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Wyniki wyszukiwania dla: STS
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Stable indirect adaptive control based on discrete-time T-S fuzzy model
PublikacjaThis paper presents an indirect adaptive fuzzy control scheme for uncertain nonlinear asymptotically stable plants.A discrete-time T-S fuzzy input-output model is employed to approximate the unknown plant dynamics. The T-S fuzzy model is fed with its own states, which are indeed its past outputs, rather than the measurements from the plants. Entirely based on this model, a feedback linearization control law is designed by using...
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Minimal number of periodic points for smooth self-maps of RP^3
PublikacjaNiech f będzie gładkim odwzorowaniem 3-wymiarowej rzeczywistej przestrzeni rzutowej w siebie, r będzie ustaloną liczbą naturalną. W artykule wyznaczona została minimalna liczba punktów r-periodycznych w gładkiej klasie homotopii odwzorowania f.
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Proper gradient otopies
PublikacjaWe prove that the inclusion of the space of proper gradient local maps into the space of proper local maps induces a bijection between the sets of the respective otopy classes of these maps.
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Lefschetz periodic point free self-maps of compact manifolds
PublikacjaLet f be a self-map of a compact connected manifold M. We characterize Lefschetz periodic point free continuous self-maps of M for several classes of manifolds and generalize the results of Guirao and Llibre [J.L.G. Guirao, J. Llibre, On the Lefschetz periodic point free continuous self-maps on connected compact manifolds,
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Bounded solutions of odd nonautonomous ODE
PublikacjaBorsuk-Ulam type argument is used in order to prove exstence of nontrivial bounded solutions to some nonautonomous differential euations which are odd with respect to the spatial variable. A Poincare compactification trick is also applied.
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Topological degree for equivariant gradient perturbations of an unbounded self-adjoint operator in Hilbert space
PublikacjaWe present a version of the equivariant gradient degree defined for equivariant gradient perturbations of an equivariant unbounded self-adjoint operator with purely discrete spectrum in Hilbert space. Two possible applications are discussed.
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General Provisioning Strategy for Local Specialized Cloud Computing Environments
PublikacjaThe well-known management strategies in cloud computing based on SLA requirements are considered. A deterministic parallel provisioning algorithm has been prepared and used to show its behavior for three different requirements: load balancing, consolidation, and fault tolerance. The impact of these strategies on the total execution time of different sets of services is analyzed for randomly chosen sets of data. This makes it possible...
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Recent progress in the development of steroid sulfatase inhibitors – examples of the novel and most promising compounds from the last decade
PublikacjaThe purpose of this review article is to provide an overview of recent achievements in the synthesis of novel steroid sulfatase (STS) inhibitors. STS is a crucial enzyme in the biosynthesis of active hormones (including estrogens and androgens) and, therefore, represents an extremely attractive molecular target for the development of hormone-dependent cancer therapies. The inhibition of STS may effectively reduce the availability...
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New potent steroid sulphatase inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives
PublikacjaIn the present work, we report a new class of potent steroid sulphatase (STS) inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives. Within the set of new STS inhibitors, 6-(1-(1,2,3-trifluorophenyl)-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate 3L demonstrated the highest activity in the enzymatic assay inhibiting the STS activity to 7.98% at 0.5 µM concentration. Furthermore, to verify...
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Synthesis and biological evaluation of thiophosphate tricyclic coumarin derivatives as steroid sulfatase inhibitors
PublikacjaSteroid sulfatase (STS) enzyme inhibition is an important approach to the management of hormone-dependent breast cancer. In this paper, we report convenient methods for the synthesis and biological evaluation of thiophosphate tricyclic coumarin analogs exhibiting STS activity. The described methods are based on the straightforward preparation of 7-hydroxy-2,3-dihydro-1H-cyclopenta[c]chromen-2-one, 3-hydroxy- 7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one,...
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Monte Carlo simulation of energy migration in uniaxially oriented polymerfilms.
PublikacjaOpisano zastosowanie metody Monte Carlo do symulowania (komputerowego) procesów fotofizycznych zachodzących w rozciąganych osiowo foliach polimerowych zawierających molekuły barwnika. Przedstawiono zaniki czasowe anizotropii emisji oraz jej zależność od koncentracji barwnika. Zbadano wpływ migracji energii na przebiegi anizotropii emisji badanego układu.
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Nauczanie urbanistyki dla architektów
PublikacjaNauczanie urbanistyki na polskich wydziałach architektury prowadzone jest głównie na politechnikach. Program nauczania tego przedmiotu tkwi głęboko nie tylko w modernizmie, ale jescze w poprzedniej epoce systemu polityczno-ekonomicznego. Obecne czasy wymagają zdecydowanej zmiany wytycznych nauczania urbanistyki i planowania przestrzennego. Młody architekt by na trudnym rynku pracy skutecznie konkurować musi nabyć w trakcie studiów...
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Human subarachnoid space width oscillations in the resting state
PublikacjaAbnormal cerebrospinal fluid (CSF) pulsatility has been implicated in patients suffering from various diseases, including multiple sclerosis and hypertension. CSF pulsatility results in subarachnoid space (SAS) width changes, which can be measured with near-infrared transillumination backscattering sounding (NIR-T/BSS). The aim of this study was to combine NIR-T/BSS and wavelet analysis methods to characterise the dynamics of the...
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Variable Order Differential Models of Bone Remodelling * *This work was supported by FCT, through IDMEC, under LAETA, projects UID/EMS/50022/2013, BoneSys, joint Polish-Portuguese project Modelling and controlling cancer evolution using fractional calculus, PERSEIDS (PTDC/EMS-SIS/0642/2014) and IF/00653/2012
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Excitation energy transport and trapping in concentrated solid solution of flavomononucleotide
PublikacjaW pracy analizowano bez promienisty transfer energii w stężonych stałych roztworach (folie polimerowe) FMN. W w/w roztworach występują świecące dimery FMN. Pokazano, że jedynie uwzględnienie powrotnego transferu energii pozwala zadowalająco wyjaśnić mechanizm przenoszenia energii w badanych układach.
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Flavin mononucleotide fluorescence intensity decay in concentrated aqueous solutions
PublikacjaCzasowo-rozdzielone widma absorpcji i fluorescencji FMN w roztworach wodnych zostały zmierzone dla szerokiego zakresu stężeń. Pokazano, że zaniki fluorescencji są silnie przyśpieszone przez obecność dimerów FMN, które stanowią niedoskonałe pułapki energii wzbudzenia. Wyniki doświadczalne porównano z rezultatami symulacji Monte-Carlo, uwzględniającej powrotny transfer energii od pułapek do donorów, stwierdzając dobrą zgodność modelu...
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Unusual fluorescence anisotropy spectra of three-component donor-mediator-acceptor systems in uniaxially stretched polymer films in the presence of energy transfer
PublikacjaW pracy analizowano transfer energii w układzie donor-mediator-akceptor w osiowo rozciąganych foliach polimerowych. Stwierdzono, że informacja zawarta w orientacji wektora pola elektrycznego wiązki światła wzbudzającego układ jest zachowana po zajściu procesu transferu energii pomiędzy molekułami w foliach rozciąganych. Natomiast w foliach nierozciąganych fluorescencja mediatora i akceptora jest bardzo silnie zdepolaryzowana.
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Fluorescence anisotropy decay in the presence of multistep energy migration and back transfer in disordered two-component systems
PublikacjaPrzeprowadzono analizę zaniku anizotropii fluorescencji w sztywnym (lepkim) układzie dwuskładnikowym donor (Rodamina 6G)- akceptor (Rodamina B) z uwzględnieniem prostego i powrotnego transferu energii. Stwierdzono bardzo dobrą zgodność danych doświadczalnych z wynikami symulacji Monte Carlo. W pracy zaprezentowano specjalnie opracowany hybrydowy algorytm symulacji Monte Carlo anizotropii emisji, który jest bardzo wydajny w porównaniu...
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Novel steroid sulfatase inhibitors based on N ‐thiophosphorylated 3‐(4‐aminophenyl)‐coumarin‐7‐O‐sulfamates
PublikacjaIn the present work, we described convenient methods for the synthesis ofN-thiophosphorylated 3-(4-aminophenyl)-coumarin-7-O-sulfamates as steroid sulfatase(STS) inhibitors. To design the structures of the potential STS inhibitors, molecularmodeling techniques were used. A computational docking method was used to deter-mine the binding modes of the synthesized inhibitors as well as to identify potentialinteractions between specified...
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Approach Manoeuvre During Emergency Ship-to-Ship Transfer Operation with Oil Spill
PublikacjaOne of the major activities during Ship to Ship (STS) transfer operation at sea is to safe approach the Ship to be Lightered (SBL) which moves on a constant heading with slow speed or drifting. In the paper described the manoeuvring problem for approaching during emergency STS transfer operation with oil spill. The approach manoeuvre is considered as a sequence of navigation manoeuvres in specific navigational environment with...
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Excitation energy migration between elongated fluorophores in uniaxially oriented polyvinyl alcohol films
PublikacjaBezpromienisty wieloetapowy transfer energii jest studiowany dla molekuł DTCI w osiowo rozciąganych i nierozciąganych foliach poliwinylowych. Wyniki pomiarów zaników anizotropii znacznie różnią się dla rozciąganych i nierozciąganych folii. Dla układów nieuporządkowanych zaobserwowano szybką depolaryzację fluorescencji wynikającą z efektywnej migracji energii. Dla częściowo uporządkowanych układów, depolaryzacja była znacznie wolniejsza...
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Performance measurements and optimization of visualization of routes traveled in the distributed dispatcher and teleinformation system for visualization of multimedia data for the Border Guard
PublikacjaMonitoring of country maritime border is an important task of the Border Guard. This activity can be enhanced with the use of the technology enabling gathering information from distributed sources, processing of that information and its visualization. The system presented in the paper is an advancement of the previously developed distributed map data exchange system. The added functionality allows to supplement the map data with...
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ANALIZA SCZEPNOŚCI MIĘDZYWARSTWOWEJ DWUWARSTWOWO WBUDOWANEJ PODBUDOWY ASFALTOWEJ NA ODCINKU KM 335+946 – 356+850 STR. P ORAZ JEJ WPŁYW NA TRWAŁOŚĆ KONSTRUKCJI NAWIERZCHNI „Budowa mostu przez rzekę Nogat w Malborku wraz z dojazdami w ciągu dróg krajowych nr 22 i 55"
PublikacjaCelem pracy jest ocena jakości połączenia dwóch warstw technologicznych podbudowy z betonu asfaltowego AC 22 35/50 o całkowitej grubości 18 cm oraz wpływ tego połączenia na trwałość konstrukcji nawierzchni drogi na odcinku km 355+946 – 356+850 str. P, wbudowanej w ramach realizacji kontraktu „Budowa mostu przez rzekę Nogat w Malborku wraz z dojazdami w ciągu dróg krajowych nr 22 i 55”.
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Synthesis and biological evaluation of N-acylated tyramine sulfamates containing C-F bonds as steroid sulfatase inhibitors
PublikacjaSteroid sulfatase (STS) is responsible for the hydrolysis of biologically inactive sulfated steroids into their active un-sulfated forms and promotes the growth of various hormone-dependent cancers (e.g., breast cancer). Therefore, the STS enzyme is a promising therapeutic target for the treatment of steroid-sensitive cancers. Herein, we report the synthesis and biological evaluation of sulfamate analogs as potential STS inhibitors...
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Forecasting of railway track tamping based on settlement of sleepers using fuzzy logic
PublikacjaThe sleepers in a railway track transfer vertical, transverse and longitudinal loads to the track ballast and subgrade. The sleepers allow for keeping the distance between the rails constant. The thickness of ballast should be between 16 and 35 cm depending on the design standard of the track, and it should be densified where the ballast supports the sleeper. The exploitation causes contamination of the ballast, crushing the material...
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Synthesis and biological evaluation of fluorinated 3-phenylcoumarin-7-O-sulfamate derivatives as steroid sulfatase inhibitors
PublikacjaIn the present work, we report the initial results of our study on a series of 3-phenylcoumarin sulfamate-based compounds containing C-F bonds as a novel inhibitors of steroid sulfatase (STS). The new compounds are potent STS inhibitors, possessing more than 10 times higher inhibitory potency than coumarin-7-O-sulfamate. In the course of our investigation, compounds 2b and 2c demonstrated the highest inhibitory effect in the enzymatic...
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Bader Ginsburg, Ruth, oraz Hartnett, Mary i Williams, Wendy W. Moimi słowami. Przeł. Anna Halbersztat i Anna Klingofer-Szostakowska. Lublin: Fame Art, 2021 (ss. 400, ISBN 9788395409660)
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Visualization of events using various kinds of synchronized data for the Border Guard
PublikacjaSTRADAR project is dedicated to streaming real-time data in a distributed dispatcher and teleinfor-mation system of the Border Guard. The Events Visualization Post is a software designed for simultaneous visualization of data of different types in BG headquarters. The software allows the operator to visualize files, images, SMS, SDS, video, audio, and current or archival data on naval situation on digital maps. All the visualized...
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Phosphate and Thiophosphate Biphenyl Analogs as Steroid Sulfatase Inhibitors
PublikacjaIn the present work, we report convenient methods for the synthesis and biological evaluation of phosphate and thiophosphate biphenyl derivatives exhibiting steroid sulfatase (STS) activity. The described synthesis is based on straightforward preparation of biphenyl-4-ol and 40-hydroxybiphenyl- 4-carboxylic acid ethyl ester modified with various phosphate or thiophosphate moieties. The inhibitory effects of these compounds were...
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Agent-based social network as a simulation of a market behaviour
PublikacjaRecent years and the outbreak of world's economic crisis in 2008 proved the crucial importance of reliable analysis of market dynamics. However, werarely apply models of proper detail level (the global prosperity forecast of 2007 can be seen as a grim proof). The behaviour of individuals and companies is far from being ideal and rational. Many claims that the economic paradigm of rational expectations (coming from J. Muth and R....
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Polymers (Polyvinylpyrrolidones) As Active Additives Modifying the Lubricating Properties of Water
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Landscape, EIA and decision-making. A case study of the Vistula Spit Canal, Poland
PublikacjaAlthough landscapes are often considered public goods, they frequently receive inadequate attention in Environmental Impact Assessments (EIAs), particularly in Poland. This neglect often leads to visible degradation during investment processes. This article examines the case of the Vistula Spit Canal, currently the largest engineering project under construction in Poland. We analysed whether the conclusions drawn in the EIA report,...
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Prussian Blue Analogues Cubes in the Organic Polymer Electrospun Fibres
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On the mixing property and the ergodic principle for nonhomogeneous Markov chains
PublikacjaW pracy rozważane są różne typy zachowania granicznego nieskończenie wymiarowych niejednorodnych łańcuchów Markowa z czasem dyskretnym. Badana jest struktura geometryczna zbioru łańcuchów Markowa w normowej i mocnej topologii operatorowej.
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Synthesis of bicoumarin thiophosphate derivatives as steroid sulfatase inhibitors
PublikacjaBased on the frameworks of 7-hydroxy-2,3-dihydro-1H-cyclopenta[c]chromen-4-one, 3-hydroxy- 7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one and 3-hydroxy-8,9,10,11-tetrahydro-7H-cyclohepta[c] chromen-6-one, a series of bicoumarin thiophosphate analogs have been synthesized and biologically evaluated. Additionally, their binding modes have been modeled using docking techniques. The inhibitory properties of the synthesized compounds...
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Synthesis and steroid sulfatase inhibitory activities of N-alkanoyl tyramine phosphates and thiophosphates
PublikacjaA series of phosphate and thiophosphate analogs based on the frameworks of N-alkanoyl tyramines have been synthesized and biologically evaluated. Their binding modes have been modeled using docking techniques. The inhibitory effects of the synthesized compounds were tested on STS isolated from the human placenta as well as the MCF-7, MDA-MB-231 and SkBr3 cancer cell lines. Most of the new STS inhibitors possessed potent activity...
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Synthesis and steroid sulfatase inhibitory activities of N-phosphorylated 3-(4-aminophenyl)-coumarin-7-O-sulfamates
PublikacjaIn the present work, we report convenient methods for the synthesis and biological evaluation of N-phosphorylated derivatives of 3-(4-aminophenyl)-coumarin-7-O-sulfamate as potential steroid sulfatase (STS) inhibitors. Their binding modes were modeled using docking techniques. The inhibitory effects of the synthesized compounds were tested on STS isolated from human placenta. All of the newly synthesised coumarin derivatives were...
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The ILs-assisted electrochemical synthesis of TiO2 nanotubes: The effect of ionic liquids on morphology and photoactivity
PublikacjaFacile and environmentally benign one-step titanium anodization method for TiO2 nanotubes (NTs) formation in a presence of ionic liquids (ILs) was proposed. Influence of the IL structure and its content in ethylene glycol electrolyte on morphology, surface properties and photoactivity of the TiO2 NTs was investigated. Possible interactions between IL and TiO2 NTs as well as the mechanism of NTs formation during anodic oxidation...
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Zespół mieszkaniowo-usługowy ZUS przy ul. Partyzantów w Gdyni, jako przykład nowoczesnego zintegrowania funkcji i formy = / ZUS residential and service complex in Partyzantów St. in Gdynia as an example of modern integration of form and function
PublikacjaArtykuł dotyczy zespołu zabudowy, który powstał w Gdyni pod koniec lat 30. XX w. Ukończenie założenia przerwał wybuch II wojny, ale pomimo tego zrealizowana część dowodzi, że zastosowane rozwiązania przestrzenne i funkcjonalne należały do najnowocześniejszych w ówczesnej Polsce.
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Steroid Sulfatase Inhibitors Based on Phosphate and Thiophosphate Flavone Analogs
PublikacjaA series of phosphate and thiophosphate flavone derivatives were synthesized and biologically evaluated in vitro for inhibition of steroid sulfatase (STS) activity. The described synthesis includes the straightforward preparation of 7-hydroxy-2-phenyl-4H-chromen-4-one 3a, 2-(4-fluorophenyl)-7-hydroxy-4H-chromen-4-one 3b, 7-hydroxy-2-(4-(trifluoromethyl)phenyl)-4H-chromen-4-one 3c, 7-hydroxy-2-(p-tolyl)-4H-chromen-4-one 3d modified...
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WSPÓŁCZESNE OCHŁODZENIE REJONU SZETLANDÓW POŁUDNIOWYCH I PÓŁNOCO-ZACHODNICH KRAŃCÓW PÓŁWYSPU ANTARKTYCZNEGO
PublikacjaThe paper discusses changes of hydro-climatic conditions occurring in the South Shetland Islands and in NW parts of the Antarctic Peninsula in the 1979–2016 years period. These changes are important for evaluation of the transformation of marine and coastal ecosystems. The general feature of these changes was a transition from the strong warming phase to the cooling phase, which took place around the year 2000. The paper presents...
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Client-side versus server-side geographic data processing performance comparison: Data and code
PublikacjaThe data and code presented in this article are related to the research article entitled “Analysis of Server-side and Client-side Web-GIS data processing methods on the example of JTS and JSTS using open data from OSM and Geoportal” (Kulawiak et al., 2019). The provided 12 datasets include multi-point and multi-polygon data of different scales and volumes, representing real-world geographic features. The datasets cover the area...
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Equitable coloring of hypergraphs
PublikacjaA hypergraph is equitablyk-colorable if its vertices can be partitioned into k sets/colorclasses in such a way that monochromatic edges are avoided and the number of verticesin any two color classes differs by at most one. We prove that the problem of equitable 2-coloring of hypergraphs is NP-complete even for 3-uniform hyperstars. Finally, we apply the method of dynamic programming for designing a polynomial-time algorithm to...
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Proportional-Derivative and Model-based Controllers used for a Serial Type Manipulator in case of a Variable Mass Payload
PublikacjaIn the paper, numerical analysis of dynamics of a variable mass system is considered. Its reference example is a serial-like manipulator composed of revolute joints and rigid bodies. Payload of its gripper is considered as its variable mass element (mass and inertia irregularly between subsequent payloads). For the rest of the system, inertia parameters are considered as known (precisely identified during the assembling process)....
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Synthesis and biological evaluation of fluorinated N-benzoyl and N-phenylacetoyl derivatives of 3-(4-aminophenyl)-coumarin-7-O-sulfamate as steroid sulfatase inhibitors
PublikacjaIn the present work, we report convenient methods for the synthesis of 3-(4-aminophenyl)-coumarin-7-O-sulfamate derivatives N-acylated with fluorinated analogues of benzoic or phenylacetic acid as steroid sulfatase (STS) inhibitors. The design of these potential STS inhibitors was supported by molecular modeling techniques. Additionally, computational docking methods were used to determine the binding modes of the synthesized inhibitors...
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Digital technologies and women's empowerment – casting the bridges
PublikacjaThis work briefly discusses the nexuses between digital technology development and adoption across societies, and its potential impact on overall welfare through women’s economic empowerment. In the first section it sets out the context and background. Next, Section 2 demonstrates the state of access to and the use of digital technologies across the world. Section 3 intends to trace the causal links and channels of digital technologies'...
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Fowl adenovirus strains 1/A and 11/D isolated from birds with reovirus infection
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Magnetic anisotropy in the exchange-biased laser-patterned thin Co/CoO films
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Analysis of the amount of retained austenite in the structure of steel rolls for sheet rolling
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Surface Plasmon-Coupled Emission of Rhodamine 110 Aggregates in a Silica Nanolayer
PublikacjaFirst analysis of strong directional surface plasmon-coupled emission(SPCE) of ground-state formed intermolecular aggregates of Rhodamine 110 (R110) insilica nanofilms deposited on silver nanolayers is reported. Until now, the processes ofenergy transport and its trapping due to aggregate formation have not been studied in the presence of SPCE. A new approach to multicomponent systems with weakly and strongly fluorescent centers...