Filters
total: 1996
-
Catalog
- Publications 1482 available results
- Journals 174 available results
- Publishing Houses 1 available results
- People 43 available results
- Inventions 2 available results
- Projects 9 available results
- Research Teams 3 available results
- e-Learning Courses 92 available results
- Events 18 available results
- Open Research Data 172 available results
displaying 1000 best results Help
Search results for: DRUG ABUSE
-
Mission impossible for cellular internalization: When porphyrin alliance with UiO-66-NH2 MOF gives the cell lines a ride
PublicationIs it possible to accelerate cell internalization by hybridization of nanomaterials? Herein we support the realization of using metal-organic frameworks (MOFs) with the assistance of rigid porphyrin structure (H2TMP) aimed at drug loading, drug release, relative cell viability, and targeted in vitro drug delivery. There are several MOFs, i.e., UiO-66-NH2 (125 ± 12.5 nm), UiO-66-NH2 @H2TMP (160 ± 14 nm), UiO-66-NH2 @H2TMP@DOX, and...
-
Przewidywane kierunki rozwoju technologii utrzymania dróg szynowych z uwzględnieniem linii dużych prędkości. Materiały Ogólnopolskiej Konferencji Naukowo-Technicznej Nowoczesne Technologie i Systemy Usprawniające Zarządzanie w Transporcie Kolejowym.
PublicationOgraniczenie nakładów na utrzymanie przy jednoczesnym zapewnieniu wysokiej jakości drogi kolejowej wymaga minimalizowania ilości podbić realizowanych w ramach napraw interwencyjnych oraz doboru, odpowiednich do warunków Polskich Linii Kolejowych, maszyn torowych
-
Badania emisji lotnych związków organicznych podczas nalewu asfaltu do autocystern oraz budowy dróg asfaltowych = Emission of volatile organic compounds from road bitumen during tank filling and road paving
PublicationOstatnio ma miejsce dyskusja poświęcona emisji lotnych związków organicznych towarzyszącej "niehermetycznemu" nalewowi asfaltów oraz budowie dróg asfaltowych. Asfalt naftowy wytwarzany jest poprzezutlenianie pozostałości z destylacji próżniowej. Zarówno na etapie destylacji próżniowej ropy naftowej, jak również w reaktorach utleniania asfaltu może dochodzić do przegrzewania wsadu na elementach grzejnych instalacji, a w wyniku zachodzi...
-
Damian Rosiak dr inż.
PeopleEducation 2010–2014: Gdansk University of Technology, Chemical Faculty (Eng.) field of study: biotechnology specialty: drug biotechnology 2014–2015: Gdansk University of Technology, Chemical Faculty (M.Sc.) field of study: biotechnology specialty: drug biotechnology 2015–2020: Gdansk University of Technology, Department of Inorganic Chemistry (Ph.D.) discipline: chemical sciences specialty: inorganic chemistry Scientific...
-
Anticancer properties of ester derivatives of betulin in human metastatic melanoma cells (Me-45)
Publication -
Voltammetric and biological studies of folate-targeted non-lamellar lipid mesophases
PublicationFolate-targeted lipid nanostructures are promising strategies for the development of biocompatible drug delivery systems. The objective of this study was to evaluate the efficacy of drug delivery to cancer cells by folate-targeted lipid mesophases, cubosomes (CUB) and hexosomes (HEX), loaded with doxorubicin (DOX). Three cancer-derived cell lines (KB, HeLa, T98G) exhibiting different expressional levels of folate receptor protein...
-
Imidazoacridinone antitumor agent C-1311 as a selective mechanism- based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes.
Publication5-Diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311), a promising antitumor agent that is also active against autoimmune diseases, was determined to be a selective inhibitor of the cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1311 might modulate the effectiveness of other drugs used in multidrug therapy. The present work aimed to identify the mechanism of the observed C-1311-mediated inactivation of CYP1A2...
-
Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: characteristics of non-enzymatic and glutathione S-transferase-mediated reactions
PublicationUnsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. A significant route of phase II drug metabolism is conjugation with glutathione (GSH), which can be non-enzymatic and/or catalyzed by GSH-dependent enzymes. The aim of this work was to investigate the GSH-mediated metabolic pathway of a representative UA, C 2028. GSH supplemented incubations of C-2028 with rat, but not with human, liver...
-
Antibiotic-Based Conjugates Containing Antimicrobial HLopt2 Peptide: Design, Synthesis, Antimicrobial and Cytotoxic Activities
PublicationRecent studies have shown that modified human lactoferrin 20−31 fragment, named HLopt2, possesses antibacterial and antifungal activity. Thus, we decided to synthesize and evaluate the biological activity of a series of conjugates based on this peptide and one of the antimicrobials with proven antibacterial (ciprofloxacin, CIP, and levofloxacin, LVX) or antifungal (fluconazole, FLC) activity. The drugs were covalently connected...
-
Topical delivery of pharmaceutical and cosmetic macromolecules using microemulsion systems
PublicationMicroemulsions are transparent, thermodynamically stable colloidal systems. Over the recent years, they have been increasingly investigated due to their potential as skin delivery vehicles for a wide range of drug molecules. The nanoscale particle size and the specificity of microemulsion components are the main features determining the skin permeation process. However, in order to effectively cross the skin barrier, the active...
-
Efekty egoistycznych ataków na poziomie mac w sieciach ad hoc o topologii wieloskokowej
PublicationStacje sieci ad hoc mogą manipulować parametrami dostępu do medium transmisyjnego dla osiągnięcia nienależnie wysokiej jakości usług. Dla środowiska sieci ad hoc o topologii wieloskokowej rozważane są ataki na mechanizmy odłożenia transmisji i klasyfikacji ruchu, przeprowadzane zarówno w stosunku do przepływów źródłowych jak i tranzytowych. Wyniki pozwalają wstępnie ocenić efekty takich ataków oraz skuteczność mechanizmów obronnych.
-
Fabrication methods of smart composite coatings - review
PublicationPostoperative bacterial infections are one of the main reasons for unsuccessful implantation of long-term implants. The development of bacterial infection requires antibiotic therapy, in extreme cases a reimplantation procedure is necessary. In order to provide materials for implants with antibacterial properties, they are subjected to modifications to create a coating that will release the drug substance, when the inflammation...
-
Ramp and chain-lift-launched lifeboats - radical concepts for evacuating cruise ships
PublicationW artykule przedstawiono dwie oryginalne koncepcje systemów ewakuacyjnych statków pasażerskich. Pierwsza z nich polega na zastosowaniu otwieranej rampy i pochylni z rolkami, na których umieszczone są w rzędzie łodzie ratunkowe, zaczepione do elementów wyciągu łańcuchowego. Druga koncepcja polega na umieszczeniu łodzi, jedna nad drugą, na wyciągu łańcuchowym. W obu systemach w trakcie ewakuacji łodzie opuszczane są grawitacyjnie...
-
Chiral analysis of chloro intermediates of methylamphetamine by one-dimensional and multidementional NMR and GC/MS
PublicationImpurity profiling and classification of abused drugs using chiral analytical techniques is of particular interest and importance because of the additional information obtained fromthis approach. When these methods are applied to the synthesis of illicitly used substances, they can supply valuable information about the conditions/chemicals used in the synthesis. We have applied GC and NMR methods to the study of intermediates found...
-
Pemphigoid - Female, 86 - Tissue image [6160730013048041]
Open Research DataThis is the histopathological image of SKIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
-
First report on echinocandin resistant Polish Candida isolates
PublicationPurpose: Candida spp. are ranked as one of the four major causative agents of fungal infections. The number of infections caused by Candida species resistant to fluconazole, which is applied as the first line drug in candidiasis treatment, increases every year. In such cases the application of echinocandin is necessary. Echinocandin susceptibility testing has become a routine laboratory practice in many countries due to the increasing...
-
Improvement of opipramol base solubility by complexation with β-cyclodextrin
PublicationOpipramol (OPI), a tricyclic antidepressant and anxiolytic compound, is administered orally in the form of a dihydrochloride. Salt form of the drug has a higher solubility in water and hence bioavailability and stability. A similar effect can be achieved by closing the hydrophobic part of the drug molecule in the cyclodextrin cavity. The paper presents opipramol inclusion complexes with beta-cyclodextrin (β-CD) in 1:1 molar ratio....
-
Polymer biodegradable coatings as active substance release systems for urological applications
PublicationCatheter-associated urinary tract infections are the result of catheterization of the bladder. The risk of infection is directly proportional to the length of the bladder catheterization. Bacteria cells have the ability to adhere and create the biofilm on the surface of catheter materials. Bacteria’s biofilm is an extremely beneficial environment of existence for microorganisms. Microorganisms that are an integral part of the biofilm...
-
Method of estimating the rolling resistance coefficient of vehicle tyre using the roller dynamometer
PublicationThe tendency in the past few years has been to introduce tyres with lower rolling resistance coefficients to the market. This paper presents a mathematical method for determining the rolling resistance coefficients variation depending on the speed. The method uses power balance which results from automobile dynamics while rolling on chassis dynamometer. The rolling resistance coefficients of tyres obtained through ‘drum test method’,...
-
Synthesis of green benzamide-decorated UiO-66-NH2 for biomedical applications
PublicationMetal-organic frameworks (MOFs) biocompatible systems can host enzymes/bacteria/viruses. Herein we synthesized a series of fatty acid amide hydrolase (FAAH)-decorated UiO-66-NH2 based on Citrus tangerine leaf extract for drug delivery and biosensor applications. Five chemically manipulated FAAH-like benzamides were localized on the UiO-66-NH2 surface with physical interactions. Comprehensive cellular and molecular analyses were...
-
Aleksandra Romanowska dr inż.
PeopleEmployee in the Highway and Transportation Engineering Department at the Faculty of Civil and Environmental Engineering, Gdansk University of Technology, Poland. Her research interests include: modelling of road traffic, road safety, trip generation, transport behaviour and preferences of academic societies, planning sustainable urban mobility. In 2019 she was granted a PhD degree, under the supervision of Prof. Kazimierz Jamroz...
-
Budownictwo Ogólne III
e-Learning Courses -
Budownictwo Przemysłowe II st. mgr ns. Ra 2021/2022 sem. letni
e-Learning Courses -
Budownictwo Ogólne III
e-Learning Courses -
Budownictwo Przemysłowe II
e-Learning Courses -
Budownictwo Przemysłowe II kurs II stopnia studia niestacjonarne
e-Learning Courses -
Budownictwo Przemysłowe I stropień I studia niestacjonarne
e-Learning Courses -
Budownictwo Przemysłowe II projektowanie
e-Learning CoursesProjektowanie z BP II jest częścią przedmiotu BP II wykładanego na II semestrze studiów magisterskich specjalności BO. Na zajęciach zajmujemy się sposobem konstruowania i obliczeniami elementów konstrukcji budowlanych występujących w budownictwie przemysłowym (i nie tylko). Zagadnienia na które kładziemy nacisk to specyficzne obciążenia np. dynamiczne i specyficzne rozwiązania konstrukcyjne np. zespolenie występujące w budownictwie...
-
Budownictwo Przemysłowe I projektowanie sem. VI ns.
e-Learning Courses -
Fluconazole resistant Candida auris clinical isolates have increased levels of cell wall chitin and increased susceptibility to a glucosamine-6-phosphate synthase inhibitor
PublicationIn 2009 Candida auris was first isolated as fungal pathogen of human disease from ear canal of a patient in Japan. In less than a decade, this pathogen has rapidly spread around the world and has now become a major health challenge that is of particular concern because many strains are resistant to multiple class of antifungal drugs. The lack of available antifungals and rapid increase of this fungal pathogen provides an incentive...
-
Modulation of UDP-glucuronidation by acridinone antitumor agents C-1305 and C-1311 in HepG2 and HT29 cell lines, despite slight impact in noncellular systems.
PublicationBackground Among the studied antitumor acridinone derivatives developed in our laboratory, 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) and 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) exhibited cytotoxic and antitumor properties against several cancer types and were selected to be evaluated in preclinical and early-phase clinical trials. In the present work, we investigated the impact of C-1305...
-
Bohdan Dołżycki dr inż.
People -
Selected symmetrically substituted carbazoles: Investigation of anticancer activity and mechanisms of action at the cellular and molecular levels
PublicationDNA topoisomerases play a critical role as essential enzymes in controlling alterations in the topology of DNA. They achieve this by orchestrating the coordinated process of breaking and rejoining DNA strands, which is crucial for maintaining the proper structure of DNA during regular cellular development. The search for and development of new potential anticancer drugs is a challenging yet immensely important area of research...
-
Wpływ parametrów wpustów deszczowych na sprawność odwodnienia powierzchnio- wego dróg i ulic.**2004, 208 s. 133 il. 150 tab. bibliogr. 84 poz.Rozprawa doktorska (28.05.2004)Promotor: dr hab. inż. Z. Suligowski.
Publication..
-
Joanna Żukowska dr hab. inż.
PeopleJoanna Żukowska (born 15.12.1974 in Kwidzyn) – road engineering and transport safety expert. She is a researcher in the field of transport, including traffic safety. Her main fields of research are: traffic risk modelling, safety trend forecasts, programming and implementation of traffic safety management systems. She is an author and co-author of many publications on transport safety, provided expertise for the Polish Infrastructure...
-
Utilizing Genome-Wide mRNA Profiling to Identify the Cytotoxic Chemotherapeutic Mechanism of Triazoloacridone C-1305 as Direct Microtubule Stabilization
PublicationRational drug design and in vitro pharmacology profiling constitute the gold standard in drug development pipelines. Problems arise, however, because this process is often dicult due to limited information regarding the complete identification of a molecule’s biological activities. The increasing aordability of genome-wide next-generation technologies now provides an excellent opportunity to understand a compound’s diverse eects...
-
Influence of the electrosynthesis conditions on the spontaneous release of anti-inflammatory salicylate during degradation of polypyrrole coated iron for biodegradable cardiovascular stent
PublicationIn this work, the spontaneous release of anti-inflammatory salicylate from polypyrrole (PPy) coated iron has been studied during degradation of the material in phosphate buffer saline at 37 C. The sodium salicylate was incorporated into PPy in a one-step electropolymerization process. The influence of the synthesis conditions such as sodium salicylate concentration, pyrrole concentration and deposition charge on drug release profile...
-
Antibacterial Porous Systems Based on Polylactide Loaded with Amikacin
PublicationThree porous matrices based on poly(lactic acid) are proposed herein for the controlled release of amikacin. The materials were fabricated by the method of spraying a surface liquid. Description is given as to the possibility of employing a modifier, such as a silica nanocarrier, for prolonging the release of amikacin, in addition to using chitosan to improve the properties of the materials, e.g., stability and sorption capacity....
-
Potential of mucoadhesive chitosan glutamate microparticles as microbicide carriers – antiherpes activity and penetration behavior across the human vaginal epithelium
Publication -
The Effect of PEG Concentration on the Release Rate of Cisplatin from PEG-Modified Silica Xerogels
Publication -
Silica-Polyethylene Glycol Matrix Synthesis by Sol-Gel Method and Evaluation for Diclofenac Diethyloammonium Release
Publication -
Electrochemical generation of microbubbles by carbon nanotube interdigital electrodes to increase the permeability and material uptakes of cancer cells
Publication -
Joanna Wolszczak-Derlacz dr hab.
PeopleI am an Associate Professor at Gdańsk University of Technology, Faculty of Management and Economics. I gained my PhD in July 2006 for which I received the Polish Prime Ministry’s Award for the outstanding doctoral thesis. Between 2007 and 2008, I was a beneficiary of the Max Weber Fellowship at the European University Institute in Florence, Italy. I conducted part of my research at the Katholieke Universiteit Leuven, Belgium...
-
Cellulose Nanomaterials in Biomedical, Food, and Nutraceutical Applications: A Review
PublicationNanotechnology with bionanomaterials have tremendous potential to enhance and utilize for nutrient and bioactive absorption, drug delivery systems, pharmaceutical, and nutraceutical field through various applications. Cellulose nanomaterials are green materials that are obtained from renewable sources and possess exceptional mechanical strength and biocompatibility. The associated unique physical and chemical properties have made...
-
Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition
PublicationHeterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based...
-
Właściwości katalityczne i biomedyczne związków zawierających jony rutenu(II) oraz rutenu(III)
PublicationRuthenium complexes appear in scientific publications mainly as catalysts in the olefins metathesis process. In this review, we want to indicate the research niche regarding the use of ruthenium(II) and ruthenium(III) complexes in other catalytic processes, i.e. polymerization or epoxidation of olefins and depolymerization. We would like to combine the catalytic properties of ruthenium(II,III) complex compounds with their biomedical...
-
The mechanism of internalization study of QDgreen−CD−FA−C−2028 conjugate at IC80 value to cancer (H460, Du-145, and LNCaP) and normal (MRC-5 and PNT1A) cells
Open Research DataThe influence of different endocytosis inhibitors on the internalization of QDgreen−CD−FA−C−2028 conjugate at IC80 value in cancer (H460, Du-145, and LNCaP) and normal (MRC-5 and PNT1A) cells. First, the cells were preincubated with: drug-free medium (no inhibitor), at 4 °C, 5 µM Cytochalasin D, 30 µM Amiloride, 80 µM Dynasore, 25 µM Pitstop 2 and 1.5...
-
The transition of HIV within and between affected populations in Poland
PublicationThe aim of the paper is the estimation of probabilities that describe the transition of HIV within and between the following three populations: homosexual and bisexual men, injecting drug users and heterosexual persons in Poland in the years 1995-2006
-
- Telomeres as targets for anticancer drug development - a computational approach
ProjectsProject realized in Faculty of Chemistry according to Homing Plus/2011-4/3 agreement from 2012-03-29
-
The new esters derivatives of betulin and betulinic acid in epidermoid squamous carcinoma treatment – In vitro studies
Publication