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Quantification of unconjugated and total ibuprofen and its metabolites in equine urine samples by gas chromatography–tandem mass spectrometry: Application to the excretion study
PublikacjaIbuprofen (IBU) is a widely used nonsteroidal anti-inflammatory drug (NSAID) in human and also veterinary medicine. NSAIDs are usually highly metabolized compounds in horses; they are often present in equine urine, mostly in their conjugated forms (glucuronides). Thus, hydrolysis to cleave the glucuronide linkage prior to anti-doping analysis is often necessary for improving detection. In this study, unconjugated and total IBU...
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Improved cytotoxicity and preserved level of cell death induced in colon cancer cells by doxorubicin after its conjugation with iron-oxide magnetic nanoparticles
PublikacjaA promising strategy for overcoming the problem of limited efficacy in antitumor drug delivery and in drug release is the use of a nanoparticle-conjugated drug. Doxorubicin (Dox) anticancer chemotherapeutics has been widely studied in this respect, because of severe cardiotoxic side effects. Here, we investigated the cytotoxic effects, the uptake process, the changes in cell cycle progression and the cell death processes in the...
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The influence of ILs on TiO2 microspheres activity towards 5-FU removal under artificial sunlight irradiation
PublikacjaIn this work, the effect of various ionic liquids (ILs), namely, choline chloride [Chol][Cl], hexadecylpyridynium chloride [HDPy][Cl], and tributylmethylammonium chloride [TBMA][Cl], on the morphology, surface compo-sition in relation to photocatalytic oxidation of 5-fluorouracil (5-FU) and phenol in the presence of TiO2 pho-tocatalysts under artificial sunlight conditions was investigated. The highest photoactivity towards cytostatic...
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Platforma IPMed jako elastyczne źródło danych dla medycznych zespołów naukowych
PublikacjaPrzedstawiono architekturę rozproszonej platformy IPMed, która umożliwia akwizycję i przechowywanie zanonimizowanych danych medycznych. Pokazano wyniki zastosowania platformy w obszarze badań z zakresu hemodynamiki układu krążenia. Uzyskane dane pozwoliły na weryfikację hipotezy zespołu badawczego i określenie reguł rekomendacji w z leczeniu udarów.
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Modernized cathodic protection system for legs of the production rig – Evaluation during ten years of service
PublikacjaThe modernization of cathodic protection system of the Baltic Beta platform legs is described. It was that the sacrificial anodes cone-shaped groups were to be placed on the seabed at a depth of 80 m. The measurements results of cathodic protection effectiveness during its ten-years operation are presented. The effectiveness was assessed based on the potential value along the entire length of the legs from the sea surface to the...
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Comparative molecular modelling of biologically active sterols
PublikacjaMembrane sterols are targets for a clinically important antifungal agent – amphotericin B. The relatively specific antifungal action of the drug is based on a stronger interaction of amphotericin B with fungal ergosterol than with mammalian cholesterol. Conformational space occupied by six sterols has been defined using the molecular dynamics method to establish if the conformational features correspond to the preferential interaction...
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Synthesis of disubstituted 1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acids derivatives
Publikacja1,3,4,9-tetrahydropyrano[3,4-b ]indole-1-acetic acid derivatives are of interest for pharmaceutical research as a core structure for synthesis of biological active substance - Etodolac (selective Cyclooxygenase-2 inhibitor, which belongs to the Non-steroidal Anti-inflammatory Drug, NSAID, that shows a clin-ically effective analgesic and anti-inflammatory activity). Here the way of synthesis of two 1,3,4,9-tetrahydropyrano[3,4-b...
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Graphene Production and Biomedical Applications: A Review
PublikacjaGraphene is a two-dimensional nanomaterial composed of carbon atoms with sp2 hybrid orbitals. Both graphene and graphene-based composite have gained broad interest among researchers because of their outstanding physiochemical, mechanical, and biological properties. Graphene production techniques are divided into top-down and bottom-up synthesis methods, of which chemical vapor deposition (CVD) is the most popular. The biomedical...
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Technical Engine for Democratization of Modeling, Simulations, and Predictions
PublikacjaComputational science and engineering play a critical role in advancing both research and daily-life challenges across almost every discipline. As a society, we apply search engines, social media, and se- lected aspects of engineering to improve personal and professional growth. Recently, leveraging such aspects as behavioral model analysis, simulation, big data extraction, and human computation is gain- ing momentum. The nexus...
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Wykorzystanie technologii cienkiego klienta w systemie informacyjnym GDASKON
PublikacjaReferat ten przedstawia propozycję adaptacji technologii cienkiego klienta do potrzeb systemu GDASKON. Propozycja ta obejmuje dwie platformy: prostszą odpowiadającą telefonom komórkowym oraz bardziej złożoną dotyczącą palmtopów. W przypadku pierwszej z platform założono, iż na wyświetlaczu telefonu komórkowego prezentowana jest jedynie informacja tekstowa, co wymusza odrzucenie generowanej przez system GDASKON informacji graficznej...
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Thermodynamics aspects of interactions between acridine derivatives and DNA
PublikacjaDNA is a molecular target for many anticancer and antiviral drugs. Therefore, a clear understanding of the interaction of small molecules with DNA is important in the rational design of ligands that can bind to DNA with high affinity and selectivity. There are several methods to investigate interactions between drug and DNA. Some of them measure changing into DNA structures, such as lengthening and untwisting of helix of DNA. Other...
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Quantum Dots as a Good Carriers of Unsymmetrical Bisacridines for Modulating Cellular Uptake and the Biological Response in Lung and Colon Cancer Cells
PublikacjaNanotechnology-based drug delivery provides a promising area for improving the efficacy of cancer treatments. Therefore, we investigate the potential of using quantum dots (QDs) as drug carriers for antitumor unsymmetrical bisacridine derivatives (UAs) to cancer cells. We examine the influence of QD–UA hybrids on the cellular uptake, internalization (Confocal Laser Scanning Microscope), and the biological response (flow cytometry...
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A rapid and sensitive method for the quantitative analysis of ibuprofen and its metabolites in equine urine samples by gas chromatography-tandem mass spectrometry
PublikacjaIbuprofen is widely used in human and veterinary medicine for the treatment of chronic pain as well as rheumatic and musculoskeletal disorders. However, t he anal- gesic and anti-inflammatory properties of Ibuprofen have contributed to frequent drug abuse in equestr ian s ports. A sensitive and rapid gas chromatography with tandem mass spectrometry based method with a simple liquid-liquid extraction and deriva- tization requiring...
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Naturally-derived hydrogels for 3D pancreatic tumor models: A short review
PublikacjaStatistics suggest a high proportion of mortality rate by pancreatic cancer, which is a solid tumor characterized by high heterogeneity and the presence of a complex extracellular matrix. The very low effectiveness of pancreatic cancer treatment roots in the high metastatic potential and drug resistance of this tumor. Therefore, the quest for efficient cellular models enabling precise mimicking in vivo conditions, and anticancer...
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Systemidentificationbasedapproachtodynamicweighing revisited
PublikacjaDynamicweighing,i.e.,weighingofobjectsinmotion,withoutstoppingthemonthe weighing platform,allowsonetoincreasetherateofoperationofautomaticweighing systems, usedinindustrialproductionprocesses,withoutcompromisingtheiraccuracy. Sincetheclassicalidentification-basedapproachtodynamicweighing,basedonthe second-ordermass–spring–dampermodeloftheweighingsystem,doesnotyieldsa- tisfactoryresultswhenappliedtoconveyorbelttypecheckweighers,severalextensionsof thistechniqueareexamined.Experimentsconfirmthatwhenappropriatelymodifiedthe identification-basedapproachbecomesareliabletoolfordynamicmassmeasurementin checkweighers.
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Zastosowanie geosyntetyków do tymczasowego wzmocnienia podłoża pod ciężki sprzęt budowlany
PublikacjaW pracy omówiono zagadnienia dotyczące wykonawstwa i projektowania tymczasowego powierzchniowego wzmocnienia podłoża, pod ciężki sprzęt budowlany, w postaci platform roboczych z zastosowaniem zbrojenia geosyntetycznego.
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Recent breakthroughs in the stability testing of pharmaceutical compounds
PublikacjaPharmaceutical development is mostly focused on the research leading to approval of a new and viable active substance. However, there is a number of old generation compounds that are still being used in contemporary medicinal practice. So that new analytical developments should cover not only the safety of newly developed drug substances, which is obvious, but should also be directed into the search of individual stability issues...
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Badanie wpływu przydziału rdzeni procesora na wydajność w środowisku skonteneryzowanym oparte na wybranym serwerze warstawy pośredniej w IoT - obserwacje i rekomendacje
PublikacjaInternet Rzeczy cieszy się coraz większym zainteresowaniem. Za- gadnienie to jest szeroko omawiane zarówno w środowisku nauko- wym, jak i w przemyśle. Ze względu na jego wielowymiarowość jest wiele aspektów, które wymagają zbadania i obserwacji. Jednym z nich jest efektywne wdrożenie i uruchomienie aplikacji w kontekście wykorzystania zasobów sprzętowych. Innym, równie istotnym, za- gadnieniem jest konteneryzacja platform IoT....
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MONITORING SYSTEM OF THE ROAD EMBANKMENT
PublikacjaThe paper presents the analysis of the monitoring system of the embankment supported on concrete columns and overlaid by a load transfer platform with the embedded steel grid. This field investigation was to study the complex interaction among the columns, the load transfer platform layer, and steel grid via in situ measurements during erection and live loading of the embankment. The study was focused on the behaviour of steel...
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Projektowanie konstrukcji tymczasowych służących wsparciu ciężkiego sprzętu do modyfikacji podłoża gruntowego
PublikacjaTymczasowe konstrukcje wzmacniające, tzw. platformy robocze, umożliwiają bezpieczne poru-szanie się oraz operowanie sprzętem do modyfikacji słabonośnego podłoża gruntowego. W Polsce nie istnieją żadne poradniki ani zbiory zaleceń dotyczące wykonawstwa platform roboczych. Natomiast projektów nie wykonuje się w ogóle. Obecnie dostępne są dwie metody projektowe - jedna oparta na kącie strefy oddziaływania obciążeń oraz druga, bazująca...
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THE ONLINE APPLICATION AND E-LEARNING IN THE COMPETENCE-BASED MANAGEMENT IN PUBLIC ADMINISTRATION ORGANIZATIONS
PublikacjaThe integration of effective management of work-related processes and utilization of human resources potential leads to the development of organization. The purpose of this paper was to examine how the principles of competences-based management can be introduced to enhance organization’s effectiveness in human resources management. A model of assessment and development of competences-based management, embracing an online application...
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An application of acoustic sensors for the monitoring of road traffic
PublikacjaAssessment of road traffic parameters for the developed intelligent speed limit setting decision system constitutes the subject addressed in the paper. Current traffic conditions providing vital data source for the calculation of the locally fitted speed limits are assessed employing an economical embedded platform placed at the roadside. The use of the developed platform employing a low-powered processing unit with a set of microphones,...
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Zastosowanie geosyntetyków w platformach roboczych i drogach tymczasowych
PublikacjaW artykule przedstawiono zagadnienia projektowania i budowy platform roboczych i dróg tymczasowych. Zaprezentowano aktualne podejście projektowe oraz nową metodę obliczeniową, uwzględniającą wykorzystanie georusztów do stabilizacji warstw kruszywa niezwiązanego.
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Does the chemical modification of Nystatin A1 affect the drug's ability to overcome the multidrug resistance of fungi?
PublikacjaAlthough the contemporary medicine keeps moving forward, disseminated infections caused by fungal pathogens are an emerging challenge. The dramatic rise of fungal diseases, especially the most life-threatening systemic mycoses is associated with a permanently growing number of immunodeficient patients. Undoubted difficulties in the treatment of fungal infections are caused by lack of highly effective and selective antifungal drugs,...
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Electrochemistry/mass spectrometry (EC/MS) for fast generation and identification of novel reactive metabolites of two unsymmetrical bisacridines with anticancer activity.
PublikacjaThe development of a new drug requires knowledge about its metabolic fate in a living organism, regarding the comprehensive assessment of both drug therapeutic activity and toxicity profiles. Electrochemistry (EC) coupled with mass spectrometry (MS) is an efficient tool for predicting the phase I metabolism of redox-sensitive drugs. In particular, EC/MS represents a clear advantage for the generation of reactive drug transformation...
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Synthesis, characterization, and interactions of single-walled carbon nanotubes modified with doxorubicin with Langmuir–Blodgett biomimetic membranes
PublikacjaThe synthesis, characterization, and the influence of single-walled carbon nanotubes (SWCNTs) modified with an anticancer drug doxorubicin (DOx) on the properties of model biological membrane as well as the comparison of the two modes of modification has been presented. The drug was covalently attached to the nanotubes either preferentially on the sides or at the ends of the nanotubes by the formation of hydrazone bond. The efficiency...
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Aplikacje i środowiska kontekstowe: Aplikacje internetowe na platformie Eclipse
PublikacjaPrzedstawiono problematykę tworzenia aplikacji internetowych na platformie Eclipse. Został omówiony standard OSGi, który jest podstawą działania i implementacji Eclipse oraz aspekty OSGi związane z komunikacją internetową. Przedstawiono istniejace frameworki w środowisku Eclipse, które umożliwiają rozwój aplikacji internetowych. Głównymi kierunkami rozwoju frameworków są: IDE do wytwarzania aplikacji oraz integracja platformy Eclipse...
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A modern approach to an unmanned vehicle navigation
PublikacjaA traditional approach to manned vehicles navigation uses a data combined form a variety of navigation sensors like satellite, inertial and time-of-flight. With support of operators perception, chart and sensor, data are analyzed and navigation decisions are made. An unmanned platforms navigation needs an operators support, who is supervising a platforms decision process, basing on navigation data obtained via variety of electronic...
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Semi complex navigation with an active optical gesture sensor
PublikacjaThis paper presents the methods of diversified touchless interactions between a user and a mobile platform utilizing the optical gesture sensor. The sensor uses 8 photodiodes to measure the reflected light in the active mode (using embedded LEDs) or it measures shadows caused by fingers in the passive mode. Several algorithms were implemented: automatic mode switching, adaptive illumination level compensation, resolution improvements...
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ИНФОРМАЦИОННО-АНАЛИТИЧЕСКАЯ СИСТЕМА ДЛЯ КОМПЛЕКСНОГО ГРАДОСТРОИТЕЛЬНОГО АНАЛИЗА
Publikacjaстатье приводится описание программного инструмента, предназначенного для анализа пространственных данных с использованием BI-платформы нового поколения PROGNOZ PLATFORM (РР). Описывается структура хранилища данных, подсистемы мониторинга, моделирования, аналитики и прогнозирования. Приводится набор тестовых параметров и примеры интерфейса Информационно-аналитической системы (ИАС), построенной на основе ГИС и PROGNOZ PLATFORM (РР),...
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Self-Association of Amphotericin B: Spontaneous Formation of Molecular Structures Responsible for the Toxic Side Effects of the Antibiotic
PublikacjaAmphotericin B (AmB) is a lifesaving antibiotic used to treat deep-seated mycotic infections. Both the pharmaceutical activity and highly toxic side effects of the drug rely on its interaction with biomembranes, which is governed by the molecular organization of AmB. In the present work we present detailed analysis of self-assembly of AmB molecules in different environments, interesting from the physiological standpoint, based...
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TWORZENIE TESTÓW Z MATEMATYKI Z WYKORZYSTANIEM PLATFORMY ENAUCZANIE
PublikacjaThe aim of the article is to present the use of the eNauczanie platform to create tests in mathematics after the first semester of mathematics at the Gdańsk University of Technology. Different types of questions will be discussed with special attention to questions that will allow to present mathematics content in an effective manner.
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MANAGING LEARNING PROCESS WITH E-LEARNING TOOL
PublikacjaThis article presents one possibility to employ Moodle, the free e-Leaning platform, to organize learning understood as a process. Behavioral approach and application to massive courses are assumed. A case study is presented, where the introduction of Moodle resulted in better student performance in homework
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Realizacja usług katalogowych i nazewniczych.
PublikacjaPrzedstawiono cechy charakterystyczne serwera usług katalogowych. Jako bazę do porównań różnych realizacji opisano założenia standardu CCITT X.500. Zaprezentowano i porównano współczesne technologie usług katalogowych i nazewniczych dla różnych platform systemowych.
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Analysis of server-side and client-side Web-GIS data processing methods on the example of JTS and JSTS using open data from OSM and geoportal
PublikacjaThe last decade has seen a rapid evolution of processing, analysis and visualization of freely available geographic data using Open Source Web-GIS. In the beginning, Web-based Geographic Information Systems employed a thick-client approach which required installation of platform-specific browser plugins. Later on, research focus shifted to platform-independent thin client solutions in which data processing and analysis was performed...
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Universal autonomous control and management system for multipurpose unmanned surface vessel
PublikacjaThe paper presents design, structure and architecture of the Universal Autonomous Control and Management System (UACAMS) for multipurpose unmanned surface vessel. The system was designed, installed and implemented on the multipurpose platform - unmanned surface vessel named HydroDron. The platform is designed to execute hydrographic survey missions with multi-variant configuration of the survey system (payload? ) including multi-beam...
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Recent advancements in LC‐MS based analysis of biotoxins: Present and future challenges
PublikacjaThere has been a rising concern regarding the harmful impact of biotoxins, source of origin, and the determination of the specific type of toxin. With numerous reports on their extensive spread, biotoxins pose a critical challenge to figure out their parent groups, metabolites, and concentration. In that aspect, liquid chromatography‐mass spectrometry (LC‐MS) based analysis paves the way for its accurate identification and quantification....
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Novel approach to interference analysis of glucose sensing materials coated with Nafion
PublikacjaA gold-based sensing platform, TiND | AuNP | Nafion, was prepared as an exemplary electrode material exhibiting a response to glucose in a neutral solution. The change of electrochemical properties after exposure to glucose and interference compounds such as vitamin C, glycine, urea, paracetamol and acetylsalicylic acid was tested.
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Przegląd budowy i funkcjonalności współczesnych bezzałogowych statków powietrznych do celów fotogrametrycznych
PublikacjaFotogrametria z lotniczych platform bezzałogowych rozumiana jako nowe narzędzie do wykonywania pomiarów łączy możliwości wykonywania pomiarów fotogrametrycznych naziemnych, lotniczych, a nawet suborbitalnych, stanowiąc jednocześnie niskobudżetową konkurencję dla klasycznej fotogrametrii lotniczej czy teledetekcji satelitarnej. W pracy przedstawiono podstawy budowy bezzałogowego statku powietrznego przeznaczonego do lotów fotogrametrycznych...
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Przegląd budowy i funkcjonalności współczesnych bezzałogowych statków powietrznych
PublikacjaFotogrametria z lotniczych platform bezzałogowych rozumiana jako nowe narzędzie do wykonywania pomiarów łączy możliwości wykonywania pomiarów fotogrametrycznych naziemnych, lotniczych, a nawet suborbitalnych, stanowiąc jednocześnie niskobudżetową konkurencję dla klasycznej fotogrametrii lotniczej czy teledetekcji satelitarnej. W pracy przedstawiono podstawy budowy bezzałogowego statku powietrznego przeznaczonego do lotów fotogrametrycznych...
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Model systemu sterowania małego obiektu bezzałogowego poruszającego się na powierzchni wody
PublikacjaW artykule przedstawiono koncepcję zastosowania innowacyjnych małych wielozadaniowych okrętów (platform) wraz z bezzałogowymi autonomicznymi obiektami wodnymi (bezzałogowe systemy morskie BSM). Połączenie możliwości innowacyjnych platform i bezzałogowych systemów morskich BSM umożliwia stworzenie bardzo innowacyjnego i efektywnego złożonego logistycznie systemu morskiego. W czasie badań przeprowadzono symulację zastosowania proponowanego...
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Technological and Media Platforms: Redefinition of Meanings as Symbolic Power over the Discourse
PublikacjaRedefining the meanings of such social terms as “likes” and “friends” on Facebook is a popular practice. In terms of consistency, the (auto)-redefinition of the term “platform” is itself particularly important from a media management perspective. The article proposes to consider the redefinition of meanings as a form of wielding non-transparent power over discourse. From this perspective, redefining a meaning is a form of holding...
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Determination of bromhexine and its metabolites in equine serum samples by liquid chromatography – Tandem mass spectrometry: Applicability to the elimination study after single oral dose
PublikacjaBromhexine (BH), expectorant used in the treatment of respiratory disorders associated with viscid or excessive mucus, is not permitted for use in the competing horse by many authorities in horseracing and Olympic disciplines. Metabolic studies are of the great importance in anti-doping field because they allow for updating the selection of the most appropriate markers for prohibited substances, such as metabolites present at higher...
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Pharmaceutical applications of surfactants
PublikacjaIn this study we focused on biological activity of various surfactants. According to our research, they con act both as carriers as well as therapeutic agents. Depending on their concentration, they can create different structures in a solution, which influence their properties. Liposomes have a significant role in drug delivery system. Surfactants in from of bilayer are analogous to natural biological cell membrane.
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Metody pomiarowe stosowane na platformach powietrznych w badaniach geologicznych
PublikacjaW pracy przedstawiono metody pomiarowe stosowane w pomiarach geologicznych z zastosowaniem platform powietrznych, takich jak samoloty, śmigłowce i bezpilotowe pojazdy (UVA). W wykrywaniu różnego rodzaju złóż bogactw mineralnych stosowana jest metoda magnetometryczna, elektromagnetyczna oraz grawimetryczna.
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Testbed for development and verification of hybrid localization systems
PublikacjaIn this paper a testbed for development and verification of hybrid localization systems is presented. It allows for systematic analysis of hybrid localization methods and speed up the development of new schemes. The proposed testbed platform is composed of subsystem for sequential data collection and testing infrastructure that can be used for investigating the localization mechanisms in controllable environment.
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Prolonged Quercetin Administration Diminishes the Etoposide-Induced DNA Damage in Bone Marrow Cells of Rats
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<p>Potential effects of microbial air quality on the number of new cases of diabetes type 1 in children in two regions of Poland: a pilot study</p>
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Potential of Liquid Biopsy in Papillary Thyroid Carcinoma in Context of miRNA, BRAF and p53 Mutation
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Environmental Phage-Based Cocktail and Antibiotic Combination Effects onAcinetobacter baumanniiBiofilm in a Human Urine Model
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