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Wyniki wyszukiwania dla: hormone-dependent cancer
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Multi-nodal PWR reactor model — Methodology proposition for power distribution coefficients calculation
PublikacjaIn the paper the multi-nodal Pressurized Water Reactor (PWR) model called Mann’s model is presented. This models is used for modelling purposes of the heat transfer from fuel to coolant in reactor core. The authors expand widely used in literature approach by defining additional coefficients for the heat transfer model. These parameters approximate the power generation distribution in the PWR reactor core according to the to the...
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Study on effective front region thickness of PCM in thermal energy storage using a novel semi-theoretical model
PublikacjaThermal energy storage in mobile applications, particularly battery of electric vehicles, is currently gaining a lot of importance. In this paper, a semi-theoretical time-dependent mathematical model of the phase change in a double shell thermal energy storage module has been developed where the inner tube is a heat exchange surface. An effective front region thickness for the melting and solidification process has been studied....
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Export diversification and dependence on natural resources
PublikacjaLow export diversification is a risk-augmenting factor for many countries dependent on natural resources. The literature tends to focus on the growth effects of resource dependence (‘resource curse’ debate) while not much is known on how it affects the variety of non-resource exports. To quantify this effect we decompose the relative Theil index using product-level export data from 160 countries over the time period 1996–2018....
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Effect of Laser Treatment on Intrinsic Mechanical Stresses in Titanium and Some of Its Alloys
PublikacjaLaser surface treatment conducted at different power levels is an option to modify titanium bone implants to produce nano- and microtopography. However, such processing can lead to excess mechanical stress within the surface layer. This research aims to calculate the level of such residual stresses after the surface processing of Ti grade IV, Ti15Mo, and Ti6Al7Nb alloys with an Nd:YAG laser. Light and scanning electron microscopies...
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Stress-driven nonlocal elasticity for nonlinear vibration characteristics of carbon/boron-nitride hetero-nanotube subject to magneto-thermal environment
PublikacjaStress-driven nonlocal theory of elasticity, in its differential form, is applied to investigate the nonlinear vibrational characteristics of a hetero-nanotube in magneto-thermal environment with the help of finite element method. In order to more precisely deal with the dynamic behavior of size-dependent nanotubes, a two-node beam element with six degrees-of freedom including the nodal values of the deflection, slope and curvature...
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Effects of Surface Energy and Surface Residual Stresses on Vibro-Thermal Analysis of Chiral, Zigzag, and Armchair Types of SWCNTs Using Refined Beam Theory
PublikacjaIn this article, vibration characteristics of three different types of Single-Walled Carbon Nanotubes (SWCNTs) such as armchair, chiral, and zigzag carbon nanotubes have been investigated considering the effects of surface energy and surface residual stresses. The nanotubes are embedded in the elastic substrate of the Winkler type and are also exposed to low and high-temperature environments. A new refined beam theory namely, one-variable...
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Fast-response optoelectronic detection of explosives’ residues from the nitroaromatic compounds detonation: field studies approach
PublikacjaWe are presenting an application of optoelectronic nitrogen dioxide (NO2) analyzer based on cavity enhanced absorption spectroscopy in the detection of traces of explosives after detonation. It has been shown that the analyzer using blue-violet laser is able to detect explosive residues after the detonation of various amounts of nitroaromatic compounds (75g-1kg) with higher efficiency than the HPLC soil sample testing equipment,...
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Reduced-cost design closure of antennas by means of gradient search with restricted sensitivity update
PublikacjaDesign closure, i.e., adjustment of geometry parameters to boost the performance, is a challenging stage of antenna design process. Given complexity of contemporary structures, reliable parameter tuning requires numerical optimization and can be executed using local algorithms. Yet, EM-driven optimization is a computationally expensive endeavour and reducing its cost is highly desirable. In this paper, a modification of the trust-region...
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Impact of diffusion coefficient averaging on solution accuracy of the 2D nonlinear diffusive wave equation for floodplain inundation
PublikacjaIn the study, the averaging technique of diffusion coefficients in the two-dimensional nonlinear diffusive wave equation applied to the floodplain inundation is presented. As a method of solution, the splitting technique and the modified finite element method with linear shape functions are used. On the stage of spatial integration, it is often assumed that diffusion coefficient is constant over element and equal to its average...
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An Island of Connectedness: Intra-Insular and Inter-Regional Communications of Rab Island (North-East Adriatic, Kvarner Gulf), Croatia
PublikacjaDrawing from archaeological data on Prehistoric and Roman settlement patterns, and respective sepulchral features, just as on later historic and cartographic sources, in this contribution it will be shown how movement along with mobility influenced on and were an integral part of settlement dynamics on the island of Rab (NE Adriatic, Croatia). The employed approach sees the practice of movement as dependent on specific social...
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Electroelastic biaxial compression of nanoplates considering piezoelectric effects
PublikacjaIn the present theoretical work, it is assumed that a piezoelectric nanoplate is connected to the voltage meter which voltages have resulted from deformation of the plate due to in-plane compressive forces whether they are critical buckling loads or arbitrary forces. In order to derive governing equations, a simplified four-variable shear deformation plate theory has been employed using Hamilton’s principle and Von-Kármán...
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The Effect of Sterols on Amphotericin B Self-Aggregation in a Lipid Bilayer as Revealed by Free Energy Simulations
PublikacjaAmphotericin B (AmB) is an effective but toxic antifungal drug, known to increase the permeability of the cell membrane, presumably by assembling into transmembrane pores in a sterol-dependent manner. The aggregation of AmB molecules in a phospholipid bilayer is, thus, crucial for the drug’s activity. To provide an insight into the molecular nature of this process, here, we report an atomistic molecular dynamics simulation study...
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Measurements of Path Loss in Off-Body Channels in Indoor Environments
PublikacjaThis paper presents a measurements of the path loss for validation of a statistical model for off-body radio channels in an indoor multipath environment, which considers the distance dependent mean path loss, and describes body shadowing and fast fading components in a statistical way. The measurement equipment and propagation indoor environment have been presented. Two different bodies and five static and two walking scenarios...
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Solid-State Modification of Poly(butylene terephthalate) with a Bio-Based Fatty Acid Dimer Diol Furnishing Copolyesters with Unique Morphologies
PublikacjaCopolyesters based on poly(butylene terephthalate) (PBT) and a bio-based fatty acid dimer diol (FADD) were prepared by solid-state modification (SSM). The chemical incorporation of the FADD into the backbone of the PBT was proven using various techniques. It was clear that the incorporation rate was diffusion-limited rather than reaction-limited. From quantitative 13C NMR a nonrandom chemical microstructure was obtained at all...
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Energy losses in hydrostatic drive:Drive investigation method compatible with diagram of power increase opposite to the direction of power flow
PublikacjaEnergy losses and efficiency of drive motor must be presented as functions of physical quantities independent of losses in the motor. Such quantities are speed and load required by the driven device, changing in the drive operating field. Speed and load decide of the useful power and, in differentiated way, of kinds and values of losses in the motor. But energy losses and efficiency of drive motors are evaluated as functions of...
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Rapid design of miniaturised branch-line couplers through concurrent cell optimisation and surrogate-assisted fine-tuning
PublikacjaIn this study, the authors introduce a methodology for low-cost simulation-driven design optimisation of highly miniaturised branch-line couplers (BLCs). The first stage of their design approach exploits fast concurrent optimisation of geometrically dependent, but electromagnetically isolated cells that constitute a BLC. The cross-coupling effects between the cells are taken into account in the second stage, where a surrogate-assisted...
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Path dependence, modularity and the offshoring of (some) physician services
PublikacjaThis paper integrates ideas from modularity and path dependency to explain the potential for and limitations of the offshoring of high value added physician services. While not all medical services are amenable to offshoring, a growing number of physician activities can be viewed as modular components which, at least technically, could be performed remotely. As a result, the presumption that concerns for efficiency dictate how...
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Phase separation in poly(butylene terephthalate)-based materials prepared by solid-state modification
PublikacjaThe morphology of a series of poly(butylene terephthalate) (PBT)/fatty acid dimer diol (FADD)-based copolyesters prepared by solid-state modi fi cation (SSM) was studied. It was shown that in copolyesters containing less than 10 wt% FADD two different phases, i.e. a PBT crystalline phase and a PBT-rich amorphous phase, are present. The FADD residues were more or less homogeneously distributed throughout the interlamellar regions....
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Globalisation and world economic poverty: The significance of hidden dimensions
PublikacjaThe aim of our research is to examine how individual dimensions of globalization affect economic poverty in the World. for this, regression models are estimated with FGT0 or FGT1 poverty measures as dependent variables and KOF indices of globalization as despendent variables. The poverty indices are estimated for 119 countries' income didtributions assuming log-normality and using Gini estimates from the WID2 database and GDP/capita...
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Sandwich Biobattery with Enzymatic Cathode and Zinc Anode Integrated with Sensor
PublikacjaCarbon paper covered with side-naphthylated multi walled carbon nanotubes was used as the conducting support for the construction of a biocathode in a hybrid biofuel cell. Laccase Carrena unicolor enzyme was employed as the catalyst for the 4e reduction of oxygen and a zinc disc covered with hopeite was used as the anode. Derivatized carbon nanotubes increase the working surface of the electrode and provide direct contact with...
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Ultrafast Intramolecular Relaxation and Wave-Packet Motion in a Ruthenium-Based Supramolecular Photocatalyst
PublikacjaThe hydrogen-evolving photocatalyst [(tbbpy)2 Ru(tpphz)Pd(Cl)2 ](2+) (tbbpy=4,4'-di-tert-butyl-2,2'-bipyridine, tpphz=tetrapyrido[3,2-a:2',3'-c:3'',2''-h:2''',3'''-j]phenazine) shows excitation-wavelength-dependent catalytic activity, which has been correlated to the localization of the initial excitation within the coordination sphere. In this contribution the excitation-wavelength dependence of the early excited-state relaxation...
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Analysis of electromagnetic disturbances in DC network of grid connected building-integrated photovoltaic system
PublikacjaThis paper focuses on conducted electromagnetic interference (EMI) emissions and propagation in the DC network of grid connected building integrated photovoltaic (PV) system. The investigated PV system, consists of ten solar panels, cabling and the grid-connected one phase inverter. The EMI simulation model of the real PV system has been developed with the aid of impedance analyzer measurements of solar panels and the DC network...
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The application of Monod equation to denitrification kinetics description in the moving bed biofilm reactor (MBBR)
PublikacjaIn this paper, the kinetic constants Vmax and KCOD occurring in the Monod equation, which describe the denitrification process in the moving bed, are determined. For this purpose, a laboratory moving bed biofilm reactor (MBBR) was used. The filling of the reactor consisted of EvU Perl carriers. The experiment was carried out with an excess of nitrate, and denitrification rate was dependent on the concentration of external organic...
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Crystal Growth, Structure, and Magnetism of the 2D Spin 1/2 Triangular Lattice Material Rb3Yb(PO4)2
PublikacjaThe single-crystal growth, crystal structure, heat capacity, and anisotropic magnetization characterization of Rb3Yb- (PO4)2, a Yb-based triangular lattice material, are presented. Single-crystal X-ray diffraction shows that Rb3Yb(PO4)2 exhibits [Yb(PO4)]∞ layers, with the Yb in an ordered plane of equilateral triangles. One phosphate group oxygen that is not a near neighbor of the magnetic Yb displays positional disorder. The...
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Interdependence between Power Grids and Communication Networks: A Resilience Perspective
PublikacjaPower network resilience is increasingly dependent on communication networks. Besides traditional generation, power networks need to accommodate increasingly high penetration levels of dispersed micro generation, mostly based on renewable sources, and increasing and challenging demand, such as electric vehicles. At the same time the deployment of enabling technologies throughout the power grid makes available new demand resources...
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HISTORY OF INITIAL ENERGY AND WATER NETWORK DEVELOPMENT IN QATAR
PublikacjaQatar: A country which had to be associated with neighboring countries like UAE or Saudi Arabia for people to know about it, stands proud today due to the ample production and exporting of Black Gold. A country with almost no vegetation or suitable weather to harvest crops, turned from being heavily dependent on trading Pearls to exporting natural oil and gas to all over the globe. The paper outlines in details the history of the...
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Local material symmetry group for first- and second-order strain gradient fluids
PublikacjaUsing an unified approach based on the local material symmetry group introduced for general first- and second-order strain gradient elastic media, we analyze the constitutive equations of strain gradient fluids. For the strain gradient medium there exists a strain energy density dependent on first- and higher-order gradients of placement vector, whereas for fluids a strain energy depends on a current mass density and its gradients....
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Prototype design and development of low-load-roof photovoltaic modules for applications in on-grid systems
PublikacjaFour prototypes of lightweight photovoltaic modules for applications in on-grid systems have been designed, developed, manufactured and tested for compliance with relevant IEC standards. Selected, commercially available materials characterized by thermogravimetry, differential scanning calorimetry, dilatometry, scanning electron microscopy and nanoindentation technique were used in frameless, adhesively-bonded sandwich-structures...
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Investigation of the vertical distribution of the sound speed of the Gulf of Gdansk in the years 2000-2010
PublikacjaThe conditions of the acoustic wave propagation in the southern Baltic are much more complex than in other shallow waters. In the typical shallow water, seasonal changes in acoustical conditions in the upper layer, of the depth of about 60-70 m, are observed. They are caused by variation of the annual meteorological conditions. Most often, in the deep water layer, acoustical conditions are stable throughout the year. However, in...
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Superconductivity in a new intermetallic structure type based on endohedral Ta@Ir7Ge4 clusters
PublikacjaWe report the observation of superconductivity at a temperature near 3.5 K for the previously unreported compound TaIr2Ge2. In addition to being a superconductor, this material displays a new crystal structure type that contains endohedral clusters, as determined by single-crystal x-ray diffraction structure refinement; the structure is more complex than those of the commonly observed tetragonal 122 intermetallic phases. Despite...
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Designing efficient A-D-A1-D-A type fullerene free acceptor molecules with enhanced power conversion efficiency for solar cell applications
PublikacjaThe achievement of highly efficient power conversion efficiency (PCE) is a big concern for non-fullerene organic solar cells (NF-OSCs) because PCE can depend on numerous variables. Here, new five novel acceptor molecules without fullerenes were developed and investigated using DFT (density functional theory) and TD-DFT (time dependent-density functional theory). Compared to the recently synthesized molecule (PZ-dIDTC6), the developed...
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CyberEye: New Eye-Tracking Interfaces for Assessment and Modulation of Cognitive Functions beyond the Brain
PublikacjaThe emergence of innovative neurotechnologies in global brain projects has accelerated research and clinical applications of BCIs beyond sensory and motor functions. Both invasive and noninvasive sensors are developed to interface with cognitive functions engaged in thinking, communication, or remembering. The detection of eye movements by a camera offers a particularly attractive external sensor for computer interfaces to monitor,...
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On dynamic modeling of piezomagnetic/flexomagnetic microstructures based on Lord–Shulman thermoelastic model
PublikacjaWe study a time-dependent thermoelastic coupling within free vibrations of piezomagnetic (PM) microbeams considering the flexomagnetic (FM) phenomenon. The flexomagneticity relates to a magnetic field with a gradient of strains. Here, we use the generalized thermoelasticity theory of Lord–Shulman to analyze the interaction between elastic deformation and thermal conductivity. The uniform magnetic field is permeated in line with...
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Butyrylcholinesterase signal sequence self-aggregates and enhances amyloid fibril formation in vitro
PublikacjaAlzheimer’s disease (AD) pathogenesis has been attributed to extracellular aggregates of amyloid β (Aβ) plaques and neurofibrillary tangles in the human brain. It has been reported that butyrylcholinesterase (BChE) also accumulates in the brain Aβ plaques in AD. We have previously found that the BChE substitution in 5′UTR caused an in-frame N-terminal extension of 41 amino acids of the BChE signal peptide. The resultant variant...
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CLEANING METHODS FOR DUST DEPOSITED ON THE FRONT COVER OF PHOTOVOLTAIC MODULE
PublikacjaPhotovoltaic modules are one of the renewable energy sources with great potential for application in various regions of the world as well as for different terrain. They are, however, sensitive to external factors, affecting the overall amount of energy generated, such as solar irradiance, shading effects and any form of soil build-up on the front glass cover of solar device. The latter issue happens over a course of weeks, months...
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Equivalence scales for continuous distributions of expenditure
PublikacjaResearch background: In the actual sizable populations of households, the standard microeconomic concept of equivalence scales is intractable since its necessary condition of equality of household welfare levels is unlikely to be fulfilled. Purpose of the article: This paper aims to develop a concept of an equivalence scale, which can be suitable for continuous distributions of expenditures in the population. Methods: Using household...
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Position and Orientation Estimation in Radio Network With Groups of Locally Synchronized Nodes
PublikacjaThis article presents a positioning system with groups of locally synchronized nodes. A mobile object is equipped with a group of several synchronized receivers that are able to measure the difference in the time of arrival of signals from reference transmitters. The reference transmitters are synchronized only in local groups, with no global synchronization between groups. It is assumed that the synchronous operation of transmitters...
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Poszukiwanie nowych leków immunosupresyjnych (Quest for new immunosuppressive drugs)
PublikacjaTransplantology is getting more and more important in medicine. Development of surgical techniques and immunosuppressive treatment enabled to establish successful transplantations with various organs and tissues. However, allografts are recognized as foreign tissues and stimulate rejection, i.e. a strong immunological response which, if not stopped, results in complete destruction of the transplanted tissue. In order to prevent...
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Phosphate tricyclic coumarin analogs as steroid sulfatase inhibitors: synthesis and biological activity.
PublikacjaIn the present work, we report convenient methods for the synthesis and biological evaluation of phosphate tricyclic coumarin derivatives as potential steroid sulfatase inhibitors. The described synthesis includes the straightforward preparation of 7-hydroxy-2,3-dihydro-1H-cyclopenta[c]chromen-4-one, 3-hydroxy-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one and 3-hydroxy-8,9,10,11-tetrahydro-7H-cyclohepta[c]chromen-6-one modified...
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Optimal selection of input features and an acompanying neural network structure for the classification purposes - skin lesions case study
PublikacjaMalignant melanomas are the most deadly type of skin cancers however detected early enough give a high chances for successful treatment. The last years saw the dynamic growth of interest of automatic computer-aided skin cancer diagnosis. Every month brings new research results on new approaches to this problem, new methods of preprocessing, new classifiers, new ideas to follow etc. In particular, the rapid development of dermatoscopy,...
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Decomposition of halogenated nucleobases by surface plasmon resonance excitation of gold nanoparticles
PublikacjaHalogenated uracil derivatives are of great interest in modern cancer therapy, either as chemotherapeutics or radiosensitisers depending on their halogen atom. This work applies UV-Vis spectroscopy to study the radiation damage of uracil, 5-bromouracil and 5- uorouracil dissolved in water in the presence of gold nanoparticles upon irradiation with an Nd:YAG ns-pulsed laser operating at 532nm at dierent uences. Gold nanoparticles...
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Structural, physicochemical and anticancer study of Zn complexes with pyridyl-based thiazolyl-hydrazones
PublikacjaThiazolyl-hydrazones (THs) exhibit a wide spectrum of biological activity that can be enhanced by complexation with various metal ions. Zn(II) complexes with α-pyridine-1,3-TH ligands may represent an alternative to the standard platinum-based chemotherapeutics. In addition, they show photoluminescence properties and thus can be regarded as multifunctional materials. In this study, we synthesized and characterized three neutral...
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Selected Technical Issues of Deep Neural Networks for Image Classification Purposes
PublikacjaIn recent years, deep learning and especially Deep Neural Networks (DNN) have obtained amazing performance on a variety of problems, in particular in classification or pattern recognition. Among many kinds of DNNs, the Convolutional Neural Networks (CNN) are most commonly used. However, due to their complexity, there are many problems related but not limited to optimizing network parameters, avoiding overfitting and ensuring good...
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The Effect of Conjugation with Octaarginine, a Cell-Penetrating Peptide on Antifungal Activity of Imidazoacridinone Derivative
PublikacjaAcridine cell-penetrating peptide conjugates are an extremely important family of compounds in antitumor chemotherapy. These conjugates are not so widely analysed in antimicrobial therapy, although bioactive peptides could be used as nanocarriers to smuggle antimicrobial compounds. An octaarginine conjugate of an imidazoacridinone derivative (Compound 1-R8) synthetized by us exhibited high antifungal activity against reference...
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Modelling charge transfer processes in C2+ -tetrahydrofuran collision for ion-induced radiation damage in DNA building blocks
PublikacjaInvestigations of collision-induced processes involving carbon ions and molecules of biological interest in particular DNA building blocks, are crucial to model the effect of radiation on cells in order to improve medical treatments for cancer therapy. Using carbon ions appears to be one of the most efficient ways to increase biological effectiveness to damage cancerous cells by irradiating deep-seated tumors. Therefore, interest...
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Usuwanie lotnych związków organicznych z fazy gazowej z zastosowaniem cieczy jonowych
PublikacjaUżycie cieczy jonowej do usuwania LZO jest limitowane przez rozpuszczalność usuwanych związków. Dane literaturowe sugerują, że ciecze jonowe jako faza membranowa mogą być z powodzeniem stosowane do selektywnej separacji węglowodorów aromatycznych z mieszanin węglowodorów aromatycznych i alifatycznych. Przedmiotem pracy było kompleksowe opisanie procesu separacji LZO z fazy gazowej z uwzględnieniem czynników wpływających na efektywność...
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Biological and antibacterial properties of chitosan-based coatings with AgNPs and CuNPs obtained on oxidized Ti13Zr13Nb titanium alloy
PublikacjaDespite numerous studies, the antibacterial efficiency and cytotoxicity of chitosan-based coatings with nanometals need further studies. The purpose of this research was to determine the biological properties of chitosan coatings implemented with either silver nanoparticles (AgNPs) or copper nanoparticles (CuNPs), that were electrophoretically deposited on electrochemically oxidized Ti13Zr13Nb alloy. The SEM tests were used to...
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The Effect of Calcination Temperature on Structure and Photocatalytic Properties of WO3/TiO2 Nanocomposites
PublikacjaSeries ofWO3/TiO2 nanocompositeswere obtained by hydrothermal method followed by calcination in the temperature range from 400∘C to 900∘C. The characteristics of photocatalysts by X-ray diffractometry (XRD), scanning electron microscope (SEM), and diffuse reflectance spectroscopy (DRS) showed that increasing the calcination temperature from 400 to 900∘C resulted in change of photocatalytic activity under UV-Vis light.Moreover,...
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π-Stacking attraction vs. electrostatic repulsion: competing supramolecular interactions in a tpphz-bridged Ru(ii)/Au(iii) complex
PublikacjaThe synthesis and characterization of a mixed metal ruthenium(II)/gold(III) complex bridged by tetrapyridophenazine (tpphz) are described. It is isostructural and isoelectronic to the well-known photocatalysts with palladium(II) or platinum(II). Concentration dependent 1H-NMR spectroscopy and XRD studies show that the electrostatic repulsion between the gold(III) moieties exceeds the attractive π-stacking interaction. Theoretical...
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A model of fuel combustion process in the marine reciprocating engine work space taking into account load and wear of crankshaft-piston assembly and the theory of semi-Markov processes
PublikacjaThe ar ticle analyses the operation of reciprocal internal combu stion engines, with mar ine engines u sed a s an example. The analysis takes into account types of energy conversion in the work spaces (cylinders) of these engines, loads of their crankshaft-piston assemblies, and types of fuel combustion which can take place in these spaces during engine operation. It is highlighted that the analysed time-dependent loads of marine...