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Opioid Growth Factor and its Derivatives as Potential Non-toxic Multifunctional Anticancer and Analgesic Compounds
PublicationIn this paper, we review the structure-activity relationship of OGF and its analogues. We highlight also OGF derivatives with analgesic, immunomodulatory activity and the ability to penetrate the blood-brain barrier and may be used as safe agents enhancing chemotherapy efficacy and improving quality of life in cancer patients. The reviewed papers indicate that Met-enkephalin and its analogues are interesting candidates for the...
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Zastosowanie sygnałów o projektowanych kształtach do diagnostyki obiektów wysoko-impedancyjnych metodą spektroskopii impedancyjnej
PublicationW artykule przedstawiono metodę szybkiej spektroskopii impedancyjnej obiektów o wysokich impedancjach (|Zx| > 1 GOhm) z zastosowaniem sygnałów o projektowanych kształtach. Sygnał pobudzenia wytwarzany jest w module DAQ U2531A i doprowadzany na wejście badanego obiektu za pośrednictwem przetwornika cyfrowo-analogowego (CA). Sygnały odpowiedzi proporcjonalne do napięcia na mierzonej impedancji Zx oraz prądu płynącego przez Zx są...
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Programmable Input Mode Instrumentation Amplifier Using Multiple Output Current Conveyors
PublicationIn this paper a programmable input mode instrumentation amplifier (IA) utilising second generation, multiple output current conveyors and transmission gates is presented. Its main advantage is the ability to choose a voltage or current mode of inputs by setting the voltage of two configuration nodes. The presented IA is prepared as an integrated circuit block to be used alone or as a sub-block in a microcontroller or in a field...
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Characterization of recombinant homocitrate synthase from Candida albicans
PublicationLYS21 and LYS22 genes from Candida albicans encoding isoforms of homocitrate synthase (HCS), an enzyme catalyzing the first committed step in the L-lysine biosynthetic pathway, were cloned and expressed as NoligoHistagged fusion proteins in Escherichia coli. The purified gene products revealed HCS activity, i.e. catalyzed the condensation of α-ketoglutarate with acetyl-coenzyme A to yield homocitrate. The recombinant enzymes were purified...
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Dynamical nonlocality in quantum time via modular operators
PublicationWe formalize the concept of the modular energy operator within the Page and Wootters timeless framework. As a result, this operator is elevated to the same status as the more studied modular operators of position and momentum. In analogy with dynamical nonlocality in space associated with the modular momentum, we introduce and analyze the nonlocality in time associated with the modular energy operator. Some applications of our...
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Time-domain measurement methods for R, L and C sensors based on aversatile direct sensor-to-microcontroller interface circuit
PublicationtIn the paper new time-domain measurement methods for determining values of resistive (R), inductive(L) and capacitive (C) sensors based on a versatile direct sensor-to-microcontroller interface for microcon-trollers with internal analog-to-digital converters (ADCs) and analog comparators (ACs) are presented.The interface circuit consists of a reference resistor Rrworking as a voltage divider, a given R, L or C sensorand a microcontroller...
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An idea of an approach to self-testing of mixed signal systems based on a quadratic function stimulation
PublicationA new approach to self-testing of the analog parts of mixed-signal electronic systems controlled by microcontrollers equipped with an ADC and a DAC is presented. It is based on a BIST and a new fault diagnosis method. A novelty is the use of the DAC as a component of the BIST, allowing to generate a stimulating signal with a quadratic function shape. It contributes to a better extraction of information about the state of the circuit...
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Ho2Pd1.3Ge2.7 – a ternary AlB2-type cluster glass system
PublicationWe report a successful synthesis of a ternary AlB2-type intermetallic compound. The phase purity was obtained by fine-tuning the Pd-Ge ratio out of the idealized 1-3. Attempts to synthesize an Er analogue were not successful. We discuss the instability of the Er analogue based on the atomic size ratio and also suggest that the increased stability of Ho2Pd1+xGe3−x in the Pd-rich range likely stems from a combination of atomic size...
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Low-cost handheld multiprobe reflectometer for the ism band
PublicationW artykule przedstawiona została procedura oraz działający model taniego miernika współczynnika odbicia na pasmo ISM. Koncepcja modelu oparta jest o reflektometr z multi próbkowaniem oraz wykorzystanie zintegrowanego detektora mocy firmy Analog Devices. Prototypowy miernik z interfejsem został zbudowany. Wyniki symulacji oraz eksperymentu zostały przedstawione.
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Structural Factors Affecting Cytotoxic Activity of (E)-1-(Benzo[d ][1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-one Derivatives
PublicationDerivatives of (E)-1-(5-alkoxybenzo[d][1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-one (1) demonstrated exceptionally high in vitro cytotoxic activity, with IC50 values of the most active derivatives in the nanomolar range. To identify structural fragments necessary for the activity, several analogs deprived of selected fragments were prepared, and their cytotoxic activity was tested. It was found that the activity depends on combined effects...
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Characteristics of an image sensor with early-vision processing fabricated in standard 0.35 µm CMOS technology
PublicationThe article presents measurement results of prototype integrated circuits for acquisition and processing of images in real time. In order to verify a new concept of circuit solutions of analogue image processors, experimental integrated circuits were fabricated. The integrated circuits, designed in a standard 0.35 µm CMOS technology, contain the image sensor and analogue processors that perform low-level convolution-based image...
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Recent developments in the synthesis and biological activity of muramylpeptides
PublicationZaprezentowano przegląd literaturowy obejmujący syntezę i aktywność biologiczną nowych analogów muramylopeptydów (MDP) oraz ich potencjalne zastosowanie w terapii nowotworowej i chorób infekcyjnych.
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Inhibitory mikrotubul w terapii przeciwnowotworowej = Inhibitors of microtubule in cancer therapy
PublicationW artykule opisano inhibitory mikrotubul, różnorodne związki chemiczne, znajdujące się w zaawansowanych przedklinicznych i wstępnych badaniach klinicznych. Pośród nich na uwagę zasługują półsyntetyczne analogi taksolu, substancje pochodzenia naturalnego, takie jak: epotilony, kombretastatyny, kolchinoidy, dolastatyny oraz syntetyczne związki o niskim ciężarze czasteczkowym: heterokombretastatyny, sulfonamidy, fenostatyny, pochodne...
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A method for evaluating durability of porous slide bearings
PublicationThe article presents the structures of porous bearings bushes and greasy lubricants, and the similarity criterion resulting from this structures. A phisical model is proposed which describes the operation of the porous slide bearing bush taking into account, via analogy, the phenomena taking place in the grease lubricant nodes instead of those observed in the bush structures.Included are the result of experimental tests of three...
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Independent and Interdependent? Agentic and Communal? Self-construals of People Fused with a Group
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New heterometallic Co/Zn, Ag/Co, and Ag/Zn imidazolates: structural characterization and catalytic activity in the oxidation of organic compounds
PublicationNanocrystalline powders of monometallic and bimetallic imidazolates of Co, Zn, and Ag were produced by a reaction carried out in water. The powders were characterized by powder X-ray diffraction and the crystal structures of new compounds Ag2ZnIm4 and Ag2CoIm4 (Im = imidazolate) were solved. Heterometallic Co/Zn imidazolates showed the standard ZIF-8 crystal structure while Ag/Zn and Ag/Co systems were isostructural with the copper...
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Rearrangement of azoxybenzocrowns into chromophoric hydroxyazobenzocrowns and the use of hydroxyazobenzocrowns for the synthesis of ionophoric biscrown compounds
PublicationThe Wallach rearrangement was used as a method for preparing p-hydroxyazobenzocrown ethers starting from different azoxybenzocrowns as substrates. Synthesis of a series of p-hydroxyazobenzocrowns under modified conditions and characterization of the obtained products are presented. o-Hydroxyazobenzocrowns were identified among the products of the photochemical rearrangement of azoxybenzocrowns. Novel biscrowns were synthesized...
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Novel Diazocrowns with Pyrrole Residue as Lead(II) Colorimetric Probes
PublicationNovel 18- and 23-membered diazomacrocycles were obtained with satisfactory yields by diazocoupling of aromatic diamines with pyrrole in reactions carried under high dilution conditions. X-ray structure of macrocycle bearing five carbon atoms linkage was determined and described. Compounds were characterized as chromogenic heavy metal ions receptors. Selective color and spectral response for lead(II) was found in acetonitrile and...
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Azo macrocyclic compounds.
PublicationArtykuł przeglądowy omawiający głównie syntezę i właściwości związków makrocyklicznych takich jak: etery koronowe, kryptandy, kaliksareny i inne, które połączono z fragmentem zawierającym resztę azobenzenową lub jej analogi. Artykuł napisany został w oparciu o prace własne autorów z lat 1992-2001 oraz na podstawie literatury obcej zebranej na podstawie Chemical Abstracts z lat 1990-2001.
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Large dynamic range high frequency fully differential CMOS transconductanceamplifier.
PublicationW pracy zaproponowano nową koncepcję układową w pełni różnicowego wzmacniacza transkonduktancyjnego CMOS o dużym zakresie dynamiki i szerokim pasmie częstotliwości. Przeprowadzone badania teoretyczne i symulacyjne potwierdziły małe zniekształcenia harmoniczne (THD), szerokie pasmo przenoszonych częstotliwości oraz duży zakres dynamiki dla sygnałów różnicowych.
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Study Analysis of Transmission Efficiency in DAB+ Broadcasting System
PublicationDAB+ is a very innovative and universal multimedia broadcasting system. Thanks to its updated multimedia technologies and metadata options, digital radio keeps pace with changing consumer expectations and the impact of media convergence. Broadcasting analog and digital radio services does vary, concerning devices on both transmitting and receiving side, as well as content processing mechanisms. However, the biggest difference is...
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Multi-Channel Virtual Instrument for Measuring Temperature—A Case Study
PublicationThe article presents the hardware and software configuration of the developed multi-channel temperature measurement system as well as calibration procedures and measurement results verifying the properties of measurement channels. The system has been developed and dedicated primarily for measuring the temperature distribution in a laboratory model simulating underground power lines. With the adopted configuration of the analog...
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Pochodne fosforylowanych cukrów jako inhibitory syntazy glcn-6-p
PublicationW artykule został opisany mechanizm działania syntazy glukozamino-6-fosforanu i syntezy wybranych analogów blokujących domenę wiążących D-fruktozo-6-fosforanu, którym jest cis-enolamina.
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Synthesis and antitumor activity of conjugates of muramyldipeptide or normuramyldipeptide with hydroxyacridine/acridone derivatives
PublicationOpisano syntezę analogów MDP oraz nor-MDP modyfikowanych w części peptydowej pochodnymi hydroksyakrydyny/akrydonu i dwóch analogów modyfikowanych pochodnymi 1-nitro-9-hydroksyetylo(propylo)aminoakrydyny. Tylko związki zawierające pochodne 1-nitro-9-hydroksyetylo(propylo)aminoakrydyny wykazały wysoką aktywność cytotoksyczną badaną na 60 liniach ludzkich komórek nowotworowych, na nowotwór prostaty i AIDS-related lymphoma (ARL). Związek...
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Software Tools to Measure the Duplication of Information
PublicationData stored in average computer system usually is not unique, portions of stored data are duplicated. When duplicated data are stored in separate files containing source code of computer program of student homework, a possibility of cheating should be seriously considered. This paper presents software tools built, in order to detect re-use of pieces of code in supplied text files. Three aspects of information atching are considered:...
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Dedicated power supply subsystem for ultra-low noise preamplifiers
PublicationIn field of electronics there is need for low-noise amplifiers. Noise have the most important influence on analog circuits. Therefore exist necessity to develop new ultra-low noise power supplies, which can cooperate with specified amplifiers and preamplifiers. It is very common that professional power supplies are very expensive and still have disadvantages. This paper proposes simple and inexpensive solution, which fulfill specific...
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Projektowanie, synteza i właściwości tetracyklicznych analogów antrachinonui akrydyny w aspekcie zjawiska oporności wielolekowej komórek nowotworo- wych.**2003, 139 s. 23 rys. 26 tab. bibliogr. 137 poz. maszyn. Rozprawa doktorska /23.04.2003/ Wydz. Chem. PG Promotor: prof. dr inż. E. Borowski.
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ortho-Fluorobenzanilides and ortho-fluorothiobenzanilides: Molecular conformations and crystal packing
PublicationSeries of 2-fluoro and 2,6-difluorobenzanilides and their thiobenzanilide analogs have been synthesized to investigate the influence of the fluorine atom on their crystal structures and self-assembly in the crystal lattice. The X-ray analysis of the single crystal revealed that the synthesized molecules adopt a geometry being deflected from planarity. The deflection was investigated by analysis of dihedral angles between mean planes...
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Measurement method for capacitive sensors for microcontrollers based on a phase shifter
PublicationA complete measurement method dedicated to capacitive sensors has been developed. It includes the development of hardware (an analogue interface circuit for microcontrollers with built-in times/counters and analogue comparators) and software (a measurement procedure and a systematic error calibration (correction) algorithm which is based on a calibration dictionary). The interface circuit consists of a low-pass filter and a phase...
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The effect of impacted third molars on second molar external root resorption, a cross-sectional cone beam computed tomography study
PublicationBackground: Third molars have the highest prevalence of impaction in teeth and can cause pathological damage on the adjacent second molars. This study aims to evaluate the effects of factors related to impacted third molars on external root resorption (ERR) in adjacent second molars using cone-beam computed tomography (CBCT). Material and Methods: In CBCTs, the effect of impacted third molars on the root surface of adjacent second...
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Diagnostyka analogowych filtrów wielosekcyjnych oparta na magistrali testującej IEEE1149.1
PublicationPrzedstawiono nową koncepcję testera JTAG BIST do samo-testowania torów analogowych opartych na wielosekcyjnych filtrach wyższego rzędu w mieszanych sygnałowo mikrosystemach elektronicznych sterowanych mikrokontrolerami i wyposażonych w magistralę testującą IEEE1149.1 (JTAG). Bazuje ona na metodzie diagnostycznej opartej na przekształce-niu transformującym próbki odpowiedzi czasowych kolejnych sekcji filtra pobudzonego impulsem...
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Room temperature depinning of the charge-density waves in quasi-two-dimensional 1T-TaS2 devices
PublicationWe report on the depinning of nearly commensurate charge-density waves in 1T-TaS2 thin films at room temperature. A combination of the differential current–voltage measurements with the low-frequency noise spectroscopy provides unambiguous means for detecting the depinning threshold field in quasi-2D materials. The depinning process in 1T-TaS2 is not accompanied by an observable abrupt increase in electric current—in striking contrast...
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Multichannel Human Body Communication
PublicationHuman Body Communication is an attractive alternative for traditional wireless communication (Bluetooth, ZigBee) in case of Body Sensor Networks. Low power, high data rates and data security makes it ideal solution for medical applications. In this paper, signal attenuation for different frequencies, using FR4 electrodes, has been investigated. Performance of single and multichannel transmission with frequency modulation of analog...
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Development of beltless respiration and heartbeat sensor based on flexible piezoelectric film
PublicationThe main goal of this work is to report initial development on a respiration and heartbeat measurement sensor that can be used in continuous monitoring conditions at a minimal impact on the patient. General description of the sensor, consisting of a PVDF film and the bonding layer, is given. Open-circuit voltage generated by the sensor is estimated by analytical and numerical calculations. Analog and digital interface used to extract...
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Wybrane uwagi o analizie dynamicznej ciała sztywnego i powłok sprężystych. Problemy dynamiki konstrukcji. Zbiór prac XI Międzynarodowego Sympozjum Dynamiki Konstrukcji.
PublicationPraca podejmuje tematykę ruchu kulistego bryły sztywnej i metod jej wyznaczania. Zastosowane procedury numeryczne testowane dla przypadku bryły sztywnej są stosowane do analizy dynamicznej powłok sprężystych na podstawie analogii równań dynamiki.
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A measurement method for capacitive sensors based on a versatile direct sensor-to-microcontroller interface circuit
PublicationIn the paper, there is presented a new time-domain measurement method for determining the capacitance values of capacitive sensors, dedicated, among others, to capacitive relative humidity sensors. The method is based on a versatile direct sensor-to-microcontroller interface for microcontrollers with internal analog comparators (ACs) and with precision voltage reference sources, e.g. digital-to-analog converters (DACs). The reference...
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Mechanochemically synthesized Mn3O4@β-cyclodextrin mediates efficient electron transfer process for peroxymonosulfate activation
PublicationThe rational surface engineering of heterogeneous catalysts is of great significance in advanced oxidation processes (AOPs) for eliminating refractory contaminants but remains challenging. In this study, β-cyclodextrin modified Mn3O4 (Mn3O4@β-CD) was prepared through a mechanochemical approach for peroxymonosulfate (PMS) activation, which achieved efficient bisphenol A (BPA) removal via electron transfer process (ETP). The reactive...
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ABC transporters Cdr1p, Cdr2p and Cdr3p of a human pathogen Candida albicans are general phospholipid translocators
PublicationFluoryzujące analogi fosfolipidów NBD-PE, NBD-PC i NBD-PS zostały wykorzystane w celu wykazania, że białko Cdr1p i jego inne homologi, Cdr2p i Cdr3p, należące do grupy białek zawierających tzw. kasetę wiążącą ATP (ABC), zachowują się jak ogólne przenośniki lipidów. Wyniki badań pokazują, że transportery typu ABC występujące w C. albicans są przenośnikami fosfolipidów i aktywność ta może być jedna z fizjologicznych funkcji białek.
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Comparison of the coordination geometries of Zn(II) and Cd(II) ions in complexes with water, methanol and bulky aryloxysilanethiolate ligands
PublicationZinc and cadmium complexes containing silanethiolate anions and methanol or water were synthesized and characterized by X-ray diffraction, FT-IR and NMR spectroscopy, and DFT calculations. Contrary to zinc, the cadmium ion utilizes very weak donors to complete its coordination sphere; it forms contacts to phenyl rings of the silanethiolate ligand. Two zinc analogs of the general formula [Zn{SSi(OAr)3}2(L)2] where L = CH3OH (2)...
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Samotestowanie toru analogowego ze wzmacniaczem w pełni różnicowym w elektronicznych systemach wbudowanych sterowanych mikrokontrole-rami
PublicationPrzedstawiono nową metodę samotestowania toru analogowego opartego na wzmacniaczu w pełni różnicowym w elektronicznych systemach wbu-dowanych sterowanych mikrokontrolerami. Bazuje ona na nowej metodzie diagnostycznej opartej na przekształceniu transformującym próbki odpo-wiedzi czasowej badanej części analogowej na pobudzenie "ujemnym" impulsem prostokątnym na wejściu Vocm na krzywe identyfikacyjne w przestrzeni pomiarowej. Metoda...
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Eksperymentalna analiza współczynników oporów lokalnych dla wybranych kształtek i złączek w systemach rur wielowarstwowych
PublicationArtykuł poświęcony jest analizie wartości współczynników oporów lokalnych dla wybranych kształtek i złączek pracujących w instalacjach z rur wielowarstwowych z tworzyw sztucznych. Badaniom poddano elementy o średnicach DN16, DN20, DN25, powszechnie wykorzystywane we współczesnych instalacjach sanitarnych. W pracy przedstawiono wybrane wyniki badań laboratoryjnych (dla rozszerzeń, kolanek i trójników) oraz ich porównanie z wartościami...
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Numerical solution analysis of fractional point kinetics and heat exchange in nuclear reactor
PublicationThe paper presents the neutron point kinetics and heat exchange models for the nuclear reactor. The models consist of a nonlinear system of fractional ordinary differential and algebraic equations. Two numerical algorithms are used to solve them. The first algorithm is application of discrete Grünwald-Letnikov definition of the fractional derivative in the model. The second involves building an analog scheme in the FOMCON Toolbox...
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A solution of the integrated µBIST for functional and diagnostic testing in mixed-signal electronic embedded systems
PublicationMain problem of the paper is testing of analog circuits and blocks in mixed-signal electronic embedded systems (EESs), using the built-in self-test (BIST) technique. The integrated mBIST based on reusing signal blocks already present in an EES, such as processors, memories, ADCs, is presented. The novelty of the solution is the extended functionality of the mBIST. It can perform 2 testing functions: functional testing and fault...
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Hot spot identification by ligand-protein surface interactions mapping – in silico study
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Simple and novel synthesis of 3-(thio)phosphoryl-β-lactams by radical cyclization
PublicationRadical cyclization of phosphono-acetenamides promoted by manganese(III) acetate leads exclusively to the formation of 3-phosphoryl-β-lactams. The thiophosphoryl analogues were also prepared using this method. In particular, the presented protocol does not require the use of noble metals, while comparable methods do.
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The exposure to UV filters: Prevalence, effects, possible molecular mechanisms of action and interactions within mixtures
PublicationSubstances that can absorb sunlight and harmful UV radiation such as organic UV filters are widely used in cosmetics and other personal care products. Since humans use a wide variety of chemicals for multiple purposes it is common for UV filters to co-occur with other substances either in human originating specimens or in the environment. There is increasing interest in understanding such co-occurrence in form of potential synergy, antagonist,...
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Reaction of thio and seleno phosphoric acid derivatives with O-thioacylated hydroxylamine
PublicationZbadano reakcję siarkowych i selenowych analogów kwasu O,O-neopentylidenofosforowego z O-tiopiwaloilo-N-tert-butylohydroksyloaminą, w której to następuje rozszczepienie wiązania N-O. Znaleziono korelację pomiędzy potencjałem utleniającym anionu pochodnej kwasu fosforowego a przebiegiem badanej reakcji.
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The biological activity of new tuftsin derivatives - induction of phagocytosis
PublicationFagocytoza odgrywa ważną rolę w ochronie organizmu przed różnymi mikroorganizmami. Proces ten może być indukowany przez różne czynniki np. endogenny immunomodulator jakim jest tuftsyna czy muramylo-dipeptyd (MDP), najmniejszy syntetyczny glikopeptyd bakteryjnej ściany komórkowej. Zsyntetyzowano nowe analogi MDP i nor-MDP z tuftsyną i retro-tuftsyną, które są zdolne do indukowania fagocytozy. Najbardziej obiecujące okazały się dwa...
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Poly(3,4-ethynenedioxythiophene)-Prussian Blue hybrid material evidence of direct chemical interaction betwenn PB andpEDOT
PublicationPrzedstawiono syntezę materiału złożonego z poli(3,4-etylenodioksytiofenu) oraz analogu błękitu pruskiego. Sieć struktury BP utworzona została wewnątrz matrycy polimerowej pEDOT-u za pomocą metody polaryzacji multicyklicznej. Chemiczne oddziaływania Fe z BP oraz siarki z pEDOT zostały potwierdzone metodą XPS. Obecność BP potwierdzono FTiR - stwierdzono obecność drgań rozciągających Fe-C oraz Fe-N. Metoda cyklowoltamperometryczna...
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Numerical solution of fractional neutron point kinetics in nuclear reactor
PublicationThis paper presents results concerning solutions of the fractional neutron point kinetics model for a nuclear reactor. Proposed model consists of a bilinear system of fractional and ordinary differential equations. Three methods to solve the model are presented and compared. The first one entails application of discrete Grünwald-Letnikov definition of the fractional derivative in the model. Second involves building an analog scheme...