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Targeting Spike‐ACE2 Interface of SARS‐CoV‐2 and its Omicron Variant: A Comparative Screening of Potential Inhibitors for Existing and Anticipating Variants Using Molecular Modelling Approach
PublikacjaThe recent COVID pandemic has shown major impact on public health and economic crisis. Despite the development of many vaccines and drugs against the severe acute respiratory syndrome (SARS) coronavirus 2, the pandemic still persists. The continued spread of the virus is largely driven by the emergence of viral variants such as α, β, γ, delta, epsilon spike, omicron and its subvariants (BA.1,2,3) which can evade the current vaccines...
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Performance of electrochemical immunoassays for clinical diagnostics of SARS-CoV-2 based on selective nucleocapsid N protein detection: Boron-doped diamond, gold and glassy carbon evaluation
PublikacjaThe 21st century has already brought us a plethora of new threats related to viruses that emerge in humans after zoonotic transmission or drastically change their geographic distribution or prevalence. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first spotted at the end of 2019 to rapidly spread in southwest Asia and later cause a global pandemic, which paralyzes the world since then. We have designed novel...
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La composition sur des lignes de fuite ou un équilibre manqué : le parti pris de l’espace dans les œuvres narratives d’Anna Langfus
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Experimental and Numerical Analysis of Air Trapping in a Porous Medium with Coarse Textured Inclusions
PublikacjaThe paper presents a 2D upward infiltration experiment performed on a model porous medium consisting of fine sand background with two inclusions made of coarser sands. The purpose of the experiment was to investigate the effects of structural air trapping, which occurs during infiltration as a result of heterogeneous material structure. The experiment shows that a significant amount of air becomes trapped in each of the inclusions. Numerical...
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Auto/bio/géo/graphies : les enjeux spatiaux de la mémoire dans les récits autobiographiques et testimoniaux du temps de la guerre chez Durocher, Langfus, Rawicz
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Działania antykryzysowe w obszarze kultury w trakcie pandemii SARS-CoV-2. Stan obecny i wnioski de lege ferenda w zakresie zwiększenia partycypacji obywatelskiej oraz instytucjonalnej
PublikacjaCelem artykułu jest analiza różnych rozwiązań prawnych w zakresie wsparcia instytucji kultury w trakcie stanu epidemii. Przeprowadzono przegląd działań Ministerstwa Kultury i Dziedzictwa Narodowego wspierających instytucje kultury w Polsce w czasie epidemii według stanu na maj 2020 r. Na podstawie analizy wskazano wnioski de lege ferenda co do nowych możliwości finansowania działań takich instytucji. Autorzy prezentują rozwiązania...
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Discrete Modelling of Micro-structural Phenomena in Granular Shear Zones
PublikacjaThe micro-structure evolution in shear zones in cohesionless sand for quasi-static problems was analyzed with a discrete element method (DEM). The passive sand failure for a very rought retaining wall undergoing horizontal translation towards the sand backfill was discussed. To simulate the behaviour of sand, the spherical discrete element model was used with elements in the form of rigid spheres with contacts moments.
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Przebieg wpracowywania kwarcowych złóż filtracyjnych przeznaczonych do usuwania manganu i azotu amonowego z wód podziemnych.The course of ripenining of quartz sand filter beds used for manganese and ammonium nitrogen removal from the groundwaters.
PublikacjaPrzeprowadzone badania wykazały, ze czas wpracowywania się kwarcowego złoża filtracyjnego w procesie odmanganiania i nitryfikacji trwał od 7 do 8 tygodni (złoże wpracowywało się jednocześnie w obu procesach) Wpracowanie uzyskano filtrując napowietrzoną wodę podziemną o stosunkowo wysokich stężeniach manganu (0,6 - 1,1 mg/l) i azotu amonowego (0,4 - 1,4 mgN/l) i niewielkich stężeniach żelaza (poniżej 0,5 mg/l). Po wpracowaniu...
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A. Computational analysis by molecular docking of thirty alkaloid compounds from medicinal plants as potent inhibitors of SARS-CoV-2 main protease(2020). Focused on analysis of the Medicinal plants that have potential therapeutic ability against COVID-19.
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Areas of Fan Research—A Review of the Literature in Terms of Improving Operating Efficiency and Reducing Noise Emissions
PublikacjaFans as industrial devices are among the most significant single recipients of driving energy. Therefore, they represent an important area of energy savings to reduce CO2 emissions. The ubiquity of fans and their operation under conditions different from the optimum provides an opportunity for more significant global reductions in the energy used to drive them. The second important aspect, besides energy efficiency, related to...
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Unités phraséologiques au pays de la traduction: transfert des collocations nomino-adjectivales avec le lexème «femme» dans la traduction de la littérature houellebecquienne du français vers l’italien et le polonais
PublikacjaThe present paper examines the transfer of nomino-adjectival collocations based on the word ‘femme’ (‘woman’) in the literary translation from French into Italian and Polish. The lexical connection analysed in the article can be defined as the habitual juxtaposition of a word with another word (or words) that has a significant frequency in a given language. The research corpus comprises seven Michel Houellebecq’s novels written...
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Micro-modelling of shear localization during quasi-static confined granular flow in silos using DEM
PublikacjaThe paper deals with the quasi-static confined flow of cohesionless sand in a plane strain model silo with parallel walls and a slowly movable bottom. Numerical modelling was carried out by the discrete element method (DEM) using spheres with contact moments to approximately capture a non-uniform shape of sand particles. Different initial void ratios of sand and silo wall roughness grades were employed. Regular triangular grooves...
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The Design Development of the Sliding Table Saw Towards Improving Its Dynamic Properties
PublikacjaCutting wood with circular saws is a popular machining operation in the woodworking and furniture industries. In the latter sliding table saws (panel saws) are commonly used for cutting of medium density fiberboards (MDF), high density fiberboards (HDF), laminate veneer lumber (LVL), plywood and chipboards of different structures. The most demanded requirements for machine tools are accuracy and precision, which mainly depend on...
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Analytics of Surfactants in the Environment: Problems and Challenges
PublikacjaSurfactants (surface active agents = SAAs) are a group of compoundswith specific physicochemical properties (amphiphilicity,solubility in polar and nonpolar liquids, ability to form micelles,adsorption at phase boundaries).1,2 Because of their properties,surface-active compounds are widely applied in industry and thehousehold (e.g., in detergents, personal-care products, paints,pesticides, petroleum products). As their applications...
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Surfactants: a real threat to the aquatic geoecosystems of lobelia lakes
PublikacjaLobelia lakes are valuable elements of the natural environment. They are characterised by low trophy, mainly in-forest location and a high transparency of water. However, similarly to other surface waters, they are subjected to increasing anthropogenic pressures, a good indicator of which is the level of surfactants, also called surface-active agents (SAAs). The aim of the study was to evaluate the intensity of anthropogenic pressures...
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STABILITY OF THE INNER SLOPE OF THE POLISH DREDGDIKES RESEARCH DIKE AT STATIONARY FLOW
PublikacjaFor long duration of the flood the water table can appear on the slope with a problem of out-wash in the case of sand type dike. If the dike corps is covered with less permeable layer some additional push-off forces and shearing can rise in the cover. In both cases the micro stability of the inner slope should be considered at normative high water for homogeneous sand type dike or sand type dike with less permeable covers. The...
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Subarachnoid Space: New Tricks by an Old Dog
PublikacjaPurpose: The purpose of the study was to: (1) evaluate the subarachnoid space (SAS) width and pial artery pulsation in both hemispheres, and (2) directly compare magnetic resonance imaging (MRI) to near-infrared transillumination/backscattering sounding (NIR-T/BSS) measurements of SAS width changes in healthy volunteers.Methods: The study was performed on three separate groups of volunteers, consisting in total of 62 subjects (33...
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Human subarachnoid space width oscillations in the resting state
PublikacjaAbnormal cerebrospinal fluid (CSF) pulsatility has been implicated in patients suffering from various diseases, including multiple sclerosis and hypertension. CSF pulsatility results in subarachnoid space (SAS) width changes, which can be measured with near-infrared transillumination backscattering sounding (NIR-T/BSS). The aim of this study was to combine NIR-T/BSS and wavelet analysis methods to characterise the dynamics of the...
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Discussion of “CPT Evaluation of Yield Stress Profiles in Soils” by Shehab S. Agaiby and Paul W. Mayne
PublikacjaVeryfication of the procedure to estimate overconsolidation ratio in sands using the results of mini-cone penetration tests in centrifuge.
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Numerical Studies on Propellers in Open Water and behind Hulls aiming to support the Evaluation of Propulsion Tests
PublikacjaA RANS based numerical analysis of propellers can contribute considerably to our understanding of propeller/hull interaction. It may also allow for a review of scaling procedures on results from experimental fluid dynamics (EFD). Using various RANS codes (Fluent, CFX, STAR-CCM+ and FreSCo+) on common test cases the authors first focused on propeller open water (POW) calculations. Next we simulated the propeller hull interaction...
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Coupling between Blood Pressure and Subarachnoid Space Width Oscillations during Slow Breathing
PublikacjaThe precise mechanisms connecting the cardiovascular system and the cerebrospinal fluid (CSF) are not well understood in detail. This paper investigates the couplings between the cardiac and respiratory components, as extracted from blood pressure (BP) signals and oscillations of the subarachnoid space width (SAS), collected during slow ventilation and ventilation against inspiration resistance. The experiment was performed on...
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Activation of endogenous regenerative potential in mammals using epigenetic inhibitor zebularine
PublikacjaIn this work, a nucleoside inhibitor of DNA methyltransferases, zebularine, was investigated as a wound healing and regeneration promoting agent. It was found that a high dose of intraperitoneally delivered zebularine improved punch wound closure in the ear pinna in mice. Both cytidine, a zebularine analogue, and uridine, a zebularine metabolite, did not promote ear pinna hole closure. The effect of zebularine on ear pinna healing...
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Impact of slow breathing on the blood pressure and subarachnoid space width oscillations in humans
PublikacjaThe aim of the study was to assess cardiac and respiratory blood pressure (BP) and subarachnoid space (SAS) width oscillations during the resting state for slow and fast breathing and breathing against inspiratory resistance. Experiments were performed on a group of 20 healthy volunteers (8 males and 12 females; age 25.3 ± 7.9 years; BMI = 22.1 ± 3.2 kg/m2). BP and heart rate (HR) were measured using continuous finger-pulse photoplethysmography....
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Social learning and knowledge flows in cluster initiatives, In: Sanz S.C., Blanco F.P., Urzelai B. (Eds). Human and Relational Resources (pp. 44-45). the 4th International Conference on Clusters and Industrial Districts CLUSTERING, University of Valencia, Spain, May 23–24 (ISBN: 978-84-09-11926-4).
PublikacjaPurpose – The purpose of the paper is to explore how learning manifests and knowledge flows in cluster initiatives (CIs) due to interactions undertaken by their members. The paper addresses the research question of how social learning occurs and knowledge flows in CIs. Design/methodology/approach – The qualitative study of four cluster initiatives helped to identify various symptoms of social learning and knowledge flows in...
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NEW EXPERIENCES IN DIKE CONSTRUCTION WITH SOIL-ASH COMPOSITESAND FINE-GRAINED DREDGED MATERIALS
PublikacjaThe supporting structure inside a coastal dike is often made of dredged non-uniform sand with good compaction proper-ties. Due to the shortage of natural construction material for both coastal and river dikes and the surplus of different processed mate-rials, new experiments were made with sand-ash mixtures and fine-grained dredged materials to replace both dike core and dikecover materials resulting in economical, environmentally...
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Effect of soil moisture on current-carrying capacity of low-voltage power cables
PublikacjaOne of the factors affecting current-carrying capacity of underground power cables is the thermal resistivity of soil. Its value in the close proximity of the cable is the most important, and for this reason, in some cases, the local soil is replaced with an another soil type or with a cement-sand mixture. The thermal resistivity of the soil is strongly affected by moisture, and in the case of a cement-sand mixture – as tested...
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Identification of quasi-periodically varying systems with quasi-linear frequency changes
PublikacjaThe problem of identification of linear quasi-periodically varying systems is considered. This problem can be solved using generalized adaptive notch filtering (GANF) algorithms. It is shown that accuracy of system parameter estimation can be increased if the results obtained from GANF are further processed using a cascade of appropriately designed filters. The resulting generalized adaptive notch smoothing (GANS) algorithms can...
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Neoneo-Kantianizm - Transcendental Philosophy as a Reflection on Validity (Geltung)
PublikacjaThe article presents the philosophical thought of Rudolf Zocher, Wolfgang Cramer and Hans Wagner, whose theoretical stance can be dubbed Neoneo-Kantianism. The article investigates their philosophical output and argues that they developed a transcendental reflection of a different kind than that of Baden Neo-Kantianism. The transcendental reflection of Neoneo-Kantianism, especially in the work of Hans Wag-ner, takes on the topic...
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Increased inspiratory resistance affects the dynamic relationship between blood pressure changes and subarachnoid space width oscillations
PublikacjaBackground and objective Respiration is known to affect cerebrospinal fluid (CSF) movement. We hypothesised that increased inspiratory resistance would affect the dynamic relationship between blood pressure (BP) changes and subarachnoid space width (SAS) oscillations. Methods Experiments were performed in a group of 20 healthy volunteers undergoing controlled intermittent Mueller Manoeuvres (the key characteristic of the procedure...
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Optimized Hydrodynamic Vortex Separator
PublikacjaThe invention discloses an optimized hydrodynamic vortex separator which comprises an outer cylinder (1), an inner cylinder (2), a sludge hopper (3), an inlet (4), an outlet (5) and a conical structure (7), wherein the outer cylinder (1) is the boundary of the outer wall of the separator; wherein the inner cylinder (2) is arranged in an inner cavity of the outer cylinder (1); the sludge hopper (3)is taken as the bottom of the...
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Occurrence of Surface Active Agents in the Environment
PublikacjaDue to the specific structure of surfactants molecules they are applied in different areas of human activity (industry, household). After using and discharging from wastewater treatment plants as effluent stream, surface active agents (SAAs) are emitted to various elements of the environment (atmosphere, waters, and solid phases), where they can undergo numerous physic-chemical processes (e.g., sorption, degradation) and freely...
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Coupling of Blood Pressure and Subarachnoid Space Oscillations at Cardiac Frequency Evoked by Handgrip and Cold Tests: A Bispectral Analysis
PublikacjaThe aim of the study was to assess blood pressure–subarachnoid space (BP–SAS) width coupling properties using time–frequency bispectral analysis based on wavelet transforms during handgrip and cold tests. The experiments were performed on a group of 16 healthy subjects (F/M; 7/9) of the mean age 27.2 ± 6.8 years and body mass index of 23.8 ± 4.1 kg/m². The sequence of challenges was first handgrip and then cold test. The handgrip...
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Selected anionic and cationic surface active agents: case study on the Kłodnica sediments
PublikacjaSurface active agents (surfactants) are a group of chemical compounds, which are used as ingredients of detergents, cleaning products, cosmetics and functional products. After use, wastes containing surfactants or their degradation products are discharged to wastewater treatment plants or directly into surface waters. Due to their specific properties of SAAs, compounds are able to migrate between different environmental compartments...
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Numerical analysis and in situ tests of the Grot Rowecki Bridge in Warsaw
PublikacjaThe paper presents the FEM analysis of the reconstructed the Grot-Rowecki Bridge over Vistula river in Warsaw. The bridge has seven spans and consists of two independent structures with the longest spans of 120 m. After reconstruction the bridge is over 10 m wider. The numerical, nonlinear analysis has been con-ducted on a global and local FEM models. These models are defined so as they strictly comply with global structural bridge...
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Pial artery and subarachnoid width response to apnoea in normal humans
PublikacjaBackground: Little is known about intracranial pressure (ICP)-cerebral haemodynamic interplay during repetitive apnoea. A recently developed method based on near-infrared transillumination/backscattering sounding (NIR-T/BSS) noninvasively measures changes in pial artery pulsation (cc-TQ) as well as subarachnoid width (sas-TQ) in humans. Method: We tested the complex response of the pial artery and subarachnoid width to apnoea...
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Strategia edukacji gminy Sadlinki 2015-2020
PublikacjaStrategia rozwoju edukacji to dokument planowania strategicznego określający główne kierunki rozwoju edukacji na terenie gminy Sadlinki; to wskazanie możliwych form rozwoju, szans oraz zagrożeń w tej dziedzinie na najbliższe lata
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Structure and evolution of the 4-helix bundle domain of Zuotin, a J-domain protein co-chaperone of Hsp70
PublikacjaThe J-domain protein Zuotin is a multi-domain eukaryotic Hsp70 co-chaperone. Though it is primarily ribosome-associated, positioned at the exit of the 60S subunit tunnel where it promotes folding of nascent polypeptide chains, Zuotin also has off-ribosome functions. Domains of Zuotin needed for 60S association and interaction with Hsp70 are conserved in eukaryotes. However, whether the 4-helix bundle (4HB) domain is conserved remains...
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Seaweed utilization issues in biogas production
PublikacjaMacroalgae can be seen as a renewable feedstock for the production of biofuels in many coastal areas around the World and especially in Baltic Sea region where the eutrophication is particularly troublesome. The investigation of anaerobic digestion technologies for extracting inexhaustible bioenergy from seaweed was conducted in many research institutions mainly in laboratory scale. Although seaweeds seem to have a great potential...
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Non-Destructive Testing of a Sport Tribune under Synchronized Crowd-Induced Excitation Using Vibration Analysis
PublikacjaThis paper presents the concept of repairing the stand of a motorbike speedway stadium. The synchronized dancing of fans cheering during a meeting brought the stand into excessive resonance. The main goal of this research was to propose a method for the structural tuning of stadium stands. Non-destructive testing by vibration methods was conducted on a selected stand segment, the structure of which recurred on the remaining stadium...
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Novel method of lung area extraction in chest perfusion computed tomography
PublikacjaChest perfusion computed tomography (pCT) is a useful technique in the medical diagnosis of how organs function. Perfusion CT scans are used to calculate perfusion parameters. In the case of automated methods of lung perfusion parameters calculation, the prior extraction of the lung area is desired to avoid unnecessary calculation in an area outside the lung cross-section and to avoid wasting time on processing signals of no diagnostic...
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Oil removal from polluted soil by washing with surfactants solutions in dynamic conditions
PublikacjaFor washing of the oil from polluted soil surfactants solutions were applied. In a research a nonionic synthetic surfactant - polyoxyethylene ether of synthetic fatty alcohol (Rokanol NL6), rhamnolipid biosurfactant JBR 425 (Jeneil Biosurfactant Co. LLC) and their mixtures were used. Results of oil removal from peat soil and sand with mixtures of surfactants solutions at concentration 0,5 g/dm...
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Morskie dziedzictwo przemysłowe a tożsamość kulturowa regionu
PublikacjaPublikacja dotyczyła znaczenia architektonicznego dziedzictwa morskiego jako szczególnie ważnego dla regionu nadmorskiego dziedzictwa przemysłowego. Problematyka referatu i publikacji dotyczyła dotychczasowych osiągnięć w tej dziedzinie oraz szans i kierunków działania w przyszłości.
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MODELING THE pH EFFECTS ON NITROGEN REMOVAL IN THE ANAMMOX-ENRICHED GRANULAR SLUDGE
PublikacjaThe aim of the study was to determine the pH effects on nitrogen removal in the anammox-enriched 10 granular sludge. The experimental data were extracted from a 4L completely-mixed batch reactor with the 11 granular sludge at different initial pH values (6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, 10.5) and constant temperature 12 T=30℃. Simulations were run in GPS-X 6.4 using a comprehensive mechanistic model Mantis2. Two 13 kinetic parameters,...
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Modeling the pH effects on nitrogen removal in the anammox-enriched granular sludge
PublikacjaThe aim of the study was to determine the pH effects on nitrogen removal in the anammox-enriched granular sludge. The experimental data were extracted from a 4L completely-mixed batch reactor with the granular sludge at different initial pH values (6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, 10.5) and constant temperature T=30℃. Simulations were run in GPS-X 6.4 using a comprehensive mechanistic model Mantis2. Two kinetic parameters, including...
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A study HIPERLAN-type noncooperative medium access control setting in a wireless LAN
PublikacjaDla dostępu MAC przeanalizowano strategię określania długości transmisji w fazie eliminacji zakładając indywidualną optymalizację uzyskanego pasma komunikacyjnego. Zaproponowano różne warianty polityki wyłaniania zwycięzcy eliminacji, mające na celu wyrównanie szans stacji kooperacyjnych i niekooperacyjnych.
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Two-dimensional vertical analysis of dam-break flow
PublikacjaW artykule przedstawiono matematyczne modelowanie przepływów ze swobodną powierzchnią w kanałach otwartych. Do symulacji przepływu użyto dwuwymiarowy pionowy model RANS. Wchodzące w skład modelu równania Naviera-Stokesa rozwiązano stosując algorytm SIMPLE dla metody różnic skończonych. Do śledzenia zmian swobodnego zwierciadła wody zastosowano metodę MAC. Analizie poddano szybkozmienny przepływ po poziomym, gładkim dnie wywołany...
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Numerical Determination of the Load-Bearing Capacity of a Perforated Thin-Walled Beam in a Structural System with a Steel Grating
PublikacjaThis article presents the results of numerical simulations of a structural system consisting of steel perforated thin-walled beams and a steel grating. The simulations were conducted using the finite element method. The analysis took into account physical and geometric nonlinearity as well as the contact between the steel grating and the beams. The main goal of the research was to develop load-bearing curves for the main beam in...
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Assessing the Risk in Urban Public Transport for Epidemiologic Factors
PublikacjaPandemics have presented new challenges for public transport organisers and operators. New diseases (e.g., influenza H1N1, severe acute respiratory syndrome—SARS, as well as, more recently, SARS-CoV-2) increase the need for new protection measures to prevent epidemic outbreaks in public transport infrastructure. The authors’ goal is to present a set of actions in the area of public transport that are adjusted to different levels...
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Warunki programowania i realizacji rozwoju regionalnego przez województwa samorzadowe po roku 2006.
PublikacjaPolskie regiony wobec strategii lizbońskiej znalazły się w nowej sytuacji uwarunkowań i wyników konkurencyjności: Przed programowaniem staż dylemat wyboru: między polaryzacją a wyrównywaniem szans. Kontrakt regionalny jest jednym z instrumentów wymagających przeformowania. Konieczne są zmiany instytucjonalne.
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Effect of Maximal Breath Hold Apnea on Pial Artery Pulsation and Subarachnoid Width in Human
PublikacjaLittle is known about intracranial pressure (ICP)-cerebral hemodynamic interplay during maximal breath-hold apnea. A recently developed method based on near-infrared transillumination/backscattering sounding (NIR-T/BSS) noninvasively measures changes in pial artery pulsation (cc-TQ) as well as subarachnoid width (sas-TQ) in humans. Changes in sas-TQ correlate with ICP to a considerable extent, whereas cc-TQ reflects the functional...