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Bortezomib induces methylation changes in neuroblastoma cells that appear to play a significant role in resistance development to this compound
PublikacjaThe anticancer activity of bortezomib (BTZ) has been increasingly studied in a number of indications and promising results for the use of this treatment have been shown in neuroblastoma. As BTZ treatment is usually administered in cycles, the development of resistance and side effects in patients undergoing therapy with BTZ remains a major challenge for the clinical usage of this compound. Common resistance development also means...
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Recent progress in ultra-low formaldehyde emitting adhesive systems and formaldehyde scavengers in wood-based panels: a review
PublikacjaTraditional wood-based panels are produced with synthetic, formaldehyde-based adhesives, commonly made from fossil-derived constituents, such as urea, phenol, melamine, etc. Along with their numerous advantages, such as chemical versatility, high reactivity and excellent adhesive performance, these adhesives are characterized by certain problems, connected with the hazardous volatile organic compounds (VOCs), mostly free formaldehyde...
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Advanced Turbine Cycles with Organic Media
PublikacjaOrganic Rankine Cycle (ORC) power plants have become very popular and have found their applications in systems with renewable sources of energy. So far their overall efficiencies are not very impressive and only for the upper temperature of about 300 °C do they exceed 20%. A drawback of these cycles is the limitation of the cycle upper temperature due to the heat exchanger technology and the materials used. However, it is possible...
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Variable‐fidelity modeling of antenna input characteristics using domain confinement and two‐stage Gaussian process regression surrogates
PublikacjaThe major bottleneck of electromagnetic (EM)-driven antenna design is the high CPU cost of massive simulations required by parametric optimization, uncertainty quantification, or robust design procedures. Fast surrogate models may be employed to mitigate this issue to a certain extent. Unfortunately, the curse of dimensionality is a serious limiting factor, hindering the construction of conventional data-driven models valid over...
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Assessment of diversity and composition of bacterial community in Sludge Treatment Reed Bed systems
PublikacjaDue to their low emission of odours and lack of the need to apply additional chemical agents, sludge treatment reed beds (STRBs) constitute an economically feasible and eco-friendly approach to sewage sludge management. Correctly designed and operated STRBs ensure effective reduction of the dry matter content coupled with the mineralisation of organic compounds. Successful operation of STRBs relies on complex interactions between...
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Activating Public Space: How to Promote Physical Activity in Urban Environment
PublikacjaPhysical activity is an essential component of a healthy lifestyle. The quality and equipment of urban public space plays an important role in promoting physical activity among people (residents, tourists). In order for recreation and sports activities to be undertaken willingly, in a safe and comprehensive manner, certain spatial conditions and requirements must be met. The distinctive feature of contemporary large cities is the...
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Urban lighting masterplan – origins, definitions, methodologies and collaborations
PublikacjaAwareness of the significance and benefits of properly designed urban lighting masterplans has been growing since the early 21 st century. There are many factors driving this notable change, such as developments in lighting technology, energy conservation, city branding design and economics, environmental impacts, human health and wellbeing, and people-oriented sociological aspects. As the profession of ‘independent urban lighting...
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Concrete mix design using machine learning
PublikacjaDesigning a concrete mix is a process of synthesizing many components, it is not a simple process and requires extensive technical knowledge. The design process itself focuses on obtaining the required strength of concrete. Very often designing a concrete mix takes into account the need to maintain the proper water-demand and frost-resistance features. The parameters that influence the concrete class most significantly are the...
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Proceedings of the fib Symposium 2019: Concrete - Innovations in Materials, Design and Structures 2019
PublikacjaDesigning a concrete mix is a process of synthesizing many components, it is not a simple process and requires extensive technical knowledge. The design process itself focuses on obtaining the required strength of concrete. Very often designing a concrete mix takes into account the need to maintain the proper water-demand and frost-resistance features. The parameters that influence the concrete class most significantly are the...
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Are We Facing a Tsunami of Vaccine Hesitancy or Outdated Pandemic Policy in Times of Omicron? Analyzing Changes of COVID-19 Vaccination Trends in Poland
PublikacjaIn this study, we analyzed Polish COVID-19 vaccination data until January 2023 from the European Centre for Disease Prevention and Control to understand individual decision making during the milder Omicron wave. Our findings show a general decline in subsequent vaccine uptake. As the number of government-provided doses increased, completion rates among certain low-risk groups dropped to less than 1%. Elderly individuals, especially...
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Transcriptomic landscape of blood platelets in healthy donors
PublikacjaBlood platelet RNA-sequencing is increasingly used among the scientific community. Aberrant platelet transcriptome is common in cancer or cardiovascular disease, but reference data on platelet RNA content in healthy individuals are scarce and merit complex investigation. We sought to explore the dynamics of platelet transcriptome. Datasets from 204 healthy donors were used for the analysis of splice variants, particularly with...
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Vibration Surveillance System with Variable Stiffness Holder for Milling Flexible Details
PublikacjaEfficient milling of the flexible details (i.e. rotor blades, thin-walled elements) using slender ball-end tools is a difficult task due to possibility of vibration occurrence. Because of the existence of certain conditions (small depths of cutting, regeneration phenomena), cutting process may lose stability and self-excited chatter vibration may appear. Frequency of the chatter vibration is close to dominant natural frequency...
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Functional fluorine-doped tin oxide coating for opto-electrochemical label-free biosensors
PublikacjaSensors operating in multiple domains, such as optical and electrochemical, offer properties making biosensing more effective than those working in a single domain. To combine such domains in one sensing device, materials offering a certain set of properties are required. Fluorine-doped tin oxide (FTO) thin film is discussed in this work as functional optically for guiding lossy modes and simultaneously electrochemically, i.e....
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Types of Markov Fields and Tilings
PublikacjaThe method of types is one of the most popular techniques in information theory and combinatorics. However, thus far the method has been mostly applied to one-dimensional Markov processes, and it has not been thoroughly studied for general Markov fields. Markov fields over a finite alphabet of size m ≥ 2 can be viewed as models for multi-dimensional systems with local interactions. The locality of these interactions is represented...
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Multiple transcriptional factors regulate transcription of the rpoE gene in Escherichia coli under different growth conditions and when the lipopolysaccharide biosynthesis is defective.
PublikacjaThe RpoE sigma factor is essential for the viability of Escherichia coli. RpoE regulates extracytoplasmic functions including lipopolysaccharide (LPS) translocation and some of its non-stoichiometric modifications. Transcription of the rpoE gene is positively autoregulated by EσE and by unknown mechanisms that control the expression of its distally located promoter(s). Mapping of 5′ ends of rpoE mRNA identified five new transcriptional...
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Assessing ecotoxicity and the endocrine potential of selected phthalates, BADGE and BFDGE derivatives in relation to environmentally detectable levels
PublikacjaThere is no doubt that the subject area of plasticmaterials (e.g., production of epoxy resins or polyesters) is inherently connected to issues concerning bisphenol A (BPA) and its analogues. Unfortunately, much less attention has been given to other compounds, which are also used for the production of these materials. Bisphenol A diglycidyl ether (BADGE) is a synthetic industrial compound obtained by a condensation reaction between...
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Fast and reliable knowledge-based design closure of antennas by means of iterative prediction-correction scheme
PublikacjaA novel framework for expedited antenna optimization with an iterative prediction-correction scheme is proposed. The methodology is comprehensively validated using three real-world antenna structures: narrow-band, dual-band and wideband, optimized under various design scenarios. The keystone of the proposed approach is to reuse designs pre-optimized for various sets of performance specifications and to encode them into metamodels...
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Transcriptomic landscape of blood platelets in healthy donors
PublikacjaBACKGROUND Blood platelet RNA-sequencing is increasingly used among the scientific community. Aberrant platelet transcriptome is common in cancer or cardiovascular disease, but reference data on platelet RNA content in healthy individuals are scarce and merit complex investigation. METHODS We sought to explore the dynamics of platelet transcriptome. Datasets from 204 healthy donors were used for the analysis of splice variants,...
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Multi-Temporal Analysis of Changes of the Southern Part of the Baltic Sea Coast Using Aerial Remote Sensing Data
PublikacjaUnderstanding processes that affect changes in the coastal zone and the ability to predict these processes in the future depends on the period for which detailed monitoring is carried out and on the type of coast. This paper analyzes a southern fragment of the Baltic coast (30 km), where there has been no anthropogenic impact (Slowinski National Park). The study was carried out covering a time interval of 65 years. Historic and...
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Low-Cost Design Optimization of Microwave Passives Using Multi-Fidelity EM Simulations and Selective Broyden Updates
PublikacjaGeometry parameters of contemporary microwave passives have to be carefully tuned in the final stages of their design process to ensure the best possible performance. For reliability reasons, the tuning has to be to be carried out at the level of full-wave electromagnetic (EM) simulations. This is because traditional modeling methods are incapable of quantifying certain phenomena that may affect operation and performance of these...
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Optimization-Based High-Frequency Circuit Miniaturization through Implicit and Explicit Constraint Handling: Recent Advances
PublikacjaMiniaturization trends in high-frequency electronics have led to accommodation challenges in the integration of the corresponding components. Size reduction thereof has become a practical necessity. At the same time, the increasing performance demands imposed on electronic systems remain in conflict with component miniaturization. On the practical side, the challenges related to handling design constraints are aggravated by the...
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Social benefits valuation of hosting non-mega sporting events
PublikacjaPurpose In the study, an attempt was made to estimate the social benefits resulting from three non-mega sporting events organized in Ergo Arena located on the border of two cities in Poland. By attributing a value to intangible social benefits, the intangible effect was determined and compared to the expenditure incurred in the construction of Ergo Arena Hall. Design/methodology/approach In order to value social intangible effects...
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ASSESSMENT OF FINANCIAL SECURITY OF AN ENTERPRISE ON THE BASIS OF BEHAVIORAL ECONOMICS
PublikacjaThe article substantiates that the level of company’s financial security depends not so much on the indicators of its activity, but on its perception of decision-makers and other stakeholders. At the same time, this perception is formed due to the continuous participation of the stakeholder in operations, constant monitoring of financial indicators, the study of current approaches to enterprise management, changes in the environment,...
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Low-cost multi-criterial design optimization of compact microwave passives using constrained surrogates and dimensionality reduction
PublikacjaDesign of contemporary microwave circuits is a challenging task. Typically, it has to take into account several performance requirements and constraints. The design objectives are often conflicting and their simultaneous improvement may not be possible; instead, compromise solutions are to be sought. Representative examples are miniaturized microwave passives where reduction of the circuit size has a detrimental effect on its electrical...
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Finite-difference time-domain analyses of active cloaking for electrically-large objects
PublikacjaInvisibility cloaking devices constitute a unique and potentially disruptive technology, but only if they can work over broad bandwidths for electrically-large objects. So far, the only known scheme that allows for broadband scattering cancellation from an electrically-large object is based on an active implementation where electric and magnetic sources are deployed over a surface surrounding the object, but whose ‘switching on’...
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Molecular identification and genotyping of Staphylococci: genus, species, strains, colnes, lineages, and interspecies exchanges
PublikacjaStaphylococci are increasingly recognized as etiological agents of many opportunistic human and animal infections, emphasizing the need for a rapid and accurate identification, even to a genotypical level of these bacteria. In the recent years, there has been a significant progress in typing and phylogenetic study of Staphylococcus species. Here, we describe molecular methods used in taxonomy as well as staphylococci characterization....
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The issue of uncertainty of visual measurement techniques for long distance measurements based on the example of applying electric traction elements in diagnostics and monitoring
PublikacjaRail transport is the most economical and energy-effective in the field of land transport, in particular electrified. In order to ensure efficient and reliable operation of electrified rail transport, the issues of monitoring and diagnostics of the traction infrastructure and vehicles are extremely important. The most critical point in the transmission of electric energy to the vehicle is the sliding contact of the current collector...
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Reliability and types of diagnosis in the process of diesel engine operation
PublikacjaThe article presents complexity of the problem concerning development of diagnosis with defined reliability by a diagnosing system (SDG) on technical condition of marine combustion engines, especially main engines. It was shown that development of the final diagnosis, the so-called initial operation diagnosis, on the operational usability (fDG on PEx) of a main engine in particular, is not possible without prior development of...
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Sensitivity analysis as a tool to optimise Human Development Index
PublikacjaResearch background: Composite indicators are commonly used as an approximation tool to measure economic development, the standard of living, competitiveness, fairness, effectiveness, and many others being willingly implemented into many different research disciplines. However, it seems that in most cases, the variable weighting procedure is avoided or erroneous since, in most cases, the so-called...
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Importance of sign conventions on analytical solutions to the wave-induced cyclic response of a poro-elastic seabed
PublikacjaThis paper discusses the influence of different sign conventions for strains and stresses, i.e. the solid mechanics sign convention and the soil mechanics sign convention, on the form of governing partial differential equations (the static equilibrium equations and the continuity equation) used to describe the wave-induced cyclic response of a poro-elastic seabed due to propagation of a sinusoidal surface water-wave. Some selected...
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Tailoring Defects in B, N-Codoped Carbon Nanowalls for Direct Electrochemical Oxidation of Glyphosate and its Metabolites
PublikacjaTailoring the defects in graphene and its related carbon allotropes has great potential to exploit their enhanced electrochemical properties for energy applications, environmental remediation, and sensing. Vertical graphene, also known as carbon nanowalls (CNWs), exhibits a large surface area, enhanced charge transfer capability, and high defect density, making it suitable for a wide range of emerging applications. However, precise...
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Diversification of investment efficiency in selected economies
PublikacjaAn assessment of the effectiveness of investments is a key element of investment processes. In order to be comprehensive and exhaustive, it should go beyond the scope of the microeconomic assessment and take into account the macroeconomic calculation of effectiveness. The prerequisite for the effectiveness of investment decisions implemented by private companies is the maximization of the return on the investments. When attempting...
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Knowledge pills in Education and Training: A Literature Review
PublikacjaObject and purpose: Knowledge pills (KPs) are a technique for transferring knowledge through short factual batches of content. In education and vocational training, they can help learners acquire specific pieces of knowledge in a few minutes, through a “microteaching” approach where learners can be involved in active and interactive exercises, quizzes, and games. Thanks to the advancements of multimedia platforms, they can contain...
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FACES OF MODERNISM - URBAN PLANNING OF SOCIAL HOUSING ESTATES IN GDANSK AND HAMBURG-ALTONA
PublikacjaThe paper aims to compare the modernistic social housing estates built during the interwar period in the Free City of Gdansk and in Altona, the small neighbour of Hamburg. The comparison is based on the analysis of the factors, which significantly affected the decisions regarding spatial transformations and the development of both cities in that time. These factors include primarily: poor living conditions, resulting from the explosive...
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Composite as a Material of the Future in the Era of Green Deal Implementation Strategies
PublikacjaComposite materials have become synonymous with modernity, desired in nearly every aspect of our daily lives, from simple everyday objects to sanitary facilities, pipelines, the construction of modern sewer networks, their renovation, water supply, and storage reservoirs, to complex structures—automotive, planes, and space science. Composites have seen a considerable rise in attention owing to their characteristics, durability,...
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Towards a modification of a regulatory framework aiming at bunker oil spill prevention from ships - A design aspect of bunker tanks vents location guided by CFD simulations
PublikacjaAlthough accidental bunker oil spills at seaway are relatively rare events, they can be pose real threat to the natural marine environment. One of the reasons for the bunker spill to occur is a design failure; one of the ways it can demonstrate is an improper location or height of vent heads, leading to a bunker oil discharge during heavy rolling, due to sloshing phenomenon. Design of a ship and her systems is guided by various...
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Global EM-Driven Optimization of Multi-Band Antennas Using Knowledge-Based Inverse Response-Feature Surrogates
PublikacjaElectromagnetic simulation tools have been playing an increasing role in the design of contemporary antenna structures. The employment of electromagnetic analysis ensures reliability of evaluating antenna characteristics but also incurs considerable computational expenses whenever massive simulations are involved (e.g., parametric optimization, uncertainty quantification). This high cost is the most serious bottleneck of simulation-driven...
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GVC and wage dispersion. Firm-level evidence from employee-employer database
PublikacjaResearch background: Wage inequalities are still part of an interesting policy-oriented research area. Given the developments in international trade models (heterogeneity of firms) and increasing availability of micro-level data, more and more attention is paid to wage differences observed within and be-tween firms. Purpose of the article: The aim of the paper is to address the research gap concerning limited cross-country evidence...
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Monolithic vs. Microservice Architecture: A Performance and Scalability Evaluation
PublikacjaContext. Since its proclamation in 2012, microservices-based architecture has gained widespread popularity due to its advantages, such as improved availability, fault tolerance, and horizontal scalability, as well as greater software development agility. Motivation. Yet, refactoring a monolith to microservices by smaller businesses and expecting that the migration will bring benefits similar to those reported by top global companies,...
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Metoda prognozowania mocy skrawania przy przecinaniu piłami polskiego drewna sosnowego z uwzględnieniem wiązkości materiału obrabianego
PublikacjaW pracy zostały przedstawione wartości właściwości materiałowych tj.: wiązkość R oraz naprężenia tnące w strefie skrawania τy, dla drewna sosnowego (Pinus sylvestris L.). Badane próbki drewna pochodziły z czterech Krain Przyrodniczo - Leśnych Polski: Bałtyckiej Krainy Przyrodniczo - Leśnej (kraina A), Karpackiej Krainy Przyrodniczo - Leśnej (kraina B), Małopolskiej Krainy Przyrodniczo - Leśnej (kraina C) oraz Wielkopolsko - Pomorskiej...
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Transcriptomic responses to wounding: meta-analysis of gene expression microarray data
PublikacjaBackground A vast amount of microarray data on transcriptomic response to injury has been collected so far. We designed the analysis in order to identify the genes displaying significant changes in expression after wounding in different organisms and tissues. This meta-analysis is the first study to compare gene expression profiles in response to wounding in as different tissues as heart, liver, skin, bones, and spinal cord, and...
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Novel therapeutic compound acridine–retrotuftsin action on biological forms of melanoma and neuroblastoma
PublikacjaPURPOSE: As a continuation of our search for anticancer agents, we have synthesized a new acridine-retrotuftsin analog HClx9-[Arg(NO2)-Pro-Lys-Thr-OCH3]-1-nitroacridine (named ART) and have evaluated its activity against melanoma and neuroblastoma lines. Both tumors develop from cells (melanocytes, neurons) of neuroectodermal origin, and both are tumors with high heterogeneity and unsatisfactory susceptibility to chemotherapies....
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Experimental study on models of cylindrical steel tanks under mining tremors and moderate earthquakes
PublikacjaThe aim of the study is to show the results of complex shaking table experimental investigation focused on the response of two models of cylindrical steel tanks under mining tremors and moderate earthquakes, including the aspects of diagnosis of structural damage. Firstly, the impact and the sweep-sine tests have been carried out, so as to determine the dynamic properties of models filled with different levels of liquid. Then,...
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Cooperation areas between universities and industry - case studies in the area of civil engineering
PublikacjaThe paper describes the areas of cooperation between universities and industry in the area of civil engineering. Presented examples are related to didactics, research grants and commissioned works. On the basis of the authors own experiences the mutual benefits of cooperation in different areas are described. As well as the assessment criteria of the areas of cooperation by the scientific community. The first area of cooperation...
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Impact of enhanced pretreatment on biological nutrient removal in municipal wastewater treatment plants
PublikacjaThe aim of this study was to determine the effect of enhanced primary treatment on: increasing primary sludge production for increased biogas production; reducing the organic load on downstream biological treatment processes and thereby reducing energy consumption for aeration; denitrification and enhanced biological phosphorus removal (EBPR) rates in the activated sludge system. For this purpose, three commercial organic polymers...
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Mechanical response of human thoracic spine ligaments under quasi-static loading: An experimental study
PublikacjaPurpose This study aimed to investigate the geometrical and mechanical properties of human thoracic spine ligaments subjected to uniaxial quasi-static tensile test. Methods Four human thoracic spines, obtained through a body donation program, were utilized for the study. The anterior longitudinal ligament (ALL), posterior longitudinal ligament (PLL), capsular ligament (CL), ligamenta flava (LF), and the interspinous ligament and...
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Journey towards light – evolutionary adaptations of humans, flora and fauna. Guidelines for safe and healthy illumination
PublikacjaThe paper examines using relatively recent discoveries on how evolution has embedded within all living organisms a natural sensitivity towards their native environment, in particular luminance levels and specific wavelengths of light. The studies conducted so far indicate that lighting installations that are visible after dark impact on humans, flora and fauna and influence our evolutionary dispositions, possibly with negative...
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Review on robust laser light interaction with titania – Patterning, crystallisation and ablation processes
PublikacjaTitanium dioxide is regarded as a very promising semiconducting material that is widely applied in many everyday-use products, devices, and processes. In general, those applications can be divided into energy or environmental categories, where a high conversion rate, and energy and power density are of particular interest. Therefore, many efforts are being put towards the elaboration of novel production routes, and improving the...
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Physics-Based Coarse-Grained Modeling in Bio- and Nanochemistry
PublikacjaCoarse-grained approaches, in which groups of atoms are represented by single interaction sites, are very important in biological and materials sciences because they enable us to cover the size- and time-scales by several orders of magnitude larger than those available all-atom simulations, while largely keeping the details of the systems studied. The coarse-grained approaches differ by the scheme of reduction and by the origin...
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Escherichia coli K-12 suppressor-free mutants lacking early glycosyltransferases and late acyltransferases. Minimal lipopolysaccharide structure and induction of envelope stress response.
PublikacjaTo elucidate the minimal lipopolysaccharide (LPS) structure needed for the viability of Escherichia coli, suppressor-free strains lacking either the 3-deoxy-d-manno-oct-2-ulosonic acid transferase waaA gene or derivatives of the heptosyltransferase I waaC deletion with lack of one or all late acyltransferases (lpxL/M/P) and/or various outer membrane biogenesis factors were constructed. Δ(waaC lpxL lpxM lpxP) and waaA mutants exhibited...