Filtry
wszystkich: 1064
-
Katalog
- Publikacje 877 wyników po odfiltrowaniu
- Czasopisma 50 wyników po odfiltrowaniu
- Konferencje 1 wyników po odfiltrowaniu
- Osoby 26 wyników po odfiltrowaniu
- Wynalazki 1 wyników po odfiltrowaniu
- Aparatura Badawcza 1 wyników po odfiltrowaniu
- Kursy Online 8 wyników po odfiltrowaniu
- Wydarzenia 7 wyników po odfiltrowaniu
- Dane Badawcze 93 wyników po odfiltrowaniu
wyświetlamy 1000 najlepszych wyników Pomoc
Wyniki wyszukiwania dla: SQUEEZE FILM ACTION
-
Financial Consequences of the Introduction of the Fit For 55 on the Example of Poland
PublikacjaIn Europe and in Poland, there is a growing conviction that climate action is a necessity. When creating long-term strategies or making current decisions, companies are increasingly taking into account issues related to sustainable development and reducing CO2 emissions. Following the signing of the Paris Agreement in 2015, countries around the world pledged to reduce greenhouse gas emissions by 2050 so that the average temperature...
-
The Effects of Pin Profile on HDPE Thermomechanical Phenomena during FSW
PublikacjaFriction stir welding (FSW) of polymeric materials has recently attracted significant attention. Herein, we present the effect of the tool pin profile on the FSW of high-density polyethylene (HDPE) joints through joint experimental analysis and thermomechanical simulations. For analysis of pin profile effects on the thermomechanical properties of HDPE joints, frustum (FPT), cubic (CPT), and triangular (TPT) pin shapes were selected...
-
Combined anticancer therapy with imidazoacridinone analogue C‐1305 and paclitaxel in human lung and colon cancer xenografts—Modulation of tumour angiogenesis
PublikacjaThe acridanone derivative 5-dimethylaminopropylamino- 8- hydroxytriazoloacridinone (C-1305) has been described as a potent inhibitor of cancer cell growth. Its mechanism of action in in vitro conditions was attributed, among others, to its ability to bind and stabilize the microtubule network and subsequently exhibit its tumour- suppressive effects in synergy with paclitaxel (PTX). Therefore, the objective of the present study...
-
Capacity Transforming challenges into opportunities
PublikacjaThe Urban Initiative Laboratory (UIL) aims to upgrade the smart city concept in Gdańsk by introducing the Food-Water-Energy (FWE) nexus to the city. It was agreed in the CRUNCH international consortium that projects on different scales would be implemented in the individual countries to test the Integrated Decision Supportive system platform, which would, in principle, concern urban scale. The regular urban scale was to be researched...
-
Studies of the Modelling Accuracy of Steam Turbine Control Systems for Diagnostic Tests of Automatic Synchronizers
PublikacjaOne of the important factors that affect the reliable operation of the power system and the rapid restitution after disaster is a quick and effective combining synchronous electric power facilities to operate in parallel. Hence, diagnostics of automatic synchronizers at every stage of their life, from building a prototype, through the whole life, until removing such devices from the operation, is an extremely important and responsible...
-
Comparability of Raman Spectroscopic Configurations: A Large Scale Cross-Laboratory Study
PublikacjaThe variable configuration of Raman spectroscopic platforms is one of the major obstacles in establishing Raman spectroscopy as a valuable physicochemical method within real-world scenarios such as clinical diagnostics. For such real world applications like diagnostic classification, the models should ideally be usable to predict data from different setups. Whether it is done by training a rugged model with data from many setups...
-
Encapsulation of Amikacin into Microparticles Based on Low-Molecular-Weight Poly(lactic acid) and Poly(lactic acid-co-polyethylene glycol)
PublikacjaThe aim of this study was to fabricate novel microparticles (MPs) for efficient and long-term delivery of amikacin (AMI). The emulsification method proposed for encapsulating AMI employed low-molecular-weight poly(lactic acid) (PLA) and poly(lactic acid-co-polyethylene glycol) (PLA−PEG), both supplemented with poly(vinyl alcohol) (PVA). The diameters of the particles obtained were determined as less than 30 μm. Based on an in-vitro...
-
On symmetric extendibility of quantum states and its applications
PublikacjaThis dissertation is focused on analysis of the symmetric extendibility of quantum states and its applications in the quantum information theory, with special attention paid to the area of quantum entanglement distillation, quantum channels theory, quantum security, and monogamy of quantum entanglement in time. We analyze geometry of the set of symmetric extendible states, i.e. such states that possess symmetric extensions and...
-
On design and analysis of flow characteristics of the last stage of gas-steam turbine
PublikacjaResearch regarding blade design and analysis of flow have been conducted for over a century. Meanwhile new concepts and design approaches were created and improved. Advancements in information technologies allowed to introduce computational fluid dynamics (CFD) and computational flow mechanics (CFM). Currently a combination of mentioned methods is used for design of turbine blades. These methods enabled us to improve flow efficiency...
-
Urban Lighting Research Transdisciplinary Framework—A Collaborative Process with Lighting Professionals
PublikacjaOver the past decades, lighting professionals have influenced the experience of the night by brightly illuminating streets, buildings, skylines, and landscapes 24/7. When this became the accepted norm, a dual perspective on night-time was shaped and the visual enjoyment of visitors after dusk was prioritized over natural nightscapes (nocturnal landscapes). During this time, researchers of artificial light at night (ALAN) observed...
-
Rethinking Sustainable Cities at Night: Paradigm Shifts in Urban Design and City Lighting
PublikacjaSince the establishment of the 17 Sustainable Development Goals (SDGs) by the United Nations General Assembly in 2015, various perspectives on sustainable cities have been developed and adopted in order to achieve a better and more sustainable future. However, background research has revealed that these goals and targets are limited because they do not take into account the growing body of lighting-related research in diverse fields...
-
Vision Zero in Poland
PublikacjaPoland’s experience of road safety work is relatively short. In the early 1990s road deaths soared to a staggering 8000 a year. A diagnosis found that Poland’s lack of systemic road safety action was to blame for those figures. In response, the state set up road safety bodies and commissioned road safety programs. In 2005, Poland followed the example of Sweden and adopted Vision Zero as a far-reaching concept of changes in road...
-
The role of glucuronidation in drug resistance
PublikacjaThe final therapeutic effect of a drug candidate, which is directed to a specific molecular target strongly depends on its absorption, distribution, metabolism and excretion (ADME). The disruption of at least one element of ADME may result in serious drug resistance. In this work we described the role of one element of this resistance: phase II metabolism with UDP-glucuronosyltransferases (UGTs). UGT function is the transformation...
-
Genotoxicity of selected pharmaceuticals, their binary mixtures, and varying environmental conditions – study with human adenocarcinoma cancer HT29 cell line
PublikacjaPharmaceutical residues are present in the environment in mixtures and their adverse effects may also result from interactions that occur between compounds. Studies presented in this work focus on genotoxicity of pharmaceuticals from different therapeutic groups in mixtures and in individual solutions impacted with different environmental conditions assessed using comet assay (alkaline approach). Binary mixtures of pharmaceuticals...
-
Evaluation of the stiffness modulus and phase angle of cold in-place recycled mix-tures for long curing periods
PublikacjaArticle presents the changes inbehaviour of cold-in place recycling mixtures made using cement and bituminous emulsion (CIR mixtures) after anelongated time of curing. Most of the available literatureregarding change instiffness modulus and phase angle presents resultsfor a maximum of several dozen days,which makesit difficult to predict the behaviour over the whole life of the compacted layer. The article...
-
Preparation and photocatalytic activity of Nd-modified TiO2 photocatalysts: Insight into the excitation mechanism under visible light
PublikacjaTitanium dioxide (TiO2) nanoparticles (NPs) modified with neodymium (Nd) in the range between 0.1 and 1.0 mol% were prepared via the hydrothermal method. The samples obtained were characterized by diffuse reflectance spectroscopy (DRS), scanning electron microscopy (SEM), X-ray fluorescence (EDX), Brunauer–Emmett–Teller (BET) method, X-ray powder diffraction analysis (XRD), X-ray photoelectron spectroscopy (XPS) and photoluminescence...
-
MODELE TRANSFERU BIZNESU DOSTOSOWANE DO POTRZEB FIRM RODZINNYCH Z SEKTORA MSP W REGIONIE MORZA BAŁTYCKIEGO – CELE I ZADANIA W PROJEKCIE INBETS BSR
PublikacjaOpisano kontekst i cele projektu Innovative Business Transfer Models for SMEs in the BSR (INBETS BSR) współfinansowanego z Europejskiego Funduszu Rozwoju Regionalnego w ramach Programu Regionu Morza Bałtyckiego w latach 2014-2020. W projekt zaangażowanych jest czternastu partnerów z regionu Morza Bałtyckiego: Danii, Estonii, Finlandii, Litwy, Łotwy, Niemiec, Polski, Rosji i Szwecji. Rolę lidera projektu pełni Baltic Sea Academy...
-
How to teach architecture? – Remarks on the edge of Polish transformation processes after 1989
PublikacjaThe political changes in Poland after 1989 have resulted in a whole range of dynamic processes including the transformation of space. Until that time the established institutional framework for spatial, urban and architectural planning policy was based on uniform provisions of the so-called planned economy. The same applied to the training of architects, which was based on a unified profile of education provided at the state’s...
-
The High Quality Business School Academic Teacher of the 21st Century – Polish Students’ Perspective
PublikacjaThe literature shows that the success and competence of future managers depend on the quality of their academic teachers. Moreover high quality study requires high quality lecturing/teaching that creates an environment in which deep learning outcomes are made possible for students. The aim was to identify the characteristics of the academic teacher working at business schools, according to the expectations of Polish students...
-
Synthesis of Cyano-Benzylidene Xanthene Synthons Using a Diprotic Brønsted Acid Catalyst, and Their Application as Efficient Inhibitors of Aluminum Corrosion in Alkaline Solutions
PublikacjaNovel cyano-benzylidene xanthene derivatives were synthesized using one-pot and condensation reactions. A diprotic Brønsted acid (i.e., oxalic acid) was used as an effective catalyst for the promotion of the synthesis process of the new starting xanthene–aldehyde compound. Different xanthene concentrations (ca. 0.1–2.0 mM) were applied as corrosion inhibitors to control the alkaline uniform corrosion of aluminum. Measurements were...
-
The effects of the IM1-12Br ionic liquid and the oxytetracycline mixture on selected marine and brackish microorganisms
PublikacjaThe number of applications and commercialized processes utilizing ionic liquids has been increasing, and it is anticipated that this trend will persist and even intensify in the future. Ionic liquids possess desirable characteristics, such as low vapor pressure, good water solubility, amphiphilicity, and stability. Nevertheless, these properties can influence their environmental behavior, resulting in resistance to biotic and abiotic...
-
Tomasz Szymański dr inż. arch.
OsobyTomasz Szymański (dr inż. arch.) jest architektem i adiunktem na Wydziale Architektury Politechniki Gdańskiej. Absolwent Wydziału Architektury Politechniki Gdańskiej. Studia zakończone dyplomem z wyróżnieniem. Zainteresowania badawcze dr. Tomasza Szymańskiego skoncentrowane są wokół kwestii dziedzictwa przemysłowego, re-use, adaptacji i rewitalizacji obiektów poprzemysłowych, obiektów poportowych i postoczniowych na nowe funkcje...
-
Wystawy światowe w Barcelonie: Problemy zachowania dziedzictwa kulturowego
PublikacjaW prezentowanej Państwu książce przedmiotem analizy są obiekty architektoniczne wystaw światowych, które - pomimo tymczasowego charakteru imprez wystawowych - pozostają jako obiekty stałe. Konstrukcja książki wykorzystuje zasadę od ogółu do szczegółu, gdzie na tle subiektywnie wyselekcjonowanych przykładów historycznych, tymczasowych obiektów wystawowych przedstawiam przypadek dwóch szczegółowo przeanalizowanych pawilonów hiszpańskich...
-
Identyfikacja regionalna i branżowa oraz poziom zaangażowania jako determinanty sukcesu inicjatywy klastrowej Interizon
PublikacjaCelem niniejszego artykułu jest analiza trzech wybranych składowych tożsamości grupowej w inicjatywie klastrowej Interizon: identyfikacji regionalnej, identyfikacji branżowej oraz zaangażowania w sprawy inicjatywy oraz ocena ich wpływu na dotychczasowe sukcesy inicjatywy. Autorki opierały się na wynikach badań zrealizowanych w 2014 roku wśród członków inicjatywy Interizon. Badania przeprowadzone były dwufazowo, w oparciu o obserwacje...
-
KRAJOBRAZOWY WYMIAR RURALISTYKI
PublikacjaTytuł Krajobrazowy wymiar ruralistyki w pełni oddaje treść pracy. Najogólniej mówiąc, rozprawa relacjonuje poszukiwania sposobów udziału krajobrazu w planowaniu przestrzennym obszarów wiejskich. Książka, wbrew swojemu układowi, nie powstawała według zwyczajowej ścieżki: od tezy, mieszczącej się w dziedzinie architektury i urbanistyki, do argumentów, które wywiedzione z tej dyscypliny, przemówiłyby za nią. Analiza stanu badań wskazywała...
-
Rola inicjatyw społecznych w ochronie dziedzictwa kulturowego na przykładzie mozaiki Anny Fiszer na ścianie kina Neptun w Gdańsku
PublikacjaStreszczenie: Rola inicjatyw społecznych w ochronie dziedzictwa kulturowego na przykładzie mozaiki Anny Fiszer na ścianie kina Neptun w Gdańsku. Celem artykułu jest wykazanie roli inicjatyw społecznych w budzeniu poczucia odpowiedzialności za dziedzictwo materialne i kulturowe. Przyjęto założenie, że dla lokalnych społeczności miasto jest przestrzenią pamięci. Nastrój, atmosfera i klimat miejsca to słowa, które określają fizyczny...
-
An Easy and Ecological Method of Obtaining Hydrated and Non-Crystalline WO3−x for Application in Supercapacitors
PublikacjaIn this work, we report the synthesis of hydrated and non-crystalline WO3 flakes (WO3−x) via an environmentally friendly and facile water-based strategy. This method is described, in the literature, as exfoliation, however, based on the results obtained, we cannot say unequivocally that we have obtained an exfoliated material. Nevertheless, the proposed modification procedure clearly affects the morphology of WO3 and leads to loss...
-
Stworzenie stereofonicznej ścieżki dźwiękowej do filmu symulującej dźwięk wielokanałowy
PublikacjaCelem referatu pracy jest przedstawienie procesu tworzenia stereofonicznej ścieżki dźwiękowej do filmu, symulującej dźwięk wielokanałowy w odsłuchu słuchawkowym. Opracowana symulacja dźwięku wielokanałowego wykorzystuje filtrację HRTF (ang. Head-Related-Transfer-Function). W celu umożliwienia jednoczesnego odsłuchu kilku partii instrumentalnych składających się na ścieżkę dźwiękową stworzona została aplikacja wraz z graficznym...
-
Personalized avatar animation for virtual reality
PublikacjaThe paper presents a method for creating a personalized animation of avatar for virtual reality application such as multiplayer on-line games. Animation is stored in a simplified version, containing only keyframes for important avatar poses. This version defines key movements, i.e. roughly describes the avatar's action. Animation is enriched by the user with new motion phases utilizing fuzzy descriptors.Various degrees of motion...
-
Future of nature, our future. A preregistered report on future time perspective, social value orientation, and pro-environmental outcomes based on data from Poland and Sweden
PublikacjaIntroduction: The objective of the study was to examine the role of social value orientation and future time perspective to account for individual differences in pro-environmental behaviors, intentions, and opinions about the link between pro-environmental action and pandemic threat (three separate models) in Polish and Swedish samples expected to differ in rate of pro-environmental behaviors (higher in Sweden). We hypothesized...
-
A Comparative Study of Fuzzy SMC with Adaptive Fuzzy PID for Sensorless Speed Control of Six-Phase Induction Motor
PublikacjaMulti-phase motors have recently replaced three-phase induction motors in a variety of applications due to the numerous benefits they provide, and the absence of speed sensors promotes induction motors with variable speed drives. Sensorless speed control minimizes unnecessary speed encoder cost, reduces maintenance, and improves the motor drive’s reliability. The performance comparison of the fuzzy sliding mode controller (FSMC)...
-
Honey antibacterial activity: A neglected aspect of honey quality assurance as functional food
PublikacjaBackground Honey is considered as a functional food with health-promoting properties. Its potent antibacterial and antibiofilm effects are the major attributes of so called ‘medical-grade honey’ which is topically used for the treatment of burns, wounds and skin disorders. Nevertheless, the current set of honey quality parameters adopted in the European Union do not include its biological properties. Furthermore, in light of the...
-
Management of Urban Waters with Nature-Based Solutions in Circular Cities—Exemplified through Seven Urban Circularity Challenges
PublikacjaNature-Based Solutions (NBS) have been proven to effectively mitigate and solve resource depletion and climate-related challenges in urban areas. The COST (Cooperation in Science and Technology) Action CA17133 entitled “Implementing nature-based solutions (NBS) for building a resourceful circular city” has established seven urban circularity challenges (UCC) that can be addressed effectively with NBS. This paper presents the outcomes...
-
Towards a method for detecting large roll motions suitable for oceangoing ships
PublikacjaThe concept of autonomous merchant ships is quite recent. The increasing interest in autonomous vessels is nowadays calling for smart technologies that are supposed to replace the human actions on board. This involves troublesome issues related to ship safety. In the future, decision-making processes that are conventionally performed by human beings on board ship will be moved ashore to the control centre and maybe even completely...
-
Hydrochar-nanoparticle integration for arsenic removal from wastewater: Challenges, possible solutions, and future horizon
PublikacjaArsenic (As) contamination poses a significant threat to human health, ecosystems, and agriculture, with levels ranging from 12 to 75% attributed to mine waste and stream sediments. This naturally element is abundant in Earth's crust and gets released into the environment through mining and rock processing, causing ≈363 million people to depend on As-contaminated groundwater. To combat this issue, introducing a sustainable hydrochar...
-
An advanced tool integrating failure and sensitivity analysis into novel modeling of the stormwater flood volume
PublikacjaAn innovative tool for modeling the specific flood volume was presented that can be applied to assess the need for stormwater network modernization as well as for advanced flood risk assessment. Field measurements for a catchment area in Kielce, Poland, were used to apply the model and demonstrate its usefulness. This model extends the capability of recently developed statistical and machine learning hydrodynamic models developed...
-
The Physical Activity Environment Policy Index for monitoring government policies and actions to improve physical activity
PublikacjaBackground A multifaceted response, including government action, is essential to improve population levels of physical activity (PA). This article describes the development process of the ‘Physical Activity Environment Policy Index’ (PA-EPI) monitoring framework, a tool to assess government policies and actions for creating a healthy PA environment. Methods An iterative process was undertaken. This involved a review of policy...
-
S09-4 The development of the Physical Activity Environment Policy Index (PA-EPI): a tool for monitoring and benchmarking government policies and actions to improve physical activity
PublikacjaBackground Insufficient physical activity (PA) is a global issue for health. A multifaceted response, including government action, is essential to improve population levels of PA. The purpose of this study was to develop the ‘Physical Activity Environment Policy Index’ (PA-EPI) monitoring framework to assess government policies and actions for creating a healthy PA environment. Methods An iterative process was undertaken. This...
-
Analysis of the Water Level Variation in the Polish Part of the Vistula Lagoon (Baltic Sea) and Estimation of Water Inflow and Outflow Transport through the Strait of Baltiysk in the Years 2008–2017
PublikacjaThe Vistula Lagoon is located in both Poland and Russia along the southern coast of the Baltic Sea. It is connected to the Baltic Sea in the Russian part by the Strait of Baltiysk. The purpose of the paper is to identify the dominant factors underlying the water level variation mechanism at Tolkmicko in the Vistula Lagoon, revealed by a statistical analysis of the measured data and a discussion on the inflow and outflow transport...
-
Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site
PublikacjaAn important stage in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) life cycle is the binding of the spike (S) protein to the angiotensin converting enzyme-2 (ACE2) host cell receptor. Therefore, to explore conserved features in spike protein dynamics and to identify potentially novel regions for drugging, we measured spike protein variability derived from 791 viral genomes and studied its properties by molecular...
-
Generalized regression neural network and fitness dependent optimization: Application to energy harvesting of centralized TEG systems
PublikacjaThe thermoelectric generator (TEG) system has attracted extensive attention because of its applications in centralized solar heat utilization and recoverable heat energy. The operating efficiency of the TEG system is highly affected by operating conditions. In a series-parallel structure, due to diverse temperature differences, the TEG modules show non-linear performance. Due to the non-uniform temperature distribution (NUTD) condition,...
-
The Distribution of Glucosinolates in Different Phenotypes of Lepidium peruvianum and Their Role as Acetyl- and Butyrylcholinesterase Inhibitors—In Silico and In Vitro Studies
PublikacjaThe aim of the study was to present the fingerprint of different Lepidium peruvianum tu- ber extracts showing glucosinolates-containing substances possibly playing an important role in preventinting dementia and other memory disorders. Different phenotypes of Lepidium peruvianum (Brassicaceae) tubers were analysed for their glucosinolate profile using a liquid chromatograph coupled with mass spectrometer (HPLC-ESI-QTOF-MS/MS platform)....
-
New 2-[(4-Amino-6-N-substituted-1,3,5-triazin-2-yl)methylthio]-N-(imidazolidin-2-ylidene)-4-chloro-5-methylbenzenesulfonamide Derivatives, Design, Synthesis and Anticancer Evaluation
PublikacjaIn the search for new compounds with antitumor activity, new potential anticancer agents were designed as molecular hybrids containing the structures of a triazine ring and a sulfonamide fragment. Applying the synthesis in solution, a base of new sulfonamide derivatives 20–162 was obtained by the reaction of the corresponding esters 11–19 with appropriate biguanide hydrochlorides. The structures of the compounds were confirmed...
-
A Comparative Study of Fuzzy SMC with Adaptive Fuzzy PID for Sensorless Speed Control of Six-Phase Induction Motor
PublikacjaMulti-phase motors have recently replaced three-phase induction motors in a variety of applications due to the numerous benefits they provide, and the absence of speed sensors promotes induction motors with variable speed drives. Sensorless speed control minimizes unnecessary speed encoder cost, reduces maintenance, and improves the motor drive’s reliability. The performance comparison of the fuzzy sliding mode controller (FSMC)...
-
Design of Jack-up Platform for 6 MW Wind Turbine: Parametric Analysis Based Dimensioning of Platform Legs
PublikacjaThe article presents the results of the research conducted within the framework of the project entitled WIND-TU-PLA (ERA-NET, MARTEC II), the general aim of which was to design and analyse supporting structures for wind turbines intended for operation on the South Baltic area. The research part described in the article aimed at developing a preliminary design for a jack-up platform which can operate on water areas with depth of...
-
LED Light Sources and Their Complex Set-Up for Visually and Biologically Effective Illumination for Ornamental Indoor Plants
PublikacjaOrnamental plants are often used in indoor environments as part of biophilic design to improve the health and wellbeing of occupants, and to support sustainable, green architecture. Unfortunately, many plants do not thrive and need to be continuously replaced, which is economically unsustainable. The wavelengths and spectrum ratio of commonly used light sources such as light emitting diode (LED), and the lack of an appropriate...
-
Settlement Networks in Polish Spatial Development Regional Plans
PublikacjaIn 1999, ten years after the great political changes in Poland, 16 self-governed regions (in Polish: voivodeship) were created. According to Polish law, voivodeship spatial development plans, or regional plans in short, determine basic elements of the settlement network. No detailed regulations indicate the specific elements of the settlement network or what features of these elements should be determined. For this reason, centres...
-
Combined Single Neuron Unit Activity and Local Field Potential Oscillations in a Human Visual Recognition Memory Task
PublikacjaGOAL: Activities of neuronal networks range from action potential firing of individual neurons, coordinated oscillations of local neuronal assemblies, and distributed neural populations. Here, we describe recordings using hybrid electrodes, containing both micro- and clinical macroelectrodes, to simultaneously sample both large-scale network oscillations and single neuron spiking activity in the medial temporal lobe structures...
-
Molecular basis for the DNA damage induction and anticancer activity of asymmetrically substituted anthrapyridazone PDZ-7
Publikacjanthrapyridazones, imino analogues of anthraquinone, constitute a family of compounds with remarkable anti-cancer activity. To date, over 20 derivatives were studied, of which most displayed nanomolar cytotoxicity towards broad spectrum of cancer cells, including breast, prostate and leukemic ones. BS-154, the most potent derivative, had IC50 values close to 1 nM, however, it was toxic in animal studies. Here, we characterize another...
-
Modulation of UDP-glucuronidation by acridinone antitumor agents C-1305 and C-1311 in HepG2 and HT29 cell lines, despite slight impact in noncellular systems.
PublikacjaBackground Among the studied antitumor acridinone derivatives developed in our laboratory, 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) and 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) exhibited cytotoxic and antitumor properties against several cancer types and were selected to be evaluated in preclinical and early-phase clinical trials. In the present work, we investigated the impact of C-1305...