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Wyniki wyszukiwania dla: adhesive agent
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Synthesis and biological activity of ester derivatives of mycophenolic acid and acridines/acridones as potential immunosuppressive agents
PublikacjaImproved derivatives of mycophenolic acid (MPA) are necessary to reduce the frequency of adverse effects, this drug exerts in treated patients. In this study, MPA was coupled with N-(x-hydroxyalkyl)-9-acridone-4-carboxamides or N-(x-hydroxyalkyl)acridine-4-carboxamides to give respective ester conjugates upon Yamaguchi protocol. This esterification required protection of phenol group in MPA. Designed conjugates revealed higher...
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One-Step Synthesis of W/O and O/W Emulsifiers in the Presence of Surface Active Agents
PublikacjaThe main goal of this study was to describe the method of the synthesis of the dodecyl-, tetradecyl-, hexadecyl- and octadecyl-propylene glycol emulsifiers in the presence of selected anionic and nonionic surfactants. Acyl propylene glycol emulsifiers were produced by esterification of propane-1,2-diol (propylene glycol, PG) with C12:0-C18:0 fatty acids in the presence of anionic sodium dodecyl sulfate (SDS) and nonionic-poly(ethylene...
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Examination of the epoxy coating system's resistance to Corrobill
PublikacjaThe tests of the influence of the surface cleaning agent on the epoxy coating were carried out. Electrochemical and corrosion tests were carried out. The effect of the preparation on the adhesion and hardness of the tested coating was tested.
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Adhesion of AlCrN coating deposited on TiB2/Ti composites sintered by SPS dedicated for high temperature tribological applications
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Changes in Nuclear Gene Expression Related to Mitochondrial Function Affect Extracellular Matrix, Collagens, and Focal Adhesion in Keratoconus
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The Effects of Cellular Membrane Damage on the Long-Term Storage and Adhesion of Probiotic Bacteria in Caco-2 Cell Line
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Quantitative assessment of the influence of tensile softening of concrete in beams under bending by numerical simulations with XFEM and cohesive cracks
PublikacjaResults of the numerical simulations of the size effect phenomenon for concrete in comparison with experimental data are presented. In-plane geometrically similar notched and unnotched beams under three-point bending are analyzed. EXtended Finite Element Method (XFEM) with a cohesive softening law is used. Comprehensive parametric study with the respect to the tensile strength and the initial fracture energy is performed. Sensitivity...
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A three-dimensional meso-scale approach with cohesive elements to concrete fracture based on X-ray μCT images.
PublikacjaArtykuł omawia wyniki numeryczne dotyczące pękania betonu uzyskane stosując trójwymiarowy model mezoskopowy z elementami kohezyjnymi. Obliczenia trójwymiarowe zostały wykonane dla zginanej belki betonowej. Beton został opisany jako model 3-fazowy. Mikrostruktura betonu odpowiadała zdjęciom tomograficznym. Wyniki numeryczne zostały porównane z wynikami doświadczalnymi. Uzyskano b. dobra zgodność między wynikami numerycznymi i doświadczalnymi.
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Two-dimensional simulations of concrete fracture at aggregate level with cohesive elements based on X-ray lCT images
PublikacjaThe paper presents results of two-dimensional meso-scale simulations of fracture in notched concrete beams subjected to three-point bending test. Concrete was assumed as a 4-phase material composed of aggregate grains placed in the cement matrix, interfacial transitional zones (ITZs) and macro-voids. The particle distribution was taken from real concrete beams on the basis of X-ray lCT images. Comprehensive numerical analyses were carried...
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Distributed Evacuation in Graphs with Multiple Exits
PublikacjaWe consider the problem of efficient evacuation using multiple exits. We formulate this problem as a discrete problem on graphs where mobile agents located in distinct nodes of a given graph must quickly reach one of multiple possible exit nodes, while avoiding congestion and bottlenecks. Each node of the graph has the capacity of holding at most one agent at each time step. Thus, the agents must choose their movements strategy...
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Consolidating logs in varying formats into a structured repository = konsolidacja logów w zmiennych formatach do strukturalnego repozytorium
PublikacjaDuring multi-agent systems development, testing and re- search, possibly voluminous logs are created at distributed agent loca-tions. These logs describe individual agents behavior and state changes. To get the complete picture of the multi-agent system working, it is necessary to consolidate these logs and to store them in a format appropriate for diverse analyzes. Specic issues arise during consolidation if the log formats are...
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Phthalocyanine Derivatives Possessing 2-(Morpholin-4-yl)ethoxy Groups As Potential Agents for Photodynamic Therapy
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The Setting Time of Polyether Impression Materials after Contact with Conventional and Experimental Gingival Margin Displacement Agents
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Metabolic Profiles of New Unsymmetrical Bisacridine Antitumor Agents in Electrochemical and Enzymatic Noncellular Systems and in Tumor Cells
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Sonochemical synthesis of rosuvastatin based novel 3-methyleneisoindolin-1-one derivatives as potential anticancer agents
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Chloroacridine derivatives as potential anticancer agents which may act as tricarboxylic acid cycle enzyme inhibitors
PublikacjaThe chloroacridines affect biological forms of melanoma in different ways. Amelanotic (Ab) melanoma (with inhibited melanogenesis and higher malignancy) was particularly sensitive to the action of the chloroacridines. The Ab melanoma cells died through apoptosis and through death without caspase activation. Diminished activity of TAC enzymes was noticed among Ab melanoma cells together with ATP/NAD depletion, especially in the...
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Novel chalcone-derived pyrazoles as potential therapeutic agents for the treatment of non-small cell lung cancer
PublikacjaLung cancer is considered to account for approximately one-fifth of all malignant tumor-related deaths worldwide and is therefore one of the most lethal malignancies. Pyrazole scaffold possesses a wide range of biological and pharmacological activities, which play important roles in medicinal chemistry. The present study reports the synthesis and in vitro biological characterization of nine pyrazoles derived from chalcones as potential...
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Metabolic Profiles of New Unsymmetrical Bisacridine Antitumor Agents in Electrochemical and Enzymatic Noncellular Systems and in Tumor Cells
PublikacjaNew unsymmetrical bisacridines (UAs) demonstrated high activity not only against a set of tumor cell lines but also against human tumor xenografts in nude mice. Representative UA compounds, named C-2028, C-2045 and C-2053, were characterized in respect to their physicochemical properties and the following studies aimed to elucidate the role of metabolic transformations in UAs action. We demonstrated with phase I and phase II enzymes...
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Design of new cholinesterase inhibitors based on phosphorus analogs of tacrine as potential anti-Alzheimer’s disease agents
PublikacjaBased on the analysis of the determined free binding energy (using the AutoDock Vina 1.1.2 docking program), the most potent cholinesterase inhibitors were selected. Moreover, studies of 3D visualization of the results of molecular modeling led to the identification of potential sites for the interaction of new potential inhibitors with amino acid residues building active sites of investigated cholinesterases.
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Influence of Installation Effects on Pile Bearing Capacity in Cohesive Soils – Large Deformation Analysis Via Finite Element Method
PublikacjaIn this paper, the whole process of pile construction and performance during loading is modelled via large deformation finite element methods such as Coupled Eulerian Lagrangian (CEL) and Updated Lagrangian (UL). Numerical study consists of installation process, consolidation phase and following pile static load test (SLT). The Poznań site is chosen as the reference location for the numerical analysis, where series of pile SLTs...
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The Effect of Surface Modification of Ti13Zr13Nb Alloy on Adhesion of Antibiotic and Nanosilver-Loaded Bone Cement Coatings Dedicated for Application as Spacers
PublikacjaSpacers, in terms of instruments used in revision surgery for the local treatment of postoperative infection, are usually made of metal rod covered by antibiotic-loaded bone cement. One of the main limitations of this temporary implant is the debonding effect of metal–bone cement interface, leading to aseptic loosening. Material selection, as well as surface treatment, should be evaluated in order to minimize the risk of fraction...
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Numerical investigations of discrete crack propagation in Montevideo splitting test using cohesive elements and real concrete micro-structure
PublikacjaThe paper is aimed at accurately predicting the discrete fracture process in concrete specimens under complex stress states in two dimensional (2D) simulations. Plain concrete specimens subjected to Montevideo splitting test (MVD) were used for consideration due to non-negligible shear stresses impact in this type of test. In order to reflect the heterogeneous nature of the concrete, the meso-structure of the samples was included...
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Pre-clinical toxicology and pathology of 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), a novel anti-cancer agent in male Beagle dogs
PublikacjaPraca zawiera wyniki badań przedklinicznych i morfologicznych pochodnej akrydyny o symbolu C-1748 przeprowadzonych na psach. Wyznaczono maksymalną dawkę tolerowaną oraz przeprowadzono analizy zmiany składu krwi i morfologii jej komórek, pracy aminotransferaz, fosfokinaz, fosfataz i innych enzymów funkcjonalnych. Obserwowano też zachowanie się zwierząt. Stwierdzono, że związek ten wykazuje stosunkowo niską toksyczność, co przy obserwowanej...
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The overexpression of CPR and P450 3A4 in pancreatic cancer cells changes the metabolic profile and increases the cytotoxicity and pro-apoptotic activity of acridine antitumor agent, C-1748
PublikacjaDrug resistance is one of the major cause of pancreatic cancer treatment failure. Thus, it is still imperative to develop new active compounds and novel approach to improve drug efficacy. Here we present 9-amino-1-nitroacridine antitumor agent, C-1748, developed in our laboratory, as a candidate for pancreatic cancer treatment. We examined (i) the cellular response of pancreatic cancer cell lines: Panc-1, MiaPaCa-2, BxPC-3 and...
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Preclusion of irreversible destruction of Dr adhesin structures by a high activation barrier for the unfolding stage of the fimbrial DraE subunit
PublikacjaFimbrie Dr uropatogennych szczepów Escherichia coli stanowią przykład eksponowanych powierzchniowo struktur adhezyjnych podlegających biogenezie według zakonserwowanego, pośród bakterii Gram-ujemnych, systemu "chaperone-usher" ("białko opiekuńcze-zewnątrzbłonowe białko kanałowe"). Powyższe struktury adhezyjne są niezbędne w procesie specyficznej adhezji bakterii do receptorów zlokalizowanych na powierzchni docelowych komórek gospodarza....
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Selected Features of Dynamic Voting
PublikacjaIn multi-agent systems composed of autonomous agents with local knowledge, it is often desirable to aggregate their knowledge in order to make an educated decision. One of the methods of agreeing to a common decision is voting. A new history-based dynamic weight protocol allows for identification of the agents which contribute to the correct system decision. The main advantage of this approach, compared to static weighted system...
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Properties of chitosan/CuNPs coatings electrophoretically deposited on TiO2 nanotubular oxide layer of Ti13Zr13Nb alloy
PublikacjaCoatings based on chitosan/CuNPs (chit/CuNPs) were obtained by a one-step electrophoretic deposition (EPD) on nanotubular oxide layer of Ti13Zr13Nb alloy. The deposition was carried out for 1 min applying voltages of 10 and 20 V with and without the addition of dispersing agent (Polysorbate 20) to the suspension. The coatings obtained for the lower voltage were more uniform than for the higher voltage. By adding a dispersing agent,...
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N-Substituted piperazine derivatives as potential multitarget agents acting on histamine H3 receptor and cancer resistance proteins
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Silicon polypodands: powerful metal cation complexing agents and solid–liquid phase-transfer catalysts of new generation
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Absence of 6-Hydroxydopamine in the Rat Brain After Treatment with Stimulants and Other Dopaminergic Agents: A Mass Fragmentographic Study
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Pd-catalysed general access to 7-membered N/O-heterocyclic compounds as potential agents against inflammation
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The hydration of the protein stabilizing agents: trimethylamine-N-oxide, glycine and its N-methylderivatives - the volumetric and compressibility studies
PublikacjaThe densities at T = (288.15, 293.15, 298.15, 303.15, and 308.15) K and sound velocities at T = 298.15 K have been measured for aqueous solutions of trimethylamine-N-oxide, glycine, N-methylglycine (sarcosine), N,N-dimethylglycine, N,N,N-trimethylglycine (betaine). From these data the apparent molar volumes, VΦ, the apparent molar isentropic compressions, KS,Φ, and the solvation numbers of solutes have been determined. The concentration...
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Synthesis of new antrapyridazone derivatives - a novel group of anticancer agents active on a multidrugresistant(MDR) tumor cell lines
PublikacjaNovel antrapyridazone derivatives were synthesized and biologically evaluated in order tobroaden the data on structure-activity relationship of this class of cytostatics. Recent literaturedata prove that acetamides react better with aryl chlorides. A new approach based onintroduction of other amides form into aromatic ring in Ullmann was tested. This new methodcould give better yields and make purification step more convenient.
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DNA methylation in cancer development, diagnosis and therapy-multiple opportunities for genotoxic agents to act as methylome disruptors or remediators
PublikacjaThe role of DNA methylation and recently discovered hydroxymethylation in the function of the human epigenome is currently one of the hottest topics in the life sciences. Progress in this field of research has been further accelerated by the discovery that alterations in the methylome are not only associated with key functions of cells and organisms, such as development, differentiation and gene expression, but may underlie a number...
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Electrochemical simulation of metabolic reduction and conjugation reactions of unsymmetrical bisacridine antitumor agents, C-2028 and C-2053
PublikacjaElectrochemistry (EC) coupled with analysis techniques such as liquid chromatography (LC) and mass spectrometry (MS) has been developed as a powerful tool for drug metabolism simulation. The application of EC in metabolic studies is particularly favourable due to the low matrix contribution compared to in vitro or in vivo biological models. In this paper, the EC(/LC)/MS system was applied to simulate phase I metabolism of the representative...
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Effect of Chitosan Solution on Low-Cohesive Soil’s Shear Modulus G Determined through Resonant Column and Torsional Shearing Tests
PublikacjaIn this study the effect of using a biopolymer soil stabilizer on soil stiffness characteristics was investigated. Chitosan is a bio-waste material that is obtained by chemical treatment of chitin (a chemical component of fungi or crustaceans’ shells). Using chitosan solution as a soil stabilizer is based on the assumption that the biopolymer forms temporary bonds with soil particles. What is important is that these bonds are biodegradable,...
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Reputacja i zaufanie w systemach teleinformatycznych z podmiotami anonimowymi podejście dynamiczne
PublikacjaAbstrakcją współczesnego systemu teleinformatycznego jest system wieloagentowy z autonomicznymi, racjonalnymi i wirtualnie anonimowymi agentami wchodzącymi we wzajemne interakcje dla wymiany usług. W referacie uzasadniono konieczność projektowania dla niego podsystemu budowy reputacji i zaufania oraz odpowiednich analiz w ujęciu dynamicznym. Dokonano przeglądu motywacyjnie zgodnych mechanizmów uczciwego raportowania usług oraz...
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Mrówczan sodu z nowym pakietem inhibitorów korozji jako ekologiczny środek do odladzania infrastruktury lotniczej.
PublikacjaPrzedstawiono wyniki badań korozji kadmowej powłoki na stali oraz korozji po zanurzeniu stopów metali w mrówczanie sodu z nowym pakietem inhibitorów korozji, zawierającym synergiczną kompozycję poliasparaginianu sodu oraz imidazolu. Ponadto wyznaczono zdolność penetracji lodu przez badany układ. Właściwo- ści opracowanej kompozycji odladzającej porównano z właściwościami środków dostępnych na rynku. Uzyskane wyniki wskazują, że otrzymany...
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The influence of combination of binding agents on fatigue properties of deep cold in-place recycled mixtures in Indirect Tensile Fatigue Test (ITFT)
PublikacjaThe publication presents fatigue properties of cold recycled mixtures for eight combinations of binding agents (cement and bituminous emulsion). Cold recycled mixtures were evaluated in Indirect Tensile Fatigue Test (ITFT) at the temperature of 20 C in controlled stress mode. As a function of horizontal stress, fatigue life is strongly influenced by combination of the binding agents. When fatigue life is analyzed as a function...
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Process zone in the Single Cantilever Beam under transverse loading. - Part II: Experimental
PublikacjaThis paper describes an experimental arrangement to evaluate stress/strain fields in the process zone of asymmetric adhesively bonded joints. A transparent polycarbonate flexible beam was bonded to an aluminium alloy rigid block with an epoxy adhesive in a Single Cantilever Beam (SCB) configuration. The flexible adherend was loaded in the direction parallel to the initial crack front at constant rate. To monitor strains induced...
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Time versus space trade-offs for randezvous in trees
PublikacjaTwo identical (anonymous) mobile agents start from arbitrary nodes of an unknown tree and have to meet at some node. Agents move in synchronous rounds: in each round an agent can either stay at the current node or move to one of its neighbors. We consider deterministic algorithms for this rendezvous task. The main result of this paper is a tight trade-off between the optimal time of completing rendezvous and the size of memory...
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On the origin of surfaces-dependent growth of benzoic acid crystal inferred through the droplet evaporation method
PublikacjaCrystal growth behavior of benzoic acid crystals on different surfaces was examined. The performed experiments documented the existence of very strong influence introduced by polar surfaces as glass, gelatin, and polyvinyl alcohol (PVA) on the growth of benzoic acid crystals. These surfaces impose strong orientation effect resulting in a dramatic reduction of number of faces seen with x-ray powder diffractions (XPRD). However,...
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On the origin of surfaces-dependent growth of benzoic acid crystal inferred through the droplet evaporation method
PublikacjaCrystal growth behavior of benzoic acid crystals on different surfaces was examined. The performed experiments documented the existence of very strong influence introduced by polar surfaces as glass, gelatin, and polyvinyl alcohol (PVA) on the growth of benzoic acid crystals. These surfaces impose strong orientation effect resulting in a dramatic reduction of number of faces seen with x-ray powder diffractions (XPRD). However,...
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On the origin of surfaces-dependent growth of benzoic acid crystal inferred through the droplet evaporation method
PublikacjaCrystal growth behavior of benzoic acid crystals on different surfaces was examined. The performed experiments documented the existence of very strong influence introduced by polar surfaces as glass, gelatin, and polyvinyl alcohol (PVA) on the growth of benzoic acid crystals. These surfaces impose strong orientation effect resulting in a dramatic reduction of number of faces seen with x-ray powder diffractions (XPRD). However,...
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Fatal sepsis in a pregnant woman with pyelonephritis caused by Escherichia coli bearing Dr and P adhesins: diagnosis based on postmortem strain genotyping
PublikacjaW pracy został opisany pierwszy śmiertelny przypadek młodej kobiety w ciąży z powodu przewlekłego zapalenia odmiedniczkowego nerek spowodowany przez szczepy E. coli z fimbriami typu Dr + i P. Badania pośmiertne wykazały, że śmierć nastąpiła z powodu posocznicy do której doszło na skutek zakażenia szczepami E. coli Dr + . Odmiedniczkowe zapalenie nerek w ciąży jest związane z wieloma powikłaniami, w tym ograniczeniem wzrostu płodu,...
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Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma
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Flexible Films as Anode Materials Based on rGO and TiO2/MnO2 in Li-Ion Batteries Free of Non-Active Agents
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Rosuvastatin based novel 3-substituted isocoumarins / 3-alkylidenephthalides: Ultrasound assisted synthesis and identification of new anticancer agents
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Novel molecules containing structural features of NSAIDs and 1,2,3-triazole ring: Design, synthesis and evaluation as potential cytotoxic agents
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Structure modification of acridine antitumor agents results in changes of enzymatic activity and gene expression of CYP3A4 isoenzyme in HepG2 cells.
PublikacjaEkspresja izoenzymu CYP3A4, który zaangażowany jest w metabolizm ok. 60% leków stosowanych klinicznie, może być modulowana przez takie czynniki jak: polimorfizm, czynniki transkrypcyjne oraz obecność ksenobiotyków. Przykładem induktorów genów kodujących izoenzym CYP3A4 jest fenobarbital i rifampicyna, których obecność w organizmie przyspiesza metabolizm innych leków stosowanych jednocześnie, które są substratami dla CYP3A4. Dlatego...