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Wyniki wyszukiwania dla: TCT-DP
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Therapeutic Potential of Carnosine and Its Derivatives in the Treatment of Human Diseases
PublikacjaDespite significant progress in the pathogenesis, diagnosis, treatment, and prevention of cancer and neurodegenerative diseases, their occurrence and mortality are still high around theworld. The resistance of cancer cells to the drugs remains a significant problem in oncology today,while in the case of neuro-degenerative diseases, therapies reversing the process are still yet to be found. Furthermore, it is important to seek new...
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Real-time isothermal DNA amplification monitoring in picoliter volumes using an optical fiber sensor
PublikacjaRolling circle amplification (RCA) of DNA can be considered as a great alternative to the gold standard polymerase chain reaction (PCR), especially during this pandemic period, where rapid, sensitive, and reliable test results for hundreds of thousands of samples are required daily. This work presents the first research to date on direct, real-time and label-free isothermal DNA amplification monitoring using a microcavity in-line...
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Catalytic Mechanism of Non-Target DNA Cleavage in CRISPR-Cas9 Revealed by Ab Initio Molecular Dynamics
PublikacjaCRISPR-Cas9 is a cutting-edge genome editing technology, which uses the endonuclease Cas9 to introduce mutations at desired sites of the genome. This revolutionary tool is promising to treat a myriad of human genetic diseases. Nevertheless, the molecular basis of DNA cleavage, which is a fundamental step for genome editing, has not been established. Here, quantum–classical molecular dynamics (MD) and free energy methods are used...
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Structure-property relationships in peroxide-assisted blends of poly(ε-caprolactone) and poly(3-hydroxybutyrate)
PublikacjaPoly(ε-caprolactone) and poly(3-hydroxybutyrate) (PCL/PHB) blends in two weight ratios (75/25 and 50/50) were reactively compatibilized in the presence of di-(2-tert-butyl-peroxyisopropyl)-benzene and dicumyl peroxide as free radical initiators. Rheological, mechanical, thermal properties and morphological features, as well as the chemical structure of PCL/PHB blends were investigated. It was found that regardless of PCL/PHB blend...
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Advanced oxidation processes (AOPs) based wastewater treatment - unexpected nitration side reactions - a serious environmental issue: A review
PublikacjaChemical compounds containing nitro group (nitro-products) are a one of toxic by-products, that can be formed during wastewater treatment processes. In case of presence of nitrite or nitrate ions, the formation of nitro-products during advanced oxidation processes (AOPs) is very common. It is caused by the reactive nitrogen species (RNs) such as nitrate radical (NO3•), nitrite radical (NO2•), nitrogen oxide radical (NO•) and peroxynirite...
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Seven Different Lighting Conditions in Photogrammetric Studies of a 3D Urban Mock-Up
PublikacjaOne of the most important elements during photogrammetric studies is the appropriate lighting of the object or area under investigation. Nevertheless, the concept of “adequate lighting” is relative. Therefore, we have attempted, based on experimental proof of concept (technology readiness level—TRL3), to verify the impact of various types of lighting emitted by LED light sources for scene illumination and their direct influence...
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Probabilistic assessment of SMRFs with infill masonry walls incorporating nonlinear soil-structure interaction
PublikacjaInfill Masonry Walls (IMWs) are used in the perimeter of a building to separate the inner and outer space. IMWs may affect the lateral behavior of buildings, while they are different from those partition walls that separate two inner spaces. This study focused on the seismic vulnerability assessment of Steel Moment-Resisting Frames (SMRFs) assuming different placement of IMWs incorporating nonlinear Soil-Structure Interaction (SSI)....
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A comparative study of pentanol (C5 alcohol) and kerosene blends in terms of gas turbine engine performance and exhaust gas emission
PublikacjaThe growing demand for sustainable and clean energy sources provides the incentive for the development of alternative fuels. Simultaneously, the development of gas turbine technologies with flexible fuel supply systems enables the use of alternative non-fossil fuels that can play key roles in contributing to global efforts in meeting emissions targets. This paper presents the current state of knowledge on the production and potential...
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Influence of Surface-Modified Montmorillonite Clays on the Properties of Elastomeric Thin Layer Nanocomposites
PublikacjaIn recent years, polyurethane nanocomposites have attracted more attention due to the massive demand for materials with increasingly exceptional mechanical, optical, electrical, and thermal properties. As nanofillers have a high surface area, the interaction between the nanofiller and the polymer matrix is an essential issue for these materials. The main aim of this study is to validate the impact of the montmorillonite nanofiller...
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Metabolic Profiles of New Unsymmetrical Bisacridine Antitumor Agents in Electrochemical and Enzymatic Noncellular Systems and in Tumor Cells
PublikacjaNew unsymmetrical bisacridines (UAs) demonstrated high activity not only against a set of tumor cell lines but also against human tumor xenografts in nude mice. Representative UA compounds, named C-2028, C-2045 and C-2053, were characterized in respect to their physicochemical properties and the following studies aimed to elucidate the role of metabolic transformations in UAs action. We demonstrated with phase I and phase II enzymes...
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Relay-aided Wireless Sensor Network Discovery Algorithm for Dense Industrial IoT utilizing ESPAR Antennas
PublikacjaIndustrial Internet of Things (IIoT) applicationsrequire reliable and efficient wireless communication. Assumingdense Wireless Sensor Networks (WSNs) operating in a harshenvironment, a concept of a Time Division Multiple Access(TDMA) based WSN enriched with Electronically SteerableParasitic Array Radiator (ESPAR) antennas is proposed andexamined in this work. The utilized...
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Blockchain technologies to address smart city and society challenges
PublikacjaNew Information and Communications Technologies (ICT) are changing the way in which the world works. These technologies provide new tools to face the issues of contemporary society (poverty, migrations, sustainable development challenges, governance, etc.). Among them, blockchain emerge as a disruptive technology able to make things in a completely different and innovative way. They can provide solutions where before there were...
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Novel molecules containing structural features of NSAIDs and 1,2,3-triazole ring: Design, synthesis and evaluation as potential cytotoxic agents
PublikacjaFor the first time the template containing structural features of more than one NSAIDs and the 1,2,3-triazole ring was explored for the identification of potential cytotoxic agents. These new and complex molecules were predicted to be effective inhibitors of PDE4B by molecular modelling studies in silico. The multi-step synthesis of these compounds were carried out starting from the well-known drug nimesulide and involved the use...
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Nowe protokoły transportowe w sieciach IP. Analiza porównawcza wybranych mechanizmów w protokołach SCTP i QUIC
PublikacjaZestaw protokolarny TCP/IP opisuje podstawową koncepcję organizacji pracy Internetu. Z tej racji jest przedmiotem zainteresowania oraz stałych analiz zarówno operatorów, użytkowników, jak też badaczy zagadnień sieciowych, a wreszcie i projektantów, by reagować na pojawiające się nowe potrzeby. Działania takie, przynajmniej częściowo, są wymuszane zarówno przez wymagania nowych multimedialnych aplikacji - na najwyższym poziomie...
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Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRL/MpJ mouse
PublikacjaBackground: The MRL/MpJ mouse is a laboratory inbred strain known for regenerative abilities which are manifested by scarless closure of ear pinna punch holes. Enhanced healing responses have been reported in other organs. A remarkable feature of the strain is that the adult MRL/MpJ mouse retains several embryonic biochemical characteristics, including increased expression of stem cell markers. Results: We explored the transcriptome...
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Wpływ wybranych parametrów środowiska na przebieg degradacji rur okładzinowych ze stali P110
PublikacjaMateriały używane na orurowanie odwiertów w poszukiwaniu i wydobyciu ropy i gazu poddawane są niekorzystnym warunkom eksploatacji takich jak: podwyższona temperatura, wysokie ciśnienie, turbulentny przepływ korozyjnych cieczy z zawieszonymi cząstkami stałymi. Jednym z gatunków stali używanych do produkcji rur okładzinowych jest stal P110 (za normą API 5CT) będąca stalą średnio-węglową, niskostopową o wysokiej wytrzymałości. Celem...
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Actions Speak Louder Than Words: Health Behaviours and Literacy of Future Healthcare Professionals
PublikacjaOur everyday behaviours in life can positively and negatively impact our health, thus cumulatively shaping our lifestyles as more or less healthy. These behaviours are often determined by our knowledge, literacy, motivations and socioeconomic backgrounds. The authors aimed to assess health behaviours and explore variables that may affect persons studying to become future healthcare professionals in Poland. This study was conducted...
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Hybrid constructed wetlands for the National Parks in Poland - a case study, requirements, dimensioning, preliminary results
PublikacjaWater and wastewater management, especially in rural areas, greatly affects loads of nutrients discharged to the Baltic Sea. In Poland, this management is unbalanced because of the dispersed development and in many locations con struction of sewerage system is uneconomic or even impossible. For this reason, a significant part of sewage from single-family houses in rural areas must be discharged into domestic sewage systems. The...
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Using Decisional DNA to Enhance Industrial and Manufacturing Design: Conceptual Approach
PublikacjaDuring recent years, manufacturing organizations are facing market changes such as the need for short product life cycles, technological advancement, intense pressure from competitors and the continuous customers’ expectation for high quality products at lower costs. In this scenario, knowledge and its associated engineering/management of every stage involved in the industrial design has become increasingly important for manufacturing...
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Identification of antigen Ag43 in uropathogenic Escherichia coli Dr+ strains and defining its role in the pathogenesis of urinary tract infections
PublikacjaUrinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are among the most common bacterial infectious diseases in the developed world. The urovirulence of UPEC is mainly associated with the surface-exposed fimbrial adhesins and adhesins of the autotransporter (AT) family. The best studied of theses proteins is antigen 43 (Ag43) mediating cell aggregation, adhesion and biofilm development as the causes of...
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Seasonal changes in organotin compounds in water and sediment samples from the semi-closed Port of Gdynia
PublikacjaThe effect of seasonal changes on the distribution of organotin compounds (OTC) in the sediments and seawaterfrom the docks of the Port of Gdynia was investigated. Sediment and seawater samples were collectedfrom four industrial docks in February (winter) and June (summer) in 2009. The samples were analyzed forbutyltin, phenyltin, octyltin, and tricyclohexyltin (total of 9 OTC derivatives). The fine fraction (b0.063 mm)accumulated...
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Polyurethane porous scaffolds (PPS) for soft tissue regenerative medicine applications
PublikacjaTissue engineering requires suitable polymeric scaffolds, which act as a physical support for regenerated tissue. A promising candidate might be polyurethane (PUR) scaffold, due to the ease of the PUR properties design, which can be adjusted directly to the intended purpose. In this study, we report a successful fabrication of porous polyurethane scaffolds (PPS) using solvent casting/particulate leaching technique combined with...
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The issues of participation in didactics of design. Case studies
PublikacjaThis article seeks to present and assess the usefulness of didactic methods aimed at preparing future architects for their role in the process of social participation. The article focuses on [a] a general overview of selected participation methods and tools, along with the examples of their application in the context of spatial management in Poland; [b] an overview of teaching methods used with a view to enhancing participation...
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New technologies and diffusion of innovative financial products: Evidence on exchange-traded funds in selected emerging and developed economies
PublikacjaExchange-traded funds (ETFs) are one of the most rapidly-expanding categories of innovative financial products that have been introduced on many financial markets, in both emerging and developed economies. Our research contributes to the present state of knowledge by examining factors, including information and communication technologies (ICTs), influencing the diffusion of ETFs. In our research, we consider also the impact of...
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Web-based real-time simulation system
PublikacjaThe paper presents the development of a simulation system composed of a real-time plant simulator with real-time controller included in the software-in-the-loop structure using web-based communication. The client-server architecture build in a TCP/IP network environment was introduced, where the server is a computing unit for real-time high temporal resolution plant simulation (and optionally also as controllers' platform) and...
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Badanie sieci świadomości sytuacyjnej dla infrastruktury elektroenergetycznej
PublikacjaWspółczesne systemy elektroenergetyczne są narażone na nowe rodzaje zagrożeń. Są one spowodowane lukami w zabezpieczeniach oraz słabościami architektonicznymi związanymi z szerszym zastosowaniem technologii teleinformatycznych (ICT) w tych systemach. Połączenie sieci elektroenergetycznych z Internetem naraża je na nowego rodzaju niebezpieczeństwa, takie jak ataki APT (ang. Advanced Persistent Threats) lub rozproszona odmowa usługi...
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Processing and structure–property relationships of natural rubber/wheat bran biocomposites
PublikacjaIn this work, wheat bran was used as cellulosic filler in biocomposites based on natural rubber. The impact of wheat bran content [ranging from 10 to 50 parts per hundred rubber (phr)] on processing, structure, dynamic mechanical properties, thermal properties, physico-mechanical properties and morphology of resulting biocomposites was investigated. For better characterization of interfacial interactions between natural rubber...
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Genotoxicity of selected pharmaceuticals, their binary mixtures, and varying environmental conditions – study with human adenocarcinoma cancer HT29 cell line
PublikacjaPharmaceutical residues are present in the environment in mixtures and their adverse effects may also result from interactions that occur between compounds. Studies presented in this work focus on genotoxicity of pharmaceuticals from different therapeutic groups in mixtures and in individual solutions impacted with different environmental conditions assessed using comet assay (alkaline approach). Binary mixtures of pharmaceuticals...
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Microbial and chemical quality assessment of the small rivers entering the South Baltic. Part I: Case study on the watercourses in the Baltic Sea catchment area
PublikacjaThe area of the Coastal Landscape Park (CLP) due to its location is extremely attractive touristic area. In the summer season, a significant increase in population density is observed, which influences surface water quality. Large numbers of tourists generate an increased amount of municipal wastewater, being treated in local treatment plants and discharged into rivers and streams. The paper presents preliminary research from summer...
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City scan as a tool to assess resilience challenges and vulnerabilities at the community level
PublikacjaThe majority of the world’s population lives in cities and cities are the key to achieving resilience. Local governments own only part of the land and can only partially decide about measures that should be taken ‘on the ground’. Local governments are therefore highly dependent on individuals, communities, and businesses to adapt and transform and take action in their own backyards or neighbourhoods. Since, for many people, climate...
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Fungal co-culture improves the biodegradation of hydrophobic VOCs gas mixtures in conventional biofilters and biotrickling filters
PublikacjaThe present study systematically evaluated the potential of Candida subhashii, Fusarium solani and their consortium for the abatement of n-hexane, trichloroethylene (TCE), toluene and α-pinene in biofilters (BFs) and biotrickling filters (BTFs). Three 3.2 L BFs packed with polyurethane foam and operated at a gas residence time of 77 s with an air mixture of hydrophobic volatile organic compounds (VOCs) were inoculated with C. subhashii,...
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System monitoringu rozdzielnic kampusu Politechniki Gdańskiej
PublikacjaW artykule opisano koncepcję, realizację programową oraz stanowisko testowe systemu monitoringu rozdzielnic kampusu Politechniki Gdańskiej. Zaproponowano realizację sprzętową oraz opracowano realizację programową systemu monitoringu rozdzielnic dla dwóch budynków: Gmachu Głównego i Centrum Obsługi Technicznej. Ważną cechą opracowanego rozwiązania jest jego skalowalność, gdyż docelowo system monitoringu będzie obejmował wszystkie...
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Mechanism of recognition of parallel G-quadruplexes by DEAH/RHAU helicase DHX36 explored by molecular dynamics simulations
PublikacjaBecause of high stability and slow unfolding rates of G-quadruplexes (G4), cells have evolved specialized helicases that disrupt these non-canonical DNA and RNA structures in an ATP-dependent manner. One example is DHX36, a DEAH-box helicase, which participates in gene expression and replication by recognizing and unwinding parallel G4s. Here, we studied the molecular basis for the high affinity and specificity of DHX36 for parallel-type...
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Mathematical modelling of gasification process of sewage sludge in reactor of negative CO2 emission power plant
PublikacjaSewage sludge is a residue of wastewater processing that is biologically active and consists of water,organic matter, including dead and alive pathogens, as well as organic and inorganic contaminants suchas polycyclic aromatic hydrocarbons (PAHs) and heavy metals. Due to the nature of sewage sludge and itspossible influence on human health and wellbeing, it is a subject of various regulations. Currently,sewage sludge is considered...
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Enhancing seismic performance of rigid and semi-rigid connections equipped with SMA bolts incorporating nonlinear soil-structure interaction
PublikacjaNowadays, using smart connections can improve the performance of buildings with some recentering features that are from the superelastic behavior of Shape Memory Alloys (SMAs). It seems that there is different rigidity between the designed connection and the real one in Steel Moment-Resisting Frames (SMRFs), which can be considered as a problematic issue due to the importance of connections in seismic performance assessment. This...
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Analysis of Residual Stresses and Dislocation Density of AA6082 Butt Welds Produced by Friction Sir Welding
PublikacjaThe Friction Stir Welding (FSW) method was employed to join AA6082 sheets. The welds were produced with different tool traverse speed (200 and 250 mm/min), rotational speed (1000 and 1250 RPM) and tool tilt angle (0 and 2 deg). Based on the analysis of XRD patterns, the total precipitation volume fractions in the nugget zones and the base material were calculated. The FSW process resulted in a reduction in the fraction of precipitates...
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Usuwanie lotnych związków organicznych z fazy gazowej z zastosowaniem cieczy jonowych
PublikacjaUżycie cieczy jonowej do usuwania LZO jest limitowane przez rozpuszczalność usuwanych związków. Dane literaturowe sugerują, że ciecze jonowe jako faza membranowa mogą być z powodzeniem stosowane do selektywnej separacji węglowodorów aromatycznych z mieszanin węglowodorów aromatycznych i alifatycznych. Przedmiotem pracy było kompleksowe opisanie procesu separacji LZO z fazy gazowej z uwzględnieniem czynników wpływających na efektywność...
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TRWAŁOŚĆ PROJEKTU ERASMUS+ SP4CE - STUDIUM PRZYPADKU
PublikacjaProjekt ERASMUS+ Partnerstwo Strategiczne na Rzecz Kreatywności i Przedsiębiorczości (ang. Strategic Partnership for Creativity and Entrepreneurship - SP4CE) dotyczył wdrażania i upowszechniania innowacyjnych rozwiązań wzmacniających współpracę europejską w dziedzinie kształcenia i szkolenia zawodowego. Działania projektowe były związane z promowaniem innowacyjnych praktyk w edukacji oraz szkoleniach poprzez wspieranie spersonalizowanych...
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User experience and user interface (UX/UI) design of Greencoin mobile application.
PublikacjaThe aim of the Greencoin mobile application is to encourage its users to change their behavior and to act pro-ecologically. The pilot version of the application will operate within the city of Gdańsk. To keep the app’s user base as large as possible, the graphical user interface should be attractive to the broadest possible audience, and the application itself should be easy and fun to use. This work is a continuation of studies...
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The role of aluminium in metal–organic frameworks derived carbon doped with cobalt in electrocatalytic oxygen evolution reaction
PublikacjaWater electrolysis is one of the most crucial processes in the development of new energy sources, where ultra-clean fuel is produced - hydrogen. Oxygen evolution reaction (OER) is the sluggish process of overall water splitting. Therefore, this study presents the design, characterization and electrochemical study of cobalt-based electrocatalysts embedded into porous carbons derived from an Al-metal–organic...
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BETWEEN IDEA AND INTERPRETATION - DESIGN PROCESS AUGMENTATION
PublikacjaThe following paper investigates the idea of reducing the human digital intervention to a minimum during the advanced design process. Augmenting the outcome attributes beyond the designer's capabilities by computational design methods, data collection, data computing and digital fabrication, altogether imitating the human design process. The primary technical goal of the research was verification of restrictions and abilities used...
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Looking for New Ideas of Public Space – Public Space Projects in Gdansk Reinforced by Art Activities
PublikacjaRevitalization of public open spaces is a complex enterprise in Poland in terms of the art, cultural andinformation aspects of this process. Simultaneously the public space should play an important role whenbuilding the quality of revitalization programs and the quality of city development. The new art and culturalactivities are the revitalization tools, which are also the good examples of bottom up ideas helping to start aprocess...
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Phytoplankton communities of polar regions–Diversity depending on environmental conditions and chemical anthropopressure
PublikacjaThe polar regions (Arctic and Antarctic) constitute up to 14% of the biosphere and offer some of the coldest and most arid Earth's environments. Nevertheless several oxygenic phototrophs including some higher plants, mosses, lichens, various algal groups and cyanobacteria, survive that harsh climate and create the base of the trophic relationships in fragile ecosystems of polar environments. Ecosystems in polar regions are characterized...
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Modyfikacja programu szkolenia kierowców wieloosiowych pojazdów specjalnych, uwzględniająca wyniki badań eksperymentalnych i symulacyjnych eksplozyjnego uszkodzenia opon
PublikacjaAktualnie obowiązujący program szkolenia kierowców specjalnych pojazdów wojskowych obejmuje zagadnienia związane z budową pojazdu, zasadami jego poprawnej eksploatacji i techniką jazdy w podstawowym zakresie. Program porusza, co prawda również problemy związane z prawidłowym postępowaniem przy wystąpieniu awarii układu napędowego, ale nie obejmuje kompleksowo techniki jazdy w przypadku poważnego uszkodzenia jednego lub więcej kół...
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Novel 2-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)-1-(1,3,5-triazin-2-ylamino)guanidine derivatives: Inhibition of human carbonic anhydrase cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII, anticancer activity, and molecular modeling studies
PublikacjaA series of novel 2-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)-1-(6-substituted-4-chloro-1,3,5-triazin-2-ylamino)guanidine derivatives 9–20 have been synthesized by substitution of chlorine atom at the 1,3,5-triazine ring in compounds 5–8 with 3- or 4-aminobenzenesulfonamide and 4-(aminomethyl)benzenesulfonamide hydrochloride. All the synthesized compounds were evaluated for their inhibitory activity toward hCA I, II,...
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Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid
PublikacjaBackground: Although Mycophenolic Acid (MPA) is applied as prodrugs in clinic as an immunosuppressant, it also possesses anticancer activity. MPA acts as Inosine-5’-Monophosphate Dehydrogenase (IMPDH) inhibitor, where the carboxylic group at the end of the side chain interacts with Ser 276 of the enzyme via hydrogen bonds. Therefore, MPA derivatives with other polar groups indicated high inhibition too. On the other hand, potent...
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Przemiany metaboliczne in vitro niesymetrycznych bisakrydyn w układach bezkomórkowych i w komórkach nowotworowych oraz określenie wpływu tych pochodnych na aktywność enzymów metabolizujących leki
PublikacjaPrzedmiotem badań prowadzonych w ramach niniejszej pracy doktorskiej są cztery niesymetryczne bisakrydyny: C-2028, C-2041, C-2045 i C-2053, wykazujące wysoką aktywność cytotoksyczną [Konopa i in. 2019]. Otrzymane wyniki wskazały, że każdy z pierścieni (imidazoakrydonu i 1-nitroakrydyny) obecny w strukturze badanych związków odgrywa inną rolę w wykazywanych przez nie właściwościach fizykochemicznych i biologicznych. Właściwości...
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Experimental Investigation of the Thermal Performance of a Wickless Heat Pipe Operating with Different Fluids: Water, Ethanol, and SES36. Analysis of Influences of Instability Processes at Working Operation Parameters
PublikacjaIn this study, the influences of different parameters on performance of a wickless heat pipe have been presented. Experiments have been carried out for an input power range from 50 W to 300 W, constant cooling water mass flow rate of 0.01 kg/s, and constant temperature at the inlet to condenser of 10 C. Three working fluids have been tested: water, ethanol, and SES36 (1,1,1,3,3-Pentafluorobutane) with different filling ratios (0.32,...
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Tuning of microstructure in engineered poly (trimethylene terephthalate) based blends with nano inclusion as multifunctional additive
PublikacjaImmiscible blends and their composites are heterogeneous and have variable morphology due to variation in mesophase regions. Tuning, i.e. controlling the phase dimension is important, thereof we report a “super-combo” effect of multiwalled carbon nanotubes (MWCNTs) in poly (trimethylene terephthalate)/polypropylene (PTT/ PP) blend system. MWCNTs act as a good reinforcing agent and compatibilizer in the otherwise immiscible PTT/...
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LED Light Sources and Their Complex Set-Up for Visually and Biologically Effective Illumination for Ornamental Indoor Plants
PublikacjaOrnamental plants are often used in indoor environments as part of biophilic design to improve the health and wellbeing of occupants, and to support sustainable, green architecture. Unfortunately, many plants do not thrive and need to be continuously replaced, which is economically unsustainable. The wavelengths and spectrum ratio of commonly used light sources such as light emitting diode (LED), and the lack of an appropriate...