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Search results for: BIOMATERIALSBIOPOLYMERSBIOCOMPOSITESNATURAL POLYMERSTISSUE ENGINEERINGREGENERATIVE MEDICINE
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Gemcitabine-Based Treatment in Poor Prognosis Patients with Relapsed and Refractory Hodgkin Lymphoma and Non-Hodgkin Lymphoma – a Multicenter Polish Experience
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PI3Kδ Inhibition by Idelalisib in Patients with Relapsed Indolent Lymphoma
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Role of rituximab in the first-line therapy of high-risk diffuse large B-cell lymphoma: a retrospective analysis by the Polish Lymphoma Research Group
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Targeting BTK with Ibrutinib in Relapsed or Refractory Mantle-Cell Lymphoma
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Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin’s Lymphoma
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Combined anticancer therapy with imidazoacridinone analogue C‐1305 and paclitaxel in human lung and colon cancer xenografts—Modulation of tumour angiogenesis
PublicationThe acridanone derivative 5-dimethylaminopropylamino- 8- hydroxytriazoloacridinone (C-1305) has been described as a potent inhibitor of cancer cell growth. Its mechanism of action in in vitro conditions was attributed, among others, to its ability to bind and stabilize the microtubule network and subsequently exhibit its tumour- suppressive effects in synergy with paclitaxel (PTX). Therefore, the objective of the present study...
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The comparison of antioxidant properties and nutrigenomic redox-related activities of vitamin C, C-vitamers, and other common ascorbic acid derivatives
PublicationThe term ‘vitamin C’ describes a group of compounds with antiscorbutic activity of L-ascorbic acid (AA). Despite AA’s omnipresence in plant-derived foods, its derivatives have also been successfully implemented in the food industry as antioxidants, including the D-isomers, which lack vitamin C activity. This study aimed to determine the relationship between redox-related activities for five derivatives of AA using electrochemical,...
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Potential plasma biomarkers of bladder cancer identified by proteomic analysis: A pilot study
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First report of seroprevalence of Toxoplasma gondii infection in sheep in Pomerania, northern Poland
PublicationIntroduction and objective. Toxoplasmosis is parasitic disease which has economic relevance for both veterinary and human medicine. In sheep, toxoplasmosis is a major cause of abortion and can thus cause reproductive problems. The current study aimed to determine the occurrence of anti-Toxoplasma gondii IgG antibodies in sheep from 13 districts of northern Poland and thereby obtain actual data about T. gondii seroprevalence in...
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Determination of benzo(a)pyrene content in PM10 using regression methods
PublicationThe paper presents an attempt of application of multidimensional linear regression to estimation of an empirical model describing the factors influencing on B(a)P content in suspended dust PM10 in Olsztyn and Elbląg city regions between 2010 and 2013. During this period annual average concentration of B(a)P in PM10 exceeded the admissible level 1.5-3 times. Conducted investigations confirm that the reasons of B(a)P concentration...
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Antimicrobial molecular nanocarrier–drug conjugates
PublicationMany antimicrobial drugs are poorly active against pathogenic microbes causing intracellular infections, such as Mycobacterium tuberculosis or Plasmodium falciparum. On the other hand, several known antimicrobial agents are not effective enough because of their limited cellular penetration. A common feature of both challenges is the inability of an active agent to cross the biological membrane(s). One of the possible approaches...
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Basic Hand Gestures Classification Based on Surface Electromyography
PublicationThis paper presents an innovative classification system for hand gestures using 2-channel surface electromyography analysis. The system developed uses the Support Vector Machine classifier, for which the kernel function and parameter optimisation are conducted additionally by the Cuckoo Search swarm algorithm. The system developed is compared with standard Support Vector Machine classifiers with various kernel functions. The average...
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Daily diet containing canned products significantly increases serum concentrations of endocrine disruptor bisphenol A in young women
PublicationNowadays, exposure to environmental factors is considered to be one of the possible causes of several lifestyle diseases, such as obesity, type 2 diabetes, cardiovascular disease, and cancer. Particularly noteworthy are endocrine‑disrupting chemicals (EDCs), which affect the metabolism of hormones and interact with their receptors, thus exerting adverse health effects. One of the most ubiquitous EDC in daily life is bisphenol A...
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Canned food as a source of bisphenol a (BPA) exposure - estimation of consumption among young women from Gdansk, Poland
PublicationBisfenol A (BPA) jest organicznym związkiem endokrynnie czynnym , który modyfikuje pracę hormonów prowadząc do niekorzystnych dla zdrowia skutków. BPA jest substancją stabilizującą chlorek poliwinylu- jednego z najczęściej stosowanych polimerów plastików, wykorzystywanego w produkcji powszechnie używanych produktów, w tym opakowań, plastikowych butelek, zabawek, papieru paragonowego; używany jest także w produkcji żywic epoksydowych...
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Coupling of Blood Pressure and Subarachnoid Space Oscillations at Cardiac Frequency Evoked by Handgrip and Cold Tests: A Bispectral Analysis
PublicationThe aim of the study was to assess blood pressure–subarachnoid space (BP–SAS) width coupling properties using time–frequency bispectral analysis based on wavelet transforms during handgrip and cold tests. The experiments were performed on a group of 16 healthy subjects (F/M; 7/9) of the mean age 27.2 ± 6.8 years and body mass index of 23.8 ± 4.1 kg/m². The sequence of challenges was first handgrip and then cold test. The handgrip...
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Clinical anatomy of the spatial structure of the right ventricular outflow trac
PublicationBackground. The right ventricular outflow tract (RVOT) is located above the supraventricular crest and reaches the level of the pulmonary valve. Detailed knowledge of the RVOT spatial structure and its morphology is extremely important for cardiac invasive therapeutic procedures. Objectives. To examine the spatial structure of the RVOT using virtual models of the right ventricle (RV) interior obtained post mortem. Material and...
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Telomere uncapping by common oxidative guanine lesions: Insights from atomistic models
PublicationOxidative damage to DNA is widely known to contribute to aging and disease. This relationship has been extensively studied for telomeres – structures that cap chromosome ends – due to their role in cell proliferation and senescence, and exceptional susceptibility to oxidation. Indeed, the repetitive telomeric DNA sequence contains the 5′-GGG-3′ motif that has the lowest ionization potential of all trinucleotides. Accordingly, experiments...
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Three-dimensional printed trachea helps to design tailored treatment for tracheobronchomalacia
PublicationTracheobronchomalacia is a rare respiratory disease that is manifesting by impaired ventilation with expiratory collapse of the tracheal wall due to softening of the supporting cartilage and hypotonia of myoelastic elements [1]. Surgery is the mainstay of treatment. We report the case of 39 -year old man with exacerbation of chronic respiratory distress. The membranous wall of the trachea and the large bronchi was stretched to...
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Interactions between bioactive components determine antioxidant, cytotoxic and nutrigenomic activity of cocoa powder extract
PublicationNumerous studies have shown, rather disappointingly, that isolated bioactive phytochemicals are not as biologically effective as natural plant products. Such a discrepancy may be explained by the concept of food synergy, which was verified in this research for cocoa extract versus its major components with regard to cancer chemoprevention. The evaluation embraced the relationship between redox properties evaluated in cell-free systems...
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Human-associated bacteria and their mobile genetic elements - important minority in wastewater and wastewater impacted ecosystems
PublicationSince human-associated bacteria have been recognized as vectors in two - way gene transmission between the pathogenic and environmental populations, health hazard connected with wastewater discharge requires reevaluation. In this paper the particular attention was given to antimicrobial-resistance of Escherichia coli and enterococci isolated from wastewater and wastewater impacted environments. The obtained results showed that...
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Influence of Diosmin Treatment on the Level of Oxidative Stress Markers in Patients with Chronic Venous Insufficiency
PublicationOxidative stress plays an important role in the pathophysiology of many human disorders, while antioxidants prevent the development of various adverse symptoms. Diosmin is a natural flavonoid applied in vascular system disorders, especially in chronic venous insufficiency (CVI), and it plays a significant part in the alleviation of CVI symptoms. Due to antioxidant activity, it also has the ability to scavenge the oxygen free radicals...
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Synteza obrazów parametrycznych w medycynie
PublicationObrazowanie medyczne dostarcza serie obrazów diagnostycznych rejestrowanych różnymi technikami i w różnych wymiarach. Szczególnie istotną rolę pełnią obrazy uzyskiwane w trzech wymiarach przestrzennych oraz w wymiarze czasu. W artykule przedstawiono metody przetwarzania danych z serii obrazów mierzonych w określonym przedziale czasie. Skupiono się na syntezie obrazów reprezentujących zmiany dynamiczne w badanych obiekcie, uzyskiwanych...
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Quality of bottled waters
PublicationBottled water is a product that is purchased by annually increasing numbers of people of all age groups. The quality control of mineral waters tends to concentrate on the determination of anion and cation levels, since it is these that govern the taste, smell and possible medicinal properties of the water. The constantly rising sales of mineral waters bring with them the ever increasing exploitation of their sources. The consequences...
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Application of the near-infrared spectroscopy in the pharmaceutical technology
PublicationNear-infrared (NIR) spectroscopy is currently the fastest-growing and the most versatile analytical method not only in the pharmaceutical sciences but also in the industry. This review focuses on recent NIR applications in the pharmaceutical technology. This article covers monitoring, by NIR, of many manufacturing processes, such as granulation, mixing or drying, in order to determine the end-point of these processes. In this...
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Determination of API content in a pilot-scale blending by near-infrared spectroscopy as a first step method to process line implementation
PublicationNear infrared (NIR) spectroscopy was used for estimation of powder blend homogeneity and manufacturing control of a medicinal product powder mixture containing active pharmaceutical ingredient (API). Aiming at initiating a Process Analytical Technology (PAT) activity, the first step was a stationary mode atline evaluation. In this, the content of pharmaceutical active compound in the powder mixtures intended to the direct tabletting...
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Tworzenie i wykorzystanie bazy wzorców zmian chorobowych
PublicationPrzedstawiono bazy danych zbudowane na potrzeby systemu wspomagania badan medycznych oraz aplikacje je wykorzystujace. Szczególna uwaga poswiecona została bazie danych wzorców medycznych, której rozmiar czyni ja jedna z wiekszych baz stosowanych w dziedzinie. Artykuł zawiera obszerny przeglad zgromadzonych w bazie przypadków chorobowych, zestawionych według rodzajów schorzen oraz według miejsca wystapienia schorzenia. Konstrukcja...
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Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery
PublicationAbstract: Five-membered 1,2,4-oxadiazole heterocyclic ring has received considerable attention because of its unique bioisosteric properties and an unusually wide spectrum of biological activities. Thus, it is a perfect framework for the novel drug development. After a century since the 1,2,4-oxadiazole have been discovered, the uncommon potential attracted medicinal chemists’ attention, leading to the discovery of a few presently...
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The influence of rest interval on total training load during 10 sets of the bench press exercise performed to concentric failure
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Preliminary phytochemical investigation of Lychnis flos-cuculi herbs
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Synthesis of New Hydrazone Derivatives and Evaluation of their Efficacy as Proliferation Inhibitors in Human Cancer Cells
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Antitumor Activity of Novel Benzensulfonamide Derivatives in View of their Physiochemical Properties Searched by Principal Component Analysis
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The Current Use of Mass Spectrometry in Combination with Other Separation Techniques in Drug Discovery Arena
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Synthesis and Cholinesterase Inhibitory Activity of N-Phosphorylated /N-Tiophosphorylated Tacrine
PublicationNovel phosphorus and thiophosphorus tacrine derivatives were designed, synthesized and their biological activity and molecular modeling was investigated as a new potential anti-Alzheimer's disease (AD) agents. All new synthesized compound exhibited lower toxicity against neuroblastoma cell line (SH-SY5Y) in comparison with tacrine. Two analogues in the series, 7 and 9, demonstrated lack of cytotoxicity against hepatocellular cells...
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Orteza bioniczna kończyny górnej
PublicationZastosowanie robotyki we współczesnej medycynie jest powszechną praktyką. Również w rehabilitacji po udarze i urazie rdzenia kręgowego możliwe jest zwiększenie skuteczności leczenia dzięki bionicznej ortezie kończyny górnej. Na wczesnym etapie stworzono model matematyczny i porównano trzy metody klasyfikacji: maszyną wektorów nośnych, K najbliższych sąsiadów i metoda drzewa decyzyjnego. Ponadto zastosowano najlepszy zestaw domen...
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Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents
PublicationAcridine and acridone analogues were prepared by Ullmann condensation and then cyclization reaction. As a result of nucleophilic substitution reaction 1-nitro-9-phenoxyacridine or 1-chloro-4-nitro-9(10H)-acridone with the corresponding peptides, the planned acridine derivatives (10a-c, 12, 17-a-d, 19) have been obtained. The cytotoxic activity of the newly obtained analogs were evaluated against melanotic (Ma) and amelanotic (Ab)...
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The Substantial Improvement of Amphotericin B Selective Toxicity Upon Modification of Mycosamine with Bulky Substituents
PublicationAbstract: Background: It is assumed that the unfavorable selective toxicity of an antifungal drug Amphotericin B (AmB) can be improved upon chemical modification of the antibiotic molecule. Objective: The aim of this study was verification of the hypothesis that introduction of bulky substituents at the amino sugar moiety of the antibiotic may result in diminishment of mammalian vitro toxicity of thus prepared AmB derivatives. Methods:...
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Molecular Design Using Selected Concentration Effects in Optically Activated Fluorescent Matrices
PublicationMolecular physics plays a pivotal role in various fields, including medicine, pharmaceuticals, and broader industrial applications. This study aims to enhance the methods for producing specific optically active materials with distinct spectroscopic properties at the molecular level, which are crucial for these sectors, while prioritizing human safety in both production and application. Forensic science, a significant socio-economic...
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Exploring the landscape of automatic cerebral microbleed detection: A comprehensive review of algorithms, current trends, and future challenges
PublicationThis paper provides the first review to date which gathers, describes, and assesses, to the best of our knowledge, all available publications on automating cerebral microbleed (CMB) detection. It provides insights into the current state of the art and highlights the challenges and opportunities in this topic. By incorporating the best practices identified in this review, we established guidelines for the development of CMB detection...
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Polysaccharide-based Nanocomposites for Biomedical Applications: A Critical Review
PublicationPolysaccharides (PSA) are taking specific position among biomaterials for advanced applications in medicine. Nevertheless, poor mechanical properties is known as the main drawback of PSA, which highlights need for PSA modification. Nanocomposites PSA (NPSA) are a class of biomaterials widely used as biomedical platforms, but despite their importance and worldwide use have not been reviewed. Herein we critically reviewed application...
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Robust and Efficient Machine Learning Algorithms for Visual Recognition
PublicationIn visual recognition, the task is to identify and localize all objects of interest in the input image. With the ubiquitous presence of visual data in modern days, the role of object recognition algorithms is becoming more significant than ever and ranges from autonomous driving to computer-aided diagnosis in medicine. Current models for visual recognition are dominated by models based on Convolutional Neural Networks (CNNs), which...
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Sustainable polymers targeted at the surgical and otolaryngological applications: Circularity and future
PublicationThe ongoing climate changes, high air and noise pollution have significant impact on humans’ health. This influence is especially visible in otolaryngology, which focuses on respiratory and hearing systems disfunctions. However, even though surgeries are done in response to diseases related to climate changes, they also have a negative impact on the environment, mostly connected with the inherence of single-use fossil fuel derived...
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Automated Reasoning Based User Interface
PublicationMotivation: The ability to directly trace how requirements are implemented in a software system is crucial in domains that require a high level of trust (e.g. medicine, law, crisis management). This paper describes an approach that allows a high level of traceability to be achieved with model-driven engineering supported by automated reasoning. The paper gives an introduction to the novel, automated user interface synthesis in...
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Bioreactor shoot cultures of Rhododendron tomentosum (Ledum palustre) for a large-scale production of bioactive volatile compounds
PublicationRhododendron tomentosum Harmaja (Ledum palustre), a peat bog plant from Ericaceae family, has been used in traditional medicine as the anti-arthritis agent. Although modern researches confirm its anti-inflammatory properties, it remains threatened by habitat degradation and possibilities to collect this endangered species from its natural environment for further biological activity studies are limited. Therefore, R. tomentosum...
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Validated HPTLC method for determination of ledol and alloaromadendrene in the essential oil fractions of Rhododendron tomentosum plants and in vitro cultures and bioautography for their activity screening
PublicationRhododendron tomentosum (Ledum palustre) is a bog shrub used in traditional medicine for treatment of respiratory and rheumatic diseases. Due to the large variability of the chemical composition of its essential oil, depending on the habitat, the in vitro cultures were established as the alternative source of the volatile fraction. There is a need to monitor a quality of the field grown as well as in vitro plant material, especially...
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Modernisation of existing hospitals
PublicationProgress in medicine and development of medical technologies directly affect the evolution of methods for treating patients in hospitals. The main task of 19th-century hospitals was patient care and nursing, while the aim of hospitals today is to diagnose and treat patients effectively in the shortest time possible. The changes which are taking place in methods of treatment affect the functional-spatial layout of hospitals. This...
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Establishing the allosteric mechanism in CRISPR‐Cas9
PublicationAllostery is a fundamental property of proteins, which regulates biochemical information transfer between spatially distant sites. Here, we report on the critical role of molecular dynamics (MD) simulations in discovering the mechanism of allosteric communication within CRISPR‐Cas9, a leading genome editing machinery with enormous promises for medicine and biotechnology. MD revealed how allostery intervenes during at least three...
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Validation of Hydraulic Mechanism during Blowout Trauma of Human Orbit Depending on the Method of Load Application
PublicationThe more we know about mechanisms of the human orbital blowout type of trauma, the better we will be able to prevent them in the future. As long as the buckling mechanism’s veracity is not in doubt, the hydraulic mechanism is not based on equally strong premises. To investigate the correctness of the hydraulic mechanism’s theory, two different methods of implementation of the hydraulic load to the finite element method (FEM) model...
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Chitosan-based inks for 3D printing and bioprinting
PublicationThe advent of 3D-printing/additive manufacturing in biomedical engineering field has introduced great potential for the preparation of 3D structures that can mimic native tissues. This technology has accelerated the progress in numerous areas of regenerative medicine, especially led to a big wave of biomimetic functional scaffold developments for tissue engineering demands. In recent years, the introduction of smart bio-inks has...
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Docking simulations, Molecular properties and ADMET studies of novel Chromane6,7diol analogues as potential inhibitors of Mushroom tyrosinase
PublicationResearch on inhibition of tyrosinase enzyme has attained significant value, because tyrosinase inhibitors have potential applications in medicine, cosmetics (as whitening agents) and in agriculture (as bioinsecticides). Determination and elucidation of new tyrosinase inhibitors are not only beneficial for medical purposes, but their promising applications in improving food quality and nutritional...
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Kobieta ciężarna i alkohol-toksyczny związek. Smółka noworodków jako materiał w diagnostyce spożywania alkoholu w czasie ciąży
PublicationKażda ilość alkoholu spożyta przez ciężarną kobietę może spowodować poronienie, przedwczesny poród, patologię łożyska, zahamowanie wzrostu wewnątrzmacicznego płodu i wystąpienie licznych wad wrodzonych wywołanych alkoholem, określanych wspólnie mianem spektrum płodowych zaburzeń alkoholowych - FASD. Mogą one objawiać się zaburzeniami psychicznymi i/lub fizycznymi. Współczesna diagnostyka u noworodków zespołu FASD opiera się najczęściej...