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Search results for: KONTENERYZACJA, DOCKER, SWARM, KUBERNETES, GITLAB, CQRS, MESH
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Chromogenic azomacrocycles with imidazole residue: Structure vs. properties
PublicationNew diazo macrocycles linked by hydrocarbon chain bearing imidazole or 4-methylimidazole residue have been synthetized with satisfactory yield (24–55%). The structure of macrocycles was confirmed by X-ray analysis and spectroscopic methods (1H NMR, MS, FTIR). Metal cation complexation studies were carried out in acetonitrile and acetonitrile-water system. It was found that azomacrocyles form triple-decker complexes with lead(II)....
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Automatic Breath Analysis System Using Convolutional Neural Networks
PublicationDiseases related to the human respiratory system have always been a burden for the entire society. The situation has become particularly difficult now after the outbreak of the COVID-19 pandemic. Even now, however, it is common for people to consult their doctor too late, after the disease has developed. To protect patients from severe disease, it is recommended that any symptoms disturbing the respiratory system be detected as...
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Automatic Breath Analysis System Using Convolutional Neural Networks
PublicationDiseases related to the human respiratory system have always been a burden for the entire society. The situation has become particularly difficult now after the outbreak of the COVID-19 pandemic. Even now, however, it is not uncommon for people to consult their doctor too late, after the disease has developed. To protect patients from severe disease, it is recommended that any symptoms disturbing the respiratory system be detected...
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Orken Mamyrbayev Professor
People1. Education: Higher. In 2001, graduated from the Abay Almaty State University (now Abay Kazakh National Pedagogical University), in the specialty: Computer science and computerization manager. 2. Academic degree: Ph.D. in the specialty "6D070300-Information systems". The dissertation was defended in 2014 on the topic: "Kazakh soileulerin tanudyn kupmodaldy zhuyesin kuru". Under my supervision, 16 masters, 1 dissertation...
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Zobaczyć i zrozumieć
PublicationPrzedstawiono rolę eksperymentu jako niezbędnego instrumentu w nauczaniu chemii. Podkreślono wagę jego osobistego odbioru i wyrabiania sobie na tej podstawie zdolności i umiejętności postrzegania oraz wnioskowania. Całość odniesiono do problemu nauczania, także w początkowym etapie studiów chemicznych, oraz roli jaką w tym procesie powinien spełniać nauczyciel.
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Obraz mówi więcej niż tysiąc słów
PublicationZbór refleksji nad przewijającym się tematem obrazowania tego co ulotne, a co jednak da się zatrzymać na wiele różnych sposobów, utrwalić i zachować i często w ten sposób uratować od zniszczenia czy zapomnienia. Tekst cały czas nawiązuje tematycznie do roli chemii w procesie utrwalania zabytków kultury.
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Silanethiolates - synthesis, properties and structures.
PublicationW pracy wskazano podstawowe drogi syntezy oraz podano zwięzłą charakterystykę silanotiolanów - w większości związków kompleksowych posiadających jako główny ligand grupę silanotiolanową, na ogół (t-BuO)3SiS. Przy pomocy odpowiednio dobranych przykładów zilustrowano właściwości tych związków - wskazano ciekawsze elementy struktury molekularnej oraz specyficzne cechy spektralne.
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Biomechanical causes for failure of the Physiomesh/Securestrap system
PublicationThis study investigates the mechanical behavior of the Physiomesh/Securestrap system, a hernia repair system used for IPOM procedures associated with high failure rates. The study involved conducting mechanical experiments and numerical simulations to investigate the mechanical behavior of the Physiomesh/Securestrap system under pressure load. Uniaxial tension tests were conducted to determine the elasticity modulus of the Physiomesh...
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Measurement of distance, velocity and angle of arrival using FMCW-CW combined waveform
PublicationA procedure of tacking small flying object based on a general principle of FMCW and Doppler radar is presented. In order to increase measurement range, this technique uses active signal source on the moving object. For simultaneous measurements of distance, radial velocity and direction (AoA) as well as simplified synchronization a combined FMCW-CW waveform is proposed. The presented measurement system was realized and verified...
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Molecular modeling and evaluation of novel dibenzopyrrole derivatives as telomerase inhibitors and potential drug for cancer therapy
PublicationDuring previous years, many studies on synthesis, as well as on anti-tumor, anti-inflammatory and anti-bacterial activities of the pyrazole derivatives have been described. Certain pyrazole derivatives exhibit important pharmacological activities and have proved to be useful template in drug research. Considering importance of pyrazole template, in current work the series of novel inhibitors were designed by replacing central...
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Nonsense-Mediated mRNA Decay: Pathologies and the Potential for Novel Therapeutics
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Molecular basis of TRF proteins and their interactions with peptides
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Structural analysis and predicting effects of natural mutations on telomerase
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Molecular basis and quantitative assessment of TRF1 and TRF2 protein interactions with TIN2 and Apollo peptides
PublicationShelterin is a six-protein complex (TRF1, TRF2, POT1, RAP1, TIN2, and TPP1) that also functions in smaller subsets in regulation and protection of human telomeres. Two closely related proteins, TRF1 and TRF2, make high-affinity contact directly with double-stranded telomeric DNA and serve as a molecular platform. Protein TIN2 binds to TRF1 and TRF2 dimer-forming domains, whereas Apollo makes interaction only with TRF2. To elucidate...
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Structural and dynamic changes adopted by EmrE, multidrug transporter protein—Studies by molecular dynamics simulation
PublicationEmrE protein transports positively charged aromatic drugs (xenobiotics) in exchange for two protons and thus provides bacteria resistance to variety of drugs. In order to understand how this protein may recognize ligands, the monomer and asymmetric apo-form of the EmrE dimer embedded in a heterogeneous phospholipid (POPE + POPG) membrane were studied by molecular dynamics simulations. Dimer is regarded as a functional form of the...
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Identification of 1H‐indene‐(1, 3, 5, 6)‐tetrol derivatives as potent pancreatic lipase inhibitors using molecular docking and molecular dynamics approach
PublicationPancreatic lipase is a potential therapeutic target to treat diet-induced obesity in humans, as obesity-related diseases continue to be a global problem. Despite intensive research on finding potential inhibitors, very few compounds have been introduced to clinical studies. In this work, new chemical scaffold 1H-indene-(1,3,5,6)-tetrol was proposed using knowledge-based approach, and 36 inhibitors were derived by modifying its...
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Docking simulations, Molecular properties and ADMET studies of novel Chromane6,7diol analogues as potential inhibitors of Mushroom tyrosinase
PublicationResearch on inhibition of tyrosinase enzyme has attained significant value, because tyrosinase inhibitors have potential applications in medicine, cosmetics (as whitening agents) and in agriculture (as bioinsecticides). Determination and elucidation of new tyrosinase inhibitors are not only beneficial for medical purposes, but their promising applications in improving food quality and nutritional...
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Structural and dynamic insights on the EmrE protein with TPP+ and related substrates through molecular dynamics simulations
PublicationEmrE is a bacterial transporter protein that forms an anti-parallel homodimer with four transmembrane helices in each monomer. EmrE transports positively charged aromatic compounds, such as TPP+ and its derivatives. We performed molecular dynamics (MD) simulations of EmrE in complex with TPP+, MeTPP+, and MBTPP+ embedded in a membrane. The detailed molecular properties and interactions were analysed for all EmrE-ligand complexes....
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Molecular basis and potential activity of HIV-1 reverse transcriptase toward trimethylamine-based compounds
PublicationReverse transcriptase (RT) inhibitors are currently used to treat human immunodeficiency virus (HIV)-1 infections. In this work, novel triethylamine derivatives were designed and studied by rigid and flexible docking and molecular dynamics (MD) approaches. An apo form of HIV-1 RT was also studied by MD simulation to analyze comparative response of protein in ligand-bound and ligand-unbound forms. Among newly designed HIV-1 RT inhibitors,...
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The structurally similar TRFH domain of TRF1 and TRF2 dimers shows distinct behaviour towards TIN2
PublicationThe telomere repeat binding-factor 1 and 2 (TRF1 and TRF2) proteins of the shelterin complex bind to duplex telomeric DNA as homodimers, and the homodimerization is mediated by their TRFH (TRF-homology) domains. We performed molecular dynamic (MD) simulations of the dimer forms of TRF1TRFH and TRF2TRFH in the presence/absence of the TIN2TBM (TIN2, TRF-interacting nuclear protein 2, TBM, TRF-binding motif) peptide. The MD results...
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Extracting functional groups of ALLINI to design derivatives of FDA‐approved drugs: Inhibition of HIV‐1 integrase
PublicationHIV‐1 integrase (IN) is crucial for integration of viral DNA into the host genome and a promising target in development of antiretroviral inhibitors. In this work, six new compounds were designed by linking the structures of two different class of HIV‐1 IN inhibitors (active site binders and allosteric IN inhibitors (ALLINIs)). Among newly designed compounds, INRAT10b was found most potent HIV‐1 IN inhibitor considering different...
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Structural, functional, and stability change predictions in human telomerase upon specific point mutations,
PublicationOverexpression of telomerase is one of the hallmarks of human cancer. Telomerase is important for maintaining the integrity of the ends of chromosomes, which are called telomeres. A growing number of human disease syndromes are associated with organ failure caused by mutations in telomerase (hTERT or hTR). Mutations in telomerase lead to telomere shortening by decreasing the stability of the telomerase complex, reducing its accumulation,...
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O zbieżności rozwiązań w nieliniowym mikropolarnym ośrodku sprężysto-plastycznym - zastosowanie elementów skończonych wyższego rzędu.
PublicationEfekty lokalizacji w nieliniowym geometrycznie sprężysto-plastycznym mikropolarnym ośrodku z osłabieniem materiału. Hipotezy Hubera-Misesa-Hencky’ego i Druckera-Pragera. Rozwiązanie równań sprężysto-plastycznych przy użyciu algorytmu powrotnego. Opis zastosowanych elementów skończonych. Przykłady numeryczne obliczeń w geotechnice.
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Architektura bezpieczeństwa systemu netBaltic
PublicationW artykule zaprezentowano założenia dotyczące zabezpieczania węzłów sieci realizowanej w ramach systemu netBaltic. Ze względu na dużą różnorodność rozważanych mechanizmów komunikacyjnych architektura bezpieczeństwa została podzielona na kilka elementów – infrastrukturę klucza publicznego (PKI), bezpieczeństwo systemowe węzłów, zabezpieczanie komunikacji w modelu samoorganizującej wieloskokowej sieci kratowej, a także sieci niewrażliwej...
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A decade of Poland`s integrated Road Safety Programme - economic develop-ment vs. road unsafety. W: [CD-ROM]. Conference proceedings. SORIC´02. 2nd Safety on Road Internationaload International Conference. Kingdom of Bah- rain, 21-23 October 2002. Bahrain: CTRS Univ. Bahrain**2002 [8 s. 5 rys. bibliogr. 5 poz. 10 lat Krajowego Programu Bezpieczeństwa Ruchu Drogowego w Polsce - rozwój ekonomiczny a niebezpieczeństwo ruchu.
PublicationReferat zawiera analizę doświadczeń z dziesięciu lat pracy oraz wdrożeń Kra-jowego Programu Bezpieczeństwa Ruchu Drogowego GAMBIT. Przedstawia również analizę przyczyn gwałtownego spadku liczby- śmiertelnych ofiar wypadków dro-gowych w Polsce w roku 2001.
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Artur Zieliński
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Mechanika analityczna, W, M, sem. 01, lato 21/22 (PG_00057017)
e-Learning Coursesmech analit
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Mechanika analityczna, W, MTR, sem. 01, lato 22/23 (PG_00057017)
e-Learning Coursesmech analit
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Mechanika analityczna, W, MTR, II st., sem. 01, letni 23/24, (PG_00057017)
e-Learning Coursesmech analit
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Biomass of macrophytobentos in the Puck Bay in 2010-2018
Open Research DataThe database contains data on qualitative composition and biomass of macrophytobenthos (flower plants and macroalgae) in samples collected in the Puck Bay area (Gulf of Gdańsk, southern Baltic Sea) at 20 stations between 2010-2018. The database contains information on sampling sites (region, geographical coordinates, depth), sample characteristics (date,...
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Program komputerowy do odtwarzania kształtu osi toru kolejowego
PublicationW pracy przedstawiono metodę odtwarzania kształtu osi toru kolejowego w płaszczyźnie poziomej na podstawie ciągłych pomiarów satelitarnych. W metodzie tej został wykorzystany algorytm projektowania odcinków trasy kolejowej położonych w łuku, w którym zastosowano analityczną formę opisu za pomocą odpowiednich formuł matematycznych. Procedura projektowania ma charakter uniwersalny − stwarza możliwość zróżnicowania rodzaju i długości...
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Optimization of Energetic Train Cooperation
PublicationIn the article, possible ways of using energy recovered during regenerative braking of trains are presented. It is pointed out that the return of recovered electricity directly to the catenary and its use in the energy cooperation of vehicles can be a no-cost method (without additional infrastructure). The method of energy cooperation between trains and its main assumptions, that uses the law of conservation of energy, are described...
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Multiscale model for blood flow after a bileaflet artificial aortic valve implantation
PublicationCardiovascular diseases are the leading cause of mortality in the world, mainly due to atherosclerosis and its consequences. The article presents the numerical model of the blood flow through artificial aortic valve. The overset mesh approach was applied to simulate the valve leaflets motion and to realize the moving mesh, in the aortic arch and the main branches of cardiovascular system. To capture the cardiac system’s response...
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Design analysis of ORC micro-turbines making use of thermal energy of oceans
PublicationThe article presents the results of the analysis of energy conversion cycles making use of thermal energy of oceans. The objects of analysis were two cases of closed Organic Rankine Cycle (ORC) power plants, which were: the cycle in which the vapour of the working medium was produced by warm oceanic water in the circum-equatorial zone, and the so-called “arctic” cycle in which this vapour was produced by non-frozen water in the circumpolar...
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Predicting cutting power for band sawing process of pine and beech wood dried with the use of four different methods
PublicationWood drying is an important stage in the woodworking process. After drying, wood is subject to a re-sawing process, for which a high quality surface, low material loss, and high efficiency are often required. In this paper, forecasted values were presented of cutting power for the re-sawing process of pine and beech wood that were dried with four different methods. Forecasting of cutting power for an industrial band saw machine...
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Searching for road deformations using mobile laser scanning
PublicationMillions of people use roads every day all over the world. Roads, like many other structures, have an estimated durability. In Poland a lot of the roads were built at the turn of the 20th and 21st c., especially for light cars. Many of these roads carry traffic and heavy goods vehicles which were not predicted when the traffic was first estimated. It creates a lot of problems with technical conditions and the infrastructure must...
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The largest companies in the TSL industry in Poland in 2011
Open Research DataThe data contained in the dataset shows that the most successful transport, forwarding and logistics company in Poland in 2011 was PKP CARGO S.A. The company is the largest carrier in the country, while in the European Union it ranks second in terms of freight transport.
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Metody zwiększania dostępności i efektywności informatycznej infrastruktury w inteligentnym mieście
PublicationW pracy omówiono metody zwiększania dostępności i efektywności informatycznej infrastruktury w inteligentnym mieście. Sformułowano dwa kryteria do oceny rozmieszczenia kluczowych zasobów w systemie smart city. Zobrazowano proces wyznaczania rozwiązań kompromisowych spośród rozwiązań Pareto-optymalnych. Omówiono metaheurystyki inteligencji zbiorowej, w tym roju cząstek, kolonii mrówek, roju pszczół oraz ewolucji różnicowej, za pomocą...
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Modelling of Geared Multi-Rotor System
PublicationIn the paper the method of modelling a speed-varying geared rotor system is presented. The proposed approach enables us to obtain an accurate low-order lumped parameter representation of the investigated system. The final model consists of reduced modal models of an undamped beam/torsional shaft system as well as a spatially lumped model of other linear and nonlinear phenomena including gear mesh interaction.
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A concept of measurement system based on the Z-Wave standard
PublicationIn the paper a new concept of measurement system based on the Z-Wave standard is presented. This standard is dedicated to use mainly in home automation systems, but its properties enable to use it in dispersed measurement systems and support wireless communication between measurement nodes in a mesh-type network. In the paper basic metrological aspects of the Z-Wave standard and an example of impedance measurement system are discussed.
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Mobile monitoring system for gaseous air pollution
PublicationThe concept of a mobile monitoring system for chemical agents control in the air is presented. The proposed system can be applied to measure industrial and car traffic air pollution. A monitoring station is relatively small and can be placed on cars or public transportation vehicles. Measured concentrations of air pollutants are collected and transferred via the GSM network to a central data base. Exemplary results from a measurement...
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Malarstwo
PublicationAutor, mieszkając od wielu lat na dwóch krańcach Europy, postrzega swoje życie w kategoriach ''podróży''. Podróży rozpiętej między Północą a Południem, pomiędzy domami, miejscami, pomiędzy lądami i morzami, ale także podróży w czasie, gdy dociera do miejsc pamiętających czasy Imperium Rzymskiego czy ekspansji Maurów na Półwyspie Iberyjskim. Wystawa prezentuje graficzny wymiar tych podróży uchwycony w szkicach, rysunkach i malarstwie.
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Hybrid biobateryy based on arylated carbon nanotubes and laccase
PublicationSingle-walled carbon nanotubes (SWCNT) were covalently modified with antracene and antraquinone and used for the construction of cathodes for biocatalytic reduction od dioxygen. The nanotubes with aromatic groups casted onto the electrode increased the working surface of the electrode and enabled efficient direct electron tarnsfer (DET) between the enzyme and the electrode. the aryl groups enter the hydrophobic pocket of the T1...
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Michał Lech dr inż.
PeopleMichał Lech was born in Gdynia in 1983. In 2007 he graduated from the faculty of Electronics, Telecommunications and Informatics of Gdansk University of Technology. In June 2013, he received his Ph.D. degree. The subject of the dissertation was: “A Method and Algorithms for Controlling the Sound Mixing Processes by Hand Gestures Recognized Using Computer Vision”. The main focus of the thesis was the bias of audio perception caused...
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Mechanizmy bezpieczeństwa w strefie C systemu netBaltic
PublicationW artykule zaprezentowano rozwiązania zaimplementowane do zabezpieczania komunikacji w warunkach sporadycznej i nieciągłej łączności (Delay Tolerant Networking – DTN) w systemie netBaltic - charakterystycznej dla strefy C tego systemu. Ze względu na dużą różnorodność rozważanych mechanizmów komunikacyjnych, architektura bezpieczeństwa całego systemu została podzielona na kilka elementów – infrastrukturę klucza publicznego (PKI),...
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Methodology of generation of CFD meshes and 4D shape reconstruction of coronary arteries from patient-specific dynamic CT
PublicationDue to the difficulties in retrieving both the time‑dependent shapes of the vessels and the generation of numerical meshes for such cases, most of the simulations of blood flow in the cardiac arteries use static geometry. The article describes a methodology for generating a sequence of time‑dependent 3D shapes based on images of different resolutions and qualities acquired from ECG‑gated coronary artery CT angiography. The precision...
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Xiaohu Li doctor
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Li Changxiong Doctor
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Xinlong Zhang Doctor
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Integration of thermographic data with the 3D object model
PublicationThe aim of the paper is to present new method for merging the 3D model data of the measured object with thermograms. Our technique is based on the combination of visual 3D imaging technique and thermal imaging technique, which maps the 2D thermograms on to 3D anatomical mesh model. The combination of these imaging modalities allows the generation of combined 3D and thermal data from which thermal signatures can be verified and...