Filters
total: 10357
-
Catalog
- Publications 9056 available results
- Journals 327 available results
- Conferences 19 available results
- People 232 available results
- Inventions 1 available results
- Projects 33 available results
- Research Equipment 8 available results
- e-Learning Courses 172 available results
- Events 12 available results
- Open Research Data 497 available results
displaying 1000 best results Help
Search results for: kinetic model development
-
European Economic Development
e-Learning Courses -
Dissociative Electron Attachment to 5-Iodo-4-thio-2′-deoxyuridine: A Potential Radiosensitizer of Hypoxic Cells
PublicationIn the search for effective radiosensitizers for tumor cells, halogenated uracils have attracted more attention due to their large cross section for dissociation upon the attachment of low-energy electrons. In this study, we investigated dissociative electron attachment (DEA) to 5-iodo-4-thio-2'-deoxyuridine, a potential radiosensitizer using a crossed electron-molecule beam experiment coupled with quadrupole mass spectrometry....
-
How proteins bind to DNA: target discrimination and dynamic sequence search by the telomeric protein TRF1
PublicationTarget search as performed by DNA-binding proteins is a complex process, in which multiple factors contribute to both thermodynamic discrimination of the target sequence from overwhelmingly abundant off-target sites and kinetic acceleration of dynamic sequence interrogation. TRF1, the protein that binds to telomeric tandem repeats, faces an intriguing variant of the search problem where target sites are clustered within short fragments...
-
Electron-Induced Decomposition of 5-Bromo-4-thiouracil and 5-Bromo-4-thio-2′-deoxyuridine: The Effect of the Deoxyribose Moiety on Dissociative Electron Attachment
PublicationWhen modified uridine derivatives are incorporated into DNA, radical species may form that cause DNA damage. This category of molecules has been proposed as radiosensitizers and is currently being researched. Here, we study electron attachment to 5-bromo-4-thiouracil (BrSU), a uracil derivative, and 5-bromo-4-thio-20 -deoxyuridine (BrSdU), with an attached deoxyribose moiety via the N-glycosidic (N1-C) bond. Quadrupole mass spectrometry...
-
Heat transfer characteristics of hybrid microjet – Microchannel cooling module
PublicationThe paper presents experimental investigation of heat transfer intensification in a microjet–microchannel cooling module. Applied technology takes benefits from two very attractive heat removal techniques. When jets are impinging on the surface, they have a very high kinetic energy at the stagnation point, also in microchannels boundary layer is very thin allowing to obtain very high heat fluxes. Main objective of this paper was...
-
Przedsiębiorczość społeczna jako klucz do skutecznej edukacji przedsiębiorczej na społecznie odpowiedzialnym uniwersytecie
PublicationCel naukowy: Celem artykułu jest prezentacja nowej propozycji kształcenia na rzecz przedsiębiorczości na studiach biznesowych (zarządzanie i ekonomia), uwzględniającej edukację w zakresie przedsiębiorczości społecznej. Problem i metody badawcze: W artykule omówiono problem edukacji przedsiębiorczej z punktu widzenia wyzwań zmieniającej się gospodarki oraz ewoluujących oczekiwań stawianych polskim uczelniom wyższym. Główną metodą...
-
Stochastic model of the process of starting piston combustion engines and the practical use of the process
PublicationW artykule zaproponowano model procesu rozruchu silników o zapłonie samoczynnym, w formie procesu semimarkowskiego, dyskretnego w stanach i ciągłego w czasie eksploatacji. Stanami tego procesu są: stan zimny silnika (s1), stan ciepły silnika (s2) i stan gorący silnika (s3). Zaproponowano również koncepcję zastosowania opracowanego modelu do określenia ilości substancji szkodliwych, jakie emitowane są w spalinach podczas rozruchu...
-
Viscoelastic model of waterhammer in single pipeline - problems and questions
PublicationW artykule dokonano analizy zastosowania lepkosprężystego modelu uderzenia hydraulicznego w pojedynczym przewodzie. Przedstawiono teoretyczne podstawy lepkosprężystego zachowania się materiału przewodu oraz matematyczny opis modelu uderzenia hydraulicznego w rurociągu z tworzywa sztucznego. Przedyskutowano główne problemy pojawiające się przy aplikacji takiego modelu. Nacisk położono na identyfikację parametrów modelu. Przeanalizowano...
-
Stochastic model of the load spectrum for main engines of sea-going ships
PublicationW artykule przedstawiono możliwość zastosowania procesów semimarkowskich do probabilistycznego opisu widma obciążeń silników o zapłonie samoczynnym, zastosowanych do napędu statków - czyli silników głównych. W rozważaniach uwzględnione zostały charakterystyki zewnętrzne mocy tego rodzaju silników. Umożliwiły one sformułowanie czteroelementowego zbioru stanów procesu obciążeń tego rodzaju silników. Do opisu rzeczywistego procesu...
-
Analysis of muscles behaviour. Part II. The computational model of muscles group acting on the elbow joint
PublicationThe purpose of this paper is to present the computational model of muscles' group describing the movements of flexion/extension at the elbow joint in the sagittal plane of the body when the forearm is being kept in the fixed state of supination/pronation. The method ofevaluating the muscle forces is discussed in detail. This method is the basis for the quantitative and qualitative verification of the proposed computational model...
-
Koncepcja i modelowanie silnika o wirującym tworniku oraz magneśnicy do zastosowania w napędzie miejskiego samochodu elektrycznego
PublicationW artykule zaprezentowano koncepcję, model oraz prototyp silnika z wirującym twornikiem oraz magneśnicą. Opisano historię powstania i zastosowania tego typu silników w motoryzacji. Przedstawiono nowoczesne rozwiązania konstrukcyjne i zastosowania we współczesnych samochodach elektrycznych i hybrydowych. Opracowano model silnika z wirującym twornikiem i magneśnicą oraz przedstawiono wybrane wyniki symulacji przeprowadzone w programie...
-
Wzory kreatywności. Koncepcja modelu prawdopodobieństwa działania kreatywnego jako narzędzie badania procesu twórczego w środowisku miejskim
PublicationWspółczesne koncepcje kształtowania miast, takie jak zrównoważony rozwój, miasto odporne, inteligentne miasto, miasto kreatywne, tworzą obecnie ramy urbanistyki o charakterze jednej uogólnionej idei kształtującej środowisko społeczno-materialne. Kontekstualne ujęcie badań kreatywności opisuje zależności między środowiskiem miejskim a twórczością w mieście kreatywnym. Ujęcie procesualne kreatywności stanowi hic et nunc urbanizmu,...
-
Diagnostic model of compression-ignition engine slide bearings for controlling the changes of their state
PublicationW artykule przedstawiono koncepcję umożliwiającą sterowanie procesami zmian stanów eksploatacyjnych silnika na podstawie modelu diagnostycznego łożysk ślizgowych. Jako model łożyska ślizgowego przyjęty został topologiczny model diagnostyczny, pozwalający na pełne i dokładne wykorzystanie oleju smarowego jako jednego z nośników informacji o stanie technicznym łożyska. Przedstawiona została przykładowa interpretacja stanów eksploatacyjnych...
-
Kluczowe kompetencje jako narzędzie do tworzenia nowych modeli biznesu w przedsiębiorstwach
PublicationKoncepcja kluczowych kompetencji wywodzi się z nurtu zasobowego, który zakłada, iż o efektywności i konkurencyjności każdego podmiotu decydują odpowiednio dobrane zasoby i umiejętności ich optymalnego wykorzystania. Model biznesu to narzędzie do realizacji strategii organizacji, które wspomaga rozwój oraz zarządzanie strategiczne w przedsiębiorstwie. Dysertacja wypełnia lukę, jaką było wskazanie na zależność pomiędzy kluczowymi...
-
Models in spatial development
e-Learning Courses -
Potentials of Water Usage in urban Neighbourhood Structures
PublicationThis paper will treat about water influence and possibility of its usage in the urban neighborhood structures (e.g. districts, real estate properties, town parts) in the context of actual regional environmental problems and according to directories determined by European targets. It is not rare yet in the basic stage of urban design that water is treated as a threat, not a chance. In result planned structures are often built,...
-
Thermal visualization of Ostwald-de Waele liquid in wavy trapezoidal cavity: Effect of undulation and amplitude
PublicationThe present study is concerned with the numerical simulations of Ostwald-de Waele fluid flow in a wavy trapezoidal cavity in the presence of a heated cylinder situated at the center of the cavity. The work consists in characterizing the mixed convection as a function of the intensity of heat flow. The flow behaviour and temperature distribution in a cavity are the main focus of this study. The lower wall of the cavity is fixed...
-
Heat transfer characteristics of hybrid microjet -microchannel cooling module
PublicationThe paper presents the experimental investigation of heat transfer intensification in a microjet- microchannel cooling module. Applied technology takes benefits from two very attractive heat removal techniques. When jets are impinging on the surface, they have a very high kinetic energy at the stagnation point, also in microchannels boundary layer is very thin allowing to obtain very high heat fluxes. Main objective of this paper...
-
Experimental validation of pressure drop models during flow boiling of R134a – effect of flow acceleration and entrainment
PublicationA crucial step to assure proficient work of power and process apparatus is their proper design. A wide array of those devices operates within boiling or condensation of the working fluid to benefit from high heat transfer rates. Two-phase flows are associated with high heat transfer coefficients because of the latent heat of evaporation and high turbulence level between the liquid and the solid surface. Predicting heat transfer...
-
Stone cutting industry waste-supported zinc oxide nanostructures for ultrasonic assisted decomposition of an anti-inflammatory non-steroidal pharmaceutical compound
PublicationPowdered stone waste (PSW) obtained from a stone cutting industrial unit was applied as support for the immobilization of nano-sized ZnO to be utilized as an effective catalyst for the catalytic conversion of acetaminophen (ACE) under ultrasonication. The incorporation of ZnO nanostructures into PSW structure enhanced the specific surface area and pore volume of the as-prepared nanocompound. The change in the value of zero point...
-
Heterogeneity of quaternary structure of glucosamine-6-phosphate deaminase from Giardia lamblia
PublicationThe oligoHis-tagged versions of glucosamine-6- phosphate deaminase from Giardia lamblia (GlmNagB-HisN, GlmNagB-HisC) were constructed and purified to hear homogeneity, and their kinetic and structural properties were compared to those of the wild-type enzyme (GlmNagB). Introduction of the oligoHis tag at the GlmNagB C-terminus resulted in almost complete loss of the catalytic activity, while the catalytic properties of GlmNagB-HisN...
-
Why Are Left-Handed G-Quadruplexes Scarce?
PublicationG-quadruplexes (G4s) are nucleic acid structures crucial for the regulation of gene expression and genome maintenance. While they hold promise as nanodevice components, achieving desired G4 folds requires understanding the interplay between stability and structural properties, like helicity. Although right-handed G4 structures dominate the experimental data, the molecular basis for this preference over left-handed helicity is unclear....
-
Ryszard S. Romaniuk profesor
PeopleProfessor of Electronics, Computer and Communications Engineering at Warsaw University of Technology, Poland; Eisenhower Fellow, Philadelphia, MA USA; SPIE Fellow, Bellingham, WA USA; Editor-in-Chief, International Journal of Electronics and Telecommunications, Polish Academy of Sciences; Photonics Spectra Magazine, EAB Member;
-
Sustainable development on the background of a general theory of regional development
PublicationThe article focuses on a presentation and discussion of the concept of "sustainable de-velopment" (SD). It contains an analysis of the concept, its characteristics, objectives and principles of implementation. Particular emphasis has been placed on presentation of the unique features of sustainable development that distinguish it from other theories of regional development. Therefore, the discussion has been preceded by a discussion...
-
INVESTIGATION OF THE CHARACTERISTICS OF A LOWEMISSION GAS TURBINE COMBUSTION CHAMBER OPERATING ON A MIXTURE OF NATURAL GAS AND HYDROGEN
PublicationT his article is devoted to the investigation of the characteristics of a low-emission gas turbine combustion chamber, which can be used in Floating Production, Storage and Offloading (FPSO) vessels and operates on a mixture of natural gas and hydrogen. A new approach is proposed for modelling the processes of burning out a mixture of natural gas with hydrogen under preliminary mixing conditions in gaseous fuel with an oxidizer...
-
Manufacturing and Recycling Impact on Environmental Life Cycle Assessment of Innovative Wind Power Plant Part 2/2
PublicationThe process of conversion of wind kinetic energy into electricity in innovative wind power plant emits practically no harmful substances into the environment. However, the production stage of its components requires a lot of energy and materials. The biggest problem during production plan-ning process of an innovative wind power plant is selection of materials and technologies and, consequently, the waste generated at this stage....
-
Molecular dynamics simulations reveal the balance of forces governing the formation of a guanine tetrad—a common structural unit of G-quadruplex DNA
PublicationG-quadruplexes (G4) are nucleic acid conformations of guanine-rich sequences, in which guanines are arranged in the square-planar G-tetrads, stacked on one another. G4 motifs form in vivo and are implicated in regulation of such processes as gene expression and chromosome maintenance. The structure and stability of various G4 topologies were determined experimentally; however, the driving forces for their formation are not fully...
-
Polityka Rozwoju/Development Policy
e-Learning CoursesZajęcia dotyczą wyzwań realizacji 11 celu Światowej Polityki Zrównoważonego Rozwoju czyli kwestii budowania odpornych społeczności miejskich w krajach rozwijających się Wykłady odbywają się w formule zdalnej w układzie zajęć zblokowanych wg indywidualnego planu. prowadząca: dr Gabriela Rembarz grem@pg.edu.pl
-
Wodociągi - model. komput., stacjon., I sem mgr 2023/2024
e-Learning CoursesKurs dotyczy przedmiotu Modelowanie systemów wodociągowych na Kierunku Inżynieria Środowiska, studia stacjonarne II stopnia, sem.I. W ramach przedmiotu (wykłady, ćwiczenia, projektowanie) dostarczana jest studentom uporządkowana, możliwie kompletna wiedza umożliwiająca wykonywanie prac projektowych i analitycznych dla systemów transportu i dystrybucji wody wodociągowej (STiDW) z wykorzystaniem modelowania komputerowego przepływów ...
-
Comparison of heat transfer characteristics in surface cooling using microjets with water, ethanol and HFE7100 as test fluids
PublicationAccurate control of cooling parameters is required in ever wider range of technical applications. It is known that reducing the dimensions of the size of nozzle leads to an increase in the economy of cooling and improves its quality. Present study describes research related to the design and construction of the nozzles and microjet study, which may be applied in many technical applications such as in metallurgy, electronics, etc....
-
Overview of new product development strategies and models
PublicationMotivation: The motivation for the overview presented in this article is to provide a starting point for considering whether existing new product development methodology and its level of detail allows product teams to develop high-quality and business-effective product concepts. Aim: The aim of this article is recognise the current state of research into new product development methodology and to present the strategies and models...
-
New propagation model for wireless monitoring systems in the container terminal environment
PublicationW artykule został poddany analizie problem szacowania tłumienia propagacyjnego na obszarze terminala kontenerowego. Została opisana kampania pomiarowa, której rezultatem było opracowanie nowego modelu propagacyjnego dla łącza radiowego pracującego w warunkach LOS i NLOS.
-
Overview of new product development strategies and models
PublicationMotivation: The motivation for the overview presented in this article is to provide a starting point for considering whether existing new product development methodology and its level of detail allows product teams to develop high-quality and business-effective product concepts. Aim: The aim of this article is recognise the current state of research into new product development methodology and to present the strategies...
-
Development of spatial structures, PG_00053620
e-Learning Courses -
Civilization Threats and Sustainable Development
e-Learning Courses -
Development of spatial structures_2023/24
e-Learning Courses -
Chemical and biological evaluation of antioxidant activity of endogenous redox-active compounds compared to plant-derived exogenous antioxidants
PublicationThe research conducted so far has shown that endogenous antioxidants, despite being regarded as the first line of antioxidant defense, may not be sufficient to maintain redox homeostasis in cells exposed to oxidative stress. The results obtained in the doctoral dissertation show that endogenous redox-active compounds were moderate or weak scavengers of ABTS and DPPH radicals, while in cellular setting, their impact on the reducing...
-
Ab initio chemical kinetics of Isopropyl acetate oxidation with OH radicals
PublicationGlobal reactivity descriptors of isopropyl acetate (IPA) and thermo-kinetic aspects of its oxidation via OH radicals have been studied. Transition state theory (TST) was utilized to estimate the bimolecular rate constants. Ten oxidation pathways have been investigated, and all of them are exothermic. The potential energy diagram has been sketched using different pre- and post-reactive complexes for all reaction pathways. Rate coefficient...
-
Homoisocitrate dehydrogenase from Candida albicans: properties, inhibition, and targeting by an antifungal pro-drug
PublicationThe LYS12 gene from Candida albicans, coding for homoisocitrate dehydrogenase was cloned and expressed as a His-tagged protein in Escherichia coli. The purified gene product catalyzes the Mg2+- and K+-dependent oxidative decarboxylation of homoisocitrate to alpha-ketoadipate. The recombinant enzyme demonstrates strict specificity for homoisocitrate. SDS-PAGE of CaHIcDH revealed its molecular mass of 42.6±1 kDa, while in size-exclusion...
-
The comparison of antioxidant properties and nutrigenomic redox-related activities of vitamin C, C-vitamers, and other common ascorbic acid derivatives
PublicationThe term ‘vitamin C’ describes a group of compounds with antiscorbutic activity of L-ascorbic acid (AA). Despite AA’s omnipresence in plant-derived foods, its derivatives have also been successfully implemented in the food industry as antioxidants, including the D-isomers, which lack vitamin C activity. This study aimed to determine the relationship between redox-related activities for five derivatives of AA using electrochemical,...
-
Webinarium „Drug Discovery, Development & Commercialization”
EventsCTWT PG zaprasza na webinarium „Drug Discovery, Development & Commercialization”. Spotkanie skierowane jest do osób zajmujących się zawodowo lub planujących swoją karierę w dziedzinie opracowywania i rozwoju leków.
-
An Approach to Trust Case Development
PublicationIn the paper we present an approach to the architectural trust case development for DRIVE, the IT infrastructure supporting the processes of drugs distribution and application. The objectives of DRIVE included safer and cheaper drugs distribution and application. A trust case represents an argument supporting the trustworthiness of the system. It is decomposed into claims that postulate some trust related properties. Claims differ...
-
Modern Methods of Software Development
PublicationSoftware development methods consist of such activities like analysis, planning, development, testing, deployment, maintenance and retirement. All of them can be divided into two main categories - traditional and agile. The objective of this paper is to review some of the most popular traditional, agile and open source development methods. Special attention was paid to the common stages of all methods - testing and maintenance.
-
Increasing the rate of sustainable change: a call for a redefinition of the concept and the model for its implementation
PublicationW pracy dokonano analizy problemu dużej rozbieżności pomiędzy zaproponowanymi strategiami a efektywnością akcji podjętych w celu wprowadzenia w praktyce zasad zrównoważonego rozwoju. Podkreślono konieczność współpracy różnych organizacji i samorządów lokalnych oraz uwzględniono rolę szkół wyższych w procesie wprowadzania zasad zrównoważonego rozwoju.
-
state aid for sustainable urban development
Open Research DataThe dataset encompassed a choice of important legal acts with respect on the usage of EFRD for urban projects, a list of selected bibliography as well as a list of selected individual notifications of state aid measures being part of the Sustainable Urban Development Programme in the period 2014- 2020. As a comparison, an example of individual EC decision...
-
Applying agiile practices to the development of safety-critical software
PublicationDevelopment of safety critical software is subjected to numerous restrictions and recommendations. To meet these requirements classical software development models (e.g. V-model) are usually applied. Agile methodologies, although rapidly increasing their popularity, were generally regarded as unsuitable for such projects. However, they offer potential benefits which provide a strong incentive to incorporate them into safety-critical...
-
A comparative study on the decolorization of Tartrazine, Ponceau 4R, and Coomassie Brilliant Blue using persulfate and hydrogen peroxide based Advanced Oxidation Processes combined with Hydrodynamic Cavitation
PublicationDecolorization of Ponceau 4R, Tartrazine, and Coomassie Brilliant Blue (CBB) was studied using hybrid processes of hydrodynamic cavitation (HC) with potassium persulfate (KPS) and hydrogen peroxide (H2O2). The different properties of these dyes such as hydrophobicity, molecular structures, and molecular weights provided this opportunity to investigate the effects of these factors by comparing the decolorization values of the dyes....
-
Interactions of telomeric proteins with nucleic acids: sequence recognition on intact and oxidatively damaged telomeres
PublicationTelomeres are complex nucleoprotein assemblies that play a vital role in the maintenance of functional ends of linear chromosomes. Telomeric DNA, composed of tandem repeats of the 5'-TTAGGG-3' motif, solves the so-called end replication problem: as chromosomes shorten with each cell division, no information is lost, and the telomere can be re-extended. In the cell, many protein factors regulate telomere length, nuclear positioning...
-
Preliminary Testing of the Influence of Modified Polycaprolactones on Anabaena Variabilis Growth in Seawater
PublicationSeveral new biodegradable polymer materials have recently come onto the global market. Mostly the results on degradation kinetic studies are presented. This paper suggests using one of the tests to estimate the impact of polymer packaging material on sea life. The microorganism chosen was Anabaena variabilis (identified in many waters, including those of the Baltic Sea, especially in the Gulf of Gdansk and Puck Bay; this cyanobacterium...
-
Model of a Maturity Capsule in Managing IT Projects
PublicationThe main purpose of this article is to present a report on the development of a model of information technology management (MITM). This model is an answer to the need to support decision making in the selection of methods and information technologies. This article presents a multisequential model (MSM) of technology selection and a model for initial processing procedures (IPP) necessary for the MITM model. The presentation of the...