Filtry
wszystkich: 1485
-
Katalog
- Publikacje 1208 wyników po odfiltrowaniu
- Czasopisma 129 wyników po odfiltrowaniu
- Konferencje 1 wyników po odfiltrowaniu
- Osoby 25 wyników po odfiltrowaniu
- Wynalazki 1 wyników po odfiltrowaniu
- Projekty 1 wyników po odfiltrowaniu
- Kursy Online 10 wyników po odfiltrowaniu
- Wydarzenia 2 wyników po odfiltrowaniu
- Dane Badawcze 108 wyników po odfiltrowaniu
wyświetlamy 1000 najlepszych wyników Pomoc
Wyniki wyszukiwania dla: controlled drug delivery
-
Evaluation of the efficiency of the duty cycle of refuse collection vehicle based on real-world data
PublikacjaIn this paper a method of the efficiency evaluation of the duty cycle of Refuse Collection Vehicle is presented. Using real world data, two representative duty cycles were analysed. Total cycle efficiency was calculated, as well as the efficiency of particular cycle phases. Then, energy needed to collect and compact the waste and energy from fuel were compared. Measured and calculated values were shown on the diagrams illustrating...
-
Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers
PublikacjaMultidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism of drug resistance. Here, we show that MDR cells display a marked increase in lysosome number. We further demonstrate that imidazoacridinones (IAs), which are cytotoxic fluorochromes,...
-
CYP3A4-dependent cellular response does not relate to CYP3A4-catalysed metabolites of C-1748 and C-1305 acridine antitumor agents in HepG2 cells
PublikacjaHigh CYP3A4 expression sensitizes tumor cells to certain antitumor agents while for others it can lower their therapeutic ef fi cacy. We have elucidated the in fl uence of CYP3A4 overexpression on the cellular response induced by antitumor acridine derivatives, C-1305 and C-1748, in two hepatocellular carcinoma (HepG2) cell lines, Hep3A4 stably transfected with CYP3A4 isoenzyme, and HepC34 expressing empty vector. The compounds...
-
Evaluation of possibilities in identification and susceptibility testing for Candida glabrata clinical isolates with the Integral System Yeast Plus (ISYP)
PublikacjaThe aim of this study was to evaluate possibilities of correct identification and susceptibility testing of C. glabrata clinical isolates with Integral System Yeast Plus (ISYP). For species identification, as the reference method, API Candida test and species-specific PCR reactions were used. The potential of antifungal susceptibility testing by the ISYP test was compared with the Sensititre Yeast One. Whilst the reference methods...
-
Molecular mechanism of proton-coupled ligand translocation by the bacterial efflux pump EmrE
PublikacjaThe current surge in bacterial multi-drug resistance (MDR) is one of the largest challenges to public health, threatening to render ineffective many therapies we rely on for treatment of serious infections. Understanding different factors that contribute to MDR is hence crucial from the global “one health” perspective. In this contribution, we focus on the prototypical broad-selectivity proton-coupled antiporter EmrE, one of the...
-
Antifungal Activity of Capridine β as a Consequence of Its Biotransformation into Metabolite Affecting Yeast Topoisomerase II Activity
PublikacjaIn the last few years,increasing importance is attached to problems caused by fungal pathogens. Current methods of preventing fungal infections remain unsatisfactory. There are several antifungal compounds whichare highly effective in some cases, however, they have limitations in usage: Nephrotoxicity and other adverse effects. In addition, the frequent use of available fungistatic drugs promotes drug resistance....
-
The Substantial Improvement of Amphotericin B Selective Toxicity Upon Modification of Mycosamine with Bulky Substituents
PublikacjaAbstract: Background: It is assumed that the unfavorable selective toxicity of an antifungal drug Amphotericin B (AmB) can be improved upon chemical modification of the antibiotic molecule. Objective: The aim of this study was verification of the hypothesis that introduction of bulky substituents at the amino sugar moiety of the antibiotic may result in diminishment of mammalian vitro toxicity of thus prepared AmB derivatives. Methods:...
-
Information-driven network resilience: Research challenges and perspectives
PublikacjaInternet designed over 40 years ago was originally focused on host-to-host message delivery in a best-effort manner. However, introduction of new applications over the years have brought about new requirements related with throughput, scalability, mobility, security, connectivity, and availability among others. Additionally, convergence of telecommunications, media, and information technology was responsible for transformation...
-
Low cost set-up for supercapacitors parameters evaluation
PublikacjaSupercapacitors are capable to store relatively high amount of energy comparing to its mass. Growing number of these devices applications requires development of new testing methods. Standard methods of evaluation of supercapacitor parameters, as cycling voltammetry, CV, galvanostatic cycling with potential limitation, GCPL, impedance measurements, require equipment of high cost...
-
Demonstrator technologii C-IED
PublikacjaArtykuł przedstawia budowę i działanie opracowanego na Politechnice Gdańskiej demonstratora technologicznego systemu AEGIS, przeznaczonego do przeciwdziałania atakom z wykorzystaniem prowizorycznych urządzeń wybuchowych detonowanych drogą radiową (RCIED — Radio Controlled Improvised Explosive Devices). Przedstawiono zaimplementowaną oryginalną metodę generowania sygnału zagłuszającego o dowolnie ukształtowanym widmie częstotliwościowym,...
-
Nanotechnologies in Development of Structural Materials and Biomaterials
PublikacjaThe nanometric materials and technologies resulted in nanostructures are reviewed. The examples of nanomaterials are shown. The typical nanotechnologies, including plastic deformation, mechanical attrition, controlled detonation, hot plasma jet synthesis, laser vaporisation, CVD and PVD, mechanical milling, annealing, ultrasonic irradiation, nanolithography, electrocrystallisation, electrospinning, sol-gel method, cryogenic laser-enhanced...
-
Electrochemical simulation of enzymatic transformations studied for the selected antitumor acridine derivatives
PublikacjaThe elucidation of the metabolic pathways and the biotransformation mechanisms of potential drugs is a crucial point in drug development. It allows to know the activation routes of the new biologically active compounds, especially in respect to their possible toxicity. Generally, in vivo or in vitro experiments with liver microsomes or hepatocytes are performed. However, these testing schemes are tedious, time consuming and of...
-
Cell-penetrating peptides – mechanism of transduction and synthesis – short review
PublikacjaPotential antimicrobial agents may be effective if they are delivered efficiently to their site of action. In many cases, lack of permeability through the cell membrane is the main problem. One of the possible solutions could be a novel intracellular delivery system involving cell-penetrating peptides (CPPs), which may improve the efficiency of many new biophar-maceuticals. Among other things, CPPs are capable of trans-porting...
-
Disciplines and measures of information resilience
PublikacjaCommunication networks have become a fundamental part of many critical infrastructures, playing an important role in information delivery in various failure scenarios triggered e.g., by forces of nature (including earthquakes, tornados, fires, etc.), technology-related disasters (for instance due to power blackout), or malicious human activities. A number of recovery schemes have been defined in the context of network resilience...
-
Urban Freight Transport Demand Modelling and Data Availability Constraints
PublikacjaThe paper provides a review of urban freight transport demand modelling approaches confronted with constrains regarding adequate data provision from a perspective of the local authorities. Demand estimation models has been selected as a reference because they are the most representative in terms of inclusion of urban freight indicators which can be transformed into a decision-support tool for evaluation of freight measures. The...
-
Influence of Self-Similar Traffic Type on Performance of QoS Routing Algorithms
PublikacjaProviding a Quality of Services (QoS) into current telecommunication networks based on packet technology is a big challenge nowadays. Network operators have to support a number of new services like voice or video which generate new type of traffic. This traffic serviced with QoS in consequence requires access to appropriate network resources. Additionally, new traffic type is mixed with older one, like best-effort. Analysis of...
-
Universal and contextualized public services: Digital public service innovation framework
PublikacjaIn view of the rising social and economic inequalities, public service delivery should be both universal, i.e. independent of the recipients' social or economic status, and contextualized, i.e. able to compensate for different local needs and conditions. Reconciling both properties requires various forms of innovations, chief among them innovations in digital public services. Building upon the four-stage model underpinning the...
-
Interline power flow controller - properties and control strategy in dynamic states
PublikacjaHigh-power electronic converter topologies, in such forms as Unified Power Flow Controllers (UPFC), Static Compensators (STATCOM) and Interline Power Flow Controllers (IPFC), have been used to enhance and optimize the use of transmission facilities, under the concept of a flexible ac transmission system (FACTS). In Europe, the anticipated proliferation of distributed-generation (DG) in the near future, driven by governmental initiatives...
-
The luminescence study of Ga2–x(Al0.68In0.32)xO3:Cr3+ coumpounds.
Dane BadawczeNear-infrared (NIR) phosphor-converted light-emitting diodes (pc-LEDs) are a highly efficient perspective NIR light source, with application hindered by a narrow emission band. In this work, we broaden the emission of a new series of NIR phosphors by controlling crystal structure disorder through cation cosubstitution. By substituting Ga3+ with (Al0.68In0.32)3+,...
-
D.C. electrical measurements of Bi2VO5.5 ceramic measured at high temperature region
Dane BadawczeD.C. electrical properties of Bi2VO5.5 ceramic was measured.
-
Tailoring the electrochemical degradation of iron protected with polypyrrole films for biodegradable cardiovascular stents
PublikacjaThe degradation of polypyrrole (PPy) coated iron is studied in phosphate buffer saline solution at 37 °C by odd random phase multisine electrochemical impedance spectroscopy (ORP-EIS). PPy is electropolymerized with anti-inflammatory salicylates incorporated in the film, as a drug release system. The modelling of EIS over time provides the quantitative description of the corrosion behaviour of the material. Thus, the reliable...
-
A method of self-testing of analog circuits based on fully differential op-amps with theTCBF classifier
PublikacjaA new approach of self-testing of analog circuits based on fully differential op-amps of mixed-signal systems controlled by microcontrollers is presented. It consists of a measurement procedure and a fault diagnosis procedure. We measure voltage samples of a time response of a tested circuit on a stimulation of a unit step function given at the common-mode reference voltage input of the op-amp. The fault detection and fault localization...
-
AEGIS — demonstrator technologii C-IED
PublikacjaW artykule przedstawiono budowę i działanie opracowanego na Politechnice Gdańskiej demonstratora technologicznego systemu AEGIS, przeznaczonego do przeciwdziałania atakom z wykorzystaniem prowizorycznych urządzeń wybuchowych detonowanych drogą radiową (RCIED — Radio Controlled Improvised Explosive Devices). Przedstawiono zaimplementowaną oryginalną metodę generowania sygnału zagłuszającego o dowolnie ukształtowanym widmie częstotliwościowym,...
-
Evolution of chemotaxis in single-cell artificial organisms
PublikacjaThe model of a liquid two-dimensional environment, which is based on physics of diffusion, allows us to simulate the diffusion of morphogenes. Artificial organisms move using a chemotaxis reacting to concentration difference. Organisms are controlled by a gene regulatory network coded in a linear genome and reproduce by division. We made a lot of experiments presenting organisms’ behaviour in various environment conditions. We...
-
State Observer for Doubly-fed Induction Generator
PublikacjaIn the paper a new state observer for doubly-fed generator has been proposed. In the new approach an extended mathematical model of the doubly fed generator is used to form equations of the introduced z type observer. Stability of the observer has been verified through poles placement analyses. The active and reactive powers of the generator are controlled by a nonlinear multiscalar control method. Simulation and experimental results...
-
MAPSERVER – INFORMATION FLOW MANAGEMENT SOFTWARE FOR THE BORDER GUARD DISTRIBUTED DATA EXCHANGE SYSTEM
PublikacjaIn this paper the architecture of the software designed for management of position and identification data of floating and flying objects in Maritime areas controlled by Polish Border Guard is presented. The software was designed for managing information stored in a distributed system with two variants of the software, one for a mobile device installed on a vessel, an airplane or a car and second for a central server. The details...
-
AEGIS - demonstrator technologii C-IED
PublikacjaW referacie przedstawiono budowę i działanie opracowanego w Politechnice Gdańskiej demonstratora technologicznego systemu AEGIS, przeznaczonego do przeciwdziałania atakom z wykorzystaniem prowizorycznych urządzeń wybuchowych detonowanych drogą radiową (RCIED - Radio Controlled Improvised Explosive Devices). Przedstawiono zaimplementowaną oryginalną metodę generowania sygnału zagłuszającego o dowolnie ukształtowanym widmie częstotliwościowym,...
-
Mobilny demonstrator technologii wytwarzania kurtyny elektromagnetycznej do ochrony przed urządzeniami IED
PublikacjaW referacie przedstawiono budowę i działanie opracowanego w Politechnice Gdańskiej demonstratora technologicznego systemu AEGIS, przeznaczonego do przeciwdziałania atakom z wykorzystaniem prowizorycznych urządzeń wybuchowych detonowanych drogą radiową (RCIED - Radio Controlled Improvised Explosive Devices). Przedstawiono zaimplementowaną oryginalną metodę generowania sygnału zagłuszającego o dowolnie ukształtowanym widmie częstotliwościowym,...
-
Synthesis and biological evaluation of fluorinated 3-phenylcoumarin-7-O-sulfamate derivatives as steroid sulfatase inhibitors
PublikacjaIn the present work, we report the initial results of our study on a series of 3-phenylcoumarin sulfamate-based compounds containing C-F bonds as a novel inhibitors of steroid sulfatase (STS). The new compounds are potent STS inhibitors, possessing more than 10 times higher inhibitory potency than coumarin-7-O-sulfamate. In the course of our investigation, compounds 2b and 2c demonstrated the highest inhibitory effect in the enzymatic...
-
Synthesis and biological evaluation of N-acylated tyramine sulfamates containing C-F bonds as steroid sulfatase inhibitors
PublikacjaSteroid sulfatase (STS) is responsible for the hydrolysis of biologically inactive sulfated steroids into their active un-sulfated forms and promotes the growth of various hormone-dependent cancers (e.g., breast cancer). Therefore, the STS enzyme is a promising therapeutic target for the treatment of steroid-sensitive cancers. Herein, we report the synthesis and biological evaluation of sulfamate analogs as potential STS inhibitors...
-
Novel anticancer strategy aimed at targeting shelterin complexes by the induction of structural changes in telomeric DNA: hitting two birds with one stone.
PublikacjaThe ends of chromosomes in mammals are composed of telomeric DNA containing TTAGGG repeats, which bind specific proteins called shelterins. This telomeric DNA together with shelterins form a cap that protects the ends of chromosomes from being recognized as sites of DNA damage and from chromosomal fusions. Many very successful antitumor drugs used in the treatment of cancer patients bind to DNA, some of them with a prominent sequence...
-
Structural Factors Affecting Cytotoxic Activity of (E)-1-(Benzo[d ][1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-one Derivatives
PublikacjaDerivatives of (E)-1-(5-alkoxybenzo[d][1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-one (1) demonstrated exceptionally high in vitro cytotoxic activity, with IC50 values of the most active derivatives in the nanomolar range. To identify structural fragments necessary for the activity, several analogs deprived of selected fragments were prepared, and their cytotoxic activity was tested. It was found that the activity depends on combined effects...
-
Influence of S-Oxidation on Cytotoxic Activity of Oxathiole-Fused Chalcones
PublikacjaSynthesis, in vitro cytotoxic activity, and interaction with tubulin of oxidized, isomeric 1-(5-alkoxybenzo[d] [1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-ones and 1-(6- alkoxybenzo[d][1,3]oxathiol-5-yl)-3-phenylprop-2-en-1- ones are described. Most of the compounds demonstrated cytotoxic activity at submicromolar concentrations. It was found that oxidation of sulfur atom of the oxathiole-fused chalcones strongly influenced activity...
-
Solubility advantage of sulfanilamide and sulfacetamide in natural deep eutectic systems: experimental and theoretical investigations
PublikacjaObjective: The aim of this study was to explore the possibility of using natural deep eutectic solvents (NADES) as solvation media for enhancement of solubility of sulfonamides, as well as gaining some thermodynamic characteristics of the analyzed systems. Significance: Low solubility of many active pharmaceutical ingredients is a well-recognized difficulty in pharmaceutical industry, hence the need for different strategies addressing...
-
Conformational Preferences of Proline Derivatives Incorporated into Vasopressin Analogues: NMR and Molecular Modelling Studies
Publikacja -
Highly Potent Antidiuretic Antagonists: Conformational Studies of Vasopressin Analogues Modified with 1-Naphthylalanine Enantiomers at Position 2
Publikacja -
CDK9: Therapeutic Perspective in HCC Therapy
Publikacja -
Current Challenges in Targeting Tumor Desmoplasia to Improve the Efficacy of Immunotherapy
Publikacja -
Investigating the disease‐modifying properties of sclerotiorin in Alzheimer's therapy using acetylcholinesterase inhibition
Publikacja -
Preliminary antifungal activity assay of selected chlorine-containing derivatives of xanthone and phenoxyethyl amines
Publikacja -
Simplified, serine‐rich theta‐defensin analogues as antitumour peptides
Publikacja -
Effects of an immunosuppressive treatment on the rat prostate
Publikacja -
Structure–activity relationships study on biological activity of peptides as dipeptidyl peptidase IV inhibitors by chemometric modeling
Publikacja -
Design and characteristics of gellan gum beads for modified release of meloxicam
Publikacja -
Aryl- and heteroaryl-substituted phenylalanines as AMPA receptor ligands
Publikacja -
Short Term Monitor of Photodegradation Processes in Ranitidine Hydrochloride Observed by FTIR and ATR FTIR
PublikacjaThe effects of degradation of ranitidine hydrochloride exposed to UVB radiation (l = 310 nm) and oxygen in a weathering chamber were studied by Fourier Transform Infrared spectroscopy (FTIR) and Attenuated Total Reflectance Fourier Transform Infrared spectroscopy (ATR-FTIR). ATR-FTIR profile indicated that the degradation was spatially heterogeneous. Significant amounts of photoproducts were detected only in a directly...
-
The Chemometric Evaluation of Antitumor Activity of Novel Benzensulfonamide Derivatives Based on their Physiochemical Properties
Publikacja -
QSAR Analysis of Compounds Exhibiting General Anesthetics’ Properties
Publikacja -
QSAR Analysis of Selected Antimicrobial Structures Belonging to Nitro-derivatives of Heterocyclic Compounds
Publikacja -
Differential scanning calorimetry for authentication of edible fats and oils - What can we learn from the past to face the current challenges?
Publikacja