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Search results for: ANTISTAPHYLOCOCCAL AGENTS
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Agent System for Managing Distributed Mobile Interactive Documents in Knowledge-Based Organizations
PublicationThe MIND architecture of distributed mobile interactive document is a new processing model defined to facilitate obtaining a proper solution in knowledge processes carried out by knowledge-based organizations. Such organizations have an established structure that defines document templates and knowledge process. The aim of the MIND architecture is to change the static document to mobile agents, which are designed to implement the...
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Characterization of a Unique Bordetella bronchiseptica vB_BbrP_BB8 Bacteriophage and Its Application as an Antibacterial Agent
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Rola agentów edukacyjnych w środowiskach zdalnego nauczania
PublicationAgent edukacyjny jest inteligentnym i autonomicznym programem, który może być zastosowany w środowiskach kształcenia na odległość. W artykule podano definicję oraz klasyfikację agentów edukacyjnych ze szczególnym wskazaniem na agenty pedagogiczne, których celem jest wsparcie dla zdobywania kompetencji przez uczniów. Wskazano także miejsce agentów w kompleksowych środowiskach nauczania za pośrednictwem Internetu. W artykule omówiono...
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Pronouncement of embedded agency in the field of social entrepreneurship
PublicationThe paper provides insights into how social entrepreneurship and the institutional theory framework can be combined. The author situates the social entrepreneurship phenomenon here, and embarks on the traditional structure vs agency debate from social sciences, sociology of organizations in particular. The concept of embedded agency is referred to and employed to explain the phenomenon of social entrepreneurship. In this paper,...
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Magnetic instrumentation and other applications of magnets in NOTES
PublicationModern surgery is developing towards a minimally invasive approach. To minimize the trauma the number of ports is either limited as in single incision laparoscopic procedures or ports are introduced through natural orifices as in nat- ural orifice translumenal endoscopic surgery (NOTES). To provide surgeons with appropriate instrumentation novel technologies are employed involving magnets. This article summarizes the theoretical...
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Science and/or Miracle? The System Approach to Miracle Events
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Camera Orientation-Independent Parking Events Detection
PublicationThe paper describes the method for detecting precise position and time of vehicles parking in a parking lot. This task is trivial in case of favorable camera orientation but gets much more complex when an angle between the camera viewing axis and the ground is small. The method utilizes background subtraction and object tracking algorithms for detecting moving objects in a video stream. Objects are classified into vehicles and...
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Multimodal Audio-Visual Recognition of Traffic Events
PublicationPrzedstawiono demonstrator systemu wykrywania niebezpiecznych zdarzeń w ruchu drogowym oparty na jednoczesnej analizie danych wizyjnych i akustycznych. System jest częścią systemu automatycznego nadzoru bezpieczeństwa. Wykorzystuje on kamery i mikrofony jako źródła danych. Przedstawiono wykorzystane algorytmy - algorytmy rozpoznawania zdarzeń dźwiękowych oraz analizy obrazu. Zaprezentowano wyniki działania algorytmów na przykładzie...
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The impact of mega sports events on the stock markets
PublicationWpływ wielkoformatowych imprez sportowych na gospodarkę może być rozpatrywany na różnych płaszczyznach. Najczęściej przywołuje się zmiany w zakresie PKB kraju lub regionu goszczącego, zmiany na rynku pracy, rozbudowę bądź modernizację infrastruktury oraz tendencje w zakresie przepływu turystycznego. Kanały oddziaływania tak dużych wydarzeń są jednak dużo szersze i obejmują ponadto: życie publiczne, polityczne i kulturalne, informację,...
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Zastosowania ontologii: Charakterystyczne cechy agentów semantycznych
PublicationNa podstawie reprezentatywnych przykładów podjeto próbę zilustrowania spektrum zastosowań agentów programowych. Wskazano główne cechy wyrózniajace poszczególne rodzaje agentów oraz ich atrybuty niezbędne dla omawianych zastosowań.
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Effects of stents under asymmetric inflow conditions
PublicationW publikacji rozważano komputerowe modele stentów przy niesymetrycznych warunkach napływu i ich wpływ na naprężenia styczne na ściankach. Umożliwia to znajdowanie kształtów stentów, które są mniej wrażliwe na brak symetrii napływu. Zmiany kształtów arterii można wiązać ze zmianami charakterystyki przepływów takimi jak m.in. naprężenia styczne na ściankach, które zwiększają ryzyko restenozy. Posłużono się również pojęciem dyssypacji...
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Extreme waves and wave events in the Baltic Sea
PublicationW pracy przedstawiono wyniki pomiarów szeregów czasowych falowania uzyskanych z boi pomiarowych, umieszczonych w kilku miejscach linii brzegowej Morza Bałtyckiego. Rozważano wpływ czasu trwania sztormu i kierunku wiatru na powstawanie pojedynczych oraz grup fal ekstremalnych. Przeprowadzono statystyczną analizę takich fal, zwracając szczególną uwagę na rozkłady ich wysokości. Dla wybranych realizacji przeprowadzono analizę spektralną...
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Anita Richert-Kaźmierska dr inż.
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A new pH/organic modifier gradient RP HPLC method for convenient determination of lipophilicity and acidity of drugs as applied to established imidazoline agents
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Acridinone antitumor agents, C-1305 and C-1299 are metabolized rather by flavin-containing monooxygenases and UDP-glucuronosyltransferases than cytochromes P450
PublicationStwierdzono, że to monooksygenazy flawinowe, a nie enzymy cytochromu P450, są głównymi enzymami frakcji mikrosomalnej, odpowiedzialnymi za detoksyfikacyjny metabolizm dwóch badanych pochodnych triazoloakrydonu. Dodatkowo C-1305 ulega sprzęganiu w czasie drugiej fazy metabolizmu z kwasem glukuronowym do postaci O-glukuronidu
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Synthesis of 7-oxo-7h-naphto[1,2,3-de]quinoline derivatives as potential anticancer agents active on multidrug resistant cell lines
PublicationOpierając się na naszym wcześniejszym stwierdzeniu, że tetracykliczne analogi antrachinonów z wbudowanym pierścieniem pirydynowym wykazują aktywną cytotoksyczność względem komórek z indukowaną opornością, przeprowadzono syntezę pochodnych 7-oxo-7h-nafto[1,2,3-de]chinoliny (3, 6-8, 10-12, 14,15 i 18) posiadających jeden lub dwa zasadowe łańcuchy boczne i różne podstawniki w pierścieniu pirydynowym, związków o potencjalnym działaniu...
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Carbon Dioxide Adsorption over Activated Carbons Produced from Molasses Using H2SO4, H3PO4, HCl, NaOH, and KOH as Activating Agents
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Carbon Dioxide Adsorption Over Activated Carbons Produced from Molasses Using H2so4, H3po4, Hcl, Naoh, and Koh as Activating Agents
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Role of Human UDP-Glucuronosyltransferases in the Biotransformation of the Triazoloacridinone and Imidazoacridinone Antitumor Agents C-1305 and C-1311 : Highly Selective Substrates for UGT1A10
Publication5-Diethylaminoethylamino-8-hydroxyimidazoacridinone, C-1311 (NSC-645809), is an antitumor agent shown to be effective against breast cancer in phase II clinical trials. A similar compound, 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone, C-1305, shows high activity against experimental tumors and is expected to have even more beneficial pharmacological properties than C-1311. Previously published studies showed that these...
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Prophylaxis of Non-communicable Diseases: Why Fruits and Vegetables may be Better Chemopreventive Agents than Dietary Supplements Based on Isolated Phytochemicals?
PublicationThe World Health Organization (WHO) report from 2014 documented that non-communicable socalled civilization diseases such as cardiovascular disease, chronic respiratory diseases, cancer or type 2 diabetes are responsible for over 50% of all premature deaths in the world. Research carried out over the past 20 years has provided data suggesting that diet is an essential factor influencing the risk of development of these diseases....
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Distributed Evacuation in Graphs with Multiple Exits
PublicationWe consider the problem of efficient evacuation using multiple exits. We formulate this problem as a discrete problem on graphs where mobile agents located in distinct nodes of a given graph must quickly reach one of multiple possible exit nodes, while avoiding congestion and bottlenecks. Each node of the graph has the capacity of holding at most one agent at each time step. Thus, the agents must choose their movements strategy...
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Collision-Free Network Exploration
PublicationA set of mobile agents is placed at different nodes of a n-node network. The agents synchronously move along the network edges in a collision-free way, i.e., in no round may two agents occupy the same node. In each round, an agent may choose to stay at its currently occupied node or to move to one of its neighbors. An agent has no knowledge of the number and initial positions of other agents. We are looking for the shortest possible...
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Conversion of Biomass and Municipal Wastes into Syngas and Hydrogen using Highly Preheated Agent (HTAG)
PublicationGasification is considered to be one of the most promising energy recovery technologies for the widespread utilization of biomass and wastes. During this process raw feedstock is converted into a combustible gas, which can then be burnt to produce thermal energy, or to run engines for mechanical or electrical power. The studies of biomass gasification demonstrate it as a friendly alternative to fossil fuels as one of renewable...
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Softwood-lignin/natural rubber composites containing novel plasticizing agent: Preparation and characterization
PublicationComposite materials based on natural rubber were obtained by using glycerolysate (decomposition prod- uct of polyurethane) as a novel plasticizer. In order to determine the effect of various lignin content, four different filler amounts were used, namely, 5 phr (parts per 100 parts of natural rubber) of lignin (WLI5G), 10 phr (WLI10G), 20 phr (WLI20G), and 40 phr (WLI40G). The reference specimen without lignin (WLI0G) was also...
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Experimental Evaluation of the Agent-Based Population Learning Algorithm for the Cluster-Based Instance Selection
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Multi-agent large-scale parallel crowd simulation with NVRAM-based distributed cache
PublicationThis paper presents the architecture, main components and performance results for a parallel and modu-lar agent-based environment aimed at crowd simulation. The environment allows to simulate thousandsor more agents on maps of square kilometers or more, features a modular design and incorporates non-volatile RAM (NVRAM) with a fail-safe mode that can be activated to allow to continue computationsfrom a recently analyzed state in...
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Electrochemical formation of the adduct between antitumor agent C_1311 and DNA nucleoside dG. 75.
PublicationPrzyjmuje się, że metaboliczna aktywacja przeciwnowotworowej pochodnej C_1311 jest procesem koniecznym dla jej aktywności przeciwnowotworowej. Wykazano wcześniej, że taka aktywacja prowadzi do kowalencyjnego wiązania się leku z DNA w komórce nowotworowej. Aby zbadać molekularny mechanizm powyższej reakcji metabolicznej przeprowadzono badania elektrochemicznego utleniania pochodnej C_1311. Wykazano w pracy, że dwa produkty elektrochemicznego...
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Anisakid Nematodes of Greenland HalibutReinhardtius hippoglossoidesfrom the Barents Sea
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Potential impact of parents' lifestyle on the occurrence of leukemia in their children
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Observation and analysis of transient luminous events in the Earth's atmosphere
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A method for counting people attending large public events
PublicationThe algorithm for people counting in crowded scenes, based on the idea of virtual gate which uses optical flow method is presented. The concept and practical application of the developed algorithm under real conditions is depicted. The aim of the work is to estimate the number of people passing through entrances of a large sport hall. The most challenging problem was the unpredicted behavior of people while entering the building....
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Performance of CMS muon reconstruction in cosmic-ray events
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Conducting polymer films for biodegradable metallic cardiovascular stents
PublicationIn recent years, there is increasing interest to create biodegradable metallic cardiovascular stents instead of using their permanent form. The most interesting materials for this purpose are iron and its alloys. However, in order to use it in clinical application, their degradation rate and biological performance need to be optimized. One promising solution is coating the metal with conducting polymer films. In this work, short...
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A MEASUREMENT SYSTEM FOR MONITORING CARDIOVASCULAR EVENTS IN SYNCOPE PATIENTS
PublicationSyncope phenomena is an abrupt and transient loss of consciousness leading to interruption of awareness of one’s surroundings and falls with risk of injury. Syncope is often followed by complete and usually rapid spontaneous recovery. It is said that half of all individuals experience syncopal event at least once during their life. The condition can occur at any age and happens in people with and without other medical problems....
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Set of experience : a knowledge structure for formal decision events
PublicationOmówiono strukturę wiedzy w obszarze formalnych zadań decyzyjnych. Zaproponowano zbiór doświadczeń jako podstawę tej struktury.
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Nanoemulsion Structural Design in Co-Encapsulation of Hybrid Multifunctional Agents: Influence of the Smart PLGA Polymers on the Nanosystem-Enhanced Delivery and Electro-Photodynamic Treatment
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Cancer stem cells in drug resistance and drug screening: can we exploit the cancer stem cell paradigm in search for new antitumor agents?
PublicationPraca przedstawia przegląd literatury dotyczącej hipotezy komórek pierwotnych nowotworu, w szczególności w ich oporności na istniejące terapie. Dyskutowane jest także zagadnienie możliwości wykorzystania wiedzy o tych komórkach do konstrukcji nowych testów do badań przesiewowych in vitro w celu poszukiwania nowych leków przeciwnowotworowych.
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CYP3A4-dependent cellular response does not relate to CYP3A4-catalysed metabolites of C-1748 and C-1305 acridine antitumor agents in HepG2 cells
PublicationHigh CYP3A4 expression sensitizes tumor cells to certain antitumor agents while for others it can lower their therapeutic ef fi cacy. We have elucidated the in fl uence of CYP3A4 overexpression on the cellular response induced by antitumor acridine derivatives, C-1305 and C-1748, in two hepatocellular carcinoma (HepG2) cell lines, Hep3A4 stably transfected with CYP3A4 isoenzyme, and HepC34 expressing empty vector. The compounds...
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Essential Oils, Silver Nanoparticles and Propolis as Alternative Agents Against Fluconazole Resistant Candida albicans, Candida glabrata and Candida krusei Clinical Isolates
PublicationDevelopment of effective and safe therapeutic treatment of fungal infections remains one of the major challenge for modern medicine. The aim of presented investigation was to analyze the in vitro antifungal activity of selected essential oils, ethanolic extracts of propolis and silver nanoparticles dropped on TiO2 against azole-resistant C. albicans (n = 20), C. glabrata (n = 14) and C. krusei (n = 10) clinical isolates. Among...
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Elucidation of chemical compounds in different extracts of two Lavandula taxa and their biological potentials: Walking with versatile agents on the road from nature to functional applications
PublicationDue to their health-promoting and nutraceutical properties, lavenders are frequently employed in the food and pharmaceutical industries. Here, we focused on investigate the chemical profile of hexane, MeOH, and water extracts of leaf, flower, and root of L. pedunculata and L. stoechas and to assess their antioxidant, enzyme inhibitory, and antibacterial properties. The highest total polyphenolic and flavonoids contents were recorded...
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Trustworthiness and Subversion in Large Service- Oriented Multi-Agent Systems under Virtual Anonymity and Blind Provider Selection
PublicationTo promote honest service provision in multi-agent systems, a Computational Trustworthiness and Rating scheme collects service ratings and computes agents' trustworthiness levels (TLs). Studies of existing schemes fail to reflect closed-loop dynamics of TLs arising from the mutual influence of agents' behavior and TLs, and to capture relevant properties. Recent simulative and analytical models produce results tied to a particular...
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INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
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Photosensitive and pH-dependent activity of pyrazine-functionalized carbazole derivative as promising antifungal and imaging agent
PublicationCarbazole skeleton plays a significant role as a structural scaffold of many pharmacologically active compounds. Pyrazine-functionalized carbazole derivative was constructed by coupling 2-amino-5-bromo-3-methylaminepyrazine (ABMAP) into 3 and 6 positions of the carbazole ring. Multi-experimental methods were used, e.g., potentiometric, spectroscopic (ATR, UV, XRD powder,1H and13C NMR), electrochemical (cyclic voltammetry), and...
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Metabolism of antitumour agent 1-nitroacridine derivative, C-1748 in pancreatic cancer cell lines
PublicationPancreatic cancer has the highest mortality rate of all major cancers because of limited treatment options. Surgical removal of the tumour is possible only in its early stage, nevertheless the asymptomatic development very often makes unable an accurate diagnose. In the case of metastatic pancreatic cancer only chemotherapy, mainly with gemcitabine, can be offered to patients. However, common resistance towards gemcitabine imposes...
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Phenylalanine-Based AMPA Receptor Antagonist as the Anticonvulsant Agent with Neuroprotective Activity—In Vitro and In Vivo Studies
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Designing optimal operational-point trajectories using an intelligent sub-strategy agent-based approach
PublicationW rozdziale opisuje się metodę projektowania optymalnej i bezpiecznego sterowania nieliniowymi procesami dynamicznymi. Poszukiwane sterowanie jest wynikiem zastosowania elementarnej strategii poszczególnych agentów, realizujšcych zadanie minimalizacji wspólnej miary kosztu sterowania. Zagadnienie projektowania optymalnego sterowania traktowane jest jako proces decyzyjny, w którym decyzje podejmowane sš w kolejnych regionach przestrzeni...
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Designing optimal operational-point trajectories using an intelligent sub-strategy agent-based approach
PublicationW rozdziale opisuje się metodę projektowania optymalnej i bezpiecznego sterowania nieliniowymi procesami dynamicznymi. Poszukiwane sterowanie jest wynikiem zastosowania elementarnej strategii poszczególnych agentów, realizujących zadanie minimalizacji wspólnej miary kosztu sterowania. Zagadnienie projektowania optymalnego sterowania traktowane jest jako proces decyzyjny, w którym decyzje podejmowane są w kolejnych regionach przestrzeni...
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The studies of imidazoacridinone antitumor agent, C-1311, in the field of metabolic transformations with cytochrome P450 isoenzymes
PublicationPraca zawiera wyniki badań metabolicznej transformacji przeciwnowotworowej pochodnej imidazoakrydonu C-1311 wobec rekombinantowych ludzkich izoenzymów P450. Związek nie ulegał transformacji w badanych warunkach, natomiast wykazano, że ma zdolność hamowania aktywności izoezymów CYP1A2 i CYP3A4.
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Application of agent-based simulated annealing and tabu search procedures to solving the data reduction problem
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SELECTING A REPRESENTATIVE DATA SET OF THE REQUIRED SIZE USING THE AGENT-BASED POPULATION LEARNING ALGORITHM
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