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Effect Of Resveratrol And Quercetin On Telomerase Regulation In Cancer Cells And Their Anti-Cancer Potential
PublicationTelomeres and telomerase are nowadays one on targets for anticancer therapy. Telomerase is expressed in ~90% of human cancer cell lines and tumor specimens, whereas its enzymatic activity is not detectable in most human somatic cells. Was found that some dietary compounds can modulate telomerase activity in cancer cells. This review summarizes the current knowledge about the effects of resveratrol and quercetin on telomerase regulation...
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The Role of Molecular Structure in Monte Carlo Simulations of the Secondary Electron Yield and Backscattering Coefficient from Methacrylic Acid
PublicationIn this paper, we show the influence of the chemical structure of four different conformers on the secondary electron emission and backscattering of an electron beam from a gel of methacrylic acid. The conformers have different permanent dipole moments, which determines the cross sections for elastic collisions with electrons. The cross sections are used in Monte Carlo simulations of an electron beam, which enters the gel of methacrylic...
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Successful Treatment of Persistent SARS-CoV-2 Infection in a B-Cell Depleted Patient with Activated Cytotoxic T and NK Cells: A Case Report
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A novel approach in wood waste utilization for manufacturing of catalyst-free polyurethane-wood composites (PU-WC)
PublicationIn recent decades, due to the increase in environmental awareness and noticeable environmental degradation, the area of wood waste management has attracted increasing attention. The purpose of this study is to develop a new type of highly filled polyurethane wood-composite (PU-WC) by the utilization of large amount of wood wastes without addition of a catalyst. Although wood-plastic composites (WPCs) are widely known, there is...
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The effect of aeration mode (intermittent vs. continuous) on nutrient removal and greenhouse gas emissions in the wastewater treatment plant of Corleone (Italy)
PublicationThe paper reports the results of an experimental study aimed at comparing two configurations of a full-scale wastewater treatment plant (WWTP): conventional activated sludge (CAS) and oxic-settling-anaerobic process (OSA) with intermittent aeration (IA). A comprehensive monitoring campaign was carried out to assess multiple parameters for comparing the two configurations: carbon and nutrient removal, greenhouse gas emissions, respirometric...
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Comparison of thresholding algorithms for automatic overhead line detection procedure
PublicationThe article presents an overview of the thresholding algorithms. It compares the algorithms proposed by Pun, Kittler, Niblack, Huang, Rosenfeld, Remesh, Lloyd, Riddler, Otsu, Yanni, Kapur and Jawahar. Additionally, it was tested how the tuning of the Pun, Jawahar and Niblack methods affects the thresholding efficiency and proposed a combination of the Pun algorithm with a priori algorithm. All presented algorithms have been implemented...
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Similarity Measures for Face Images: An Experimental Study
PublicationThis work describes experiments aimed at finding a straightforward but effective way of comparing face images.We discuss properties of the basic concepts, such as the Euclidean, cosine and correlation metrics, test the simplest version of elastic templates, and compare these solutions with distances based on texture descriptors (Local Ternary Patterns). The influence of selected image processing methods (e.g. bilateral ltering)...
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Application of the distributed transfer function method and the rigid finite element method for modelling of 2-D and 3-D systems
PublicationIn the paper application of the Distributed Transfer Function Method and the Rigid Finite Element Method for modelling of 2-D and 3-D systems is presented. In this method an elastic body is divided into 1-D distributed parameter elements (strips or prisms). The whole body (divided into strips or prism) is described by a set of coupled partial differential equations. Solving this equations in the state space form it is possible...
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Geometrically nonlinear FEM analysis of 6-parameter resultant shell theory based on 2-D Cosserat constitutive model
PublicationWe develop the elastic constitutive law for the resultant statically and kinematically exact, nonlinear, 6-parameter shell theory. The Cosserat plane stress equations are integrated through-the- thickness under assumption of the Reissner-Mindlin kinematics. The resulting constitutive equations for stress resultant and couple resultants are expressed in terms of two micropolar constants: the micropolar modulus Gc and the micropolar...
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Laminated plates and shells - first ply failure analysis within 6-parameter shell theory
PublicationThis work describes Tsai-Wu and Hashin criteria modifications, dictated by nonlinear 6-parameter shell theory with asymmetric strain measures and drilling rotation. The material law is based on standard orthotropic elastic constants for a non-polar continuum, under plane state of stress. First ply failure loads of cylindrical panel subjected to pressure and flat compressed plate are estimated by means of Finite Element Analysis....
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Diagnostics of historic columns using wave propagation
PublicationThis paper presents a numerical analysis of elastic wave propagation in columns of historical buildings for diagnostics purposes. Numerical calculations were performed using the finite element method in the Abaqus software package. The analysis was carried out for three types of brick columns: a full column, a column filled with debris, and a column empty inside. The excitation was in the form of a wave packet and signals of propagating...
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Numerical FDM modelling of wave propagation in concrete structure
PublicationThe article presents application of finite difference method to damage detection and its size evaluation in concrete structure by elastic wave propagation method. The simulations of wave propagation in concrete structure were performed for six different damage scenarios. Damages were modelled as areas with changed material properties. Investigation focused on the influence of damage size on the energy of wave reflection. Presented...
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Badania eksperymentalne słupów CFST z betonem zwykłym i ekspansywnym
PublicationPraca przedstawia badania eksperymentalne ponad 40 słupów CFST. Analizie poddano wyniki siły niszczącej słupy w aspekcie grubości stalowego płaszcza, smukłości słupa, rodzaju betonu wypełniającego stalową rurę (zwykły i ekspansywny) i jego wytrzymałości a także sposobu obciążania słupa (przez rdzeń lub przez cały przekrój). Sprawdzono efektywność słupów CFST z użyciem betonu ekspansywnego i zwykłego rozumianą jako stosunek nośności...
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Fracture in Asymmetric Bonded Joints
PublicationAdhesion was studied in asymmetric bonded joints using fracture mechanics tests. The asymmetric bonded joints consist of two different type and/or thickness materials bonded by an adhesive. Mentions of asymmetric bonded joint tests employed so far are rare in the literature. They are imperfect and therefore are not standardized. Accordingly three new tests were introduced in this work to study bonded joints. The new metrological...
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Functionalization of Parylene During Its Chemical Vapor Deposition
PublicationTwo possible mechanisms for the reaction of four halogenated (metha)acrylate-based molecules with Parylene [poly (paraxylylene)] during its chemical vapor deposition were proposed. The chemical reactivity of acrylate double bond with the paraxylylene biradical was calculated for all four (metha)acrylate-based molecules. These calculations allowed the evaluation of the energetically favorable mechanism and indeed a direct correlation...
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Low-Profile Interdigitated UHF RFID Tag Antenna for Metallic Objects
PublicationThis article presents a novel miniature interdigitated ultra-high frequency (UHF) radio frequency identification (RFID) tag antenna that can be placed on metallic objects. The tag structure comprises two horizontal strip lines, each loaded with seven identical open stubs, and an integrated circuit (IC) chip connected directly to the feed lines in the middle of the structure. The perfect match to the IC chip’s impedance is realized...
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The Effect of Fly Ash Microspheres on the Pore Structure of Concrete
PublicationThe fly ash microspheres (FAMs) formed during the mineral transformation stage in coal combustion are hollow spherical particles with a density less than water. This paper presents the results of X‐ray micro‐computed tomography and an automatic image analysis system of the porosity in the structure of hardened concrete with microspheres. Concrete mixtures with ordinary Portland cement and two substitution rates of cement by microspheres—5%...
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Three phase transient model of wet coal pyrolysis
PublicationA one-dimensional transient mathematical model was developed to describe the thermal and flow phenomena during coal pyrolysis in a coke oven. The model was solved numerically using partly implicit methods for gas flow and heat transfer problems. It was successfully validated with industrial-scale measurements of temperature change in the middle-plane of the coke oven chamber. The evolution of temperature and pressure, distributions...
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Propagation of acoustic pulses in some fluids with yield stress
PublicationThis study is devoted to the derivation of approximate equations governing acoustic pulses in flows with yieldstress, including some time-dependent flows with a slow dependence on time of yield stress and apparent viscosity. Themodeling of yield stress and apparent viscosity in the vicinity of a zero deformation rate allows us to consider a thixotropicfluid as a Bingham plastic with coefficients that are dependent on time. The...
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Composite GFRP U-shaped footbridge
PublicationThe paper presents proposals for the use of glass fiber reinforced polymer composites for the construction of engineering objects, known and commonly used in the shipbuilding industry. An example of a pedestrian footbridge was used in this case, which, despite the considerable thickness of the structural material, was made using infusion technology in one production cycle. The designed and produced footbridge span is durable, dynamically...
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CONCRETE MIX DESIGN USING ABRAMS AND BOLOMEY METHODS
PublicationOne way to reduce the consumption of cement is to optimize its use. Many known methods of concrete design, based on the Abrams law and the Bolomey method. Therefore, the authors chose those methods for analysis. The concrete composition with the assumed strength class, calculated by any method differs significantly. This applies especially to the cement content, as its content in the composition of concrete varies from 20 to 50%....
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Performance of isotropic constitutive laws in simulating failure mechanisms in scaled RC beams
PublicationResults of numerical calculations of reinforced concrete (RC) beams are presented. Based on experimental results on longitudinally reinforced specimens of different sizes and shapes are investigated. Four different continuum constitutive laws with isotropic softening are used: one defined within continuum damage mechanics, an elasto-plastic with the Rankine criterion in tension and the Drucker-Prager criterion in compression, a...
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On the well posedness of static boundary value problem within the linear dilatational strain gradient elasticity
PublicationIn this paper, it is proven an existence and uniqueness theorem for weak solutions of the equilibrium problem for linear isotropic dilatational strain gradient elasticity. Considered elastic bodies have as deformation energy the classical one due to Lamé but augmented with an additive term that depends on the norm of the gradient of dilatation: only one extra second gradient elastic coefficient is introduced. The studied class...
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Radio- and photosensitization of DNA with compounds containing platinum and bromine atoms
Publication. Irradiations of plasmid DNA by both X-rays and UV light in the presence and absence of compounds containing platinum and bromine atoms were performed in order to asses the sensitization potential of these compounds. Plasmid DNA pBR322 was incubated with platinum (II) bromide, hydrogen hexabromoplatinate (IV), hydrogen hexahydroxyplatinate (IV) and sodium hexahydroxyplatinate (IV). Incubation was followed by X-ray or UV irradiations....
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Cross section calculations for electron scattering from platinum chemotherapeutic compounds
PublicationCross section for electron impact ionization of carboplatin, C6H12N2O4Pt, and oxaliplatin, C8H14N2O4Pt, have been calculated within binary-encounter-Bethe model for energies from the ionization threshold up to 5000 eV. Cross section for elastic electron scattering from carboplatin and oxaliplatin molecules have also been derived using independent atom method (IAM) and additivity rule for collision energies ranging from 50 eV to...
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Mechanical properties for preliminary design of structures made from PVC coated fabric
PublicationIn this paper, laboratory tests necessary for the identification of non-linear elastic immediate properties of the PVC coated polyester fabric (like AF 9032) are described. The material parameters are specified on the basis of the uniaxial tensile tests in the warp and weft directions as well as on the base of the biaxial tensile tests. For the identification process techniques based on the least squares method are used. The authors...
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Investigation of abdomen surface deformation due to life excitation: implications for implant selection and orientation in laparoscopic ventral hernia repair
PublicationVentral hernia is a common medical problem. Statistically there are around 10% recurrences of the sickness. The authors' former investigation proved edges of the hernia orifice displacements to be one of the factors causing recurrence. Thus, experimental investigation of the abdomen surface deformation due to some normal activities of people is studied.The extreme strains, their localization and directions are identified. The acquired...
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Design of septic tanks placed on cohesive soils
PublicationThe paper presents a short review of literature with regard to design and erection of the reinforced concrete and concrete tanks. The authors investigated the underground septic tank with of 10 m3 capacity placed on cohesive soils. The authors compared the values of internal forces for soils in drained and undrained conditions with different geotechnical parameters: loamy sand of liquidity index IL = 0.1 and IL = 0.7 and clay with...
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On the use of uniaxial one-parameter damage laws for estimating fatigue life under multiaxial loading
PublicationThe goal of this paper is to evaluate the capabilities of different one-parameter fatigue laws to estimate crack initiation in notched components under multiaxial loading. Fatigue damage is accounted for through stress-based, strain-based, and energy-based approaches while the cyclic plasticity at the notch-controlled process zone is estimated using linear-elastic simulations. The results show that energy-based formulations established...
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Acceleration waves in the nonlinear micromorphic continuum
PublicationWithin the framework of the nonlinear elastic theory of micromorphic continua we derive the conditions for propagation of acceleration waves. An acceleration wave, also called a wave of weak discontinuity of order two, can be treated as a propagating nonmaterial surface across which the second derivatives of the placement vector and micro-distortion tensor may undergo jump discontinuities. Here we obtain the acoustic tensor for...
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Comparison of anti-plane surface waves in strain-gradient materials and materials with surface stresses
PublicationHere we discuss the similarities and differences in anti-plane surface wave propagation in an elastic half-space within the framework of the theories of Gurtin–Murdoch surface elasticity and Toupin–Mindlin strain-gradient elasticity. The qualitative behaviour of the dispersion curves and the decay of the obtained solutions are quite similar. On the other hand, we show that the solutions relating to the surface elasticity model...
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FEM ANALYSIS AND EXPERIMENTAL TESTS OF RIGID RISER HANGING SYSTEM
PublicationThe article presents the analysis, project, and experimental examination of an original rigid riser for Coil Tubing Pipes. The principle of riser operation is based on the use of friction forces. The research included the FEM analysis of the designed riser, calculations of the required bolt tensions, and checking the effect of the clamping force on stress distribution in the pipeline. The results of computer simulation were verified...
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On stress singularity near the tip of a crack with surface stresses
PublicationIn the framework of the simplified linear Gurtin–Murdoch surface elasticity we discuss a singularity of stresses and displacements in the vicinity of a mode III crack. We show that inhomogeneity in surface elastic properties may significantly affect the solution and to change the order of singularity. We also demonstrate that implicitly or explicitly assumed symmetry of the problem may also lead to changes in solutions. Considering...
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Detection of defects in PMMA beam using shear waves - numerical simulation and experiment
PublicationTest doświadczalny falami sprężystymi jest częścią systemu diagnostycznego belek. Autorzy badają pole przyspieszeń wywołane przepływem fal ultradźwiękowych i jego modyfikacje wynikające z wprowadzonych uszkodzeń belki. Artykuł porównuje wyniki eksperymentalne z symulacjami numerycznymi MES. The experimental test introduced in the paper is the part of the diagnostic system utilizing the elastic waves. The authors investigate the...
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Computer application for railway track realignment
PublicationThe topic of this article is the issue of railway track realignment. For this purpose, a computer software application was created that supports computations and generates a report needed for regulation of the trajectory of the railway. This program gives the ability to import data from measurement of the railway trajectory and then perform the calculation of the mathematical realignment. The result of this calculation is the basis...
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A Reaction of Thioamides with Zinc Ammoniates Leading to Simple Amidines. Discovery of a New Zwitterionic Monomethylamidine
PublicationThe reaction of thioamides with the R1R2N-ZnCl ammoniates leads to N-mono-, N,N'-di-, N,N-disubstituted, and unsubstituted amidines with high concns. of amines in abs. ethanol. The efficient direct formation of the N,N'-dimethylamidine can be explained by a greater reactivity of methylamine compared with dimethylamine. Discovery of a new zwitterion (induced by a carbonyl oxygen) suggests that the stabilization in the thymine...
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Convenient Syntheses of N-Methylthioamides: A Migration of the H2S Molecule in the Thioamide-nitrile System
PublicationThe reaction of thioamides with the R1R2N-ZnCl ammoniates leads to N-mono-, N,N'-di-, N,N-disubstituted, and unsubstituted amidines with high concns. of amines in abs. ethanol. The efficient direct formation of the N,N'-dimethylamidine can be explained by a greater reactivity of methylamine compared with dimethylamine. Discovery of a new zwitterion (induced by a carbonyl oxygen) suggests that the stabilization in the thymine...
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Design of Microstrip UWB Balun Using Quasi-TEM Approach Aided by the Artificial Neural Network
PublicationThe design procedure for UWB balun realized in the microstrip technology is proposed in the paper. The procedure applies Artificial Neural Network which corrects the dimensions of the approximate design found by appropriate scaling of the dimensions of the prototype. The scale coefficients for longitudinal and transverse dimensions of microstrip lines are determined from electromagnetic modeling based on transmission line equations....
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Redox State Sensitive Spectroscopy of the Model Compound [(H-dcbpy)(2)Ru-II(NCS)(2)](2-) (dcbpy=2,2 '-Bipyridine-4,4 '-dicarboxylato)
PublicationThe charge transfer reaction mechanism in a ruthenium polypyridine model complex with isothiocyanato ligands, i.e., [(H-dcbpy)(2)Ru(NCS)(2)](2-) 2Bu(4)N(+) (Ru2H) (dcbpy = 2,2'-bipyridine-4,4'-dicarboxylato), has been investigated by combining UV-vis absorption, resonance Raman spectroscopy, and electrochemical methods. Understanding the photophysics of light-harvesting complexes of this class is an indispensable prerequisite to...
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Neon-Bearing Ammonium Metal Formates: Formation and Behaviour under Pressure
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Water-Lubricated Sintered Bronze Journal Bearings—Theoretical and Experimental Research
PublicationWater lubricated bearings are used from many years in shipbuilding, hydro power and other industries because of their advantages such as: extensive serviceable life, low coefficient of friction, longevity of shaft sleeve, good abrasion resistance, low maintenance required, unit simplicity, no danger of pollution and low price. Various types of water lubricated sliding bearings have been tested at the Technical University of Gdansk...
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Torsional elasticity and energetics of F1-ATPase
PublicationFoF1-ATPase is a rotary motor protein synthesizing ATP from ADP driven by a cross-membrane proton gradient. The proton flow through the membrane-embedded Fo generates the rotary torque that drives the rotation of the asymmetric shaft of F1. Mechanical energy of the rotating shaft is used by the F1 catalytic subunit to synthesize ATP. It was suggested that elastic power transmission with transient storage of energy in some compliant...
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Assessment of Thermal Stresses in Asphalt Mixtures at Low Temperatures Using the Tensile Creep Test and the Bending Beam Creep Test
PublicationThermal stresses are leading factors that influence low-temperature cracking behavior of asphalt pavements. During winter, when the temperature drops to significantly low values, tensile thermal stresses develop as a result of pavement contraction. Creep test methods can be suitable for the assessment of low-temperature properties of asphalt mixtures. To evaluate the influence of creep test methods on the obtained low-temperature...
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Synthesis, Molecular Structure, Anticancer Activity, and QSAR Study of N-(aryl/heteroaryl)-4-(1H-pyrrol-1-yl)Benzenesulfonamide Derivatives
PublicationA series of N-(aryl/heteroaryl)-4-(1H-pyrrol-1-yl)benzenesulfonamides were synthesized from 4-amino-N-(aryl/heteroaryl)benzenesulfonamides and 2,5-dimethoxytetrahydrofuran. All the synthesized compounds were evaluated for their anticancer activity on HeLa, HCT-116, and MCF-7 human tumor cell lines. Compound 28, bearing 8-quinolinyl moiety, exhibited the most potent anticancer activity against the HCT-116, MCF-7, and HeLa cell lines,...
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Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents
PublicationAcridine and acridone analogues were prepared by Ullmann condensation and then cyclization reaction. As a result of nucleophilic substitution reaction 1-nitro-9-phenoxyacridine or 1-chloro-4-nitro-9(10H)-acridone with the corresponding peptides, the planned acridine derivatives (10a-c, 12, 17-a-d, 19) have been obtained. The cytotoxic activity of the newly obtained analogs were evaluated against melanotic (Ma) and amelanotic (Ab)...
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Selection of circuit geometry for miniaturized microwave components based on concurrent optimization of performance and layout area
PublicationThe paper presents a framework for automated EM-driven circuit geometry selection of miniaturized microwave components. Selection of a particular layout is based directly on miniaturization rates achieved for a set of candidate circuit geometries. Size reduction of the considered structures is obtained by replacing their main building blocks (i.e., conventional transmission lines) with slow-wave composite cells and meander lines....
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Positron binding to alkali-metal hydrides: The role of molecular vibrations
PublicationThe bound vibrational levels for J=0 have been computed for the series of alkali-metal hydride molecules from LiH to RbH, including NaH and KH. For all four molecules the corresponding potential-energy curves have been obtained for each isolated species and for its positron-bound complex (e+XH). It is found that the calculated positron affinity values strongly depend on the molecular vibrational state for which they are obtained...
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NEW CONCEPT OF HYBRID PROPULSION WITH HYDROSTATIC GEAR FOR INLAND WATER TRANSPORT
PublicationThe article presents the development of author’s concept of a diesel/hydraulic propulsion system for inland watercraft. Due to specific nature of vessel navigation on rivers, classical propulsion systems with shaft lines can be effectively replaced by systems with hydraulic power transmission. A solution is also presented of a hybrid design with extra electric port having the form of a pumping system driven from a battery of accumulators....
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Thermal Properties of PLA/TPS Blends
PublicationFour types of polymer compositions having different amount of potato starch, glycerin and poly(lactic acid) was obtained and characterized by DSC. Adding of TPS to PLA lowered Tg.
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Valence and ionic lowest-lying electronic states of small esters studied by high resolution vacuum ultraviolet photoabsorption, photoelectron spectroscopy and ab initio calculations
PublicationEsters are an important class of oxygenated volatile organic compounds used in food flavorings, perfumes and other cosmetic products. They are present in fruits and pheromones and are emitted to the atmosphere naturally. Esters are also formed in the atmosphere as a product of the oxidation of ethers. Some of them form poly-molecule chains and are used in plastics. Phosphoesters form DNA backbone, while nitroesters are known for...