucyjnym planowaniu manewrów antykolizyjnych
PublicationArtykuł przedstawia koncepcję systemu wspomagania decyzji nawigatora statku opartego na wątkach badań prowadzonych wcześniej przez autora. System będzie rozszerzał funkcjonalność systemów dotychczasowych o możliwość szczegółowego planowania bezpiecznej trajektorii statku na wodach zamkniętych, z dużą liczbą statków obcych i ograniczeniami toru wodnego. Artykuł zawiera dyskusję możliwych podejść do planowania manewrów, optymalizacji...
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Innovative investment funds and stability of financial systems: Nonparametric study of exchange-traded funds in Europe
PublicationThe main aim of the paper is investigation of the potential contribution of exchange-trade funds (ETFs) to the instability of the European financial systems. The paper begins with presentation of the key theoretical concepts with regard to ETFs and financial stability. We discuss the key attributes of ETFs as the innovative category of investment funds, their hypothesized impact on the financial stability as well as briefly describe...
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Polarisation effects in low-energy positron–molecule scattering
PublicationThe UK molecular R-matrix method has been adapted to treat positron collisions from polyatomic targets. A simple empirical enhancement factor which corrects for the underestimation of electron–positron polarisation and correlation effects in the calculations performed with the static-plus-polarization model at low scattering energies is presented. Application of this model to positron scattering from carbon dioxide at energies...
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Low-energy positron scattering from gas-phase uracil
PublicationQuantum scattering calculations are presented for the interaction of low energy positrons with the uracil molecule, an important component of biological systems. The rotational elastic and inelastic cross sections and vibrational inelastic cross sections are reported and compared with existing experiments, indicating a general trend of the cross sections different from the experimental findings and in line with what should be expected...
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Potential applications of by-products from the coffee industry in polymer technology – Current state and perspectives
PublicationCoffee is one of the most popular beverages in the world, and its popularity is continuously growing, which can be expressed by almost doubling production over the last three decades. Cultivation, processing, roasting, and brewing coffee are known for many years. These processes generate significant amounts of by-products since coffee bean stands for around 50% of the coffee cherry. Therefore, considering the current pro-ecological...
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Rethinking Sustainable Cities at Night: Paradigm Shifts in Urban Design and City Lighting
PublicationSince the establishment of the 17 Sustainable Development Goals (SDGs) by the United Nations General Assembly in 2015, various perspectives on sustainable cities have been developed and adopted in order to achieve a better and more sustainable future. However, background research has revealed that these goals and targets are limited because they do not take into account the growing body of lighting-related research in diverse fields...
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Luminescent collisions of He+ and He++ ions with H2 molecules at energies below 2 keV
PublicationSpectroscopic studies of collisions between He+ and He++ ions with H2 gas target have been performed in the 200–600nm wavelength range. Atomic lines of hydrogen Balmer series and several helium lines were identified and their excitation functions between 50 eV and 1keV (2keV for He++) were determined.
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Synthetic strategies in construction of organic macromolecular carrier–drug conjugates
PublicationMany metabolic inhibitors, considered potential antimicrobial or anticancer drug candidates, exhibit verylimited ability to cross the biological membranes of target cells. The restricted cellular penetration ofthose molecules is often due to their highhydrophilicity. One of the possible solutions to this problem is aconjugation of an inhibitor with a molecular organic nanocarrier. The conjugate thus formed should beable to penetrate...
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A concept of software extension of 3D low-PRF radar systems to 4D semi-medium-PRF radar systems
PublicationWe present a concept of software modification of three-dimensional (3D) radar systems, designed to work in the low pulse repetition frequency mode, that equips them with the ability to estimate the radial velocity and to properly measure the range of targets that are detected outside the radar’s instrumented range. Despite the fact that the proposed modifications are designed so as to require only minor changes in software, they...
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Diver Observations by Means of Acoustic Methods
PublicationSearching for objects, especially small ones, moving under water near its the free surface, is always not an easy task. Designing tools for the detection of such targets is a real challenge when the possibility of a terrorist attack is a real threat. This paper presents some aspects of diver detection by means of acoustics methods, both active (side scan sonar) and passive ones (linear receiving antenna). This approach is quite...
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Regionalna strategia w obszarze polityki rynku pracy w województwie pomorskim
PublicationCelem artykułu jest przedstawienie strategii i planów działań w obszarze rynku pracy przygotowanych przez władze samorządowe województwa pomorskiego.. Władze regionalne i lokalne województwa pomorskiego opracowały szereg dokumentów wytyczających główne kierunki polityki rynku pracy. Najważniejsze z nich to „Strategia rozwoju województwa pomorskiego do roku 2020” oraz „Regionalny Plan Działań na Rzecz Zatrudnienia dla województwa...
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The Efficiency of Polish Stock Market: Ordinal Patterns Approach
PublicationZunino et al. analyzed the problem of discrimination of developed and emergent markets by the use of ordinal patterns methods: number of forbidden patterns and ordinal pattern probability distribution as a basis for entropy and statistical measure of complexity. In this paper we apply the same methodology for the analysis of Polish stock market (index WIG). The results indicate that Polish market belongs neither to developed, nor...
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Polish FDI in Central Asian Countries
PublicationSince gaining independence, Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan and Uzbekistan gradually opened their markets to foreign investors. Before Poland’s accession to the European Union, the activities of Polish investors in Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan and Uzbekistan were based on bilateral treaties concluded by Poland with those countries. Later, except Turkmenistan, they were governed by the partnership...
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Synthesis of green benzamide-decorated UiO-66-NH2 for biomedical applications
PublicationMetal-organic frameworks (MOFs) biocompatible systems can host enzymes/bacteria/viruses. Herein we synthesized a series of fatty acid amide hydrolase (FAAH)-decorated UiO-66-NH2 based on Citrus tangerine leaf extract for drug delivery and biosensor applications. Five chemically manipulated FAAH-like benzamides were localized on the UiO-66-NH2 surface with physical interactions. Comprehensive cellular and molecular analyses were...
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On the hardness of computing span of subcubic graphs
PublicationIn the paper we study the problem of finding ξ-colorings with minimal span, i.e. the difference between the largest and the smallest color used.
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A decentralised model of the regulating ancillary services market
PublicationThe article presents a model of regulating ancillary services provision in a dencetralised manner. A concept of the operation of local markets for ancillary services is presented.
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Social development and ICT adoption. Recent evidence from developing world
PublicationThis paper is designed to provide empirical evidence on the relationship between the process of ICT diffusion and social development across selected low-income and lowermiddle- income countries during the period of 2000 and 2014. It main target it so identify whether in low-income and lower-middle-income economies, ICT development and social development (social empowerment) are correlated.
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Evaluation of antimicrobial activities of powdered cuttlebone against Klebsiella oxytoca, Staphylococcus aureus, and Aspergillus flavus
PublicationBackground: The presence of medicines in the environment is considered as a serious threat to the human health. The entrance of these substances into the water sources causes soil pollution, which eventually leads to the environmental pollution and it creates some problems for the public health. Also, increasing antibiotic resistant bacteria has attracted the attention of researchers to the use of natural resources such as marine...
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Antibiotic-sterol interactions provide insight into the selectivity of natural aromatic analogues of amphotericin B and their photoisomers
PublicationAromatic heptaene macrolides (AHMs) belong to the group of polyene macrolide antifungal antibiotics. Members of this group were the first to be used in the treatment of systemic fungal infections. Amphotericin B (AmB), a non-aromatic representative of heptaene macrolides, is of significant clinical importance in the treatment of internal mycoses. It includes the all-trans heptaene chromophore, whereas the native AHMs contain two...
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Charakterystyka energetyczna budynków mieszkalnych wielorodzinnych w perspektywie wymagań 2017-2021
PublicationOpracowanie zawiera analizę charakterystyki energetycznej przykładowego budynku mieszkalnego wielorodzinnego przeprowadzoną w perspektywie wymagań 2017-2021 r. Wskazano w niej elementy mające wpływ na zapotrzebowanie budynku na energię użytkową, końcową i nieodnawialną energię pierwotną (wskaźnik EP). Zidentyfikowano jednocześnie możliwe problemy ze spełnieniem wymagań określonych w przepisach techniczno-budowlanych oraz wskazano...
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Properties and determination of pesticides in fruits and vegetables
PublicationThe intensive development of agriculture means that more and more toxic organic and inorganic compounds are entering theenvironment. Because of their widespread use, stability, selective toxicity and bioaccumulation, pesticides are among the mosttoxic substances contaminating the environment. They are particularly dangerous in fruit and vegetables, by which people areexposed to them. It is therefore crucial to monitor pesticide...
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Pulsed Laser Deposition of Bismuth Vanadate Thin Films—The Effect of Oxygen Pressure on the Morphology, Composition, and Photoelectrochemical Performance
PublicationThin layers of bismuth vanadate were deposited using the pulsed laser deposition technique on commercially available FTO (fluorine-doped tin oxide) substrates. Films were sputtered from a sintered, monoclinic BiVO4 pellet, acting as the target, under various oxygen pressures (from 0.1 to 2 mbar), while the laser beam was perpendicular to the target surface and parallel to the FTO substrate. The oxygen pressure strongly affects...
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Role of methylation in electron scattering on X(CH3)4 (X = C, Si, Ge) molecules
PublicationTotal cross sections (TCS) for low-energy electron scattering from X(CH3)4 (where X = C, Si, Ge) molecules have been measured using linear transmission method. Present results and those obtained previously for XH4 molecules were used to determine how methylation of the target is reflected in TCS energy dependence.
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IT Business Standards as an Ontology Domain
PublicationThe aim of this paper is to report a selection of Semantic Web aspects pertaining to ontology development activities in the domain of the IT business standard (TOGAF 9) such as formulating competency questions, conceptualization of the domain, resolution of the source knowledge deficiency and applying common design patterns in the OWL formalization. Authors also try to determine target groups that may benefit from such ontology...
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Analiza i badania systemu antyspoofingowego GPS
PublicationArtykuł dotyczy problemu spoofingu w systemie GPS, polegającego na niepowołanej transmisji sygnałów imitujących sygnały odbierane z satelitów GPS. Takie działanie prowadzi do wyznaczenia przez odbiornik nawigacyjny nieprawidłowego położenia, prędkości i czasu. Zostały opisane metody przeciwdziałania spoofingowi, w szczególności poprzez przestrzenne przetwarzanie sygnałów. Przedstawiono wyniki badań symulacyjnych efektywności tych...
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Computed vibrational excitation ofCF4by low-energy electrons and positrons: Comparing calculations and experiments
PublicationQuantum calculations for the excitation of the asymmetric modes of the CF4 target gas, ν3 and ν4, by impact of low-energy electrons and positrons are carried out in the energy range around 1 eV and are compared with recent experimental findings. The similarities and differences between the two types of projectiles, and the two different modes, are analyzed and discussed vis à vis the present accord with the experimental results.
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Central and Eastern European States from an International Perspective: Economic Potential and Paths of Participation in Global Value Chains
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Implementation mechanism of impact investing in the post-conflict regions
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The (lack of) momentum effect in the UAE stock market
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A note on value investing in the UAE stock market
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Is there a low-risk anomaly in the UAE stock market?
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Air temperature and sovereign bond returns
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An Application of Factor Pricing Models to the Polish Stock Market
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The Impact of Trade Integration with the European Union on Productivity in a Posttransition Economy: The Case of Polish Manufacturing Sectors
PublicationThis paper addresses the relationship between productivity growth in Polish manufacturing sectors and forces stemming from trade integration with the European Union. Empirical analysis (1995-2006) is based on sector-level bilateral data concerning both domestic (Polish) and foreign (partner countries from the enlarged European Union) markets' characteristics and their degree of openness. The main results indicate that, both in...