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Wyniki wyszukiwania dla: proteolytic modulation
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Characteristic and specificity of protease activity of thermophilic bacteria Meiothermus ruber
PublikacjaThe primary purpose of research was to establish the possibility of using thermophilic bacteria Meiothermus ruber as a source of proteolytic enzymes. The main reason of searching new proteases is their commercial value especially in production of detergents, food, pharmaceuticals, leather, diagnostics or waste management. The development of this type processes will be possible by utilization of enzymes which have unique characteristics...
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A population of human brain cells expressing phenotypic markers of more than one lineage can be induced in vitro to differentiate into mesenchymal cells
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Phenylalanine derivatives with modulating effects on human α1-glycine receptors and anticonvulsant activity in strychnine-induced seizure model in male adult rats
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Modified SPWM Technique with Zero-Sequence Voltage Injection for a Five-Phase, Three-Level NPC Inverter
PublikacjaThis article presents a modified sinusoidal pulse-width modulation (SPWM) scheme for a five-phase, three-level neutral-point-clamped inverter. The modulation scheme deploys a modified min–max function to inject the zero-sequence components into the reference modulating signals; hence enabling the effective utilization of the DC-link voltage. Balanced split-input DC-link voltages were achieved through further incorporation of adjustable...
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Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints
PublikacjaOur previous studies have shown that murine fibroblast cells, in which PARP-1 gene was inactivated by gene disruption, are extremely sensitive to triazoloacridone compound C-1305, an inhibitor of DNA topoisomerase II with unusual properties. Here, we show that pharmacological inhibition of PARP-1 activity by its inhibitor compound NU1025, sensitizes human cervical carcinoma HeLa cells to compound C-1305 compared to treatment with...
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Population modelling of <i>Acartia</i> spp. in a water column ecosystem model for the South-Eastern Baltic Sea
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Human Induced Pluripotent Stem Cell-Derived Microvesicles Transmit RNAs and Proteins to Recipient Mature Heart Cells Modulating Cell Fate and Behavior
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The Portrait of Cyberchondria—A Cross-Sectional Online Study on Factors Related to Health Anxiety and Cyberchondria in Polish Population during SARS-CoV-2 Pandemic
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Badania przesiewowe w kierunku depresji w wybranej dorosłej poulacji wiejskiej - doniesienie wstępne = Screening for depression in adult rural population-preliminary study
PublikacjaZe względu na częste występowanie zaburzeń depresyjnychoraz ich współistnienie z chorobami somatycznymi i niekorzystny wpływ na przebieg leczenia podkreśla się wagę badań przesiewowych których głównym celem jest zarówno dokonanie szybkiej, wstępnej diagnozy, jak i ocena częstości występowania danego zaburzenia.
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Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe — recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency
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Measurement of plasma 25-hydroxyvitamin D2, 25-hydroxyvitamin D3 and 3-epi-25-hydroxyvitamin D3 in population of patients with cardiovascular disease by UPLC-MS/MS method
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Mutual Clutter Suppression Techniques for FM Sonars
PublikacjaThe article presents methods that help in the elimination of mutual clutter as well as the consequences of two FM sounding signal sonars operating in the same body of water and frequency band. An in-depth analysis of mutual clutter was carried out. The effects of sounding signal differentiation were determined, as was the Doppler effect on mutual clutter suppression. One of the methods analysed is of particular interest in a situation...
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High prevalence of carriers of variant c.1528G>C of HADHA gene causing long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD) in the population of adult Kashubians from North Poland
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Optimization of Chemical Functionalities of Indole-2-carboxamides To Improve Allosteric Parameters for the Cannabinoid Receptor 1 (CB1)
Publikacja5-Chloro-3-ethyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide (1; ORG27569) is a prototypical allosteric modulator for the cannabinoid type 1 receptor (CB1). Here, we reveal key structural requirements of indole-2-carboxamides for allosteric modulation of CB1: a critical chain length at the C3-position, an electron withdrawing group at the C5-position, the length of the linker between the amide bond and the phenyl ring...
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Znajomość własnego ciśnienia tętniczego i rozpowszechnienie nadciśnienia tętniczego w populacji wiejskiej - Program Kiełpino = The cognizance of patient's own blood pressure values and the hypertension prevalence among rural population - Kiełpino program
PublikacjaNadciśnienie tętnicze jest jedną z najczęstszych chorób przewlekłych występujących w Polsce. Nieleczone nadciśnienie tętnicze prowadzi do licznych powikłań, jest przyczyna przedwczesnej umieralności, wpływa na pogorszenie komfortu życia pacjenta i zwiększa koszty leczenia. Ocena znajomości własnego ciśnienia tętniczego krwi oraz rozpowszechnienia nadciśnienia tętniczego u pacjentów w wiejskiej praktyce lekarza rodzinnego - jest...
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Efficiency of gas mixtures detection by resistive gas sensors
PublikacjaResistive gas sensors are very popular and are commonly used to detect various gases and their mixtures. Theeir main disadvantage is very limited selectivity. Practical use of gas sensors in environenmental applications requires determination of concentration of a few mixed gases at the same time. We would like to present recent results of gas detection improvement by utilizing a single gas sensor and additional measurements to...
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Changes in enzymatic activity of fish and slaughter animals meat after high pressure treatment at subzero temperatures
PublikacjaThe aim of this study was to determine changes in the activity of proteolytic enzymes and transglutaminase of fish and mammal meat after pressurization at subzero temperatures. The activity was measured at the optimal pHs determined for enzymes from particular types of tested meat. It was found that increasing the pressure in the range of 60–193 MPa, did not change significantly the activity of acidic proteases of cod flesh, while...
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Andreas Hoff (ed.) (2011). Population Ageing in Central and Eastern Europe. Societal and Policy Implications. Farnham, UK & Burlington, VT, USA: Ashgate, 260 pp. ISBN 978 0 7546 7828 1 (hardback)
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Habitat displacement effect between two competing owl species in fragmented forests
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EFFICIENCY OF GAS MIXTURES DETECTION BY RESISTIVE GAS SENSORS
PublikacjaResistive gas sensors are very popular and are commonly used to detect various gases and their mixtures. Their main disadvantage is very limited selectivity. Practical use of gas sensors in environmental applications (e.g., in sewage systems to protect workers, in air conditioning systems to monitor atmosphere quality) requires determination of concentration of a few mixed gases at the same time. We would like to present recent...
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Direct electrical brain stimulation of human memory: lessons learnt and future perspectives
PublikacjaModulation of cognitive functions supporting human declarative memory is one of the grand challenges of neuroscience, and of vast importance for a variety of neuropsychiatric, neurodegenerative and neurodevelopmental diseases. Despite a recent surge of successful attempts at improving performance in a range of memory tasks, the optimal approaches and parameters for memory enhancement have yet to be determined. On a more fundamental...
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Antimicrobial Activity of Chimera Peptides Composed of Human Neutrophil Peptide 1 (HNP-1) Truncated Analogues and Bovine Lactoferrampin
PublikacjaThree chimera peptides composed of bovine lactoferrampin and the analogue of truncated human neutrophil peptide 1 were synthesized by the solid-phase method. In two compounds peptide chains were connected via isopeptide bond, whereas in the third one disulfide bridge served as a linker. All three chimeras displayed significantly higher antimicrobial activity than the constituent peptides as well as their equimolar mixtures. The...
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Application of human bile salts for in vitro digestion models
PublikacjaIn this study, experimental in vitro models simulating the environment of the human gastrointestinal tract were used to assess the impact of physiological surfactants, such as bile salts, on the kinetics of digestion. Bile salts are biosurfactants synthesised in the liver and secreted together with bile into the small intestine. There are many reports on the role of bile salts in lipolysis, but the knowledge of their influence...
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Andrzej Klimczuk Economic Foundations for Creative Ageing Policy, Volume 1: Context and Considerations Palgrave Macmillan, 2015. 208 p. $115.00.
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Four Level Diode-Clamped Back-To-Back Converter with Active DC Link Voltage Control
PublikacjaThis article presents the design and control of 4L-DC back-to-back converter. To solve the DC link voltage balancing problem in four-level converter a new three-level double chopper topology based on PO-PWM modulation was designed and successfully tested. Also, the paper describes two phase space vector pulse width modulation 2P-SVPWM based on the shape function of finite elements. The control structure with modified Dead-Beat...
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Determination of chlorine concentration using single temperature modulated semiconductor gas sensor
PublikacjaA periodic temperature modulation using sinusoidal heater voltage was applied to a commercial SnO2 semiconductor gas sensor. Resulting resistance response of the sensor was analyzed using a feature extraction method based on Fast Fourier Transformation (FFT). The amplitudes of the higher harmonics of the FFT from the dynamic nonlinear responses of measured gas were further utilized as an input for Artificial Neural...
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BIODIVERSITY OF YEASTS ISOLATED FROM CAVES OF THE POLISH TATRA MOUNTAINS, AND ITS BIOTECHNOLOGICAL POTENTIAL
PublikacjaMost of the Earth’s biosphere is permanently or periodically exposed to temperatures below 5°C. Cold habitats harbor a wide diversity of psychrophiles. For many years Antarctica has been the geographic area preferred for studying the diversity and properties of cold-adapted microorganisms. However, the non-Antarctic habitats like Himalayas or Alps are also extensively explored. The Tatra Mountains are Europe’s second-highest massif...
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Distinct hippocampal-prefrontal neural assemblies coordinate memory encoding, maintenance, and recall
PublikacjaShort-term memory enables incorporation of recent experience into subsequent decision-making. This processing recruits both the prefrontal cortex and hippocampus, where neurons encode task cues, rules, and outcomes. However, precisely which information is carried when, and by which neurons, remains unclear. Using population decoding of activity in rat medial prefrontal cortex (mPFC) and dorsal hippocampal CA1, we confirm that mPFC...
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Distributed Evolutionary Algorithm for Path Planning in Navigation Situation
PublikacjaThis article presents the use of a multi-population distributed evolutionary algorithm for path planning in navigation situation. The algorithm used is with partially exchanged population and migration between independently evolving populations. In this paper a comparison between a multi-population and a classic single-population algorithm takes place. The impact on the ultimate solution has been researched. It was shown that using...
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Estimation of interior-permanent-magnet-synchronous-motor rotor position by analysis of phase-current derivatives
PublikacjaThis paper describes an algorithm for estimation of IPMSM rotor angular position. The algorithm uses derivatives of motor phase currents resulting from PWM modulation to obtain the rotor position. The presented method is designed for medium- and high-speed range, since it is based on determination of the EMF vector. Calculation of the motor position is performed in every PWM cycle. The standard SV-PWM method is used to determine...
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An Extended Control of the Input Angle for Matrix Converters Connected with the Non-Unity Power Factor Loads.
PublikacjaThis paper proposes a novel PWM modulation algorithm for Multiphase Conventional Matrix Converters (MCMC), with 3 inputs and k outputs, using the transfer function of the load angle. The proposed approach extends the range of power angle control at the input during the operation with a maximum voltage transfer ratio. The proposed concept is based on the Direct Analytic Voltage PWM (DAV--PWM) modulation with an elliptical trajectory...
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IPMSM rotor position estimator based on analysis of phase current derivatives
PublikacjaThis paper describes an algorithm for estimation of IPMSM angular rotor position. The algorithm uses derivatives of motor phase currents resulting from PWM modulation to obtain the rotor position. The presented method is designed for medium- and high-speed range, since it is based on determination of the EMF vector. Algorithm is characterised by a very simple formulae. The calculation of rotor position is performed in every PWM...
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Hybrid analogues of SFTI-1 modified in P1 position by β- and γ-amino acids and N-substituted β-alanines
PublikacjaA series of compounds containing either non-proteinogenic beta-/gamma-amino acids or N-substituted beta-alanine residues (beta-peptoid units) in P-1 specificity position were synthesized based on the structure of sunflower trypsin inhibitor 1 (SFTI-1). The compounds were synthesized on a solid support; the N-substituted beta-alanines (beta Nhlys and beta Nhphe) were introduced into a peptidomimetic chain via a two-step approach...
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Fluctuation enhanced gas sensing with WO3-based nanoparticle gas sensors modulated by UV light at selected wavelengths
PublikacjaThe sensitivity and selectivity of WO3-based gas sensors can be enhanced by UV-irradiation-induced modulation, especially if different wavelengths are employed. We used fluctuation-enhanced gas sensing, based on measurements of resistance fluctuations in the gas sensor, to study the effects of such modulation on the noise intensity for ambient atmospheres of synthetic air without and with additions of small amounts of ethanol,...
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Increasing the Utilization of dc-link Voltage of a Five-Leg VSI Based on Rotor Angle Control of Dual Induction Motors
PublikacjaThis paper introduces an increased utilization of the dc-link voltage of a five-leg voltage source inverter (VSI) based on the rotor flux angle control technique for dual induction motors, IM. The main purpose is to utilize additional abilities provided by a multi-motor drive system in limited operating conditions. Generally, a multi-motor drive system is widely used in electric vehicles (EVs), traction systems and in several industrial...
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A Simplified SVPWM Technique for Five-leg Inverter with Dual Three-phase Output
PublikacjaThis article proposes a simplified space vector pulse-width modulation (SVPWM) technique five-leg inverter with dual three-phase output. An idea to fed the dual tree-phase machine by the multiphase voltage source inverters (VSIs) is not new. Dual- and multi-motor drive systems are widely used in the industry applications. The most popular fields are: electric vehicles (EVs) and traction systems. Moreover, the specific characteristic...
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High Efficiency Dual-Active-Bridge Converter with Triple-Phase-Shift Control for Battery Charger of Electric Vehicles
PublikacjaAn optimal modulation scheme with triple-phase-shift (TPS) control could increase the efficiency in the entire load range for a dual-active-bridge (DAB) converter under wide output voltage range conditions. Therefore, this study proposes a convergent approach to TPS mode selection, coupled with an optimal modulation scheme, ensuring the circuit’s efficiency over the entire range in the realm of a high-power and high-efficiency...
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Application of Maximum Lenght Sequence in Silent Sonar
PublikacjaSilent sonars are designed to reduce the distance over which their sounding pulses can be detected by intercept sonars. In order to meet this objective, we can use periodical sounding signals that have low power, a very long duration and wide spectrum. If used in the silent sonar's receiver, matched filtration ensures very good detection of motionless or slow moving targets. However, it is more difficult to detect echo signals...
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Wpływ zmian struktury demograficznej ludności na lokalny rynek pracy
PublikacjaNa wzrost konkurencyjności gospodarki wpływa wiele czynników. Jednym z nich mogą być dostępne zasoby ludzkie. Ważna jest nie tylko dynamika zmian liczby ludności, również jej struktura. Celem niniejszego opracowania jest zbadanie zmian zachodzących na rynku pracy, będących konsekwencjami zmian struktury demograficznej ludności, które w przyszłości mogą wywierać negatywny wpływ na sytuację społeczno-gospodarczą regionu i kraju....
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Control strategy for the multilevel cascaded H-bridge converter
PublikacjaThe paper presents the control strategy for Cascaded H-bridge (CHB) converter . The converter output voltage using Space-Vector Pulse Width Modulation (SV-PWM) strategy is controlled. The DC-link voltages are controlled by appropriate choice of H-Bridges and appropriate choice of active and passive vectors.
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Synergistic effect of TiO2 photocatalytic advanced oxidation processes in the treatment of refinery effluents
PublikacjaDifferent types of photolytic and photocatalytic advanced oxidation processes (AOPs) were used for treatment of refinery effluents from bitumen production. The treatment efficiency was evaluated by analyzing chemical oxygen demand (COD), biological oxygen demand (BOD5), volatile organic compounds (VOCs) and sulfide ions concentration. The studies revealed a synergistic effect of application of external oxidants (O3, H2O2, O3/H2O2)...
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Gender as a moderator between Present-Hedonistic time perspective and depressive symptoms or stress during COVID-19 lock-down
PublikacjaAlthough numerous studies have addressed the impact of the COVID-19 lock-downs on psychological distress, scarce data is available relating to the role of Present-Hedonistic (PH) time perspective and gender differences in the development of depressive symptoms and stress during the period of strict social distancing. We hypothesized that gender would moderate the relationship between PH and depressiveness or stress levels, such...
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Pomiary grubości cienkich warstw metodą modulacji chromatycznej.
PublikacjaTematem artykułu jest pomiar grubości struktur cienkowarstwowych szerokostosowanych w optoelektronice, transparentnych warstw dielektrycznych. Grubość jest najistotniejszym parametrem warstwy i determinuje jej właściwościoptyczne. Metoda pomiaru grubości cienkich warstw powinna być bezkontaktowa, nieniszcząca, niekosztowna oraz odporna na zakłócenia
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Reliable OFDM Data Transmission with Pilot Tones and Error-Correction Coding in Shallow Underwater Acoustic Channel
PublikacjaThe performance of Underwater Acoustic Communication (UAC) systems are strongly related to the specific propagation conditions of the underwater channel. Horizontal, shallow-water channels are characterised by extremely disadvantageous transmission properties, due to strong multipath propagation and refraction phenomena. The paper presents the results of communication tests performed during a shallow, inland-water experiment with...
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A new concept of PWM duty cycle computation using the Barycentric Coordinates in a Three-Dimensional voltage vectors arrangement
PublikacjaThe paper presents a novel approach to the Pulse Width Modulation (PWM) duty cycle computing for complex or irregular voltage vector arrangements in the two (2D) and three–dimensional (3D) Cartesian coordinate systems. The given vectors arrangement can be built using at least three vectors or collections with variable number of involved vectors (i.e. virtual vectors). Graphically, these vectors form a convex figure, in particular,...
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An improved frequency estimator for an adaptive active noise control scheme
PublikacjaAn improved frequency tracker is proposed for the recently introduced self optimizing narrowband interference canceller (SONIC). The scheme is designed for disturbances with quasi-linear frequency modulation and, under second-order Gaussian random-walk assumption, can be shown to be statistically efficient. One real-world experiment and several simulations show that a considerable improvement in disturbance rejection may be achieved...
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Photocatalysts for Solar Energy Conversion
PublikacjaPhotocatalytic oxidation over suspended solid photocatalysts (e.g., titanium dioxide) has been proposed as a sustainable process for treatment and purification of water and wastewater as well as the process for photoconversion of solar energy to hydrogen, methane, and other low hydrocarbons. Solar radiation could be used to drive heterogeneous electrochemical reactions at the surface of an optically active photocatalyst (e.g.,...
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Emisyjność elektromagnetyczna przekształtników energoelektronicznych z modulacją rozproszoną
PublikacjaJednym z niepożądanych efektów ubocznych intensywnego rozwoju układów energoelektronicznych jest ich znaczna emisyjność elektromagnetyczna w zakresie zaburzeń przewodzonych i promieniowanych. Istnieje wiele metod ograniczania emisyjności tych układów, jednak ich skuteczność nie zawsze jest wystarczająca do spełnienia wymagań związanych z kompatybilnością elektromagnetyczna. W pracy zaprezentowano wyniki pomiarów skuteczności ograniczania...
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Kompleksowa analiza symulacyjna układu napędowego zespołu trakcyjnego
PublikacjaThe paper describes an approach to comprehensive analysis of traction electric drive. The drivetrain of ED-74 electric unit equipped with four inverter-fed induction motors was modeled in Matlab/Simulink. The model consists of functional blocks as: motors, inverters, drive controllers, filters. Structure and operation of the model was described. Chosen simulation results were presented and discussed. Two methods of modeling the...
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Asynchronous Charge Carrier Injection in Perovskite Light-Emitting Transistors
PublikacjaUnbalanced mobility and injection of charge carriers in metal-halide perovskite light-emitting devices pose severe limitations to the efficiency and response time of the electroluminescence. Modulation of gate bias in methylammonium lead iodide light-emitting transistors has proven effective in increasing the brightness of light emission up to MHz frequencies. In this work, a new approach is developed to improve charge carrier...