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Search results for: tendon repair
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H2AX phosphorylation, its role in DNA damage response and cancer therapy
PublicationDouble-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired, may have severe consequences for cell survival, as they lead to chromosome aberrations, genomic instability, or cell death. Various physical, chemical, and biological factors are involved in DSB induction. Cells respond to DNA damage by activating the so-called DNA damage response (DDR), a complex molecular mechanism developed to detect...
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Multi Parameter Sliding Test Result Evaluation for The Selection of Material Pair for Wear Resistant Components of a Hydraulic motor Dedicated for Use With Environmentally Friendly Working Fluids
PublicationIn the paper the method and results are presented of the testing of tribological performance of a number of hard materials available commercially. The tests consisted in unidirectional sliding with liquid lubrication. The load and velocity regime chosen were similar to a standard four-ball lubricity test with constant velocity and load increasing over time. The regime was modified in such a way that over the initial part of the...
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Multi Parameter Sliding Test Result Evaluation for the Selection of Material Pair for Wear Resistant Components of a Hydraulic Motor Dedicated for Use with Environmentally Friendly Working Fluids
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Multi parameter sliding test result evaluation for the selection of material pair for wear resistant components of a hydraulic motor dedicated for use with environmentally friendly working fluids
PublicationW referacie przedstawiono zastosowanie metody badań tribologicznych pozwalającej na dokonywanie doboru najlepszych skojarzeń tribologicznych z wybranej populacji poprzez parametryczną ocenę wyników z wielu rodzajów testów tribologicznych wykonywanych na identycznych skojarzeniach materiał - smar - materiał.
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Synthetic lipopeptides as potential topical therapeutics in wound and skin care: in vitro studies of permeation and skin cells behaviour
PublicationSeveral Gly-His-Lys analogues were obtained to investigate their antimicrobial properties. Three lipophilic analogues with the structure numbering 1b, 2b, 4b, exhibit significant effect against bacteria and were selected for in vitro evaluation of skin cells behaviour. In the present studies, an in vitro model of wound repair, proliferative cell staining, and tracking of living cells were used. Cell proliferation and cell migration,...
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MutS3: a MutS homologue of unknown biological function
PublicationThe homologues of MutS proteins are widespread among both Prokaryotes and Eukaryotes. MutS designated as MutS1 is a part of MMR (mismatch repair) system which is responsible for removal of mispaired bases and small insertion/deletion loops in DNA. Initially, the only MutS homologues known were those engaged in mismatch repair and these were later designated as MutS1. Subsequently, the MutS2 homologue was distinguished. MutS2 does...
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The influence of the carbon equivalent on the weldability of high-strength low-alloy steel in the water environment
PublicationFrom many years, the high strength low alloy steels are often used for offshore constructions. This constructions, due to the environment in which they work, require more frequent repairs than the constructions from the land. For economic reasons, repairs take place in the underwater conditions, however water significantly decreases the weldability of steel. The paper presents the results of the CTS weldability test for S460ML...
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Towards temperature-dependent coarse-grained potentials of side-chain interactions for protein folding simulations. I: Molecular dynamics study of a pair of methane molecules in water at various temperatures
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STUDY ON THE RELATIONSHIP BETWEEN VEHICLE MAINTENANCE AND FUEL CONSUMPTION
PublicationA contemporary road vehicle (RV) is a rather complex system, consisting of a large number of subsystems, assemblies, units, and elements (parts). While operating, an RV interacts with the environment, and its elements interact with each other. Consequently, the properties (parameters) of these elements change in the process - hardness, roughness, size, relative position, gapping, etc. A partial solution to the presented problems...
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The concept of estimation of elevator shaft control measurement results in the local 3D coordinate system.
PublicationGeodetic control measurements play an important part because they provide information about the current state of repair of the construction, which has a direct impact on the safety assessment of its exploitation. Authors in this paper have focused on control measurements of the elevator shaft. The article discusses the problem of determining the deviation of elevator shaft walls from the vertical plane in the local 3D coordinate...
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Underwater Welding of Duplex Stainless Steel
PublicationThe present work was conducted to assess the weldability of duplex stainless steel at underwater conditions. Interest of underwater welding of this steel grade is connected with necessity of preparing welding repair technologies for subsea pipelines widely used in offshore oil and gas industry. The GMA local cavity welding method was used in the investigations. Welded beads were performed underwater at 0.5 m depth and in the air....
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Regression points in non-intrusive polynomial chaos expansion method and D-optimal design
PublicationThe paper addresses selected issues of uncertainty quantification in the modelling of a system containing surgical mesh used in ventral hernia repair. Uncertainties in the models occur e.g. due to variability of abdominal wall properties among others. In order to include them, a non-intrusive regression-based polynomial chaos expansion method is employed. Its accuracy depends on the choice of regression points. In the study a relation...
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Dynamic Response of the Suspended on a Single Cable Footbridge
PublicationThe article presents numerical simulations, dynamic in situ load tests and a structural health monitoring (SHM) system installed in a suspended on a single cable footbridge. Numerical simulations performed prior to construction indicated the possibility of structural dynamics problems, finally confirmed in the course of dynamic test loading. In the dynamic load course the bridge deck developed vibrations displaying accelerations...
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Electrically Conductive Carbon‐based (Bio)‐nanomaterials for Cardiac Tissue Engineering
PublicationA proper self-regenerating capability is lacking in human cardiac tissue which along with the alarming rate of deaths associated with cardiovascular disorders makes tissue engineering critical. Novel approaches are now being investigated in order to speedily overcome the challenges in this path. Tissue engineering has been revolutionized by the advent of nanomaterials, and later by the application of carbon-based nanomaterials...
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Experimental study and numerical optimization of tensegrity domes – A case study
PublicationThe paper deals with the design, experimental analysis and numerical optimization of tensegrity dome models. Two structures are analyzed – a Geiger system dome (preliminary dome), with PVC-U bars and PA6/PP/PET tendons and a Fuller system dome (target dome), with wooden bars and steel cables as tendons. All used materials are experimentally tested in terms of Young's modulus and yield stress values, the compressed bars are also...
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Electromodulation and magnetomodulation of exciton dissociation in electron donor (starburst amine) : electron acceptor (bathocuproine) system
PublicationElectric field dependencies of electromodulated photoluminescence and photocurrents as well as the magnetic field effects on photocurrents, photovoltaic characteristics, electromodulated photoluminescence and photoluminescence have been investigated in vacuum evaporated films of m-MTDATA:BCP (4,4',4''-tris(N-(3-methylphenyl)-N-phenylamino)triphenylamine and bathocuproine) system. The electromodulation processes do remain in accordance...
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Wytrzymałość pętli wplatanych na linach podwójnie plecionych
PublicationCechą wyróżniającą statki żaglowe z grona innych obiektów pływających są żagle. To cecha widoczna, za którą kryją się mniej romantyczne elementy, takie jak maszty, liny i osprzęt. Rozpostarcie białych płócien na maszcie i następnie żeglowanie wymaga sprawnego operowania nimi, co wiąże się z doborem odpowiedniego ich zestawu, ułożenia i napięcia. To maszty są kręgosłupem takielunku, a liny jego mięśniami i ścięgnami. Do poprawnego...
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ANALYSIS OF THE INCREASE OF CONSTRUCTION COSTS IN URBAN REGENERATION PROJECTS
PublicationThe subject of this paper is the analysis and evaluation of the reasons for construction costs increases in urban regeneration projects. The analysis considers major refurbishments of real estates’, as well as heavy repair and modernization of the road system. For the period mentioned, the costs from works and expenditure schedules were compared with the costs of additional works, which shows the percentage cost increase in relation...
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Naprawa po pożarze stalowej wielokondygnacyjnej wieży produkcyjnej z zastosowaniem sprężanych elementów wzmocnienia
PublicationPożar we wnętrzu wielokondygnacyjnego obiektu produkcyjnego o stalowej konstrukcji ramowej spowodował znaczne uszkodzenia w zakresie stalowych stropów międzykondygnacyjnych oraz części głównych słupów nośnych obiektu. Pomimo dużych strat w obrębie konstrukcji i lekkiej obudowy obiektu oraz długiej akcji gaśniczej udało się uratować w całości baterię technologicznych silosów magazynowych zlokalizowanych na jego dachu. Wydane bezpośrednio...
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Dynamic polarizability of the relativistic hydrogenlike atom: Application of the Sturmian expansion of the Dirac-Coulomb Green function
PublicationWe utilize the Sturmian expansion of the Dirac-Coulomb Green function [R. Szmytkowski, J. Phys. B 30, 825 (1997)] to obtain components of the dynamic dipole polarizability tensor of the relativistic hydrogenlike atom in the ground state. It is found that the tensor may be expressed in terms of two independent quantities: a scalar polarizability and a vector polarizability, the latter being of the relativistic origin. In the static...
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Challenge for the sustainable city - is the Garden City idea still relevant?
PublicationTekst ma na celu porównanie europejskiej architektury mieszkaniowej powsta-łej w okresie ostatnich stu lat po obu stronach Żelaznej Kurtyny oraz przy-wołanie historycznych zasad jej kształtowania. Rozważa współczesne tenden- cje i poglądy nt. zrównoważonego projektowania miasta oraz zachęca do ref-leksji nad aktualnością idei Miasta-Ogrodu.
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CrossTalk opposing view: Which technique for controlling resistant hypertension? Carotid chemoreceptor denervation/modulation
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Rebuttal from L. E. K. Ratcliffe, W. Pijacka, F. D. McBryde, A. P. Abdala, D. J. Moraes, P. A. Sobotka, E. C. Hart, K. Narkiewicz, A. K. Nightingale and J. F. R. Paton
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TGF-β gene polimorphisms as risk factors for asthma control among clinic patients
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Immunization with an anti-idiotypic antibody against the broadly lipopolysaccharide-reactive antibody WN1 222-5 induces Escherichia coli R3-core-type specific antibodies in rabbits
PublicationThe mouse monoclonal antibody (mAb) WN1 222-5 recognizes a carbohydrate epitope in the inner core region of LPS that is shared by all strains of Escherichia coli and Salmonella enterica and is able to neutralize their endotoxic activity in vitro and in vivo. Immunization of mice with mAb WN1 222-5 yielded several anti-idiotypic mAbs one of which (mAb S81-19) competitively inhibited binding of mAb WN1 222-5 to E. coli and Salmonella...
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Perfectly Wetting Mixtures of Surfactants from Renewable Resources: The Interaction and Synergistic Effects on Adsorption and Micellization
PublicationThis paper presents a study of the surface properties of mixtures of surfactants originating from renewable sources, i.e., alkylpolyglucoside (APG), ethoxylated fatty alcohol (AE), and sodium soap (Na soap). The main objective was to optimize the surfactant ratio which produces the highest wetting properties during the analysis of the solution of the individual surfactants, twoand three-component mixtures, and at different pH values....
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Density functional theory-based simulations of sum frequency generation spectra involving methyl stretching vibrations: effect of the molecular model on the deduced molecular orientation and comparison with an analytical approach
PublicationThe knowledge of the first hyperpolarizability tensor elements of molecular groups is crucial for a quantitative interpretation of the sum frequency generation (SFG) activity of thin organic films at interfaces. Here, the SFG response of the terminal methyl group of a dodecanethiol (DDT) monolayer has been interpreted on the basis of calculations performed at the density functional theory (DFT) level of approximation. In particular,...
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Effect of the Combined Therapy of the Muscle Energy Technique and Trigger Point Therapy on the Biophysical Parameters of the Trapezius Muscle: a Randomized Clinical Trial
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Interaction of cisplatin and two potential antitumoral platinum(ii) complexes with a model lipid membrane: a combined NMR and MD study
PublicationIn this study, the interaction of cisplatin (1) and two potential antitumoral Pt(II) complexes (2 and 3) with a model DMPC bilayer was investigated by multinuclear NMR spectroscopy and MD simulations in order to understand its implication for the different antitumoral properties shown by the three complexes. In particular, 31P, 13C and 2H solid state NMR experiments were performed to obtain information on the phase structure, phase...
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A new division of bacterial UvrA homologues
PublicationThe UvrA protein is a DNA-binding and damage-recognition enzyme which participates in the prokaryotic type nucleotide excision repair (NER) pathway. It has recently been noted that some bacterial genomes comprise additional uvrA genes which encode five distinct types of UvrA homologue. We investigated the sequences of over 2400 bacterial genomes and found 130 examples of bacteria containing uvrA 2 genes. The sequence analyses conducted...
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ATTEMPT AT EVALUATING THE INFLUENCE OF BENDING STRESS ON SHAFT WEAR PROCESSES IN WATER LUBRICATED SLIDING BEARING WITH A RUBBER BUSHING
PublicationWater lubricated bearings find increasingly wide application in shipbuilding or hydro–power industry, the popularity stemming from their numerous advantages. Unfortunately, as it turns out, water lubricated bearings do not always meet expectations, as on occasion they become subject to intense, premature wear which requires costly repair. One of the still unexplained phenomena is the process of excessive bearing wear, in particular...
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The UK's banking system as financial hub for Islamic banking
PublicationThis paper examines the phenomenon of London as "the Islamic banking hub". It contends that London has become not only an international centre for Islamic finance, but also that there is big interest and demand for Islamic banking products. The authors are also positive that Islamic banking may be a certain solution for the problems that Europe has been suffering since 2007 when the global debt crisis started. Our intention is...
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Schemat powstawania rys na przykładzie osiowo rozciąganego pręta żelbetowego
PublicationW artykule przedstawiono w sposób schematyczny ideę powstawania kolejnych rys w konstrukcjach żelbetowych na przykładzie osiowo rozciąganego pręta. Opisano początkowy oraz końcowy stan zarysowania. Wyprowadzono wzór na szerokość rysy. Przedstawiono interpretację geometryczną rys dla fazy początkowego zarysowania oraz efekt tension stiffening na przykładzie elementu osiowo rozciąganego. Przedstawiono przykładowe obliczenia miary...
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Acceleration waves in the nonlinear micromorphic continuum
PublicationWithin the framework of the nonlinear elastic theory of micromorphic continua we derive the conditions for propagation of acceleration waves. An acceleration wave, also called a wave of weak discontinuity of order two, can be treated as a propagating nonmaterial surface across which the second derivatives of the placement vector and micro-distortion tensor may undergo jump discontinuities. Here we obtain the acoustic tensor for...
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Linear viscoelastic transversely isotropic model based on the spectral decomposition of elasticity tensors
PublicationThe linear viscoelasticity is still a useful model in the engineering for studying the behavior of materials loaded with different loading rates (frequencies). Certain types of materials reveal also an anisotropic behavior: fiber reinforced composites, asphalt concrete mixtures, or wood, to name a few. In general, researchers try to identify experimentally the dependence of engineering constants like: directional Young’s moduli...
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Investigation of the aerodynamics of an innovative verticalaxis wind turbine
PublicationThis paper presents a preliminary three dimensional analysis of the transient aerodynamic phenomena occurring in the innovative modification of classic Savonius wind turbine. An attempt to explain the increased efficiency of the innovative design in comparison with the traditional solution is undertaken. Several vorticity measures such as enstrophy, absolute helicity and the integral of the velocity gradient tensor second invariant...
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Modelling and Measurement of Folk Guitar: Truss Rod and Strings in Numerical Analysis of Tone
PublicationThe study makes an attempt to model a complete vibrating guitar including its non-linear features, specifically the tension-compression of truss rod and tension of strings. The purpose of such a model is to examine the influence of design parameters on tone. Most experimental studies are flawed by uncertainties introduced by materials and assembly of an instrument. Since numerical modelling of instruments allows for deterministic...
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Building modernization located in the conservation protection zone in the aspect of technical conditions
PublicationThe paper presents a description of the technical condition of the building after many years of operation and analyzes the impact of the current use and the lack of regular periodic repairs on the technical efficiency of the building. The influence of the technical solutions applied during the construction of the building on the current limitations related to the planned, target change in the way of use was discussed. Variant conceptual...
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Activation of endogenous regenerative potential in mammals using epigenetic inhibitor zebularine
PublicationIn this work, a nucleoside inhibitor of DNA methyltransferases, zebularine, was investigated as a wound healing and regeneration promoting agent. It was found that a high dose of intraperitoneally delivered zebularine improved punch wound closure in the ear pinna in mice. Both cytidine, a zebularine analogue, and uridine, a zebularine metabolite, did not promote ear pinna hole closure. The effect of zebularine on ear pinna healing...
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PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells
PublicationTwo cellular proteins encoded by the breast and ovarian cancer type 1 susceptibility (BRCA1 and BRCA2) tumor suppressor genes are essential for DNA integrity and the maintenance of genomic stability.Approximately 5-10% of breast and ovarian cancers result from inherited alterations or mutations in these genes.Remarkably, BRCA1/BRCA2-deficient cells are hypersensitive to selective inhibition of poly(ADPribose) polymerase 1 (PARP-1),...
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Wpływ rodzaju zanieczyszczenia powierzchni odlewu ze staliwa LH14 na jakość napoin wykonanych elektrodą otuloną
PublicationNapawanie jest szeroko stosowaną metodą naprawiania powierzchni. Pozwala między innymi na uzupełnienie miejsc, w których uprzednio wystąpiły wżery korozyjne. Techniki napawania wykorzystywane są również do przywracania pierwotnego kształtu zużytych części. W pracy wykonano badania napoin wykonanych elektrodami otulonymi na czołowych powierzchniach cylindrycznych próbek ze staliwa LH14. Proces wykonywano dwoma rodzajami elektrod:...
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From DNA damage to G2 arrest: the many roles of topoisomerase II. W: Prog-ress in Cell Cycle Research. Ed. Meijer L., Jezequel A., Roberge M. London: Plenum Publ. Comp. Ltd**2003 vol. 5 chapt. 30 s. 295-300 Od uszkodzeń DNA do bloku w G2: wiele ról dla topoizomerazy II.
PublicationInhibitory DNA topoizomerazy II sa jednymi z najbardziej szeroko stosowanymi lekami przeciwnowotworowymi. Związki te indukuja pekniecia nici DNA i bloku progresji cyklu komorkowego w fazie G2. Jednak topoizomeraza II jest nie tylko celem molekularnym dla lekow przeciwnowtworowych ale enzym ten pelniwazna role w odpowiedzi komorkowej na dzialanie wielu lekow uszkadzajacych DNA. Topoizomeraza tworzy kompleksy molekularne z bialkami...
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The role of epigenetics in regeneration
PublicationComplex changes in chromatin structure and at the transcriptional level occur from the creation of a single parental gamete throughout fertilization, embryo development and the life of an adult organism. Epigenetic changes, such as methylation and hydroxymethylation of DNA or histone methylation and acetylation, are an important part of these processes. Epigenetic regulation has an essential influence on gene expression level. DNA...
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LNG TANK IN ŚWINOUJŚCIE: NONLINEAR ANALYSIS OF THE TANK DOME ELEMENTS BEHAVIOUR
PublicationIn this paper, the dome of a tank in the Świnoujście LNG terminal is analysed. Some of the rafter ribs at the connection with hangers were not mounted during construction of the tank dome. Therefore, it has become necessary to estimate its response, which has been done with the aid of some computational models of the dome, that have been created in the finite element method environment. Different local models are studied, aiming...
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Load testing of a suspended footbridge in Radom (Poland)
PublicationThe footbridge in Radom is a suspended bridge of an interesting architectural form. The structure was de-signed for 4 kN/m2 of crowd loading. Dynamic calculations were not included in the design. The structure’s acceptance tests took place on the 14th of October 2016. The behaviour of the footbridge in static testing met the expectations. Unfortunately, as a result of dynamic tests, dangerous behaviour of the footbridge was revealed....
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Nanotechnologia w architekturze – korzyści i problemy wynikające z zastosowania nanotechnologii w aspekcie cyklu życia budynku
PublicationDynamiczny rozwój technologii zawsze odgrywał ważną rolę w procesie kształtowania architektury. Postęp w dziedzinie inżynierii materiałowej już od Rewolucji Przemysłowej pozwalał na osiąganie co raz bardziej skomplikowanych i jednocześnie wytrzymałych konstrukcji budynków. Obecnie, w dziedzinie architektury, zaczyna pojawiać się pojęcie nanotechnologii, która pozwala zmieniać stosowane materiały w bardziej wydajne i odporne....
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Non-standard binary weighted number systems
PublicationZdefiniowano szeroką klasę binarnych systemów wagowych. Wszystkie sa wzajemnie jednoznaczne ale mogą być zupełne lub niezupełne. Jeżeli wagi systemu są kolejnymi liczbami naturalnymi to system jest minimalny.Jesli wagi sa kolejnymi potęgami podstawy Z to system jest maksymalny. W przestrzeni między tymi systemami znajdują się inne systemy binarne. Kilka z nich przedstawiono w referacie.
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Stosowanie rur gęstożebrowanych w poziomych skraplaczach płaszczowo-rurowych
PublicationW artykule zwrócono uwagę na możliwości poprawy wymiany ciepła w poziomych skraplaczach płaszczowo-rurowych dzięki zastosowaniu w ich konstrukcji rurek gęstożebrowanych. Przedstawiono wyniki badań cieplno-przepływowych modelowego skraplacza takiej konstrukcji typ K 15-70 oraz prototypowego skraplacza przemysłowego typ FSPR 20-4-A. W obu przypadkach zastosowanie rur gęstożebrowanych pozwoliło znacznie poprawić wskaźniki cieplno-konstrukcyjne...
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Wymiana ciepła i opory przepływu w wymiennikach płytowo-żebrowych stosowanych w chłodniczych bateriach termoelektrycznych.
PublicationW artykule wskazano na ważne z technicznego punktu widzenia zalety urządzeń termoelektrycznych w zastosowaniu do klimatyzacji powietrza. Przedstawiono wybrane wyniki badań wymiany ciepła i oporów przepływu uzyskane dla trzech powierzchni płytowo-żebrowych przeznaczonych do współpracy z ''zimnymi'' spoinami modułów termoelektrycznych. Zwrócono uwagę na istotne problemy natury technologicznej w konstrukcji tego typu powierzchni...
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50 lat ''CHŁODNICTWA'' na Politechnice Gdańskiej.
PublicationPrzedstawiono 50-letnią historię kształcenia w dziedzinie chłodnictwa na Politechnice Gdańskiej. Omówiono ważniejsze dokonania naukowo-badawcze, w tym tematykę prac doktorskich pracowników tworzących Katedrę a następnie Zespół Chłodnictwa. Sporo uwagi poświęcono osiągnięciom dydaktycznym poprzez kształcenie na unikalnej w kraju specjalności ''Systemy, Urządzenia Chłodnicze i Klimatyzacyjne''. Omówiono dokonania ostatnich lat w...