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Wyniki wyszukiwania dla: PROTEIN FOLDING
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Depression as is Seen by Molecular Spectroscopy. Phospholipid- Protein Balance in Affective Disorders and Dementia
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MUTL PROTEIN AS A COMMON CONSTITUENT OF VSP, BER, NER AND MMR REPAIR SYSTEMS
PublikacjaMutS and MutL proteins are renowned mostly for their functions in well-characterized, post-DNA replication mismatch repair system (MMR). However, there is growing evidence that MMR system is not the only field of action of these proteins. Moreover, involvement in MMR does not even have to be their primary function. There are some reports indicating involvement of MutL in BER, NER and VSP (very short patch repair). MutL protein...
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A comparative study of water distribution and dehydrin protein localization in maturing pea seeds
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Mapping Mechanostable Pulling Geometries of a Therapeutic Anticalin/CTLA-4 Protein Complex
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Chitosan-protein scaffolds loaded with lysostaphin as potential antistaphylococcal wound dressing materials.
PublikacjaAIMS: The development of technology for preparing chitosan-protein scaffolds loaded with lysostaphin, which potentially could be used as dressing for wound treatment and soft tissue infections caused by Staphylococcus aureus. METHODS AND RESULTS: The unique technology of chitosan solubilization using gaseous CO(2) instead of organic or inorganic acids was used for the incorporation of lysostaphin, the enzyme that exhibits bactericidal...
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Unusual structural properties of water within the hydration shell of hyperactive antifreeze protein
PublikacjaMany hypotheses can be encountered explaining the mechanism of action of antifreeze proteins. One widespread theory postulates that the similarity of structural properties of solvation water of antifreeze proteins to ice is crucial to the antifreeze activity of these agents. In order to investigate this problem, the structural properties of solvation water of the hyperactive antifreeze protein from Choristoneura fumiferana were...
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Karaś P., Kochanowicz K., Pitek M., Domański P., Obuchowski I., Tomiczek B., Liberek K.: Evolution towards simplicity in bacterial small heat shock protein system// eLife -, (2023), s.1-21
PublikacjaEvolution can tinker with multi-protein machines and replace them with simpler single-protein systems performing equivalent functions in an equally efficient manner. It is unclear how, on a molecular level, such simplification can arise. With ancestral reconstruction and biochemical analysis, we have traced the evolution of bacterial small heat shock proteins (sHsp), which help to refold proteins from aggregates using either...
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A novel degree-hour method for rational design loading
PublikacjaCooling degree-hours (CDH) received the broadest application in evaluation of the ambient air cooling efficiency in power engineering (engine intake air cooling systems) and air conditioning. The current CDH numbers are defined as a drop in air temperature multiplied by associated time duration of performance and their summarized annual number is used to estimate the annual effect achieved due to sucked air cooling in power plants...
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TEMPERATURE INFLUENCE ON TIRE ROLLING RESISTANCE MEASUREMENTS QUALITY
PublikacjaGlobal warming makes it necessary to reduce energy consumption, which in the case of motor vehicles, is connected, among other things, with reduction of resistive forces acting on a vehicle during its motion. One of the most important components of those forces is rolling resistance, which is very difficult to measure, especially in road conditions. The article deals with issues related to the influence of the thermal state of...
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Impact of thermal loading into the structural performance of ships: A review
PublikacjaThe presented study reviews the recent advances done regarding the impact of thermal loading on the structural performance of ships. Firstly, the studies related to the mechanical and thermal properties of typical materials used in shipbuilding are outlined. Secondly, a brief introduction to the heat transfer analysis, Finite Element modelling and thermal stresses is provided. Finally, the review of papers dealing with the structural...
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A polynomial algorithm for finding T-span of generalized cacti
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Weldability of high strength steels in wet welding conditions
PublikacjaIn this paper are characterized problems of high strength steel weldability in underwater wet welding conditions. Water as a welding environment intensifies action of unfavourable factors which influence susceptibility to cold cracking of welded steel joints. The susceptibility to cold cracking of S355J2G3 steel and S500M steel in wet conditions was experimentally estimated (by using Tekken test). It was concluded that the steels...
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Decreasing CO2 Emissions By Reducing Tire Rolling Resistance
PublikacjaThe first motor vehicle was built by Nicolas Cugnot almost 250 years ago and since then there has been a continuous process of motor vehicles’ improvements, as well as development of new road pavements. The fuel crisis of the 70s of the 20th century made it clear to vehicle builders that measures should be taken to reduce vehicle fuel consumption and it contributed to an increased interest in electric vehicles. Although significant...
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APPLICABILITY OF INLET AIR FOGGING TO MARINE GAS TURBINE
PublikacjaThe dependency of marine gas turbine on the ambient temperature leads to a decrease of the gas turbine power output in arid areas. Very often gas turbine power output demand is high and the power margins originally designed into the driver , has been exhausted. In such circumstances the inlet air fogging is an effective compensation of gas turbine power. In this paper an analysis of inlet air fogging applicability to marine gas...
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Random field model of foundations at the example of continuous footing
PublikacjaThe purpose of the paper is to indicate an efficient method of foundation settlement analysis taking into account the variability of soil properties. The impact of the random variable distribution (Gauss or Lognormal) describing soil stiffness on foundation deposits was assessed. The Monte Carlo simulation method was applied in the computations. The settlements of the strip foundation with the subsoil described by a single random...
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Strength analysis of container ship subjected to torsional loading
PublikacjaThe objective of this work is to investigate the torsional response of a container ship, with particular consideration of the warping effect. Two different models are investigated. In the first case, the full length model of a ship is analyzed and a distributed load is applied with the use of a novel approach. The model is supported in the torsional centre of the cross-section, which is derived analytically. In the second case,...
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Design of thermal cutting table - welding technology and construction
PublikacjaW referacie przedstawiono pionierską pracę dyplomową stopnia inżynierskiego, wykonaną przez dwoje studentów Wydziału Mechanicznego Politechniki Gdańskiej zgodnie z systemem CDIO (Conceive, Design, Implement, Operate). W ramach pracy studenci zaprojektowali stół do cięcia termicznego metali (rysunki i obliczenia wytrzymałościowe metodą elementów skończonych), opracowali technologię spawania stołu oraz samodzielnie go wykonali. Stół...
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Bead-on-Plate Underwater Wet Welding on S700MC Steel
PublikacjaThe participation of high strength steels in marine and offshore structures is increasing, which makes it necessary to develop recommendations for underwater repair welding works. The article presents the results of bead-on-plate welded specimens made of S700MC high strength steel in underwater wet welding conditions by covered elec- trodes. Three specimens with heat input values in the range 0.91-1.05 kJ/mm were made. The specimens...
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Influence of Road Wetness on Tire-Pavement Rolling Resistance
PublikacjaRolling resistance of tires is one of the most important factors influencing energy consumption of road vehicles, especially on rural roads. For practical reasons, most of rolling resistance measurements are usually performed for dry road conditions. Based on the fact that roads are wet during a considerable time over the year and as part of the projects MIRIAM, ROLRES and ROSANNE, the TUG (Technical University of Gdańsk) in Poland...
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The influence of road surface unevenness on tyre rolling resistance
PublikacjaThe geometric characteristics of road surface substantially affect the interaction between tyre and road. Depending on pavement texture wavelength, the texture chiefly affects tyre/road friction, rolling resistance, interior and exterior noise, tyre wear, and ride comfort. The article presents results of investigations on the influence of road surface unevenness on the rolling resistance of passenger car and truck tyres. The tests...
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INFLUENCE OF LOAD AND INFLATION PRESSURE ON THE TYRE ROLLING RESISTANCE
PublikacjaTyre load and inflation pressure are important factors controlling rolling resistance of road vehicles. The article presents results obtained in the Technical University of Gdańsk during laboratory and road measurements of different car tyres rolling on different pavements. The knowledge of rolling resistance characteristics is important for modelling car dynamics as well as fuel consumption. It is also necessary to establish proper...
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Complex Root Finding Algorithm Based on Delaunay Triangulation
PublikacjaA simple and flexible algorithm for finding zeros of a complex function is presented. An arbitrary-shaped search region can be considered and a very wide class of functions can be analyzed, including those containing singular points or even branch cuts. The proposed technique is based on sampling the function at nodes of a regular or a self-adaptive mesh and on the analysis of the function sign changes. As a result, a set of candidate points...
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Manufacturing of resistant joints by rolling for light tubular structures
PublikacjaKoncepcja łączenia aluminiowych elementów rurowych z zastosowaniem nagniatania plastycznego jest alternatywą do istniejących metod łączenia przez spawanie i skręcanie. W artykule prezentowane są oryginalne wyniki badań wpływu parametrów nagniatania wewnętrznego i zewnętrznego oraz różnych postaci powierzchni łączonych na wytrzymałość złącza (aluminium-aluminium) pod wpływem rozciągających sił osiowych.Badania przeprowadzono na...
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Evolutionary approach to solving multi-ship encounter situations
PublikacjaW artykule wprowadzono nowe podejście do rozwiązywania sytuacji spotkań wielu statków poprzez połączenie założeń teorii gier z programowaniem ewolucyjnym. Spotkanie wielu statków jest zamodelowane jako gra rozgrywana przez ''myślących graczy'' - statki o różnych, potencjalnie zmiennych strategiach. Rozwiązanie - zbiór kooperujących (niekolidujących) trajektorii jest znajdowane za pomocą algorytmu ewolucyjnego.
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On root finding algorithms for complex functions with branch cuts
PublikacjaA simple and versatile method is presented, which enhances the complex root finding process by eliminating branch cuts and branch points in the analyzed domain. For any complex function defined by a finite number of Riemann sheets, a pointwise product of all the surfaces can be obtained. Such single-valued function is free of discontinuity caused by branch cuts and branch points. The roots of the new function are the same as the...
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Tyre rolling resistance and its influence on fuel consumption
PublikacjaRolling resistance of tyres is one of the major resistive forces acting on any wheeled vehicle. Unfortunately, it is also one of the forces very difficult to measure. It is estimated that in certain traffic conditions (like for example constant speed driving with slow or moderate speed) so called Rolling Resistance Impact Factor may be as high as 0.3. This means that reduction of rolling resistance by 50% would lead to 15% of energy...
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Influence of compaction effectiveness on interlayer bonding of asphalt layers
PublikacjaThe paper presents the results of research on the interlayer bonding of asphalt layers compacted in the laboratory and in the field. To measure the interlayer bonding at a temperature of 20°C the Leutner test apparatus was used and load was applied at a rate of 50 mm/minute. Three types of interlayer interfaces were tested: no tack coat and tack coats made of two types of the pure bitumen emulsions. Four compaction techniques were...
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Test loading of the longest span arch bridge in Poland
PublikacjaBridge structures undergo thorough examination during test loading before they come into use. The aim of the examination is to check the correctness of the working structure and construction design assumptions. Test loading on the bridge is preceded by examination specification. This paper describes computational model and test loading results carried out during examibation of the bridge over the Vistula within the bypass of Puławy...
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Effects of workpiece feeding errors on multi-rip saws
PublikacjaW pracy przedstawiono przyczyny i efekty błędów prowadzenia materiału na wielopiłach tarczowych. Ich znajomość umożliwia szybką diagnostykę przyczyn, a także skuteczną minimalizację błędów prowadzenia materiału.
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Probability of flooding a compartment (the pi factor) - a critique and a proposal
PublikacjaArtykuł podaje krytyczny przegląd stanu wiedzy dot. obliczania prawdopodobirństwa zatopienia przedziału (mnożnika pi), ze szczególnym uwzględnieniem projektu badawczego ''Harder'' oraz podaje poprawne rozwiązanie dotyczące tego mnożnika. Kończy się propozycją przepisu do zamieszczenia w konwencji SOLAS.
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Compact Planar Balun for the UWB Dipole Feeding Network
PublikacjaW pracy opisano wyniki z badań numerycznych ultra szerokopasmowego symetryzatora planarnego o zredukowanych wymiarach. Układ został zaprojektowany w oparciu o konfigurację opisaną w literaturze. Względem konfiguracji bazowej, układ przeprojektowano na inne podłoże. W celu weryfikacji przydatności układu, przeprowadzono symulację anteny dipolowej zasilanej opisywanym symetryzatorem. Na podstawie otrzymanych rezultatów przekazano...
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Advances in Sheet Metal Forming Processes of Lightweight Alloys
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Analysis of Rolling Resistance of Tires With Run Flat Insert
PublikacjaRun flat properties are required for tires intended for special applications like military or rescue vehicles. Run-Flat inserts make possible to drive a car or truck, with certain restrictions, also when inflation pressure is very low or non-existing (after tire damage). Rolling resistance of tires rolling the inserts increases considerably in relation to the rolling resistance of properly inflated tires. This paper presents results...
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Modernization of the Trailer for Tyre/Road Rolling Resistance Measurements
PublikacjaIn the article the ways of defining tyre rolling resistance are presented. The advantages of the laboratory tests of tyre/road rolling resistance and the advantages and disadvantages of on the road tyre/road rolling resistance tests are described. The description of the special trailer used for tyre/road rolling resistance measurements designed and constructed in the Faculty of Mechanical Engineering at Gdansk University of Technology,...
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Parallelisation of genetic algorithms for solving university timetabling problems
PublikacjaAlgorytmy genetyczne stanowią ważną metodę rozwiązywania problemów optymalizacyjnych. W artykule skupiono się na projekcie równoległego algorytmu genetycznego pozwalającego uzyskiwać uniwersyteckie rozkłady zajęć, spełniające zarówno twarde jak i miękkie ograniczenia. Czytelnika wprowadzono w niektóre znane sposoby zrównoleglenia, przedstawiono również podejście autorów, ykorzystujące MPI. Przyjęto strukturę zarządzania opartą...
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Finding deformation of the straight rail track by GNSS measurements
PublikacjaW 2009 roku na Politechnice Gdańskiej i Akademii Marynarki Wojennej w Gdyni zostały przeprowadzone, po raz pierwszy, ciągłe pomiary satelitarne toru kolejowego z wykorzystaniem względnej metody fazowej na bazie polskiej Aktywnej Sieci Geodezyjnej ASG-EUPOS i serwisu czasu rzeczywistego RTK (GPRS) - NAVGEO. Przeprowadzona analiza wykazała silny związek między lokalizacją odbiornika GNSS i dokładnością wyznaczania pozycji, wpływ...
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The Rolling Contact Fatigue of PVD Coated Spur Gears
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Application of Numerical Simulations on 10GN2MFA Steel Multilayer Welding
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Numerical Simulations of X22CrMoV12-1 Steel Multilayer Welding
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Heat Source Models in Numerical Simulations of Laser Welding
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Crowdsourcing and Volunteer Computing as Distributed Approach for Problem Solving
PublikacjaIn this paper, a combination between volunteer computing and crowdsourcing is presented. Two paradigms of the web computing are described, analyzed and compared in detail: grid computing and volunteer computing. Characteristics of BOINC and its contribution to global Internet processing are shown with the stress put onto applications the system can facilitate and problems it can solve. An alternative instance of a grid computing...
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A polynomial algorithm for finding T-span of generalized cacti.
PublikacjaW pracy opisano wielomianowy algorytm wyznaczający optymalne T-pokolorowania dla uogólnionych kaktusów.
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Measurement of filling and discharging loads in a full scale hopper.
PublikacjaArtykuł przedstawia wyniki doświadczalne naporu piasku na ścinanie uzyskane podczas napełniania i opróżniania leja silosu o pojemności 2.5 m3. Pokazane zostały wartości naporu w funkcji czasu oraz kształt powierzchni górnej materiału dla poszczególnych etapów napełniania i opróżniania.
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The surface contact characteristics after sliding and rolling burnishing.
PublikacjaW pracy przedstawiono zastosowanie nowej metody SCGC i odpowiedniego programu komputerowego JKC do oceny pomierzonej mikrostereometrii powierzchni części maszyn, głównie na potrzeby kontroli jakości. Na przykładzie powierzchni nagniatanych wykazano cechy nowej metody: wizualizację ułatwiającą wyobrażenie pomierzonej sfery chropowatości, położenie w niej najważniejszych parametrów oceny (rozkład geometrycznej powierzchni kontaktu,...
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An approach to fatigue assessment of metals under biharmonic loading.
PublikacjaRozpatrywane są kryteria nieograniczonej i ograniczonej trwałości zmęczeniowej metalicznych elementów poddanych biharmonicznemu naprężeniu, którego jedna składowa ma niską częstość. Założono, że składowa ta może być traktowana jako wolno zmieniające się w czasie naprężenie średnie. Kryteria zmęczeniowe sformułowano za pomocą równań Goodmana i Soderberga. Dyskutowane są wyniki przykładowych obliczeń.
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Numerical simulation of extreme flooding in a built-up area
PublikacjaPrzedstawiono dwie numeryczne symulacje propagacji gwałtownej fali powodziowej przez schematyczny model obszaru zabudowanego. Do obliczeń wykorzystano równania przepływu wody płytkiej. Wyniki obliczeń porównano z dostępnymi pomiarami wykonanymi w laboratorium hydraulicznym ENEL-CESI w Mediolanie. Uzyskano zadowalającą zgodność symulacji z eksperymentami.
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Dissection of σE‐dependent cell lysis in Escherichia coli: roles of RpoE regulators RseA, RseB and periplasmic folding catalyst PpiD
PublikacjaTo understand the mechanism of sigma(E)-dependent cell lysis, we examined the consequences of deletion derivatives of rpoE regulators rseA, rseB and rseC on sigma(E) transcription, on levels of free versus membrane-bound sigma(E) and on OMP-biogenesis limiting factor(s) that could impact cell lysis. RT-PCR showed that individual nonpolar DeltarseA and DeltarseB increased the rpoE expression to varying extents, with pronounced induction...
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Mechanism of Osmolyte Stabilization–Destabilization of Proteins: Experimental Evidence
PublikacjaIn this work, we investigated the influence of stabilizing (N,N,N-trimethylglycine) and destabilizing (urea) osmolytes on the hydration spheres of biomacromolecules in folded forms (trpzip-1 peptide and hen egg white lysozyme─hewl) and unfolded protein models (glycine─GLY and N-methylglycine─NMG) by means of infrared spectroscopy. GLY and NMG were clearly limited as minimal models for unfolded proteins and should be treated with...
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Recent Developments in Data-Assisted Modeling of Flexible Proteins
PublikacjaMany proteins can fold into well-defined conformations. However, intrinsically-disordered proteins (IDPs) do not possess a defined structure. Moreover, folded multi-domain proteins often digress into alternative conformations. Collectively, the conformational dynamics enables these proteins to fulfill specific functions. Thus, most experimental observables are averaged over the conformations that constitute an ensemble. In this...
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Dynamics of Chains as a Tool to Study Thermomechanical Properties of Proteins.
PublikacjaPolymer dynamics can be formulated on different levels of detail. One approach eliminates microscopic degrees of freedom and a polymer molecule is represented by a simplified structure—a chain. In the simplest case monomers of ideal chain have fixed length, and their orientation is independent of the orientations and positions of neighbouring monomers. This is reason that two monomers can co-exist at the same place. Ideal chain...