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Wyniki wyszukiwania dla: ACETON
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Highly efficient maximum power point tracking control technique for PV system under dynamic operating conditions
PublikacjaThe application of small-scale electrical systems is widespread and the integration of Maximum Power Point Tracking (MPPT) control for Photovoltaic systems with battery applications further enhances the techno-economic feasibility of renewable systems. For this purpose, a novel MPPT control system using Dynamic Group based cooperation optimization (DGBCO) algorithm is utilized for PV systems. The population in the DGBCO is divided...
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Lipopolysaccharides: regulated biosynthesis and structural diversity
PublikacjaThe cell envelope of Gram-negative bacteria contains two distinct membranes, an inner (IM) and an outer (OM) membrane, separated by the periplasm, a hydrophilic compartment that includes a thin layer of peptidoglycan. The most distinguishing feature of such bacteria is the presence of an asymmetric OM with phospholipids located in the inner leaflet and lipopolysaccharides (LPSs) facing the outer leaflet. The maintenance of this...
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A new 1-nitro-9-aminoacridine derivative targeting yeast topoisomerase II able to overcome fluconazole-resistance
PublikacjaFungal resistance remains a significant threat and a leading cause of death worldwide. Thus, overcoming microbial infections have again become a serious clinical problem. Although acridine derivatives are widely analyzed as anticancer agents, only a few reports have demonstrated their antifungal activity. In an effort to develop biologically active antifungals, twelve novel C-857 (9-(2′ -hydroxyethylamino)-1-nitroacridine) and...
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Comparison of nitrogen and VFA removal pathways in autotrophic and organotrophic anammox reactors
PublikacjaOrganotrophic anammox is a promising process for treating both nitrogen and organic containing wastewater than that of the traditional autotrophic anammox for sole nitrogen removal. However pathways of nitrogen removal particularly at metagenomic level in both processes are still unknown. Here we report, metabolic pathways of nitrogen removal in two lab-scale sequencing batch reactors (SBR), one autotrophic and another organotrophic...
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Systematic review examining the evidence for impact of school policies on physical activity
PublikacjaBackground Epidemiological evidence has demonstrated that physical activity can have substantive health benefits for children and young people. The 'Policy Evaluation Network' is a multi-disciplinary research network across 7 European countries and New Zealand aimed at building capacity and evaluating the level of impact of policy interventions for promoting healthy lifestyles. The Toronto Charter identified 'whole-of-school' programmes...
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Electrochemical simulation of metabolic reduction and conjugation reactions of unsymmetrical bisacridine antitumor agents, C-2028 and C-2053
PublikacjaElectrochemistry (EC) coupled with analysis techniques such as liquid chromatography (LC) and mass spectrometry (MS) has been developed as a powerful tool for drug metabolism simulation. The application of EC in metabolic studies is particularly favourable due to the low matrix contribution compared to in vitro or in vivo biological models. In this paper, the EC(/LC)/MS system was applied to simulate phase I metabolism of the representative...
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Dibutyl phthalate disrupts conserved circadian rhythm in Drosophila and human cells
PublikacjaPeople are constantly exposed to phthalates, due to their common use in the production of plastics, pharmaceuticals, cosmetics and skin care products. The ability of phthalates to disrupt endocrine signaling, leading to developmental, reproductive and metabolic defects, has been studied, yet how phthalates interfere with these biological functions is still unclear. To uncover DBP interacting molecular pathways, we raised Drosophila...
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Architects and urban planners in the face of energy transition - smart cities energy aspects in shaping building structures and cities
PublikacjaContemporary architects and urban planners are facing steadily increasing challenges. The growing problems around environmental issues, shrinking natural resources and climate action are just some of them. Currently, planning should also include balancing with all the aspects of sustainable development such as not only the environmental issues, but also social and economic ones. How to meet them in the era of energy transition...
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The Contemporary aspects of revitalization of the buildings and the port areas
PublikacjaPort cities are the forefront of globalization. The continued growth of international trade of goods and services has now played a major role in shaping the economic and social world. Strategies for mutual cooperation and follow-up between countries, cities and regions are increasingly complex. On the one hand it brings profits, on the other leads to destabilization and the need for transformation and constant modernization. Port...
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Structural studies of a cold-adapted dimeric Beta-D-galactosidase from Paracoccus sp. 32d
PublikacjaThe crystal structure of a novel dimeric [beta]-D-galactosidase from Paracoccus sp. 32d (Par[beta]DG) was solved in space group P212121 at a resolution of 2.4 Å by molecular replacement with multiple models using the BALBES software. This enzyme belongs to glycoside hydrolase family 2 (GH2), similar to the tetrameric and hexameric [beta]-D-galactosidases from Escherichia coli and Arthrobacter sp. C2-2, respectively. It is the second...
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The Future of the University? Social Activism among Young Polish Scholars
PublikacjaThe question “Quo vadis, Academia?” is posed by scholars, research administrators, journalists and is also ofound in public opinion in Poland in different contexts. Authors of the article do not call into question the necessity of changes of contemporary universities, but they think that the source of changes should be characterized by a bottom-up approach, especially by those who have already achieved extraordinary scientific...
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Force transfer and stress distribution in short cantilever deep beams loaded throughout the depth with a various reinforcement
PublikacjaDeep beams used as the main reinforced concrete structural elements which taking over the load and stiffening construction are often found in high-rise buildings. The architecture of these buildings is sometimes sophisticated and varied, arouse the admiration of the majority of recipients, and thus causing an engineering challenge to correctly design the structural system and force transfer. In such structures is important to shape...
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CREATIVE PLACEMAKING IN POLAND. CAN ART BECOME AN EFFECTIVE TOOL OF URBAN REGENERATION?!
PublikacjaThe main aim of the paper is to examine the role of creative placemaking in shaping the urban environment in Polish cities. It also focuses on challenges and obstacles that creative placemaking projects encounter in Polish realities. Creative placemaking is a “micro-development” strategy (Johnson 2009) that focuses on cultural participation, com¬munity engagement and highlights the social role of arts and culture. Artistic interventions...
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CFFT columns in road through railroad crossings
PublikacjaThere were 12801 road through railroad one-level crossings in Poland in 2018. 215 accidents happened at them in 2018. In order to increase safety in rail and road traffic two-level crossings should be used. They are definitely safer and make the traffic more smooth. In the design and construction of two-level intersections of railway and road or path columns of circular cross-section are often used. They can be successfully replaced...
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Possibility of Using Tea Fungus for Fermentation of Beetroot and Carrot Pomace Beverages
PublikacjaFermented beverages obtained from plant-based raw materials are becoming more popular due to their beneficial effects on human health. These include kombucha beverages, which are obtained by fermenting tea brew using the so-called tea fungus, which includes acetic acid bacteria and osmophilic yeast. A consortium of these microorganisms could also be used to prepare functional fermented beverages obtained from extracts of vegetable...
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Anticancer imidazoacridinone C-1311 inhibits hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and angiogenesis
PublikacjaAntitumor imidazoacridinone C-1311 is a DNA-reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor. Here, we demonstrate the mechanism of C-1311 inhibitory action on novel targets: hypoxia-inducible factor-1α (HIF-1α), vascular-endothelial growth factor (VEGF), and angiogenesis. In a cell-free system, C-1311 prevented HIF-1α binding to an oligonucleotide encompassing a canonical hypoxia-responsive element (HRE),...
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Covalent DNA modification by products of myrosinase catalysed glucosinolate degradation in cell-free system
PublikacjaThe bioactive phytochemicals found in Brassica vegetables belonging to glucosinolates (GLS) and especially the products of their degradation isothiocyanates (ITC) and indoles are regarded as the most promising cancer chemopreventive compounds. These secondary metabolites constitute defence system repelling or preventing the development of agrophages attacking brassica plants. The antibiological properties of these compounds suggest...
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Regenarative tourism – between theory and practice
PublikacjaPurpose: The aim of this article is to present a shift in thinking in terms of implementing the systems and practices needed to transition to a regenerative approach in tourism. The article aims to provide concrete ways to change thinking and move towards a regenerative paradigm in the tourism industry. Design/methodology/approach: This viewpoint paper defines regenerative tourism and explores its principles and the possibilities...
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Glucosinolates from lepidium peruvianum as potential antiamnestic drugs
PublikacjaLepidium peruvianum (maca) (Brassicaceae) is a naturally occurring plant mainly in the high Andes of Peru. In recent years, it has been intensively researched in terms of its influence on various diseases and towards health improvement. Alzheimer’s disease is an incurable disease that most often affects adults over the age of 60. As since 2003 the US Food and Drug Administration (FDA) did not approve any new drug for Alzheimer’s...
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Impact response of two-layered grouted aggregate fibrous concretecomposite under falling mass impact
PublikacjaTwo-layered Grouted Aggregates Fibrous Concrete Composite (TGAFCC) is a new category concrete which became popular recently and attracted the attention of researchers globally. Recent studies indicated that TGAFCC has notable improvement in mechanical properties, which has been sufficiently documented. However, the impact behaviour of TGAFCC when combined with Glass Fibre Mesh (GFM) and Textile Fibre Mesh (TFM) is still unexplored....
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Systemic analysis of a manufacturing process based on a small scale bakery
PublikacjaThe main aim of the article is to present two new innovative concepts of reliability of a functioning manufacturing system in the process of making bread in small-scale bakeries. Reliability is understood as one of the representations of an operator acting on specifc streams in time to - t. One of these represents the global reliability of a system as a function of parallel action of all the streams of the system in time to to...
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Cold recycled mixtures for binder courses - laboratory evaluation of mechanical properties
PublikacjaCold recycled mixtures composed with cement and bituminous emulsion are nowadays commonly used material for base layer. Typical pavement with cold recycled mixtures usually consists of two asphalt courses (wearing and binding course) constructed over cold recycled base. Therefore the next step in cold recycling is possibility of design of binding courses with recycled materials, but with potential to obtain high quality mixtures...
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Prediction of Overall In Vitro Microsomal Stability of Drug Candidates Based on Molecular Modeling and Support Vector Machines. Case Study of Novel Arylpiperazines Derivatives
PublikacjaOther than efficacy of interaction with the molecular target, metabolic stability is the primary factor responsible for the failure or success of a compound in the drug development pipeline. The ideal drug candidate should be stable enough to reach its therapeutic site of action. Despite many recent excellent achievements in the field of computational methods supporting drug metabolism studies, a well-recognized procedure to model...
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Propagacja fal w kotwach gruntowych: zastosowanie w wykrywaniu uszkodzeń.
PublikacjaTematem referatu są badania eksperymentalne i obliczenia numeryczne dotyczące propagacji fal sprężystych w kotwach gruntowych. Badania są ukierunkowane na nieniszczącą diagnostykę kotwi skalnych i gruntowych, gdzie z racji charakteru pracy takiego elementu, ocena jego stanu jest utrudniona. Głównym celem badań jest uzyskanie podstawowych informacji na temat stanu technicznego elementu konstrukcyjnego, ewentualnych zniszczeń otuliny...
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Concrete mix design using machine learning
PublikacjaDesigning a concrete mix is a process of synthesizing many components, it is not a simple process and requires extensive technical knowledge. The design process itself focuses on obtaining the required strength of concrete. Very often designing a concrete mix takes into account the need to maintain the proper water-demand and frost-resistance features. The parameters that influence the concrete class most significantly are the...
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Proceedings of the fib Symposium 2019: Concrete - Innovations in Materials, Design and Structures 2019
PublikacjaDesigning a concrete mix is a process of synthesizing many components, it is not a simple process and requires extensive technical knowledge. The design process itself focuses on obtaining the required strength of concrete. Very often designing a concrete mix takes into account the need to maintain the proper water-demand and frost-resistance features. The parameters that influence the concrete class most significantly are the...
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Detecting the medieval cod trade: a new method and first results
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Effect of free water on the quasi‑static compression behavior of partially‑saturated concrete with a fully coupled DEM/CFD approach.
PublikacjaThe work aims to numerically investigate the quasi-static response of partially fluid-saturated concrete under two-dimensional uniaxial compression at the mesoscale. We investigated how the impact of free pore fluid content (water and gas) affected the quasi-static strength of concrete. The totally and partially fluid-saturated concrete behavior was simulated using an improved pore-scale hydro-mechanical model based on DEM/CFD....
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Comparison of heat transfer characteristics in surface cooling using microjets with water, ethanol and HFE7100 as test fluids
PublikacjaAccurate control of cooling parameters is required in ever wider range of technical applications. It is known that reducing the dimensions of the size of nozzle leads to an increase in the economy of cooling and improves its quality. Present study describes research related to the design and construction of the nozzles and microjet study, which may be applied in many technical applications such as in metallurgy, electronics, etc....
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Advancing the evidence base for public policies impacting on dietary behaviour, physical activity and sedentary behaviour in Europe: The Policy Evaluation Network promoting a multidisciplinary approach
PublikacjaNon-communicable diseases (NCDs) are the leading cause of global mortality. As the social and economic costs of NCDs have escalated, action is needed to tackle important causes of many NCD’s: low physical activity levels and unhealthy dietary behaviours. As these behaviours are driven by upstream factors, successful policy interventions are required that encourage healthy dietary behaviours, improve physical activity levels and...
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Youth Civic Participation in the South Baltic Region. Example of Lithuania, Poland and Sweden
PublikacjaThe aim of this study was to show youth civic participation as a social inclusion element in the Southern Baltic region in need of reinforcement, based on the examples of selected municipalities from Lithuania, Poland and Sweden. The authors focused on the diagnosis of key elements of youth civic engagement at local and cross-border level, taking into account the context of national youth policies and the European Union policy....
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Research on the Use of Mobile Devices and Headphones on Pedestrian Crossings—Pilot Case Study from Slovakia
PublikacjaThe topic of the use of mobile devices and headphones on pedestrian crossings is much less explored in comparison to the use of the mobile phone while driving. Recent years have seen many discussions on this issue, especially in foreign countries. The Slovak Republic, however, has not been giving it enough attention (and it is not mentioned in the National Road Safety Plan for the Slovak Republic from 2011 to 2020). This paper...
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The added value of using the HEPA PAT for physical activity policy monitoring: a four-country comparison
PublikacjaBackground Public policy is increasingly recognized as an important component of physical activity promotion. This paper reports on the current status of physical activity policy development and implementation in four European countries based on the Health-Enhancing Physical Activity Policy Audit Tool (HEPA PAT) developed by WHO. It compares the findings to previous studies and discusses the general utility of this tool and its...
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Nutrient loss from three small-size watersheds in the southern Baltic Sea in relation to agricultural practices and policy
PublikacjaAgriculture is the major contributor of waterborne nutrient fluxes into the Baltic Sea, one of the world’s most eutrophication-sensitive areas. Poland, as a large, densely populated state ohf the Baltic Region, with dominating agricultural land use, largely contributes to riverborne loads of N and P. The aim of our study was to examine the input of nutrients from three small first-order agricultural watersheds (Bladzikowski Stream,...
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Bile salts in digestion and transport of lipids
PublikacjaBecause of their unusual chemical structure, bile salts (BS) play a fundamental role in intestinal lipid digestion and transport. BS have a planar arrangement of hydrophobic and hydrophilic moieties, which enables the BS molecules to form peculiar self-assembled structures in aqueous solutions. This molecular arrangement also has an influence on specific interactions of BS with lipid molecules and other compounds of ingested food...
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Quantum dots conjugates with unsymmetrical bisacridines enhance cytotoxicity of these antitumor compounds in lung cancer cells and have protecting effects on normal cells
PublikacjaBackground: In recent years, with the rapid development of nanotechnology and its extensive applications in the medicine, nanocarriers for anticancer drug delivery have gained a great importance. Spherical semiconductor nanocrystals, frequently called quantum dots (QDs) are very attractive nanomaterials for bioimaging applications and they possess properties as potential candidates for drug carrier. Unsymmetrical bisacridines (UAs),...
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NEIGHBOURHOOD SPORT AS A TOOL OF URBAN REGENERATION - A WARSAW CASE STUDY
PublikacjaThere are many connections between sport and urban regeneration. They can be observed while organizing top-down projects, such as sporting mega-events. But sport and urban renewal can also be linked within bottom-up sport initiatives, ones that relate mostly to physical recreation or sport for all. The main goals of physical activity is caring for health, improving fitness, practicing hobbies, and achieving social integration....
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Coupled DEM/CFD analysis of impact of free water on the static and dynamic response of concrete in tension regime
PublikacjaW tym artykule zbadano numerycznie quasi-statyczne i dynamiczne zachowanie częściowo nasyconego płynem betonu w warunkach dwuwymiarowego (2D) jednoosiowego rozciągania w mezoskali. Obliczono, jaki wpływ ma zawartość wolnego płynu porowego (gazu i wody) na proces pękania i wytrzymałość betonu w rozciąganiu. Do symulacji zachowania betonu całkowicie i częściowo nasyconego płynem w warunkach quasi-statycznych i dynamicznych wykorzystano...
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Interpreting the expansion of sea fishing in medieval Europe using stable isotope analysis of archaeological cod bones
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Use of LIDAR Data in the 3D/4D Analyses of the Krakow Fortress Objects
PublikacjaThe article presents partial results of studies within the framework of the international project "Cultural Heritage Through Time" (CHT2). The subject of the study were forts of the Krakow Fortress, which had been built by the Austrians between 1849-1914 in order to provide defence against the Russians. Research works were aimed at identifying architectural changes occurring in different time periods in relation to selected...
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Możliwości sterowania mocą bierną elektrowni wiatrowej : Reactive power control methods in wind parks
PublikacjaReferat poświęcony jest zagadnieniu sterowania mocą bierną w elektrowniach wiatrowych. W pierwszej części referatu opisano tło problemu sterowania mocą bierną w parkach wiatrowych, podano powody, dla których moc bierna powinna podlegać regulacji oraz zarysowano metody, które mogą być do niej użyte. W celu sprawdzenia proponowanych metod kompensacji, zbudowano model matematyczny elektrowni wiatrowej, którego poszczególne elementy...
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Electrochemical simulation of enzymatic transformations studied for the selected antitumor acridine derivatives
PublikacjaThe elucidation of the metabolic pathways and the biotransformation mechanisms of potential drugs is a crucial point in drug development. It allows to know the activation routes of the new biologically active compounds, especially in respect to their possible toxicity. Generally, in vivo or in vitro experiments with liver microsomes or hepatocytes are performed. However, these testing schemes are tedious, time consuming and of...
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Pilicides effectively hinder chaperone-usher interactions in all Gram-negative bacteria
PublikacjaThe chaperone-usher pathway of adhesive structures biogenesis is highly conserved in all Gram-negative bacteria. Pili are polymers of thousands protein subunits that possess conserved immunoglobuline-like structure denoted by lack of the seventh G strand. The effect of this structural defect is a hydrophobic acceptor cleft. The folding of protein subunits is strictly dependent on the action of specific periplasmic chaperone protein...
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Caffeine Inhibits Differentiation Of Lung Cancer Stem Cells By Modulating Their Respiratory Metabolism
PublikacjaIt is ell established that many tumor types contain a fraction of cells, with stem cell-like properties, called cancer stem cells (CSCs), that are resistant to apoptosis induced by therapeutic agents. The presence of CSCs may explain why a standard anticancer treatment, that eliminates only differentiated cancer cells, does not lead to cancer cure.We previously showed the existence of caffeine-sensitive mechanism that controls...
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Crack Resistance of Asphalt Concrete Subjected to Environmental Factors
PublikacjaThe paper presents an analysis of the influence of environmental factors on the cracking susceptibility of asphalt concrete resulting in a change in the durability of asphalt pavement. In order to assess the phenomenon, laboratory tests were carried out taking into account the destructive effects of moisture, freeze-thaw cycle and long-term ageing. The influence of both factors occurring simultaneously was also verified. Due to...
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The bile salt/phospholipid ratio determines the extent of in vitro intestinal lipolysis of triglycerides: Interfacial and emulsion studies
PublikacjaThis study focused on the protein-stabilised triglyceride (TG)/water interfaces and oil-in-water emulsions, and explored the influence of varying molar ratios of bile salts (BSs) and phospholipids (PLs) on the intestinal lipolysis of TGs. The presence of these two major groups of biosurfactants delivered with human bile to the physiological environment of intestinal digestion was replicated in our experiments by using mixtures...
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Spectroscopic studies on physicochemical properties of selected unsymmetrical bisacridine derivatives and NMR analysis of their interactions with the model sequence Pu22 aided by molecular dynamics
PublikacjaIn recent years, new promising acridine derivatives have appeared, belonging to the unsymmetrical bisacridines (UAs) family with high anticancer activity. Both their physicochemical properties and their mechanism of action at the molecular level have not been thoroughly analyzed so far. Four derivatives were selected for the study, termed as: C-2028, C-2041, C-2045 and C-2053. The first aim of this work was to determine the protonation...
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Literature review of user needs, toward user requirements
PublikacjaThis report has been developed in the frame of the IEA SHC Task 61 Subtask A “User requirements”. The main objective was to rethink and reformulate user requirements to lighting (daylighting and electric lighting) in public buildings on the basis of a thorough literature study. The work is a joint effort of a number of scientists and represents collective knowledge in this topic. The concept of Lighting quality is the one, among...
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Analytical methods for exhaustive characterization of Brassica plants and dietary products based on them
PublikacjaGlucosinolates (GLs), and particularly two classes of their degradation products - isothiocyanates (ITC) and indoles - released upon myrosinase catalyzed hydrolysis, belong to the most promising chemopreventive dietary components. Despite their wide use in plant research, studies on chemopreventive mechanisms and industrial utilization in the production of e.g. dietary supplements, the methods of reliable characterization of myrosinase-GLs...
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Topological invariants for equivariant flows: Conley index and degree
PublikacjaAbout forty years have passed since Charles Conley defined the homotopy index. Thereby, he generalized the ideas that go back to the calculus of variations work of Marston Morse. Within this long time the Conley index has proved to be a valuable tool in nonlinear analysis and dynamical systems. A significant development of applied methods has been observed. Later, the index theory has evolved to cover such areas as discrete dynamical...