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Wyniki wyszukiwania dla: PSORIASIS GENETICS, GWAS, EPIGENETIC CHANGES, MIRNA
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Reasons for changes in the value of unit pressure of compression products supporting external treatment
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Possible effects of the 1984 St. Clair River ice jam on bed changes
PublikacjaThis study examines the possible effect of the record ice jam of 1984 in the St. Clair River on river bed changes and conveyance. Numerical simulations were made to examine the flow and bed shear stresses during the jam formation and release periods. Simulation results indicate that the ice jam in the river did not cause a significant increase in bed shear stress compared to pre- and post-jam open water conditions. The insignificant...
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Changes in gene methylation patterns in neonatal murine hearts: Implications for the regenerative potential
PublikacjaBackground The neonatal murine heart is able to regenerate after severe injury; this capacity however, quickly diminishes and it is lost within the first week of life. DNA methylation is an epigenetic mechanism which plays a crucial role in development and gene expression regulation. Under investigation here are the changes in DNA methylation and gene expression patterns which accompany the loss of regenerative potential. Results The...
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Annual changes of basic parameters of bottom sediments from the Klodnica River Catchment
PublikacjaThe Klodnica River Catchment is heavily contaminated ecosystem located in area of the Upper Silesia Industrial Region. In this area various forms of human activity can be observed (e.g. mining coal underground, metallurgy, power/heat plants, wastewater discharged directly into the river). The impact of industrial and municipal wastes on this aquatic system causes to changes in the hydrographic network of river and the waters quality. In...
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CHALLENGES TO NATIONAL ECONOMIES OF SELECTED EU COUNTRIES IN THE CONTEXT OF DEMOGRAPHIC CHANGES IN SOCIETY
PublikacjaThe countries of Central and Eastern Europe, which acceded to the EU in 2004, are facing a great challenge related to transformations in the level and demographic structure of the population. The observed adverse demographic developments require taking decisive actions aimed at curbing the negative trend. The purpose of this paper is to present changes in the level and demographic structure of population and their impact on...
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Arctic catchment as a sensitive indicator of the environmental changes: distribution and migration of metals (Svalbard)
PublikacjaArctic regions experience metal pollution, despite their remote location, and the distribution and migration of those metals determine their potential impact on the local environment. Here, a High-Arctic catchment (Revelva, Svalbard) located remotely from human-induced pollution sources is studied with respect to the distribution and migration of chosen trace elements (Ag, Al, As, B, Ba, Bi, Ca, Cd, Co, Cr, Cu, Cs, Mo, Ni, Pb,...
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The Revitalization Processes of the Port Structures in Gdynia and Gdansk on the Background of Contemporary Port Changes
PublikacjaTransformations of the port facilities against the modernization of the port structures are present in many city-port centers since more than 50 years. The modernization taking place in the ports located in Gdynia-Gdansk mainly concerns communication availability and adapted to the multimodal technology of transport and transshipment. Developing specialized tech-terminals serving a specific type of load, causes development of the...
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Statistical evaluation of the changes in cellulose properties caused by the stepwise solvent exchange and esterification
PublikacjaThe objective of the research was to empirically confirm the changes in cellulose reactivity caused by the pre-treatment with solvents of different polarity. Therefore, 5 solvents varying in their polar component of surface tension from 0 to 4.6 mN/m were chosen. Their impact on the biopolymer properties was carefully analysed concerning chemical structure, crystallinity and surface characteristics. It was revealed that the length...
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Study of Soil Temperature and Moisture Changes in a Physical Model of an Underground Cable Line
PublikacjaThe ampacity of power cables is highly dependent on the thermal resistivity of the soil in which they are laid. The lower it is, the higher this ampacity. The thermal resistivity of the soil decreases as its moisture increases. Therefore, it is preferable that the soil around the cables has high moisture. Unfortunately, the heat generated in heavily loaded cables causes the migration of moisture from the surrounding soil, which...
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Changes in the Global Competitiveness Index 4.0 Methodology: The Improved Approach of Competitiveness Benchmarking
PublikacjaThe Global Competitiveness Index (GCI) developed by the World Economic Forum (WEF) is used as a standard for measuring a country’s competitiveness. However, in literature, the GCI has been accused of numerous methodological flaws. Consequently, in 2018, the WEF introduced significant methodological changes. This study aims to examine whether the methodological modifications in the GCI’s structure increase its ability to capture...
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Hydrological responses to large-scale changes in land cover of river watershed: Review
PublikacjaDespite many studies on the hydrological responses to forest cover changes in micro and mesoscale watersheds, the hydrological responses to forest cover alterations and associated mechanisms through the large spatial scale of the river watershed have not been comprehensively perceived. This paper thus reviews a wide range of available scientific evidence concerning the impacts exerted by the forest removal on precipitation, water...
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THE SITUATION OF WOMEN IN THE POLISH LABOUR MARKET IN THE LIGHT OF CHANGES IN THE PENSION SECURITY SYSTEM
PublikacjaThe aim of the study is to examine the opinion of a group of women on their economic activity and decisions related to retirement. The first part of the article reviews previous research related to the economic activity of older people with a special focus on women. In the empirical part of the article, women’s opinions on issues related to retirement were analyzed. The research was carried out in 2016 on a sample of 45 women,...
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THE EFFECT OF DRYING INTENSITY ON THE COLOR CHANGES OF PINE WOOD (PINUS SYLVESTRIS L.)
PublikacjaThe effect of the selection of drying process parameters on the color change of Scots pine wood (Pinus Sylvestris L.) is presented. In this work the experimental studies have been performed. The research focused on the influence of drying intensity on the changes of color after drying process. Intensity of drying process was determined on the basis of the average drying gradient. To determine the color of wood before and after...
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Revealing dynamic changes of the volatile profile of food samples using PTR–MS
PublikacjaVolatile compounds carry valuable information regarding the properties of foodstuffs. Volatiles emitted from food can be used as, for example, indicators of quality, shelf-life, or authenticity. A better understanding of the multitude of transformations which occur during food processing could facilitate the optimisation of production, increase the desirability of food products, and also their wholesomeness. However, as some of...
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Physical, Chemical and Biological Changes in the Gulf of Gdańsk Ecosystem (Southern Baltic Sea).
PublikacjaPrzedstawiono fizyczne, chemiczne i biologiczne zmiany zachodzące w ekosystemie Zatoki Gdańskiej (Południowy Bałtyk. Opisano klimat (temp. wody, opady poziom morza, zasolenie), fluktuację stężeń związków biogennych (azotany,fosforany, krzemiany), poziom organicznych zanieczyszczeń (POP´s, PcB´, pestycydy, WWA) oraz zmiany w biologicznym życiu morza.
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The Changes of Groundwater Quality on the ''Czarny Dwór'' Intake in the Light of Polish-Swedish Investigations.
PublikacjaW wyniku badań przeprowadzonych w latach 2002-2003 na ujęciu ''Czarny Dwór''stwierdzono zmiany składu chemicznego i pogorszenie jakości płytko występu-jących wód gruntowych oraz wód powierzchniowych. Objawiło się to przedewszystkim podwyższoną twardością wody oraz wysokimi i zmiennymi koncentrac-jami siarczanów i azotu amonowego. Stwierdzono, że zmiany te są spowodowanegłównie przez ogródki działkowe zlokalizowane w najbliższym...
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Integrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism
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Kinetics and mechanism of the dehydrohalogenation of Ar2CHCX3 and Ar2CHCHX2 by strong N-bases
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Analysis of TL and OSL kinetics in lithium magnesium phosphate crystals
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Photoluminescence Kinetics of YAG Crystals Activated with Ce, and Ce and Mg
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Study of the Kinetics of Ammonia Synthesis and Decomposition on Iron and Cobalt Catalysts
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Kinetics studies of recrystallization process of metallic catalysts for ammonia synthesis
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Numerical solution of fractional neutron point kinetics in nuclear reactor
PublikacjaThis paper presents results concerning solutions of the fractional neutron point kinetics model for a nuclear reactor. Proposed model consists of a bilinear system of fractional and ordinary differential equations. Three methods to solve the model are presented and compared. The first one entails application of discrete Grünwald-Letnikov definition of the fractional derivative in the model. Second involves building an analog scheme...
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Kinetics of photochromic reactions in a 10-membered dibenzoazo crown ether
PublikacjaPrzedstawiono rezultaty pomiarów kinetyki fotochromowych reakcji dla jednego z serii eterów koronowych zawierających fragment azobenzenowy. Badano 10-członową dibenzoazokoronę, która ulega odwracalnej foto i termicznej izomeryzacji, podobnie jak macierzysty azobenzen. Eksperymenty były prowadzone w matrycy pMMA. Reakcja izomeryzacji monitorowana była spektrofotometrycznie. Czynnik przedwykładniczy dla termicznej izomeryzacji cis-trans...
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A study of the kinetics of bismuth telluride synthesis by an oxide reduction method
PublikacjaThe kinetics of a reduction of bismuth and tellurium oxides in a hydrogen atmosphere, leading to the formation of thermoelectric bismuth telluride is investigated. The evaluation of the reaction kinetics was based on a thermogravimetric analysis performed in non-isothermal conditions. A non-parametric analysis method and the Friedman method were used for the evaluation of the data. Additionally, for a better understanding of the...
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Kinetics of cross-linking processes of fast-curing polyurethane system
PublikacjaThis work focuses on the application of thermal analysis and kinetics investigations to analyze chemical processes during cross-linking of the complex fast-curing polyurethane system. Non-isothermal Differential Scanning Calorimetry (DSC) measurements were performed for both stoichiometric mixtures of polyol and isocyanate component and for mixture with large isocyanate excess. Isoconversional methods were used to calculate initial...
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The paradigm change of flexible production systems desing
PublikacjaNiniejszy artykuł pokazuje zmiany paradygmatu projektowania i eksploatacji elastycznych systemów produkcyjnych, na przykładzie różnych modeli systemów nowej generacji NGMS (Next Generation Manufacturing System). Dokonano analizy porównawczej wybranych rozwiązań w przedmiotowym obszarze, formułując prognozy rozwojowe w oparciu o zaproponowane megatrendy rozwojowe: miniaturyzacji, sieciowości (networking), mobilności, i wirtualizacji....
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The Courts Public image - The Desired Direction of Change
PublikacjaThis paper proposes to scientifically explore notions of court identity, principles of shaping a court system's image, and best practices in positive court image development relating to thhe courts in Poland
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Towards a Universal Model of Engineering Change Management
PublikacjaThe paper deals with the issue of engineering change management (ECM). ECM has received much less attention in the literature than general change management. Moreover, due to their specifics (complexity and multifaceted nature), hitherto developed ECM models are difficult to implement in companies. The paper aims to develop a simplified, universal, and hence easily applicable model of ECM. We based our assumptions on a case study...
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Energy of change in commercial, innovative and inteligent spaces
PublikacjaW artykule miasto zostanie zakwalifikowane do przestrzeni komercyjnych, które charakteryzuje ciągłe dążenie do atrakcyjności. Napędza to wykorzystywanie rozwiązań innowacyjnych w zakresie kształtowania przestrzeni, będących nowym źródłem miejskiej energii. W artykule uwaga skupi się innowacyjności przestrzeni, wynikającej z udziału technologii informacyjnych, które na styku z architekturą i sztuką czynią tą przestrzeń inteligentną....
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PROBABLE RAINFALL IN GDAŃSK IN VIEW OF CLIMATE CHANGE
PublikacjaOne of the manifestations of climate changes is the occurrence of a greater number of precipitation events, characterized by greater rain intensity that affects the economic stability of cities. Gdańsk is an example of a city in which such events have occurred since the beginning of the twenty-first century. Due to the altitude differences in the area of Gdańsk city (between –2 m and 180 m a.s.l.), the occurrence of extreme atmospheric...
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Change of myocardial impedance during experimental ischemia.
PublikacjaW pracy omówiono możliwość monitorowania procesu niedotlenienia za pomocą pomiarów immitancyjnych. Przedstawiono skonstruowane stanowisko pomiarowe ze szczególnym uwypukleniem właściwości sondy pomiarowej. Przedstawiono wyniki eksperymentalnego niedotlenienia u świń wywołanego zamknięciem LAD.
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Generic invariant measures for iterated systems of interval homeomorphisms
PublikacjaIt is well known that iterated function systems generated by orientation preserving homeomorphisms of the unit interval with positive Lyapunov exponents at its ends admit a unique invariant measure on (0, 1) provided their action is minimal. With the additional requirement of continuous differentiability of maps on a fixed neighbourhood of {0,1} { 0 , 1 } , we present a metric in the space of such systems which renders it complete....
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Dynamical description of quantum computing: generic nonlocality of quantumnoise
PublikacjaWe develop a dynamical non-Markovian description of quantum computing in the weak-coupling limit, in the lowest-order approximation. We show that the long-range memory of the quantum reservoir (such as the 1/t4 one exhibited by electromagnetic vacuum) produces a strong interrelation between the structure of noise and the quantum algorithm, implying nonlocal attacks of noise. This shows that the implicit assumption of quantum error...
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Immunophenotyping and transcriptional profiling of in vitro cultured human adipose tissue derived stem cells
PublikacjaAdipose-derived stem cells (ASCs) have become an important research model in regenerative medicine. However, there are controversies regarding the impact of prolonged cell culture on the ASCs phenotype and their differentiation potential. Hence, we studied 10 clinical ASCs replicates from plastic and oncological surgery patients, in six-passage FBS supplemented cultures. We quantified basic mesenchymal cell surface marker transcripts...
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Polish small and medium enterprises : chances, barries and challenges
PublikacjaLata dziewięćdziesiąte przyniosły gospodarce polskiej bardzo szybki wzrost sektora małych i średnich przedsiębiorstw. Jego dynamika miała jednak tendencję gasnącą, szczególnie u progu XXI wieku. Wyjaśnienie przyczyn tych zjawisk może stanowić przesłankę dla oceny bieżącej polityki państwa wobec MSP, a także dla formułowania założeń przyszłej polityki na tym obszarze. Prezentowane opracowanie pokazuje, jak działania państwa w zakresie...
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The Prognostic Value of Whole-Blood PSMB5, CXCR4, POMP, and RPL5 mRNA Expression in Patients with Multiple Myeloma Treated with Bortezomib
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The Prognostic Value of Whole-Blood PSMB5, CXCR4, POMP and RPL5 mRNA Expression in Patients with Multiple Myeloma Treated with Bortezomib
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Functional nuclear retention of pre-mRNA involving Cajal bodies during meiotic prophase in European larch (Larix decidua)
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Utilizing Genome-Wide mRNA Profiling to Identify the Cytotoxic Chemotherapeutic Mechanism of Triazoloacridone C-1305 as Direct Microtubule Stabilization
PublikacjaRational drug design and in vitro pharmacology profiling constitute the gold standard in drug development pipelines. Problems arise, however, because this process is often dicult due to limited information regarding the complete identification of a molecule’s biological activities. The increasing aordability of genome-wide next-generation technologies now provides an excellent opportunity to understand a compound’s diverse eects...
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Seeking genetic signature of radiosensitivity - a novel method for data analysis in case of small sample sizes
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Host genetic background affects the course of infection and treatment response in patients with chronic hepatitis B
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Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women
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Patient rights, risk, and responsibilities in the genetic era – a right to know, a right not to know, or a duty to know?
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Human-associated bacteria and their mobile genetic elements - important minority in wastewater and wastewater impacted ecosystems
PublikacjaSince human-associated bacteria have been recognized as vectors in two - way gene transmission between the pathogenic and environmental populations, health hazard connected with wastewater discharge requires reevaluation. In this paper the particular attention was given to antimicrobial-resistance of Escherichia coli and enterococci isolated from wastewater and wastewater impacted environments. The obtained results showed that...
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Selection of optimal location and rated power of capacitor banks in distribution network using genetic algorithm
PublikacjaIn this paper, the problem of placement and rated power of capacitor banks in the Distribution Network (DN) is considered. We try to suggest the best places for installing capacitor banks and define their reactive power. The considered formulation requires the optimization of the cost of two different objectives. Therefore the use of properly multiobjective heuristic optimization methods is desirable. To solve this problem we use...
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Retrospective analysis of genetic diversity of Klebsiella oxytoca isolated in Poland over a 50-year period.
PublikacjaAnaliza genetyki populacji i określenie powiązań filogenetycznych pomiędzy szczepami może być niezwykle użytecznym podejściem w określaniu rozprzestrzeniania się wzorów genetycznych różnych gatunków bakterii na potrzeby epidemiologiczne. Nie ma danych, które opisywałyby długoterminowe sytuacje epidemiologiczne powodowane przez wielolekooporne, oportunistyczne szczepy Klebsiella oxytoca metodami molekularnymi. Celem przedstawionych...
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A novel genetic approach to provide differentiated levels of service resilience in IP-MPLS/WDM networks
PublikacjaThis paper introduces a novel class-based method of survivable routing for connection-oriented IP-MPLS/WDM networks, called MLS-GEN-H. The algorithm is designed to provide differentiated levels of service survivability in order to respond to varying requirements of end-users. It divides the complex problem of survivable routing in IP-MPLS/WDM networks into two subproblems, one for each network layer, which enables finding the...
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Evaluation of multiple genetic markers for typing drug-resistant Mycobacterium tuberculosis strains from Poland
PublikacjaW publikacji przedstawiono wyniki genotypowania wielolekoopornych szczepów Mycobacterium tuberculosis izolowanych od pacjentów z Polski.
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Future of medicine: personalized oncology
PublikacjaUnderstanding genetic and epigenetic mechanisms of tumorigenesis allows identifying many vital mutations affected the formation of various malignancies. This led to the discovery of a new therapeutic approach, based on molecular mechanisms in the world of medicine, which is called personalized medicine (PM). This review aims to outline the state of the art of the personalized medicine in treatment, taking into account anti-cancer...