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Synthesis and biological evaluation of thiophosphate tricyclic coumarin derivatives as steroid sulfatase inhibitors
PublikacjaSteroid sulfatase (STS) enzyme inhibition is an important approach to the management of hormone-dependent breast cancer. In this paper, we report convenient methods for the synthesis and biological evaluation of thiophosphate tricyclic coumarin analogs exhibiting STS activity. The described methods are based on the straightforward preparation of 7-hydroxy-2,3-dihydro-1H-cyclopenta[c]chromen-2-one, 3-hydroxy- 7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one,...
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Impact of enhanced pretreatment on biological nutrient removal in municipal wastewater treatment plants
PublikacjaThe aim of this study was to determine the effect of enhanced primary treatment on: increasing primary sludge production for increased biogas production; reducing the organic load on downstream biological treatment processes and thereby reducing energy consumption for aeration; denitrification and enhanced biological phosphorus removal (EBPR) rates in the activated sludge system. For this purpose, three commercial organic polymers...
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Natural and synthetic acridines/acridones as antitumor agents: their biological activities and methods of synthesis.
PublikacjaPraca stanowi przegląd opisanych w literaturze chemicznej modyfikacji struktur naturalnych i syntetycznych pochodnych akrydyny i akrydonu. Artykuł obejmuje swym zakresem metody syntezy, a także wpływ budowy cząsteczek tych związków na ich aktywność przeciwnowotworową oraz mechanizm działania.
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Operating and economical conditions of cooling water control for marine steam turbines condensers
PublikacjaW pracy dokonano analizy ekonomicznej i eksploatacyjnej sterowania pracą pomp wody chłodzącej skraplacze turbin okrętowych. Wzięto pod uwagę cechy konstrukcyjne pomp wody chłodzącej skraplacze główne i najnowsze wyniki badań dla takich pomp w zastosowaniach lądowych. Uwagę skupiono przede wszystkim na turbinowych parowych siłowniach okrętowych.
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The influence of selenium addition during seeds' germination on the biological properties of obtained sprouts
PublikacjaSelenium plays a vital role in human body, because in the form of aminoacids (Se-methionine, Se-cysteine) it is found in the active centres of over 25 enzymes, including those regarded as 'cytoprotective'. Unfortunatelly, its daily intake in Poland and other European countries is lower than predicted by dietary recommendations. The consequences of selenium deficiency in diet might be severe, including higher susceptibility to cardio-vascular...
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ECONOMICAL AND SAFE METHOD OF GRANULAR MATERIAL STORAGE IN SILOS IN OFFSHORE PORT TERMINALS
PublikacjaThe article discusses issues related with storage of granular materials in silos made of corrugated sheets and reinforced with vertical ribs. Advantages and disadvantages of these structures are named, and typical technological solutions used by largest silo producers are presented. Moreover, basic assumptions of Eurocode 3 are discussed in the context of determining the buckling load capacity of a ribbed jacket. Alternative methods...
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Novel therapeutic compound acridine–retrotuftsin action on biological forms of melanoma and neuroblastoma
PublikacjaPURPOSE: As a continuation of our search for anticancer agents, we have synthesized a new acridine-retrotuftsin analog HClx9-[Arg(NO2)-Pro-Lys-Thr-OCH3]-1-nitroacridine (named ART) and have evaluated its activity against melanoma and neuroblastoma lines. Both tumors develop from cells (melanocytes, neurons) of neuroectodermal origin, and both are tumors with high heterogeneity and unsatisfactory susceptibility to chemotherapies....
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Mixed integer nonlinear optimization of biological processes in wastewater sequencing batch reactor
PublikacjaWastewater treatment plays a key role for humanity. The waste entering lakes, rivers, and seas deteriorates daily quality of life. Therefore, it is very important to improve the efficiency of wastewater treatment. From a control point of view, a biological wastewater treatment plant is a complex, non-linear, multidimensional, hybrid control system. The paper presents the design of the optimizing hierarchical control system applied...
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Physical, Chemical and Biological Changes in the Gulf of Gdańsk Ecosystem (Southern Baltic Sea).
PublikacjaPrzedstawiono fizyczne, chemiczne i biologiczne zmiany zachodzące w ekosystemie Zatoki Gdańskiej (Południowy Bałtyk. Opisano klimat (temp. wody, opady poziom morza, zasolenie), fluktuację stężeń związków biogennych (azotany,fosforany, krzemiany), poziom organicznych zanieczyszczeń (POP´s, PcB´, pestycydy, WWA) oraz zmiany w biologicznym życiu morza.
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Rational design, synthesis and biological evaluation of thiadiazinoacridines: a new class of antitumor agents.
PublikacjaZsyntetyzowano serię związków o potencjalnej zdolności do wiązania się z DNA z grupy tiadiazinoakrydyn poprzez cyklizację odpowiednich pochodnych 9-imino-4-nitro-9,10-dihydroakrydyny. Zbadano ich zdolność do wiązania się z DNA oraz cytotoksyczność względem kilku linii komórek nowotworwych. Badania aktywności przeciwnowotworowej wobec białaczki P388 wskazały na zgodność tych wyników z wynikami cytotoksyczności in vitro. Wykazano,...
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Phytochemical screening and biological evaluation of Greek sage (Salvia fruticosa Mill.) extracts
PublikacjaThis study explores the influence of extraction solvents on the composition and bioactivity of Salvia fruticosa extracts. Ultrasound-assisted extraction with water, ethanol and their mixtures in variable proportions was used to produce four different extracts. An untargeted UPLC/MS‑based metabolomics was performed to discover metabolites profile variation between the extracts. In the analyzed samples, 2704 features had been detected,...
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Phosphate tricyclic coumarin analogs as steroid sulfatase inhibitors: synthesis and biological activity.
PublikacjaIn the present work, we report convenient methods for the synthesis and biological evaluation of phosphate tricyclic coumarin derivatives as potential steroid sulfatase inhibitors. The described synthesis includes the straightforward preparation of 7-hydroxy-2,3-dihydro-1H-cyclopenta[c]chromen-4-one, 3-hydroxy-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one and 3-hydroxy-8,9,10,11-tetrahydro-7H-cyclohepta[c]chromen-6-one modified...
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The influence of pre- and postharvest treatments on selected biological and epigenetic activities of Brassica sprouts
PublikacjaIntroduction The Brassica vegetables are rich in glucosinolates (GLs), which are enzymatically hydrolysed to bioactive isothiocynates (ITC) and indoles, regarded as the most promising chemopreventing agents. However, in the majority of brassica sprouts the GL conversion into these beneficial derivatives occurs at the level of about 1 %, while in cabbage leaves exceeds 70%. Since sprouts represent plant material, which is frequently...
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BIOLOGICAL AGE ASSESSMENT ALGORITHMS BASED ON X-RAY IMAGES OF BONE TISSUE
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Influence of Different Nanometals Implemented in PMMA Bone Cement on Biological and Mechanical Properties
PublikacjaCemented arthroplasty is a common process to fix prostheses when a patient becomes older and his/her bone quality deteriorates. The applied cements are biocompatible, can transfer loads, and dampen vibrations, but do not provide antibacterial protection. The present work is aimed at the development of cement with antibacterial effectivity achieved with the implementation of nanoparticles of different metals. The powders of Ag,...
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LC-ESI-MS profiling of Potentilla norvegica and evaluation of its biological activities
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Preliminary investigations on biological treatment of aqueous phase separated from cutting fluids
PublikacjaZaprezentowano wyniki fizykochemicznego podczyszczania przepracowanych cieczy obróbkowych pochodzących z różnych źródeł. Emulsje przepracowanych cieczy obróbkowych zostały rozdzielone na fazę organiczną i wodną z wykorzystaniem różnych koagulantów. Wydzielona faza wodna została następnie poddana biologicznemu oczyszczaniu z wykorzystaniem osadu czynnego. W wyniku oczyszczania ścieków uzyskano 59-88% obniżenie wartości ChZT.
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Significant Down-Regulation of “Biological Adhesion” Genes in Porcine Oocytes after IVM
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Analysis of Potential Exposure to Components of Municipal Solid Waste in a Mechanical Biological Treatment
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Application of pH measurements for the following the course of biological treatment of wastewater and its control
PublikacjaZaprezentowano wyniki badań przeprowadzonych w skali laboratoryjnej w reaktorze imitującym działanie reaktora SBR. Oczyszczaniu poddano ścieki syntetyczne z dodatkiem glukozy. W trakcie oczyszczania ścieków monitorowano zmiany pH, redox, przewodności oraz stężenia azotu amonowego, azotanów i fosforanów. Stwierdzono korelację między pH i zmianami stężenia fosoranów oraz brak podobnej zależności dla związków azotowych.
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Solid phase synthesis and biological activity of linear tuftsin and retro-tuftsin derivatives
PublikacjaPrzedstawiono syntezę na fazie stałej nowych pochodnych tuftsyny i retro-tuftsyny i ich mikrobiologiczne właściwości. Otrzymane pochodne zawierały wiązanie izopeptydowe między epsilon-aminową grupą lizyny a takimi aminokwasami jak: Ala, beta-Ala, Val, Ile, Gly.
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Optical, colloidal and biological properties of up-converting nanoparticles embedded in polyester nanocarriers
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CRF1 receptor splicing in epidermal keratinocytes: Potential biological role and environmental regulations
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Properties of PEEK-supported films of biological substances prepared by the Langmuir-Blodgett technique
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Few-Layered Hexagonal Boron Nitride: Functionalization, Nanocomposites, and Physicochemical and Biological Properties
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Hexagonal Boron Nitride Functionalized with Au Nanoparticles—Properties and Potential Biological Applications
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Scaffolds Loaded with Dialdehyde Chitosan and Collagen—Their Physico-Chemical Properties and Biological Assessment
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The role of particulate and colloidal substrate in biological nutrient removal activated sludge systems
PublikacjaThe authors investigated COD fractionation according to the physical state (soluble/colloidal/particulate) in four wastewater treatment plants (WWTPs) in northern Poland. It was found that particulate and colloidal organic compounds constituted up to 70% of total COD. On the other hand, according to literature data, municipal wastewater contains readily and slowly biodegradable substrates in the amount of approximately 10-30% and...
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Biological Activity of Compounds Exhibiting Local Anesthetics's Properties Evaluated by QSAR Approach
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Nutritional Value and Biological Activity of Gluten-Free Bread Enriched with Cricket Powder
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Comparison of the Toxicity of Pristine Graphene and Graphene Oxide, Using Four Biological Models
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Gallic Acid-Functionalized, TiO2-Based Nanomaterial—Preparation, Physicochemical and Biological Properties
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Membrane Filtration-Assisted Enzymatic Hydrolysis Affects the Biological Activity of Potato Juice
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Thymus serpyllum Essential Oil and Its Biological Activity as a Modern Food Preserver
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Synthesis, biological activity and molecular modelling studies of tricyclic alkylimidazo-, pyrimido- and diazepinopurinediones
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The SARS-CoV-2 and mental health: From biological mechanisms to social consequences
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ANALYZING TITLES OF ECONOMY NEWS TO UNDERSTAND IMPACT OF COVID-19 ON ECONOMICAL SITUATION
PublikacjaCovid-19 affected the whole world in a short time, causing serious panic and uncertainty in society. Because it was an unprecedented disease, the medical community has worked hard to find out how to deal with it, and it continues to do so. The rapid spread of the disease, the shortage of hospital capacity and the increase in deaths drove the whole world to a closure, so to speak. In this time period, life in the world came to a...
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Supervisory fuzzy control system for biological processes in sequencing wastewater batch reactor
PublikacjaThe paper proposes the design of the supervisory heuristic fuzzy control system applied to a Sequencing Batch Reactor (SBR) in the Wastewater Treatment Plant (WWTP). Based on real data records and the biological process and aeration system models, a control system for biological processes has been designed. The supervisory control system performs management of the reactor work cycle, determines the phase length, controls the sludge...
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Model of aeration system at biological wastewater treatment plant for control design purposes
PublikacjaThe wastewater treatment plant (WWTP) is a dynamic, very complex system, in which the most important control parameter is the dissolved oxygen (DO) con-centration. The air is supplied to biological WWTP by the aeration system. Aera-tion is an important and expensive activity in WWTP. The aeration of sewage ful-fils a twofold role. Firstly, oxygen is provided as the main component for biolog-ical processes. Secondly, it supports...
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The concept of research on ecological, energy and reliability effects of modified marine fuel oils application to supply compression-ignition engines in real conditions
PublikacjaWithin the article, basic assumptions of the research project financed by Regional Fund for Environmental Protection and Water in Gdansk were described. The project concerns the experimental investigations carried out on laboratory compression-ignition engine in conditions of its supply with a non-standard marine fuel oil. Configuration and measuring capability of laboratory test bed presently being constructed were introduced....
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EU Project of Life Programme “Algae Service for Life” Creates Tools for Ecological Service to Mitigate Cyanobacteria and Macroalgae Blooms in Freshwater Ecosystems
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Acclimation of denitrifying activated sludge to a single vs. complex external carbon source during a start-up of sequencing batch reactors treating ammonium-rich anaerobic sludge digester liquors
PublikacjaIn this study, denitrification of ammonium- reach anaerobic sludge digester liquor was investigated during start-up periods of two laboratory- scale ‘‘fill-and-draw’’ reactors. One reactor was fed with a single carbon source (ethanol), whereas the other reactor was fed with a complex carbon source (fusel oil). During two acclimation experiments, the structure of microbial community involved in denitrification was analyzed using...
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Characteristics and fate of organic nitrogen in municipal biological nutrient removal wastewater treatment plants
PublikacjaThe aim of this study was to investigate the occurrence and fate of colloidal and dissolved organic nitrogen (CON and DON) across biological nutrient removal (BNR) activated sludge bioreactors. Primary and secondary effluent total nitrogen (TN) measurements and component fractionation, CON and DON concentration profiles across BNR bioreactors, and laboratory batch experiments with the process mixed liquor were carried out at several...
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Synthesis of functionalized new conjugates of batracylin with tuftsin/ retro-tuftsin derivatives and their biological evaluation
PublikacjaNew batracylin conjugates with tuftsin/retro-tuftsin derivatives were designed and synthesized using T3P as a coupling agent. The conjugates possess an amide bond formed between the carboxyl group of heterocyclic molecule and the N-termini of the tuftsin/retro-tuftsin chain. The in vitro cytotoxic activity of the new analogues and their precursors was evaluated using a series of human and murine tumor cells. BAT conjugates containing...
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Chemical modification of natural immunomodulators tuftsin and muramyl dipeptide significantly influence their biological activity
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Assessment of the usefulness of bacterial cellulose produced by Gluconacetobacter xylinus E25 as a new biological implant
PublikacjaBionanocellulose (BNC) is a clear polymer produced by the bacterium Gluconacetobacter xylinus. In our current study, “Research on the use of bacterial nanocellulose (BNC) in regenerative medicine as a function of the biological implants in cardiac and vascular surgery”, we carried out material analysis, biochemical analysis, in vitro tests and in vivo animal model testing. In stage 1 of the project, we carried out physical and...
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An overview of the cognitive and biological effects of city nighttime illumination including a London case study
PublikacjaCurrent scientific research demonstrates how critical the effects of city nighttime illumination are upon cognitive and biological health1 – which needs to be adequately acknowledged, understood and addressed by conscious cities and the plans they develop. Until recent decades, the design of nighttime lighting was determined mostly by electrical engineers who often applied technical standards to meet the requirements of vehicle-focused...
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The relationship between standard reduction potentials of catechins and biological activities involved in redox control
PublikacjaRedox homeostasis involves factors that ensure proper function of cells. The excess reactive oxygen species (ROS) leads to oxidative stress and increased risk of oxidative damage to cellular components. In contrast, upon reductive stress, insufficient ROS abundance may result in faulty cell signalling. It may be expected that dietary antioxidants, depending on their standard reduction potentials (E°), will affect both scenarios....
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Adaptive stochastic and hybrid nonlinear optimization algorithms for improving the effectiveness of the biological processes at WWTP
PublikacjaWastewater treatment plays an important factor in the modern world. Insufficient treatment may result in environmental pollution which can further lead to disasters and diseases. However, processes that take place inside wastewater treatment plants (WWTP) are highly complex in nature, therefore it is difficult to design an efficient, optimal control system. The problem regarding biochemical reactions inside Sequential Batch Reactor...
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Induced-fit binding of laccase to gold and carbon electrodes for the biological fuel cell applications
PublikacjaAnalogues of laccase natural substrates (syringic, veratric, ferulic, vanillic, isovanillic, 3,5-dimethoxybenzoic aldehydes) were employed to bind and orient laccase molecules in a way which facilitates adsorption of the catalyst molecules and their electrical connection with the conductive support. Laccase was bound efficiently to these substrates both on gold and carbon electrodes forming, respectively, 2D and 3D films sensitive...