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Search results for: in vitro biodegradation
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Identification of antigen Ag43 in uropathogenic Escherichia coli Dr+ strains and defining its role in the pathogenesis of urinary tract infections
PublicationUrinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are among the most common bacterial infectious diseases in the developed world. The urovirulence of UPEC is mainly associated with the surface-exposed fimbrial adhesins and adhesins of the autotransporter (AT) family. The best studied of theses proteins is antigen 43 (Ag43) mediating cell aggregation, adhesion and biofilm development as the causes of...
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Amberlyst-15 catalysed synthesis of novel indole derivatives under ultrasound irradiation: Their evaluation as serotonin 5‑HT2C receptor agonists
PublicationA series of indole based novel Schiff bases was designed as potential agonists of 5‑HT2C receptor that was supported by docking studies in silico. These compounds were synthesized via Amberlyst-15 catalysed condensation of an appropriate pyrazole based primary amine with the corresponding indole-3-aldehyde under ultrasound irradiation at ambient temperature. A number of target Schiff bases were obtained...
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Encapsulation of Amikacin into Microparticles Based on Low-Molecular-Weight Poly(lactic acid) and Poly(lactic acid-co-polyethylene glycol)
PublicationThe aim of this study was to fabricate novel microparticles (MPs) for efficient and long-term delivery of amikacin (AMI). The emulsification method proposed for encapsulating AMI employed low-molecular-weight poly(lactic acid) (PLA) and poly(lactic acid-co-polyethylene glycol) (PLA−PEG), both supplemented with poly(vinyl alcohol) (PVA). The diameters of the particles obtained were determined as less than 30 μm. Based on an in-vitro...
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Projektowanie, synteza oraz badanie aktywności biologicznej amidosiarczanowych inhibitorów sulfatazy steroidowej zawierających w swojej konstytucji ugrupowania fosforowe lub wiązania C-F
PublicationWedług Światowej Organizacji Zdrowia (WHO) estrogeny są jednymi z głównych czynników stymulujących wzrost nowotworów hormonozależnych. Dlatego też, projektowanie oraz synteza nowych, skuteczniejszych środków wpływających na biosyntezę estrogenów stanowi ogromne wyzwanie dla współczesnej medycyny. W ostatnich latach liczne ośrodki naukowe na całym świecie prowadzą intensywne badania związane z poszukiwaniem nowych, skutecznych inhibitorów...
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Nowe estrowe i amidowe pochodne inhibitorów syntazy glukozamino-6-fosforanu - synteza i aktywność biologiczna
PublicationPrzedmiotem rozprawy doktorskiej są modyfikacje chemiczne analogów glutaminy – kwasu N3-(4-metoksyfumaroilo)-S-2,3-diaminopropanowego (FMDP) oraz kwasu N3-[(E)-4-fenylo-4-okso-2-butenoilo]-S-2,3-diaminoaminopropanowego (BADP). Związki te są inhibitorami syntazy glukozamino-6-fosforanu i mimo ich silnych właściwości inhibicyjnych, nie wykazują zdolności do hamowania wzrostu drobnoustrojów. Brak aktywności przeciwdrobnoustrojowej...
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SOILPROM Modelling pollutant transport across the soil-water-atmosphere continuum, and impacts on ecosystem services
ProjectsProject realized in Department of Geotechnical and Hydraulic Engineering according to 101156589 - SOILPROM - HORIZON-MISS-2023-SOIL-01 agreement from 2024-05-17
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Distant Non-Obvious Mutations Influence the Activity of a Hyperthermophilic Pyrococcus furiosus Phosphoglucose Isomerase
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3. E-TECH: Online education in practice for teachers. Advanced
e-Learning CoursesTo enroll to this course please write an e-mail at: alina.guzik@pg.edu.pl
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2 - E-TECH: Online education in practice for teachers. Intermediate
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[ILiT, IŚGiE] Process engineering in circular economy 20/21 Summer
e-Learning CoursesKurs jest przeznaczony dla doktorantów szkoły doktorskiej w dyscyplnach: inżynieria lądowa i transport (SzD), III stopnia, stacjonarne inżynieria środowiska, górnictwo i energetyka (SzD), III stopnia, stacjonarne The course is addressed to PhD students of the doctoral school in disciplines: civil engineering and transport environmental engineering, mining and power engineering Course type: lecture Total hours of...
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1 - E-TECH: Online education in practice for teachers. Foundations
e-Learning CoursesThis module has been designed to help teachers to get the very best out of online learning education. We've created it to support many aspects of your learning online. The aim is to provide skills to create and engage with your teaching materials online. After completion the course you can download your Certifacte.
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[Soft Skills] 2022 Didactic methods in the modern teaching process
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NEW AND FAST ANALYTICAL TECHNIQUES IN FOOD QUALITY ANALYSIS 2024
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[NCh, ICh] Physical Chemistry of Organic Compounds in Natural Waters
e-Learning Courses{mlang pl} Dyscyplina: Nauki chemiczne Zajęcia obieralne dla doktorantów Prowadzący: prof. dr hab. Tadeusz Górecki Liczba godzin: 15 {mlang} {mlang en} Discipline: Chemical science Elective course for PhD students Academic teacher: prof. dr hab. inż. Tadeusz Górecki Total hours of training: 15 teaching hours {mlang}
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Safety and risk in transportation systems - summer semester 2023/2024
e-Learning CoursesPodstawy teorii bezpieczeństwa i ryzyka w kontekście aplikacji w systemach transportowych.
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Source and Channel Coding in Radio Communication Systems 2023/2024
e-Learning CoursesKurs służy jako narzędzie pomocnicze do realizacji przedmiotu.
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Design of measurement systems in integrated programming environments [2024/25]
e-Learning CoursesThe winter school on "Design of Measurement Systems in Integrated Programming Environments" as a part of the educational offering of the INNOVATIVE LEARNING CAMPUS within the ENHANCE+ Alliance.
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White light thermoplasmonic activated gold nanorod arrays enable the photo-thermal disinfection of medical tools from bacterial contamination
PublicationThe outspread of bacterial pathogens causing severe infections and spreading rapidly, especially among hospitalized patients, is worrying and represents a global public health issue. Current disinfection techniques are becoming insufficient to counteract the spread of these pathogens because they carry multiple antibiotic-resistance genes. For this reason, a constant need exists for new technological solutions that rely on physical...
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Hazard assessment of sediments from a wetland system for treatment of landfill leachate using bioassays
PublicationFour bioassays were used in this study for the hazard assessment of sediments from sediment traps and several ponds in a treatment wetland for landfill leachate at Atleverket, Sweden. In the 6-day solid phase microbiotest with the sediment-dwelling crustacean Heterocypris incongruens both acute and chronic effects were observed with a gradual decrease and loss of toxicity with treatment in the wetland system. Some samples showed...
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Emerging anticancer activity of candidal glucoseamine-6-phosphate synthase inhibitors upon nanoparticle-mediated delivery
PublicationNumerous glutamine analogues have been reported as irreversible inhibitors of the glucosamine-6-phosphate (GlcN-6-P) synthase in pathogenic Candida albicans in the last 3.5 decades. Among the reported inhibitors, the most effective N3-(4-methoxyfumaroyl)-L-2,3- diaminopropanoic acid (FMDP) has been extensively studied in order to develop its more active analogues. Several peptide−FMDP conjugates were tested to deliver FMDP to its...
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Novel 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives as potent anticancer agents – Synthesis, molecular structure, QSAR studies and metabolic stability
PublicationA series of new 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives have been synthesized and evaluated in vitro by MTT assays for their antiproliferative activity against cell lines of colon cancer HCT-116, cervical cancer HeLa and breast cancer MCF-7. The obtained results indicated that these compounds display prominent cytotoxic effect. The best anticancer properties have been observed for derivatives...
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Multiple transcriptional factors regulate transcription of the rpoE gene in Escherichia coli under different growth conditions and when the lipopolysaccharide biosynthesis is defective.
PublicationThe RpoE sigma factor is essential for the viability of Escherichia coli. RpoE regulates extracytoplasmic functions including lipopolysaccharide (LPS) translocation and some of its non-stoichiometric modifications. Transcription of the rpoE gene is positively autoregulated by EσE and by unknown mechanisms that control the expression of its distally located promoter(s). Mapping of 5′ ends of rpoE mRNA identified five new transcriptional...
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Imidazoacridinone antitumor agent C-1311 as a selective mechanism- based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes.
Publication5-Diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311), a promising antitumor agent that is also active against autoimmune diseases, was determined to be a selective inhibitor of the cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1311 might modulate the effectiveness of other drugs used in multidrug therapy. The present work aimed to identify the mechanism of the observed C-1311-mediated inactivation of CYP1A2...
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Genetic Determinants and Biofilm Properties Useful in Estimation of UTI Pathogenicity of the Escherichia coli Strains Isolated from Free-Living Birds
PublicationBackground/Objectives: According to the One Health concept, wild birds can be indicators of ecosystem pollution and disease incidence. Escherichia coli strains are widespread worldwide, but there are still few reports on the association of human infections with a potential reservoir of highly pathogenic human strains in wild birds. Fecal E. coli with uropathogenic potential (UPEC) can be transmitted between birds and humans and...
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A mechanistically approached review upon assorted cell lines stimulated by athermal electromagnetic irradiation
PublicationThe probable influence of electromagnetic irradiation on cancer treatment has been deduced from the interaction of artificial electromagnetic emissions with biological organisms. Nonetheless, the suspected health effects induced by electromagnetic-based technology imply that such a treatment may contaminate the adjacent healthy cells. Thus, gaining mechanistic insights into the problem is required to avoid athermal health hazards....
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Teloxantron inhibits the processivity of telomerase with preferential DNA damage on telomeres
PublicationTelomerase reactivation is one of the hallmarks of cancer, which plays an important role in cellular immortalization and the development and progression of the tumor. Chemical telomerase inhibitors have been shown to trigger replicative senescence and apoptotic cell death both in vitro and in vivo. Due to its upregulation in various cancers, telomerase is considered a potential target in cancer therapy. In this study, we identified...
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Determination of estrogenic endocrine disruptors in environmental samples - a review of chromatographic methods
PublicationWśród związków endokrynnych to estrogeny zarówno naturalne jak i syntetyczne zostały wskazane i opisane jako związki niosące ze sobą największy potencjał aktywności estrogennej. Wysoki potencjał estrogenny jaki posiadają związki z grupy hormonów płciowych potwierdziły badania przeprowadzone zarówno in vitro jak i in vivo. W dużej części (50-95%) próbek ścieków pochodzących z oczyszczalni ścieków zostały wykryte związki z grupy...
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Essential Oils, Silver Nanoparticles and Propolis as Alternative Agents Against Fluconazole Resistant Candida albicans, Candida glabrata and Candida krusei Clinical Isolates
PublicationDevelopment of effective and safe therapeutic treatment of fungal infections remains one of the major challenge for modern medicine. The aim of presented investigation was to analyze the in vitro antifungal activity of selected essential oils, ethanolic extracts of propolis and silver nanoparticles dropped on TiO2 against azole-resistant C. albicans (n = 20), C. glabrata (n = 14) and C. krusei (n = 10) clinical isolates. Among...
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LC–MS/MS analysis, antioxidant and anticholinergic properties of galanga (Alpinia officinarum Hance) rhizomes
PublicationGalanga (Alpinia officinarum Hance) is a pungent and aromatic rhizome, which is a member of the ginger family (Zingiberaceae). The rhizomes of this plant have been used as a traditional medicine in far east countries for relieving stomach ache, invigorating the circulatory system, treating colds, and reducing swelling. The aim of this study was to investigate antioxidant and anticholinergic properties of galanga. For this purpose,...
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Nutritional and Pharmaceutical Properties of Bioactive Compounds in Organic and Conventional Growing Kiwifruit
PublicationThe bioactivity of two kiwifruit’s cultivars growing under organic and conventional conditions were studied and compared. The bioactive compounds were extracted with water and ethanol using similar conditions which are applied in pharmaceutical applications and for daily fruit consumption such as tea drink. Antioxidant radical scavenging assays [ferric-reducing/antioxidant power (FRAP); cupric reducing antioxidant capacity (CUPRAC);...
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Honey antibacterial activity: A neglected aspect of honey quality assurance as functional food
PublicationBackground Honey is considered as a functional food with health-promoting properties. Its potent antibacterial and antibiofilm effects are the major attributes of so called ‘medical-grade honey’ which is topically used for the treatment of burns, wounds and skin disorders. Nevertheless, the current set of honey quality parameters adopted in the European Union do not include its biological properties. Furthermore, in light of the...
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Processing of Polyester-Urethane Filament and Characterization of FFF 3D Printed Elastic Porous Structures with Potential in Cancellous Bone Tissue Engineering
PublicationThis paper addresses the potential of self-made polyester-urethane filament as a candidate for Fused Filament Fabrication (FFF)-based 3D printing (3DP) in medical applications. Since the industry does not provide many ready-made solutions of medical-grade polyurethane filaments, we undertook research aimed at presenting the process of thermoplastic polyurethane (TPU) filament formation, detailed characteristics, and 3DP of specially...
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Development of a Peptide Derived from Platelet-Derived Growth Factor (PDGF-BB) into a Potential Drug Candidate for the Treatment of Wounds
PublicationObjective: This study evaluated the use of novel peptides derived from platelet-derived growth factor (PDGF-BB) as potential wound healing stimulants. One of the compounds (named PDGF2) was subjected for further research after cytotoxicity and proliferation assays on human skin cells. Further investigation included evaluation of: migration and chemotaxis of skin cells, immunological and allergic safety, the transcriptional analyses...
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Ensembling noisy segmentation masks of blurred sperm images
PublicationBackground: Sperm tail morphology and motility have been demonstrated to be important factors in determining sperm quality for in vitro fertilization. However, many existing computer-aided sperm analysis systems leave the sperm tail out of the analysis, as detecting a few tail pixels is challenging. Moreover, some publicly available datasets for classifying morphological defects contain images limited only to the sperm head. This...
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Selected topics in electrical engineering – modelling of, electrical machines [2021/22]
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CAD. Integrated Architectural Design BSc in Arch., sem 3 2022/2023
e-Learning CoursesDuring the course students will learn how to use BIM (Building Information Modelling) tools to model the project site and to develop preliminary design concept.Students will work in pairs or groups, using Autodesk Revit software for terrain, site and building modelling.
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Environmental Protection in Energetics, L, E, sem.01, zimowy 22/23
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Environmental Protection in Energetics, W, E, sem.01, zimowy 22/23
e-Learning CoursesThe principle of sustainable development. Non-renewable and renewable energy sources. Environmental aspects of the use of different energy sources. Atmospheric pollution. Methods of reducing the emission of pollutants into the atmosphere. Waste and hazardous waste. Water and Wastewater. Legal aspects of environmental protection.
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Supplementary Course in Higher Physics DPE tutorial (PG_00056611) zima 21/22
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Advances in materials engineering instrumentation: new trends and applications 2022/2023
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[Soft Skills] 2 YEAR Didactic methods in the modern teaching process
e-Learning Courses{mlang pl} Dyscyplina: wszystkie dyscypliny Zajęcia obowiązkowe dla doktorantów 2 roku Prowadząca: dr hab. Joanna Mytnik, prof. uczelni Liczba godzin: 15 Forma zajęć: warsztaty {mlang} {mlang en} Discipline: all disciplines Obligatory course for 2nd-year PhD students Academic teacher: Joanna Mytnik, Ph.D., ass. prof. Total hours of training: 15 teaching hours Course type: workshop {mlang} Soft skills, area I - didactic...
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Environmental Protection in Energetics, L, E, sem.1, zimowy 24/25
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[Soft Skills] Workshop in research ethics gr.2 AEEITK, ITIT, IMe
e-Learning Courses{mlang pl} Dyscyplina: Wszystkie dyscypliny Zajęcia obowiązkowe dla doktorantów III roku Prowadzący: A. Karalus Liczba godzin: 5 {mlang} {mlang en} Discipline: All disciplines Obligatory course for 3rd year PhD students Academic teacher: A. Karalus Total hours of training: 5 teaching hours {mlang}
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[Soft Skills] Workshop in research ethics gr.3 NCh, IMa, NF
e-Learning Courses{mlang pl} Dyscyplina: Wszystkie dyscypliny Zajęcia obowiązkowe dla doktorantów III roku Prowadzący: A. Karalus Liczba godzin: 5 {mlang} {mlang en} Discipline: All disciplines Obligatory course for 3rd year PhD students Academic teacher: A. Karalus Total hours of training: 5 teaching hours {mlang}
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Application of Mathematics in Technology, ET, sem 3, 23/24, (PG_00049767)
e-Learning CoursesApplication of Mathematics MOODLE ENV localdevtestprod
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Environmental Protection in Energetics, L, E, sem.1, zimowy 23/24
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DAYLIGHT IN ARCHITECTURE (Elective Project I: MSc term 1) - 23-24
e-Learning CoursesThe objectives of this course are: To familiarize students with the role and importance of daylight in shaping building spaces and interiors. To learn about the basics of daylight simulations in the context of complex design decisions and for LEED and BREEAM, integrated design purposes. Proposed assignments 1 & 2: 1. Daylight analysis exterior, the interior of the iconic building (sunlight provision, daylight factor, and...
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Elective design I: Waterfront Areas in a Changing Climate – Solutions for Gdańsk
e-Learning CoursesElective design I:Waterfront Areas in a Changing Climate – Solutions for Gdańsk for MSc in Arch. Seminars & assignments: 30 hTeacher: Lucyna Nyka, Jakub Szczepański, Justyna Borucka + assist. teacher from Gdańsk Tech Waterfront Areas in a Changing Climate – Solutions for Gdańsk – This course explores challenges, conflicts and concepts in waterfront areas, their connection to architectural and urban design in the time of...
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XII edition – 2019-21, International MBA in Strategy, Programme and Project Management
e-Learning Courses