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Wyniki wyszukiwania dla: DECISIONAL DNA SET OF EXPERIENCE KNOWLEDGE STRUCTURE KNOWLEDGE REPRESENTATION KNOWLEDGE ENGINEERING DECISION MAKING
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Dynamically positioned ship steering making use of backstepping method and artificial neural networks
PublikacjaThe article discusses the issue of designing a dynamic ship positioning system making use of the adaptive vectorial backstepping method and RBF type arti cial neural networks. In the article, the backstepping controller is used to determine control laws and neural network weight adaptation laws. e arti cial neural network is applied at each time instant to approximate nonlinear functions containing parametric uncertainties....
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Mathematical Modeling of Ice Dynamics as a Decision Support Tool in River Engineering
PublikacjaThe prediction of winter flooding is a complicated task since it is affected by many meteorological and hydraulic factors. Typically, information on river ice conditions is based on historical observations, which are usually incomplete. Recently, data have been supplemented by information extracted from satellite images. All the above mentioned factors provide a good background of the characteristics of ice processes, but are not...
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Graph Representation Integrating Signals for Emotion Recognition and Analysis
PublikacjaData reusability is an important feature of current research, just in every field of science. Modern research in Affective Computing, often rely on datasets containing experiments-originated data such as biosignals, video clips, or images. Moreover, conducting experiments with a vast number of participants to build datasets for Affective Computing research is time-consuming and expensive. Therefore, it is extremely important to...
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Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?
PublikacjaThe structure of B-DNA, the physiological form of the DNA molecule, has been a central topic in biology, chemistry and physics. Far from uniform and rigid, the double helix was revealed as a flexible and structurally polymorphic molecule. Conformational changes that lead to local and global changes in the helix geometry are mediated by a complex choreography of base and backbone rearrangements affecting the ability of the B-DNA...
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DNA modification by 1-nitroacridine derivatives. Comparison of 32P-Postlabeling and restriction enzyme analysis method for the detection of DNA adducts formed by 1-nitroacridines C-1748 and C-857
Publikacja4-podstawione 1-nitroakrydyny reprezentują nową grupę pochodnych akrydyny, zsyntetyzowanych na Politechnice Gdańskiej. Metoda 32P-postlabellingu wykazała, że pochodne C-1748 i C-857 tworzą od 4-6 adduktów DNA w systemie komórkowym i bezkomórkowym o innym rozkładzie plam chromatograficznych, jednakże niezależnym od zastosowanego systemu aktywacyjnego. Metoda enzymatycznej analizy restrykcyjnej pozwoliła natomiast śledzić kinetykę...
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Optimizing Construction Engineering Management Using Metaheuristic Methods and Bayesian Networks
PublikacjaThe construction of buildings invariably involves time and costs, and disruptions impact ongoing construction projects. Crisis situations in management strategies, structural confusion, and finan-cial miscalculations often arise due to misguided decision-making. This article proposes a method that combines the learning of Bayesian Networks and heuristic techniques to optimize deci-sion-making processes in construction scheduling....
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An Analysis of External Finance Availability on SMEs’ Decision Making: A Case Study of the Emerging Market of Poland
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SafeCity – a GIS-based tool profiled for supporting decision making in urban development and infrastructure protection
PublikacjaThis paper presents a system for analysis of municipal Critical Infrastructures, which offers integrated tools for target analysis, hazard scenario simulations and spatial analysis within a remotely accessible Web-based Geographic Information System. The system has been applied to research conducted in the city of Gdansk with the aid of blast attack, chemical leakage and flood hazard scenarios, as well as a spatial density algorithm,...
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Bridging challenges of clinical decision support systems with a semantic approach. A case study on breast cancer
PublikacjaThe integration of Clinical Decision Support Systems (CDSS) in nowadays clinical environments has not been fully achieved yet. Although numerous approaches and technologies have been proposed since 1960, there are still open gaps that need to be bridged. In this work we present advances from the established state of the art, overcoming some of the most notorious reported difficulties in: (i) automating CDSS, (ii) clinical workflow...
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Playback Attack Detection: The Search for the Ultimate Set of Antispoof Features
PublikacjaAutomatic speaker verification systems are vulnerable to several kinds of spoofing attacks. Some of them can be quite simple – for example, the playback of an eavesdropped recording does not require any specialized equipment nor knowledge, but still may pose a serious threat for a biometric identification module built into an e-banking application. In this paper we follow the recent approach and convert recordings to images, assuming...
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How can analysts use multicriteria decision analysis?
PublikacjaProper decision making in multifacitated situation is very challenging task. It is especially difficult if there are many alternatives and criteria that are often contradictory. Analytical chemistry and related sciences involve many situations where decisions on complex problems are made. The support tools may be the use of MCDA (Multi-criteria Decision Analysis) algorithms. They formalize the decision process, make it transparent...
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Oral Health-Related Knowledge, Attitudes and Behaviours of Arab Dental Students: Multi-National Cross-Sectional Study and Literature Analysis 2000–2020
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Crossroad between current knowledge and new perspective of diagnostic and therapy of late-onset schizophrenia and very late-onset schizophrenia-like psychosis: An update
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Artemisia abrotanum L. (Southern Wormwood)—History, Current Knowledge on the Chemistry, Biological Activity, Traditional Use and Possible New Pharmaceutical and Cosmetological Applications
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Interstrand crosslinking of DNA by C-1311 (Symadex) and other imidazoacridinones
PublikacjaImidazoakrydony, w tym pochodna C-1311 (Symadex) znajdująca się w pierwszej fazie badań klinicznych prowadzonych w USA, należą do grupy bardzo aktywnych związków przeciwnowotworowych zsyntetyzowanych w Katedrze Technologii Leków i Biochemii PG. Za pomocą zmodyfikowanej metody Parsons'a wykazaliśmy, że C-1311 indukuje, w sposób zależny od stężenia, międzyłańcuchowe wiązania sieciujące w komórkach różnych nowotworów ludzkiego pochodzenia...
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Electroanalytical and spectroscopic procedures for examination of interactions between double stranded DNA and intercalating drugs
PublikacjaPrzedstawiono metodę elektrochemicznego opisu oddziaływań dsDNA ze związkiem biologicznie czynnym w warunkach, w których zarówno badany związek jak i cząsteczka DNA są w roztworze elektrolitu. Opracowano warunki pomiaru, gdzie ani związek, ani DNA nie adsorbuje na elektrodzie. Wykazano, podobnie jak podczas badania innymi metodami, że oddziaływania są dwojakiego rodzaju: elektrostatyczne i poporzez interkalację.
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Agent System for Managing Distributed Mobile Interactive Documents
PublikacjaThe MIND architecture of distributed mobile interactive document is a new processing model defined for facilitate informed decision-making in non-algorithmic decision-making processes carried out by knowledge-based organizations. The aim of this architecture is to change the static document to mobile agents, which are designed to implement the structure of the organization through autonomous migration between knowledge workers...
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Geometric analogue of holographic reduced representation
PublikacjaHolographic reduced representations (HRRs) are distributed representations of cognitive structuresbased on superpositions of convolution-bound n-tuples. Restricting HRRs to n-tuples consisting of 1,one reinterprets the variable binding as a representation of the additive group of binary n-tupleswith addition modulo 2. Since convolutions are not defined for vectors, the HRRs cannot be directlyassociated with geometric structures....
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Thermodynamics aspects of interactions between acridine derivatives and DNA
PublikacjaDNA is a molecular target for many anticancer and antiviral drugs. Therefore, a clear understanding of the interaction of small molecules with DNA is important in the rational design of ligands that can bind to DNA with high affinity and selectivity. There are several methods to investigate interactions between drug and DNA. Some of them measure changing into DNA structures, such as lengthening and untwisting of helix of DNA. Other...
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Two highly thermostable paralogous single-stranded DNA-binding proteins from Thermoanaerobacter tengcongensis
PublikacjaThe thermophilic bacterium Thermoanaerobacter tengcongensis has two single-stranded DNA-binding (SSB) proteins, designated TteSSB2 and TteSSB3. In a SSB complementation assay in Escherichia coli, only TteSSB3 took over the in vivo function of EcoSSB. We have cloned the ssb genes obtained by PCR and have developed E. coli overexpression systems. The TteSSB2 and TteSSB3 consist of 153 and 150 amino acids with a calculated molecular...
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Interaction of antitumor triazoloacridone C-1305 and its analogs with telomeric DNA
PublikacjaBadaliśmy oddziaływanie pochodnej triazoloakrydonu C-1305 i jego bliskich analogów strukturalnych z oligonukleotydami zawierającycmi sekwencje telomerowe TTAGGG oraz oligonukleotydami sfałdowanymi w strukturę G-kwadrupleksu. Wykazaliśmy, że spośród badanych związków pochodna C-1305 wykazała największą specyficzność w stosunku do telomerowego DNA. Związek ten stabilizował także strukturę G-kwadrupleksu, podczas gdy jego analogi...
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Wikipedia Articles Representation with Matrix'u
PublikacjaIn the article we evaluate different text representation methods used for a task of Wikipedia articles categorization. We present the Matrix’u application used for creating computational datasets ofWikipedia articles. The representations have been evaluated with SVM classifiers used for reconstruction human made categories.
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Holistic collision avoidance decision support system for watchkeeping deck officers
PublikacjaThe paper presents a 3-stage synthesis-based Decision Support System for watchkeeping deck officers. Its functional scope covers conflict detection, maneuver selection, and maneuver execution, all phases supplemented by collision alerts. First, a customized elliptic ship domain is used for checking if both OS and TS will have enough free space. A survey-based navigators’ declarative OS arena is then used to determine the time at...
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Time for a paradigm shift in shared decision-making in trauma and emergency surgery? Results from an international survey
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QEEG-based neural correlates of decision making in a well-trained eight-year-old chess player
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Cellular senescence induced by DNA damage and its role in carcinogenesis and chemotherapy
PublikacjaUszkodzenia DNA indukują w komórce różne procesy, w tym starzenie komórkowe, co może uruchamiać proces karcinogenezy jak i być związane z odpowiedzią na leki przecinowotworowe. Biologiczna rola starzenia komórkowego nie jest jednak jasna. Zasugerowano, że proces starzenia komórkowego może hamować proces karcinogenezy poprzez indukcję nieodwracalnego zahamowania wzrostu przez czynniki genotoksyczne. Indukcja starzenia komórkowego...
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President and Manager of the court versus networking in justice system - "Extending of Delimitation"
PublikacjaCurrent knowledge and empirical studies concering the networks collaboration in public sector, the role of decision-making centre in the building of network structure, strategy formulation and evaluation is fragmentary.
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Evidence-Based Risk Management for Civil Engineering Projects Using Bayesian Belief Networks (BBN)
PublikacjaThe authors are seeking new methods for improving the efficiency of the investments associated with the maintenance and operation of existing civil engineering structures. It is demonstrated how the knowledge about the elements of construction and operation phases and their relationships, combined with monitoring data can be used for more effective management of the risks associated with civil engineering projects. The methodology...
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Methods for Elucidation of DNA-Anticancer Drug Interactions and Their Applications in the Development of New Drugs
PublikacjaDNA damaging agents including anthracyclines, camptothecins and platinum drugs are among most frequently used drugs in the chemotherapeutic routine. Due to their relatively low selectivity for cancer cells, administration is associated with adverse side effects, whereas the inherent genotoxicity of these drugs is associated with risk of developing secondary cancers. Development of new drugs, which could be spared of these drawbacks...
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Open-Set Speaker Identification Using Closed-Set Pretrained Embeddings
PublikacjaThe paper proposes an approach for extending deep neural networks-based solutions to closed-set speaker identification toward the open-set problem. The idea is built on the characteristics of deep neural networks trained for the classification tasks, where there is a layer consisting of a set of deep features extracted from the analyzed inputs. By extracting this vector and performing anomaly detection against the set of known...
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Numerical calculations of behaviour of ship double-bottom structure during grounding
PublikacjaIdeą projektu CORET jest dodanie do obecnej konstrukcji dna podwójnego statku specjalnych powłok polimerowo-betonowych w celu zwiększenia odporności na rozszczelnienie podczas kolizji, czy wejścia na mieliznę. Aby poprawnie zaprojektować te bariery ochronne konieczne jest przeprowadzenie symulacji numerycznej. Tworzenie modelu numerycznego konstrukcji podczas kolizji jest bardzo złożone i wymaga wykonania symulacji pomocniczych...
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A fuzzy logic model for forecasting exchange rates
PublikacjaThis article is devoted to the issue of forecasting exchange rates. The objective of the conducted research is to develop a predictive model with the use of an innovative methodology - fuzzy logic theory - and to evaluate its effectiveness in times of prosperity and during the financial crisis. The model is based on sets of rules written by the author in the form of IF-THEN, where expert knowledge is stored. This model is the result...
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Introducing concurrent engineering to space and satellite technology undergraduate course
PublikacjaIn recent decade concurrent engineering has become a de facto leading methodology of work in space, aeronautics and sometimes even automotive industry. It has been used in designing ESA space missions for 20 years now, with rst Concurrent Design Facility (CDF) built in ESTEC in 1998. Still, it has not become a universal standard in engineering, and universities are specically reluctant to adopt it into their curricula. As a result,...
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Comet assay-based methods for measuring DNA repair in vitro; estimates of inter- and intra-individual variation.
PublikacjaZdolność do naprawy uszkodzeń DNA jest jednym z najważniejszych wyznaczników podatności na choroby nowotworowe. Dlatego też użytecznym staje się możliwość pomiaru stopnia naprawy DNA w próbkach materiału badawczego pobranego od ochotników. Celem pracy było, po pierwsze, opracowanie w warunkach in vitro prostej metody (z wykorzystaniem techniki testu kometowego), w której naprawa DNA odbywa się poprzez wycinanie nukleotydów (NER)....
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Epigenetic Basis of Regeneration: Analysis of Genomic DNA Methylation Profiles in the MRL/MpJ Mouse
PublikacjaEpigenetic regulation plays essential role in cell differentiation and dedifferentiation, which are the intrinsic processes involved in regeneration. To investigate the epigenetic basis of regeneration capacity, we choose DNA methylation as one of the most important epigenetic mechanisms and the MRL/MpJ mouse as a model of mammalian regeneration known to exhibit enhanced regeneration response in different organs. We report the...
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Modelling assisted phytoremediation of soils contaminated with heavy metals – Main opportunities, limitations, decision making and future prospects
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Cost of Equity of Coal-Fired Power Generation Projects in Poland: Its Importance for the Management of Decision-Making Process
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Cooperation areas between universities and industry - case studies in the area of civil engineering
PublikacjaThe paper describes the areas of cooperation between universities and industry in the area of civil engineering. Presented examples are related to didactics, research grants and commissioned works. On the basis of the authors own experiences the mutual benefits of cooperation in different areas are described. As well as the assessment criteria of the areas of cooperation by the scientific community. The first area of cooperation...
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Novel thermostable single-stranded DNA-binding protein (SSB) from Deinococcus geothermalis
PublikacjaW celu zbadania właściwości biochemicznych białka wiążącego się do jednoniciowego DNA (SSB) pochodzącego z Deinococcus geothermalis (DgeSSB), sklonowano gen ssb otrzymany w reakcji PCR, a następnie uzyskano wydajną biosyntezę białka DgeSSB. Gen składa się z 900 par zasad, kodujących białko złożone z 300 reszt aminokwasowych, o wyliczonej masie molekularnej równej 32.45 kDa. Sekwencja aminokwasowa wykazuje 43, 44% i 75% identyczności...
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Engineering education for smart grid systems in the quasi-industrial environment of the LINTE^2 laboratory
PublikacjaSmart grid systems are revolutionising the electric power sector, integrating advanced technologies to enhance efficiency, reliability and sustainability. It is important for higher education to equip the prospective smart grid professional with the competencies enabling them to navigate through the related complexities and drive innovation. To achieve this, interdisciplinary education programmes are necessary, addressing inter...
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Implementing fuzzy logic to generate user profile in decisional DNA television: the concept and initial case study
PublikacjaIn the paper the concept and case study of a novel approach that generates a television user's profile utilizing principles of fuzzy logic is presented.
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Establishing intelligent enterprise through community of practice for product innovation
PublikacjaThis paper presents the idea of implementing the virtual Community of Practice for Product Innovation processes towards the establishment of intelligent enterprise. Since the fourth industrial revolution is passing through the developing phase, implementation of Cyber-Physical Production Systems require more realistic approach. Knowledge Management and Engineering plays an important role in manufacturing industries facing global...
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Towards New Mappings between Emotion Representation Models
PublikacjaThere are several models for representing emotions in affect-aware applications, and available emotion recognition solutions provide results using diverse emotion models. As multimodal fusion is beneficial in terms of both accuracy and reliability of emotion recognition, one of the challenges is mapping between the models of affect representation. This paper addresses this issue by: proposing a procedure to elaborate new mappings,...
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GRA1 protein vaccine confers better immune response compared to codon-optimized GRA1 DNA vaccine
PublikacjaW publikacji oszacowano immunogenność i właściwości protekcyjne szczepionki anty-Toxoplasma gondii opartej na białku rekombinantowym GRA1 oraz dwóch rodzajach szczepionek DNA (plazmidu zawierającego gen kodujący białko GRA1 dzikiego typu oraz modyfikowanego genu kodującego białko GRA1). Uzyskane wyniki sugerują lepsze właściowści immunoprotekcyjne rekombinantowego białka antygenowego niż szczepionek DNA.
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Quantum structure in competing lizard communities
PublikacjaAlmost two decades of research on applications of the mathematical formalism of quantum theory as a modeling tool in domains different from the micro-world has given rise to many successful applications in situations related to human behavior and thought, more specifically in cognitive processes of decision-making and the ways concepts are combined into sentences. In this article, we extend this approach to animal behavior, showing...
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Optimization-Based Robustness Enhancement of Compact Microwave Component Designs with Response Feature Regression Surrogates
PublikacjaThe ability to evaluate the effects of fabrication tolerances and other types of uncertainties is a critical part of microwave design process. Improving the immunity of the device to parameter deviations is equally important, especially when the performance specifications are stringent and can barely be met even assuming a perfect manufacturing process. In the case of modern miniaturized microwave components of complex topologies,...
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A Universal Theory of Wisdom . A Mind - oriented Approach
PublikacjaThe purpose of the paper is to synthesize the issues of human wisdom in terms of minds which create knowledge-based judgment. We form a transdisciplinary, big-picture view of the wisdom of humans. Findings: Wisdom is the right judgment and choice in the context of the art of living. Practical implications: Wisdom can be developed within the set of minds. Social implications: To pursue wisdom in thinking and action, one must extend...
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Stereo Camera Upgraded to Equal Baseline Multiple Camera Set (EBMCS)
PublikacjaThe paper presents the results of using a set of five cameras called Equal Baseline Multiple Camera Set (EBMCS) for making 3D images, disparity maps and depth maps. Cameras in the set are located in the vicinity of each other and therefore the set can be used for the purpose of stereoscopy similarly as a stereo camera.EBMCS provides disparity maps and depth maps which have a better quality than these maps obtained with the use...
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Financial impact analysis of going public at the Warsaw Stock Exchange: Using Fuzzy Set Theory to understand behaviours of mature companies
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Asymptotic behaviour in the set of nonhomogeneous chains of stochastic operators
PublikacjaWe study different types of asymptotic behaviour in the set of (infinite dimensional) nonhomogeneous chains of stochastic operators acting on L1(μ) spaces. In order to examine its structure we consider different norm and strong operator topologies. To describe the nature of the set of nonhomogeneous chains of Markov operators with a particular limit behaviour we use the category theorem of Baire. We show that the geometric structure...