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Wyniki wyszukiwania dla: DNA DAMAGE RESPONSE,NON-SMALL-CELL LUNG CANCER, PHARMACEUTICS, TARGET IDENTIFICATION
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Gender, education and motivation of onwers of small firms and their growth
PublikacjaAlmost every article on the growht of SMEs begins with noting the lack of a unified theory or a model of growth in thei group of companies, although the growth of small and medium sized enterprises has been the subject of research for many years and early theories about it appeared already before the Second World War. In the paper some conlusions about the relation between gender, education and motivation of owner and the small...
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Development of a Response Assessment Tool for a Floating Dock System
PublikacjaDocking operations of ships require a response assessment to ensure structural and personnel safety. Environmental loads and improper ballast adjustments are the main threats to the docking operations. They can cause severe structural damages and stability loss to a floating dock system which includes a floating dock and a docked vessel, even if the velocities of the dock and the vessel are very low during the docking process....
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Profiles of a broad spectrum of epigenetic DNA modifications in normal and malignant human cell lines: Proliferation rate is not the major factor responsible for the 5-hydroxymethyl-2′-deoxycytidine level in cultured cancerous cell lines
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ON THE NON-LOCALITY OF TRIPARTITE NON-SINGALING BOXES EMERGING FROM WIRINGS
PublikacjaIt has been recently shown, that some of the tripartite boxes admittin g bilocal decom- position, lead to non-locality under wiring operation applied to t wo of the subsystems [R. Gallego et al. Physical Review Letters 109 , 070401 (2012)]. In the following, we study this phenomenon quantitatively. Basing on the known classes of bo xes closed un- der wirings, we introduce multipartite monotones which are count erparts of bipartite ones...
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Detection of Toxoplasma gondii Infection in Small Ruminants: Old Problems, and Current Solutions
PublikacjaToxoplasmosis is a parasitic zoonosis of veterinary importance, with implications for public health. Toxoplasma gondii infection causes abortion or congenital disease in small ruminants. Moreover, the consumption of infected meat, cured meat products, or unpasteurized milk and dairy products can facilitate zoonotic transmission. Serological studies conducted in various European countries have shown the high seroprevalence of specific...
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PCR test for Microsporum canis identification
PublikacjaMicrosporum canis, for which the natural hosts are cats and dogs, is the most prevalent zoophilic agent causing tinea capitis and tinea corporis in humans. We present here a diagnostic PCR test for M. canis, since its detection and species identification is relevant to the choice of treatment and to the understanding of a probable source of infection. An M. canis-specific PCR was evaluated using 130 clinical isolates of dermatophytes...
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A Convenient Way to Methylated 2-Imidazolines. Syntheses of Fluorene and Triazine Cyclic Diamidines
PublikacjaOne N-methyl- and 4-substituted 2-imidazolines are described. Fluorene bisimidazolines were obtained in good yield (64-92%), starting from 2,7-dicyanofluorene and ammonium sulfide. In a two-step procedure the crude bisthioamide was reacted with excess diaminoalkane-ethanol (1:1 mixt.) in an oil bath. This new procedure is superior over std. methods. For the sake of comparison, a new triazine bisimidazoline (I) was prepd. by...
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The Methods for RTS Noise Identification
PublikacjaIn the paper authors present two methods, which allows to identify the RTS noise in noise signal of semiconductor devices. The first one was elaborated to identify the RTS noise and also to estimate the number of its levels. The second one can be used to estimate all of the parameters of Gaussian and non-Gaussian components in the noise signal in a frequency domain.
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Piperine Targets Different Drug Resistance Mechanisms in Human Ovarian Cancer Cell Lines Leading to Increased Sensitivity to Cytotoxic Drugs
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The Significance of MicroRNAs Expression in Regulation of Extracellular Matrix and Other Drug Resistant Genes in Drug Resistant Ovarian Cancer Cell Lines
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The influence of 4-substituted and unsubstituted derivatives of 1-nitroacridine on the cell cycle and induction of apoptosis in human cancer HT29 and HeLa S3.
PublikacjaZbadano wpływ pochodnych 1-nitroakrydyny C-1748 i C-857, w stężeniach biologicznie istotnych, na cykl życiowy oraz indukcję apoptozy komórek raka jelita grubego HT29 oraz raka szyjki macicy HeLa S3. Metodą cytometrii przepływowej wykazano, że 4-metylo-1-nitroakrydyna C-1748 powoduje akumulację komórek HT29 w fazie S i komórek HeLa S3 w fazie G2 cyklu komórkowego zaś związek C-857 indukuje akumulację komórek HT29 i HeLa S3 w fazie...
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Transmission measurements between two geometrically small Vivaldi antennas performed in non-anechoic propagation conditions
Dane BadawczeThe dataset contains unprocessed measurements of complex transmission (and reflection) characteristics obtained in non-anechoic regime for a geometrically small, broadband spline-parameterized Vivaldi structure. The measurement setup comprises two Vivaldi antennas with the same topology where one is used as a reference structure, and another one as...
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Set of Experience and Decisional DNA: Experience-Based Knowledge Structures
PublikacjaThis chapter presents a description of Set of Experience Knowledge Structure (SOEKS) and Decisional DNA (DDNA), argumentation for a knowledge representation, composition, configuration and metrics. SOEKS is a combination of filtered and amalgamated information obtained from formal decision events. It facilitates effective explicit representation of decisional experience taken from different technologies. SOEKS comprises variables,...
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Wybrane metody badania poziomu metylacji DNA w komórkach eukariotycznych
PublikacjaMetylacja regionów promotorowych jest jednym z głównych mechanizmów regulacji transkrypcji genów u eukariota. W komórkach ssaczych metylacja DNA zachodzi głównie na reszcie cytozyny występującej w dinukleotydach CpG i jest katalizowana przez metylotransferazy DNA (DNMT1, DNMT3A i DNMT3B) (Turek Plewa, Jagodziński 2005). Mapowanie 5 metylocytozyny w DNA genomowym jest jednym z narzędzi do badania wpływu metylacji na tkankowo-specyficzną...
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Beata Krawczyk dr hab.
Osobydr hab. Beata Krawczyk, prof. uczelni Stopnie naukowe, wykształcenie, kwalifikacje Beata Krawczyk uzyskała tytuł magistra biologii na Wydziale Biologii (wówczas: Wydział Biologii i Nauk o Ziemi), Uniwersytetu Gdańskiego w 1986 roku, a doktorat z biologii molekularnej na Wydziale Biologii (wówczas: Wydział Biologii, Geografii i Oceanologii) Uniwersytetu Gdańskiego w 1996 roku. Stopień doktora habilitowanego w zakresie nauk biologicznych...
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Wage response to global production links: evidence for workers from 28 European countries (2005–2014)
PublikacjaUsing rich individual-level data on workers from 28 European countries, this study provides the first so extensive cross-country assessment of wage response to global production links within GVC in the period 2005–2014. Unlike the other studies, the authors (i) address the importance of backward linkages in globally integrated production structures (capturing imports of goods and services needed in any stage of the production of...
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Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity
PublikacjaSeven conjugates composed of well-known fluoroquinolone antibacterial agents, ciprofloxacin (CIP) or levofloxacin (LVX), and a cell-penetrating peptide transportan 10 (TP10-NH2) were synthesised. The drugs were covalently bound to the peptide via an amide bond, methylenecarbonyl moiety, or a disulfide bridge. Conjugation of fluoroquinolones to TP10-NH2 resulted in congeners demonstrating antifungal in vitro activity against human...
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Binding free energy of selected anticancer compounds to DNA - theoreticalcalculations
PublikacjaPraca dotyczy swobodnej energii wiązania z DNA trzech związków o działaniu przeciwnowotworowym (mitoksantronu i dwóch pochodnych pirymidoakrydyny). Obliczenia wykorzystywały metody Poissona-Boltzmanna (udział elektrostatyczny) i metody SASA (udział nieelektrostatyczny). W wyniku badań zaproponowano struktury kompleksów jakie tworzą badane ligandy z DNA.
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Goblet Cell Ratio in Combination with Differentiation and Stem Cell Markers in Barrett Esophagus Allow Distinction of Patients with and without Esophageal Adenocarcinoma
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Emphysema affects the number and appearance of solitary pulmonary nodules identified in chest low-dose computed tomography: a study on high risk lung cancer screenees recruited in Silesian District
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Knowledge management implementation in small and micro KIBS : A categorization
Publikacjahe main goal of the paper is to provide a statistical categorization of small and micro knowledge-intensive business service (KIBS) companies, based on their knowledge management (KM) attitude. Since knowledge is the main production factor and output of these companies, it is essential to achieve a better understanding of how they manage this resource. A questionnaire-based survey was conducted on a sample of Polish small and micro...
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Effect of oxidation and in vitro intestinal hydrolysis on phospholipid toxicity towards HT29 cell line serving as a model of human intestinal epithelium
PublikacjaOxidation of food-derived phospholipids (PLs) can influence nutrient digestion and induce oxidative stress in gastrointestinal epithelium. In this study, hen egg yolk PL fraction was used to evaluate the effect of lipoxygenase (LOX)-induced PL oxidation on the rate of PL hydrolysis catalyzed by pancreatic phospholipase A2 (PLA2) in the presence of bile salts (BSs). Then, PL/BS solutions containing native or oxidized PLs were used...
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Robust identification of quadrocopter model for control purposes
PublikacjaThe paper addresses a problem of quadrotor unmanned aerial vehicle (so-called X4-flyer or quadrocopter) utility model identification for control design purposes. To that goal the quadrotor model is assumed to be composed of two abstracted subsystems, namely a rigid body (plant) and four motors equipped with blades (actuators). The model of the former is acquired based on a well-established dynamic equations of motion while the...
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The use of a one-step PCR method for the identification of Microsporum canis and Trichophyton mentagrophytes infection of pets
PublikacjaIntroduction: Dermatophytes are a closely related group of keratinophilic fungi. They encompass important etiological agents of superficial fungal infections. These fungi are able to invade keratinized tissues of humans and animals, causing dermatophytosis (ringworm) of hair, nails or skin. The aim: Traditional diagnostics of ringworm is based on morphological identification of cultured fungi and is time-consuming. Materials and methods:...
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Experience based decisional DNA to support smart product design
PublikacjaThis paper presents the idea of Smart Virtual Product Development (SVPD) system to support product design. The foundations of the system are based upon smart knowledge management techniques called Set of Experience Knowledge Structure (SOEKS) and Decisional DNA (DDNA). It enhances the industrial product development process by using the previous experiential knowledge gathered from the formal decisional activities. This experiential...
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Non-isolating bondage in graphs
PublikacjaA dominating set of a graph $G = (V,E)$ is a set $D$ of vertices of $G$ such that every vertex of $V(G) \setminus D$ has a neighbor in $D$. The domination number of a graph $G$, denoted by $\gamma(G)$, is the minimum cardinality of a dominating set of $G$. The non-isolating bondage number of $G$, denoted by $b'(G)$, is the minimum cardinality among all sets of edges $E' \subseteq E$ such that $\delta(G-E') \ge 1$ and $\gamma(G-E')...
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Neural Manoeuvre Detection of the Tracked Target in ARPA Systems
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Bearing errors passive sonar stationary target location
PublikacjaPrzedstawiono metodę wyznaczania współrzędnych nieruchomego celu na podstawie namiarów wykonywanych w sonarze pasywnym. Określono wymagania odnośnie ruchu sonaru, przy których błędy wyznaczania współrzędnych są minimalne. Podano zależności umożliwiające analityczne wyznaczanie błędów współrzędnych. Poprawność wyników analizy potwierdzono eksperymentami numerycznymi.
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On a threshold induced bias in fish target strength estimation.
PublikacjaPrzedstawiono statystyczny opis zjawiska wpływu progu rejestracji ech od ryb na estymatę siły celu ryb. Pokazano sposób korekcji wykorzystujący zależności pomiędzy funkcjami rozkładu prawdopodobieństwa poziomu echa i charakterystyki wiązki. Przedstawiono wyniki symulacji.
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Morphology of damage inflicted on brittle polymer in lubricated contact under cyclic static load
PublikacjaIn this article morphology of damage inflicted on the polymethylmethacrylate (PMMA) plate in static point lubricated contact with a ball made of five different materials under cyclic normal load has been presented. It is argued that the counterface material and lubricating film play an important role in the damage process and the extent of damage inflicted in the PMMA plate.
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Adaptive Wavelet-Based Correction of Non-Anechoic Antenna Measurements
PublikacjaNon-anechoic measurements represent an affordable alternative to evaluation of antenna performance in expensive, dedicated facilities. Due to interferences and noise from external sources of EM radiation, far-field results obtained in non-ideal conditions require additional post-processing. Conventional correction algorithms rely on manual tuning of parameters, which make them unsuitable for reliable testing of prototypes. In this...
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In-service measurement of the small wind turbine test stand for structural health monitoring
PublikacjaThis paper presents the research activity performed on a Small Wind Turbine (SWT) test stand. Commercially available turbine was modified towards incorporation of the sensors system for condition monitoring. Installed sensors measure angular shaft position, torque applied from the wind loads, vibration accelerations and last but not least rotational speed. All gathered data are then transferred and processed in Test.Lab by means...
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Dynamic modeling of non-cylindrical curved viscoelastic single-walled carbon nanotubes based on the second gradient theory
PublikacjaThis paper is devoted to the theoretical study of the dynamic response of non-cylindrical curved viscoelastic single-walled carbon nanotubes (SWCNTs). The curved nanotubes are largely used in many engineering applications, but it is challenging in understanding mechanically the dynamic response of these curved SWCNTs when considering the influences of the material viscosity. The viscoelastic damping effect on the dynamic response...
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Tuning of the Anti-Breast Cancer Activity of Betulinic Acid via Its Conversion to Ionic Liquids
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Role of the Synergistic Interactions of Environmental Pollutants in the Development of Cancer
PublikacjaThere is a growing awareness that the large number of environmental pollutants we are exposed to on a daily basis are causing major health problems. Compared to traditional studies that focus on individual pollutants, there are relatively few studies on how pollutants mixtures interact. Several studies have reported a relationship between environmental pollutants and the development of cancer, even when pollutant levels are below...
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Implementing a CSR Strategy in a Small Enterprise - a Case Study
PublikacjaAs a result of employees’ meetings conducted according to Kaizen workshops formula and seeking new development directions for the company (including CSR actions) various product and service innovations have been implemented. Also a market niche has been discovered, and as a consequence the company gained another profitable aspect of the business activity. The atmosphere and contribution in performing tasks have improved among...
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Gastroesophageal Reflux Disease in Children with Interstitial Lung Disease
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Cellular uptake of biotransformed graphene oxide into lung cells
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Sensors integration in the smart home environment - a proposal to solve the problem with user identification
PublikacjaIn this preliminary study we, investigate the possibility of user recognition techniques suitable on smart home devices like chairs, beds, aiming for low–power, high accuracy and quick response time. We propose the two well know technique: voice speaker recognition and accelerometer signal from device mounted on the chair, and the third one optical system basing on IR LED transmitter/receiver circuit. The preliminary results proved...
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Molecular identification and genotyping of Staphylococci: genus, species, strains, colnes, lineages, and interspecies exchanges
PublikacjaStaphylococci are increasingly recognized as etiological agents of many opportunistic human and animal infections, emphasizing the need for a rapid and accurate identification, even to a genotypical level of these bacteria. In the recent years, there has been a significant progress in typing and phylogenetic study of Staphylococcus species. Here, we describe molecular methods used in taxonomy as well as staphylococci characterization....
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Effects of Column Base Flexibility on Seismic Response of Steel Moment-Frame Buildings
PublikacjaSteel Moment Resisting Frames (SMRFs) are very popular lateral load resisting systems in many seismically active regions. However, their seismic response is strongly dependent on the rotational fixity of column base connections. Despite many studies (both experimental and numerical) in this particular area, available approaches for estimating column base flexibility have been validated only against laboratory test data. In the...
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New Polymethoxyflavones from Hottonia palustris Evoke DNA Biosynthesis-Inhibitory Activity in An Oral Squamous Carcinoma (SCC-25) Cell Line
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DNAffinity: a machine-learning approach to predict DNA binding affinities of transcription factors
PublikacjaWe present a physics-based machine learning approach to predict in vitro transcription factor binding affinities from structural and mechanical DNA properties directly derived from atomistic molecular dynamics simulations. The method is able to predict affinities obtained with techniques as different as uPBM, gcPBM and HT-SELEX with an excellent performance, much better than existing algorithms. Due to its nature, the method can...
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Optical fiber aptasensor for label-free bacteria detection in small volumes
PublikacjaHighly sensitive devices for fast bacteria detection are sought to be developed with the task of quantifying the worldwide problem of pathogenic bacteria and thus helping to take control over spreading bacterial infections. This work concerns a sensing solution based on microcavity in-line Mach-Zehnder interferometer (μIMZI) induced in an optical fiber. Such a device exhibits ultrahigh sensitivity to refractive index changes...
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T cell Activation Is Driven by an ADP-Dependent Glukosinase Linking Enhanced Glycolysis with Mitochondrial Reactive Oxygen Species Generation
PublikacjaMitochondria-originating reactive oxygen species control T cell receptor (TCR)-induced gene expression. Here, we show that TCR-triggered activation of ADP-dependent glucokinase (ADPGK), an alternative, glycolytic enzyme typical for Archaea, mediates generation of the oxidative signal. We also show that ADPGK is localized in the endoplasmic reticulum and suggest that its active site protrudes toward the cytosol. The ADPGK-driven...
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Common variants of DNA repair genes and malignant melanoma
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Correction: Profiles of a broad spectrum of epigenetic DNA modifications in normal and malignant human cell lines: Proliferation rate is not the major factor responsible for the 5-hydroxymethyl-2′-deoxycytidine level in cultured cancerous cell lines
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Deep Learning-based Recalibration of the CUETO and EORTC Prediction Tools for Recurrence and Progression of Non–muscle-invasive Bladder Cancer
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A procedure for elastoplastic hardening function identification.
PublikacjaThe inverse analysis method for identifying a nonlinear hardening function,which governs a plastic yielding of soil and rock materials in the framework of elastoplastic theory is presented. A concept of two stage finite element based on spatial discretization of computational space and hardening function space is introduced. The proposed inverse analysis can be classified as the output least squares method. The Levenberg Marquard...
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Small cell carcinoma, NOS - Female, 73 - Tissue image [12060630017623461]
Dane BadawczeThis is the histopathological image of BRONCHUS AND LUNG tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.