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Wyniki wyszukiwania dla: CHIRAL PHARMACEUTICALS
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Towards an analysis framework for operational risk coupling mode: A case from MASS navigating in restricted waters
PublikacjaMaritime Autonomous Surface Ships (MASSs) constitute highly interconnected and tightly coupled multistate systems. Incorporating the coupling effects of both interactions and dependencies is centrally important to ensure navigation safety of MASSs. This paper proposes a framework for examining the coupling effects in the operational modes (OM) of MASSs. Failure Modes (FMs) of MASSs related to interactions with the environment and...
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How can HSR promote inter-city collaborative innovation across regional borders?
PublikacjaMany studies have shown that high-speed rail (HSR) can reshape the spatial pattern of economic geography. However, there needs to be more logical argumentation and rigorous empirical design on the paths and mechanisms involved. This paper considers the impact of the border effect on HSR links and innovation clusters from the perspective of inter-regional collaborative innovation. It provides a logical and compact theoretical...
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Facilitating free travel in the Schengen area—A position paper by the European Association for Biometrics
PublikacjaDue to migration, terror-threats and the viral pandemic, various EU member states have re-established internal border control or even closed their borders. European Association for Biometrics (EAB), a non-profit organisation, solicited the views of its members on ways which biometric technologies and services may be used to help with re-establishing open borders within the Schengen area while at the same time mitigating any adverse...
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A risk comparison framework for autonomous ships navigation
PublikacjaMaritime autonomous surface ships (MASS) may operate in three predefined operational modes (OM): manual, remote, or autonomous control. Determining the appropriate OM for MASS is important for operators and competent authorities that monitor and regulate maritime traffic in given areas. However, a science-based approach to this respect is currently unavailable. To assist the selection of the proper OM, this study presents a risk-based...
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Theory and application of Near-infrared spectroscopy
PublikacjaIn recent years one can observe a significant increase in the requirements on quality control in all industrial sectors. The growing number of involved analyses makes the traditional, time consuming, requiring use of large quantities of reagents, thus expansive methods inconvenient especially for industrial applications. Fortunately, there is a very fast, cheap and not invasive analytical method that is increasingly used in qualitative...
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Intelligent microbearing project with memory of stress-strain history
PublikacjaTaking into account the increasing need of intelligent micro-bearing with memory, this paper presents the optimization, simulation and practical application of operating parameters(load carrying capacity, friction forces, friction coefficient, wear), simulation for hydrodynamic HDD micro-bearing with curvilinear nano-grooved journal profile. One of the reason of such journal profile is that this journal profile contributes to the...
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The effect of thermal modification on the quality of the milled surface of beech and pine wood
PublikacjaThe article deals with the effect of thermal modification on the quality of the created surface during milling on CNC milling cutters. The quality of the created surface is evaluated based on surface roughness, specifically its roughness parameter Ra. The observed surface is created by a shank cutter with a diameter of 20 mm and three cutting edges in a spiral at a standard speed of 18,000. min-1. The article compares thermally...
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Which Simulator to Choose for Next Generation Wireless Network Simulations? NS-3 or OMNeT++
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Novel applications of noise in sensing and communications
PublikacjaPrzedstawiono zaproponowane w ostatnich latach sposoby wykorzystania szumów do wykrywania gazów, jako źródła informacji o atmosferze otaczającej czujnik. Ponadto, przedstawiono możliwości wykorzystania zjawisk losowych do bezpiecznej komunikacji.
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Central Vagotonic Effects of Atropine Modulate Spectral Oscillations of Sympathetic Nerve Activity
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The supramolecular organization of self-assembling chlorosomal bacteriochlorophyll c, d, or e mimics
PublikacjaBacteriochlorophylls (BChls) c, d, and e are the main light-harvesting pigments of green photosynthetic bacteria that self-assemble into nanostructures within the chlorosomes forming the most efficient antennas of photosynthetic organisms. All previous models of the chlorosomal antennae, which are quite controversially discussed because no single crystals could be grown so far from these organelles, involve a strong hydrogen-bonding...
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Fluctuation-Enhanced Sensing for Biological Agent Detection and Identification
PublikacjaPrzedstawiono wcześniejsze wyniki badań dotyczące trzech różnych sposobów wykrywania obecności substancji biologicznych za pomocą zjawisk fluktuacyjnych: 1) wirusów wnikających do komórek, 2) zapachów emitowanych przez mikroby, 3) rozkładu widma i wartości chwilowych szumów podczas rozpraszania światła używanego do wykrywania zarodników na podstawie wyznaczenia współczynnika dyfuzji opisująceo ich ruch.We survey and show our earlier...
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Antibody Cross-Reactivity in Serodiagnosis of Lyme Disease
PublikacjaLyme disease is a tick-borne disease caused by spirochetes belonging to the Borrelia burgdorferi sensu lato complex. The disease is characterized by a varied course; therefore, the basis for diagnosis is laboratory methods. Currently, a two-tiered serological test is recommended, using an ELISA as a screening test and a Western blot as a confirmatory test. This approach was introduced due to the relatively high number of false-positive...
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Clinical studies of detecting COVID-19 from exhaled breath with electronic nose
PublikacjaThe COVID‑19 pandemic has attracted numerous research studies because of its impact on society and the economy. The pandemic has led to progress in the development of diagnostic methods, utilizing the polymerase chain reaction (PCR) as the gold standard for coronavirus SARS‑CoV‑2 detection. Numerous tests can be used at home within 15 min or so but of with lower accuracy than PCR. There is still a need for point‑of‑care tests available...
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Extracting functional groups of ALLINI to design derivatives of FDA‐approved drugs: Inhibition of HIV‐1 integrase
PublikacjaHIV‐1 integrase (IN) is crucial for integration of viral DNA into the host genome and a promising target in development of antiretroviral inhibitors. In this work, six new compounds were designed by linking the structures of two different class of HIV‐1 IN inhibitors (active site binders and allosteric IN inhibitors (ALLINIs)). Among newly designed compounds, INRAT10b was found most potent HIV‐1 IN inhibitor considering different...
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Experimental and Theoretical Insights into the Intermolecular Interactions in Saturated Systems of Dapsone in Conventional and Deep Eutectic Solvents
PublikacjaSolubility is not only a crucial physicochemical property for laboratory practice but also provides valuable insight into the mechanism of saturated system organization, as a measure of the interplay between various intermolecular interactions. The importance of these data cannot be overstated, particularly when dealing with active pharmaceutical ingredients (APIs), such as dapsone. It is a commonly used anti-inflammatory and...
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Optimizing Construction Engineering Management Using Metaheuristic Methods and Bayesian Networks
PublikacjaThe construction of buildings invariably involves time and costs, and disruptions impact ongoing construction projects. Crisis situations in management strategies, structural confusion, and finan-cial miscalculations often arise due to misguided decision-making. This article proposes a method that combines the learning of Bayesian Networks and heuristic techniques to optimize deci-sion-making processes in construction scheduling....
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Room temperature synthesis of water-dispersible Ln 3+ :CeF 3 (Ln = Nd, Tb) nanoparticles with different morphology as bimodal probes for fluorescence and CT imaging
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Mechanical, durability, depolluting and electrical properties of multifunctional mortars prepared with commercial or waste carbon-based fillers
PublikacjaCarbon-based fillers from industrial wastes and commercial ones were compared to improve the properties of lime-based mixes. As commercial fillers, graphene nanoplatelets and activated carbon were used, whereas as industrial wastes a char obtained by the gasification of biomasses and a used foundry sand were chosen. Carbon-based wastes were found to be a good cost-effective alternative to commercial carbon based fillers to increase...
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Organic solvents aggregating and shaping structural folding of protein, a case study of the protease enzyme
PublikacjaLow solubility of reactants or products in aqueous solutions can result in the enzymatic catalytic reactions that can occur in non-aqueous solutions. In current study we investigated aqueous solutions containing different organic solvents / deep eutectic solvents (DESs) that can influence the protease enzyme's activity, structural, and thermal stabilities. Retroviral aspartic protease enzyme is responsible for the cleavage of the...
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The possibility of application of the potentiometric sensor with all-solid-state electrodes containing lipid-polymer membranes for classification of tested black leaf teas in terms of their quality
PublikacjaPotentiometric sensor with all-solid-state electrodes containing lipid-polymer membranes for a set of black leaf teas coming from four countries (China, India, Sri Lanka and Kenia) classification was applied. The tested tea samples were reassigned to quality classes marked with numbers I–V according to the information available. The sensor results of tea samples are presented in the form of radar charts. It was observed that, in...
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Metody i mikrosystemy pomiarowe impedancji do diagnostyki grubowarstwowychpowłok antykorozyjnych.**2003, 104 s. 90 rys. 18 tab. bibliogr. 106 poz. Rozprawa doktorska (04.03.2003 r.), Wydz. ETI. Promotor: prof. dr inż. R. Zielonko.
PublikacjaPraca jest rozprawą doktorską, której celem było opracowanie nowych metodpomiarowych i procedur diagnostycznych powłok antykorozyjnych, zwłaszczagrubowarstwowych, drogą identyfikacji parametrów impedancyjnych ich modeli(układów zastępczych), nadających się do realizacji praktycznej w mikrosys-temach pomiarowych przeznaczonych do pracy w terenie oraz realizacja przyk-ładowego mikrosystemu pomiarowo-diagnostycznego powłok...
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A novel analytical approach in the assessment of unprocessed Kaffir lime peel and pulp as potential raw materials for cosmetic applications
PublikacjaVolatile fraction of fruits is a rich source of bioactive and aroma compounds, which can be used in the cosmetics industry after meeting relevant criteria. This is particularly evident in citrus fruits, especially in Citrus hystrix, in which the headspace consists mainly of terpenes. Due to the insufficient sensitivity of analytical methods, essential oils are used in investigations in contrast to fresh fruits. Therefore, a novel...
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Superconductivity in the Cu(Ir1−xPtx)2Se4spinel
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Clinical characteristics, antihypertensive medication use and blood pressure control among patients with treatment-resistant hypertension
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From ashes to porous hierarchical nanocarbon electrode: Upcycling secondary waste materials through self-catalytic chemical vapour deposition
PublikacjaMetal and metal oxide particles are abundant in various ash-based wastes. Utilizing these as catalyst sources for the fabrication of carbon nanomaterials could present a valuable approach to reduce our reliance on non-renewable and costly catalyst sources, thereby facilitating large-scale nanomaterial production. In this context, secondary waste materials (SWMs) are by-products resulting from the (complete or partial) combustion...
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Electrochemistry meets enzymes: Investigation of the biotransformation pathway of C-1311 based on electrochemical simulation in comparison to in vitro methods.
PublikacjaThe knowledge of the metabolic pathways and the biotransformation of new drugs is one of the major challenges in pharmaceutical research. It is crucial for elucidation of degradation routes of the new biologically active compounds, especially in the area of possible toxicity. Conventional in vitro drug metabolism studies are based on incubating drug candidate with e.g. hepatocytes or, most importantly, liver cell microsomes and...
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A method for the production of D-tagatose using a recombinant Pichia pastoris strain secreting beta-D-galactosidase from Arthrobacter chlorophenolicus and a recombinant L-arabinose isomerase from Arthrobacter sp. 22c
PublikacjaD-Tagatose is a natural monosaccharide which can be used as a low-calorie sugar substitute in food, beverages and pharmaceutical products. It is also currently being tested as an anti-diabetic and obesity control drug. D-Tagatose is a rare sugar, but it can be manufactured by the chemical or enzymatic isomerization of D-galactose obtained by a beta-D-galactosidase-catalyzed hydrolysis of milk sugar lactose and the separation of...
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Czy ścieki oczyszczone stanowią istotne źródło farmaceutyków w środowisku wodnym?
PublikacjaJak dotąd nie zostały jeszcze wprowadzone regulacje prawne dotyczące stopnia redukcji mikrozanieczyszczeń i/lub ich maksymalnych stężeń na odpływie z oczyszczalni. Niemniej jednak zgodnie ze stanowiskiem Komisji Europejskiej i innych organizacji, istnieje potrzeba ich monitoringu oraz dopracowania metod usuwania mikrozanieczyszczeń w celu poprawy jakości wód będących odbiornikiem ścieków oczyszczonych. Dlatego też zachęca się OŚ...
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Migration of trace elements and radioisotopes to various fractions of solid wastes generated as a result of the sewage sludge incineration process
PublikacjaThe research was aimed at providing new knowledge in the field of chemical characteristics of solid waste generated in the process of combustion of sewage sludge in fluidized bed furnaces. The research material consisted of disposed fluidized beds (DFB), sewage sludge ash (SSA) and air pollution control residues (APC) from three Polish installations for the thermal treatment of sewage sludge. Natural radionuclides as well as anthropogenic...
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The impact of training and neurotrophins on functional recovery after spinal cord transection: cellular and molecular mechanisms contributing to motor improvement
PublikacjaBeneficial effects of locomotor training on the functional recovery after complete transection of the spinal cord indicate that in chronic spinal animals spontaneous recovery processes are enhanced and shaped by the training. The mechanisms of that use-dependent improvement are still not fully understood. This review tackles three aspects of this issue: (1) neurochemical attributes of functional improvement...
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Targeting Spike‐ACE2 Interface of SARS‐CoV‐2 and its Omicron Variant: A Comparative Screening of Potential Inhibitors for Existing and Anticipating Variants Using Molecular Modelling Approach
PublikacjaThe recent COVID pandemic has shown major impact on public health and economic crisis. Despite the development of many vaccines and drugs against the severe acute respiratory syndrome (SARS) coronavirus 2, the pandemic still persists. The continued spread of the virus is largely driven by the emergence of viral variants such as α, β, γ, delta, epsilon spike, omicron and its subvariants (BA.1,2,3) which can evade the current vaccines...
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Successive cytotoxicity control by evolutionary surface decorated electronic push-pull green ZnCr-LDH nanostructures: Drug delivery enlargement for targeted breast cancer chemotherapy
PublikacjaThe reason for the increasing bioavailability and biocompatibility of the porous nanomaterials in the presence of different (bio)molecules is still unknown. The role of difference functional groups and their interactions with the potential bioavailability and biocompatibility is of great importance. To investigate the potential contribution of the electronic effects (especially on the surface of the porous nanomaterials) on their...
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A fast time-frequency multi-window analysis using a tuning directional kernel
PublikacjaIn this paper, a novel approach for time-frequency analysis and detection, based on the chirplet transform and dedicated to non-stationary as well as multi-component signals, is presented. Its main purpose is the estimation of spectral energy, instantaneous frequency (IF), spectral delay (SD), and chirp rate (CR) with a high time-frequency resolution (separation ability) achieved by adaptive fitting of the transform kernel. We...
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The Emergence of ETFs in Asia-Pacific
PublikacjaThe major objective of this book is to contribute to the present state of knowledge by exploring empirical links between the processes of diffusion of financial innovations— exchange-traded funds—and growing deployment of ICT across Asia-Pacific countries, between 2004 and 2017. We examine the evolutionary patterns of ETFs on selected Asia-Pacific stock exchanges and verify the hypothesized relationship between increasing ICT penetration...
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Protect our right to light
Publikacja“The struggle for light” is how the Swiss architect Le Corbusier described the history of architecture in 1935. Today, with the skies crowded out by buildings in modern cities, those words should ring in the ears of policymakers and planners. Skyscraper construction is booming. China is the leader, last year completing 88 of the 143 buildings around the world that are taller than 200 metres (see ‘Vertical growth’). As the nation’s...
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The development of an indirect ELISA for the detection of goose parvovirus antibodies using specific VP3 subunits as the coating antigen
PublikacjaIn Poland, the leader in goose production in Europe, goose parovirus infection, or Derzsy’s disease (DD), must be reported to the veterinary administration due to the serious economic and epizootic threat to waterfowl production. Prophylactic treatment for DD includes attenuated live or inactivated vaccines. Moreover, the control of DD includes the monitoring of maternal derived antibody (MDA) levels in the offspring and antibody...
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Superconductivity in the Cu(Ir1-xPtx)2Se4 spinel
PublikacjaWe report the observation of superconductivity in the CuIr2Se4 spinel induced by partial substitution of Pt for Ir. The optimal doping level for superconductivity in Cu(Ir1-xPtx )2Se4 is x = 0.2, where Tc is 1.76 K. A superconducting Tc vs composition dome is established between the metallic, normal conductor CuIr2Se4 and semiconducting CuIrPtSe4. Electronic structure calculations show that the optimal Tc occurs near the electron count...
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Exploring the meaning of night shift placement in nursing education: A European multicentre qualitative study
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Ovarian tissue cryopreservation by stepped vitrification and monitored by X-ray computed tomography
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Rapid PD-L1 detection in tumors with PET using a highly specific peptide
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Corrigendum to “Rapid PD-L1 detection in tumors with PET using a highly specific peptide” [Biochemical and Biophysical Research Communications 483/1 (2017) 258–263]
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Determination of MDPBP in postmortem blood samples by gas chromatography coupled with mass spectrometry
PublikacjaMDPBP (1-(3,4-methylenedioxyphenyl)-2-(1-pyrrolidinyl)-1-butanone) is a new psychoactive substance sold on the black market. It has been a controlled drug of abuse in Poland and China since 2015 as some toxic and fatal cases connected with use of synthetic cathinone derivatives were observed. The fatal case outlined here concerns a 19 year-old man, who was found dead with an envelope containing white powder lying nearby the cadaver....
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DATA JOURNALS AND DATA PAPERS IN VARIOUS RESEARCH AREAS AND SCIENTIFIC DISCIPLINES – BIBLIOMETRIC ANALYSIS BASED ON INCITES
PublikacjaThe main aim of this work is to provide insight into a bibliometric analysis of Data Journals and Data Papers in terms of research areas, disciplines, publication year and country. In particular, we calculated many bibliometric indicators, especially: the number of publications and citations. Furthermore, this work also investigated the top 20 journals in which scientists published the largest number of Data Papers. It was found...
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Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site
PublikacjaAn important stage in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) life cycle is the binding of the spike (S) protein to the angiotensin converting enzyme-2 (ACE2) host cell receptor. Therefore, to explore conserved features in spike protein dynamics and to identify potentially novel regions for drugging, we measured spike protein variability derived from 791 viral genomes and studied its properties by molecular...
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QUANTITATIVE EASING POLICY AND ITS IMPACT ON THE GLOBAL ECONOMY
PublikacjaBased on the analysis of the impact of quantitative easing policies on the global economy, there was concluded that the world’s largest central banks and widespread debt stimulation have created the model of economic growth. This model was based on the productivity growth. The lack of productivity growth in the developed world, the active integration of developing countries (first of all China and India) in the global economy have...
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Evaluation of a new freezing protocol containing 20% dimethyl sulphoxide concentration to cryopreserve human ovarian tissue
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Reducing the Probability of Failure in Manufacturing Equipment by Quantitative FTA Analysis
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Rozważania nad procesem stanowienia prawa w Polsce i Chinach na przestrzeni wieków. Wybrane zagadnienia
PublikacjaNiniejsza monografia jest zbiorem rozdziałów poświęconych zarówno historii prawa polskiego, jak i prawa chińskiego. Zakreślone w ten sposób szerokie pole badawcze umożliwiło tym samym zróżnicowany przegląd rozważań nad procesem stanowienia prawa w Polsce i Chinach na przestrzeni wielu wieków. Zakres tematyczny poszczególnych rozdziałów jest odzwierciedleniem prowadzonych badań oraz zainteresowań naukowych poszczególnych autorów...
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Discussion of Derivability of Local Residual Stress Level from Magnetic Stray Field Measurement
PublikacjaThe NDT procedure dubbed ‘metal magnetic memory’ method and the related ISO 24497 standard has found wide industrial acceptance in some countries, mainly in Russia and China. The method has been claimed by some researchers (Roskosz and Bieniek in NDT&E Int 45:55–62, 2012; Wilson et al. in Sens Actuators A 135:381–387, 2007) as having potential for quantitative determination of local residual stress state in engineering structures,...