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Wyniki wyszukiwania dla: EPIGENETIC DRUGS
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mikrokontrolery stm8s - pierwsze kroki (2)
PublikacjaArtykuł zawiera drugą część krótkiego kursu programowania mikrokontrolerów STM8S
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The Combination of Beta-Blockers and ACE Inhibitors Across the Spectrum of Cardiovascular Diseases
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Preclinical toxicological examination of a putative prostate cancer-specific 4-methyl-1-nitroacridine derivative in rodents
PublikacjaW pracy przedstawiono wyniki przedklinicznych badań toksykologicznych zwiazków C-1748 i C-857 na szczurach Copenhagen i myszach BALB/c, po podaniu dootrzewnowym lub dożylnym. U myszy dawki letalne (LD50) dla C-1748 wynosiły odpowiednio 9 i 13,4 mg/kg w porównaniu z 2,2 i 3 mg/kg dla C-857. U szczurów po podaniu dootrzewnowym lub dożylnym dla C-1748 dawki LD50 wynosiły odpowiednio 4 i 1,3 mg/kg. Nie stwierdzono zmian w liczbie komórek...
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Two novel nucleoside ester derivatives of chlorambucil as potential antileukemic prodrugs: a preliminary study
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Fatal iatrogenic vinorelbine poisoning
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Polyacrylamide substrate viscosity impact on temozolomide activity in glioblastoma cells by flow cytometry and rheological measurements
Dane BadawczeDataset includes raw data on cell lines LN-229 and LN-18 treated with temozolomide measured by flow cytometry, rheometry and cell projections. It also includes calculations necessary for creation of figures and conclusions based on those figures in the publication titiled: "Substrate viscosity impairs temozolomide-mediated inhibition of glioblastoma...
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Bisphenols (A, S, and F) affect the basic hormonal activity determined for pharmaceuticals – Study of Saccharomyces cerevisiae
PublikacjaPharmaceuticals and analogs of bisphenol A (BPA) are increasingly threatening environmental pollutants. In this study, mixtures of selected pharmaceuticals (diclofenac sodium salt, chloramphenicol, oxytetracycline hydrochloride, fluoxetine hydrochloride, estrone, ketoprofen, progesterone, gemfibrozil and androstenedione) were prepared with BPA and its two analogs (namely, bisphenols F and S) at such ratios to reflect environmentally...
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Sposoby Realizacji Maszyn Wirtualnych Zintegrowanych z Procesorem
PublikacjaW pracy przedstawiono dwa proponowane sposoby realizacji maszyny wirtualnej zintegrowanej z procesorem. Pierwszy z nich opiera się o rozbudowaną pamięć podręczną instrukcji, drugi bazuje na mechanizmie zarządzania pamięcią przez procesor. Pierwszy z przedstawionych sposobów jest dobrym rozwiązaniem do zastosowania w systemach wbudowanych, zaś drugi nadaje się do stosowania z pełnowymiarowymi systemami operacyjnymi.
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Gabriela Rembarz dr inż. arch.
OsobyGabriela Rembarz inżynier-architekt, urbanista, naukowiec, dydaktyk i aktywna projektantka, jest doktorem nauk technicznych w dyscyplinie architektura i urbanistyka, Ukończyła studia magisterskie na Wydziale Architektury i Urbanistyki Politechniki Gdańskiej, uzupełniając je specjalizacją w Ochronie Środowiska w ramach międzyuczelnianego CENVIG Center of Environmental Studies (Politechnika Gdańska) akredytowanego przez Roskilde...
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Pathogenesis of psoriasis in the “omic” era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis
PublikacjaPsoriasis is a systemic disease that is strictly connected with metabolic disorders (insulin resistance, atherogenic dyslipidemia, arterial hypertension, and cardiovascular diseases). It occurs more often in patients with a more severe course of the disease. Obesity is specially an independent risk factor and it is associated with a worse treatment outcome because of the high inflammatory activity of visceral fatty tissue and...
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The impact of interactions between polyphenolic antioxidants on the redox-related chemical and biological properties of their mixtures – the extension of food synergy concept.
PublikacjaThe results of studies indicate that chemopreventive efficiency of isolated phytochemicals is lower than that of polyphenol-rich foods. This discrepancy has been ascribed to the food synergy concept that assumes additive or even synergistic influence of different food ingredients on human health. The results presented in the dissertation made it possible to propose an alternative and innovative explanation of these observations. The...
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Screening of predicted synergistic multi-target therapies in glioblastoma identifies new treatment strategies
PublikacjaAbstract Background IDH-wildtype glioblastoma (GBM) is a highly malignant primary brain tumor with a median survival of 15 months after standard of care, which highlights the need for improved therapy. Personalized combination therapy has shown to be successful in many other tumor types and could be beneficial for GBM patients. Methods We performed the largest drug combination screen to date in GBM, using a high-throughput effort...
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Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia
PublikacjaInduction of proteins involved in drug metabolism and in drug delivery has a significant impact on drug-drug interactions and on the final therapeutic effects. Two antitumor acridine derivatives selected for present studies, C-1748 (9-(2’-hydroxyethylamino)-4-methyl-1-nitroacridine) and C-1305 (5-dimethylaminopropylamino-8-hydroxy-triazoloacridinone), expressed high and low susceptibility to metabolic transformations with liver...
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Engineering method of tire rolling resistance evaluation
PublikacjaTire rolling resistance is one of the most difficult tire parameters to measure. The reason is that for modern tires the force of rolling resistance corresponds to 0.5–1% of tire load, thus measurements of very small forces must be performed in a heavily loaded system. This constitutes great problems, especially in road conditions. Laboratory measurements are easier to perform, as the environment may be better controlled, but roadwheel...
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Pisemna opinia biegłego z dziedziny chemii analitycznej na okoliczności szczegółowo wskazane w postanowieniu z dnia 27 lipca 2009.
PublikacjaEkspertyza dla Sądu Okręgowego w Toruniu - Wydział Drugi Karny, na okoliczność sfałszowania oleju napędowego.
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- Telomeres as targets for anticancer drug development - a computational approach
ProjektyProjekt realizowany w Wydział Chemiczny zgodnie z porozumieniem Homing Plus/2011-4/3 z dnia 2012-03-29
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Selective Cytostatic and Cytotoxic Anticancer Effects of Bisfunctional Agents: A Strategy for the Design of DNA Binding Agents
PublikacjaVarious agents have been synthesized and proved useful for the National Cancer Institute's anticancer testing as potential new drugs, but most agents suffer side effects from their limited selectivity against cancer cells over healthy ones. Therefore, this paper attempts to describe drugs in terms of the level of tumor cell selectivity which they possess to define the features of mols. that are essential for useful cytotoxicity....
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COLON, Descending colon - Female, 66 - Tissue image [9020730024811751]
Dane BadawczeThis is the histopathological image of COLON tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Mission impossible for cellular internalization: When porphyrin alliance with UiO-66-NH2 MOF gives the cell lines a ride
PublikacjaIs it possible to accelerate cell internalization by hybridization of nanomaterials? Herein we support the realization of using metal-organic frameworks (MOFs) with the assistance of rigid porphyrin structure (H2TMP) aimed at drug loading, drug release, relative cell viability, and targeted in vitro drug delivery. There are several MOFs, i.e., UiO-66-NH2 (125 ± 12.5 nm), UiO-66-NH2 @H2TMP (160 ± 14 nm), UiO-66-NH2 @H2TMP@DOX, and...
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Determination of MDPBP in postmortem blood samples by gas chromatography coupled with mass spectrometry
PublikacjaMDPBP (1-(3,4-methylenedioxyphenyl)-2-(1-pyrrolidinyl)-1-butanone) is a new psychoactive substance sold on the black market. It has been a controlled drug of abuse in Poland and China since 2015 as some toxic and fatal cases connected with use of synthetic cathinone derivatives were observed. The fatal case outlined here concerns a 19 year-old man, who was found dead with an envelope containing white powder lying nearby the cadaver....
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New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets
PublikacjaInfections of Candida spp. etiology are frequently treated with azole drugs. Among azoles, the most widely used in the clinical scenario remains fluconazole (FLC). Promising results in treatment of dangerous, systemic Candida infections demonstrate the advantages of combined therapies carried out with combinations of at least two different antifungal agents. Here, we report five conjugates composed of covalently linked FLC and...
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Damian Rosiak dr inż.
OsobyWykształcenie Studia I stopnia - inżynierskie, kierunek BIOTECHNOLOGIATytuł pracy inżynierskiej: "Reakcja halogenków rtęci(II) z wybranymi N-benzoilotiomocznikami i charakterystyka strukturalna jej produktów"Promotor: prof. dr hab. inż. Barbara Becker, prof. zw. PG Studia II stopnia - magisterskie, kierunek BIOTECHNOLOGIATytuł pracy magisterskiej: "Reakcje halogenków rtęci(II) z wybranymi tiomocznikami i charakterystyka produktów"Praca...
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Selection of effective cocrystals former for dissolution rate improvement of active pharmaceutical ingredients based on lipoaffinity index
PublikacjaNew theoretical screening procedure was proposed for appropriate selection of potential cocrystal formers possessing the ability of enhancing dissolution rates of drugs. The procedure relies on the training set comprising 102 positive and 17 negative cases of cocrystals found in the literature. Despite the fact that the only available data were of qualitative character, performed statistical analysis using binary classification...
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Detoxification of the tricyclic antidepressant opipramol and its analog – IS-noh by UGT enzymes before and after activation by phase I enzymes in rat liver microsomes
PublikacjaThe present studies were carried out to evaluate the simultaneous one-pot metabolism of opipramol (IS-opi) and analog (IS-noh) by phase I and phase II enzymes present in rat liver microsomes (RLM) as an alternative to separate testing with recombinant enzymes. This approach allows for more time-saving and cost-effective screening of the metabolism of newly discovered drugs. We also considered that the lack of results for phase...
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Badanie znaczenia atrybutów bazy wiedzy.
PublikacjaW pracy przedstawiono dwie metody umożliwiające wyznaczanie miary znaczenia wybranych atrybutów bazy wiedzy. W pierwszej metodzie wykorzystano teorię zbiorów przybliżonych i podano definicje miary znaczenia atrybutów oparte na liczbie reguł sprzecznych. Druga metoda wykorzystująca teorię zbiorów rozmytych pozawala na zdefiniowanie dwóch sposobów oceny miary znaczenia. Pierwsza miara opiera się na liczbie reguł sprzecznych,...
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Voltammetric and biological studies of folate-targeted non-lamellar lipid mesophases
PublikacjaFolate-targeted lipid nanostructures are promising strategies for the development of biocompatible drug delivery systems. The objective of this study was to evaluate the efficacy of drug delivery to cancer cells by folate-targeted lipid mesophases, cubosomes (CUB) and hexosomes (HEX), loaded with doxorubicin (DOX). Three cancer-derived cell lines (KB, HeLa, T98G) exhibiting different expressional levels of folate receptor protein...
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Topical delivery of pharmaceutical and cosmetic macromolecules using microemulsion systems
PublikacjaMicroemulsions are transparent, thermodynamically stable colloidal systems. Over the recent years, they have been increasingly investigated due to their potential as skin delivery vehicles for a wide range of drug molecules. The nanoscale particle size and the specificity of microemulsion components are the main features determining the skin permeation process. However, in order to effectively cross the skin barrier, the active...
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Fabrication methods of smart composite coatings - review
PublikacjaPostoperative bacterial infections are one of the main reasons for unsuccessful implantation of long-term implants. The development of bacterial infection requires antibiotic therapy, in extreme cases a reimplantation procedure is necessary. In order to provide materials for implants with antibacterial properties, they are subjected to modifications to create a coating that will release the drug substance, when the inflammation...
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Opioid Growth Factor and its Derivatives as Potential Non-toxic Multifunctional Anticancer and Analgesic Compounds
PublikacjaIn this paper, we review the structure-activity relationship of OGF and its analogues. We highlight also OGF derivatives with analgesic, immunomodulatory activity and the ability to penetrate the blood-brain barrier and may be used as safe agents enhancing chemotherapy efficacy and improving quality of life in cancer patients. The reviewed papers indicate that Met-enkephalin and its analogues are interesting candidates for the...
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Results of the effect of mixtures of ketoprofen with three cations on the germination of Sorghum bicolor (sorghum) seeds
Dane BadawczeThe research data includes an attempt to verify whether the addition of cations (sodium, ammonium and potassium) at levels found in the environment would affect the toxicity of pharmaceuticals to Sorghum Bicolor grain. Ion concentrations were selected based on studies of water samples collected in water bodies receiving wastewater from wastewater treatment...
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Results of the effect of mixtures of ketoprofen with three anions on the germination of Sorghum bicolor (sorghum) seeds
Dane BadawczeThe research data includes an attempt to verify whether the addition of anions (bromide, chloride and fluoride) at levels found in the environment would affect the toxicity of pharmaceuticals to Sorghum Bicolor grain. Ion concentrations were selected based on studies of water samples collected in water bodies receiving wastewater from wastewater treatment...
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Biological and mechanical properties of bone cement with nanoparticles - in vivo and in vitro research
PublikacjaDespite antibiotics preventive treatment, before and after an implant implementation, risk of infection are real. These infections at the implant surface develop in a few months after applying them into the body. To prevent the development of bacteria and to reduce the risk of infection, implants coated with nanoparticles come into use. The Mechanical Department of the Technical University of Gdańsk carried out a research with...
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Chemical Aspects of Biological Activity of Isothiocyanates and Indoles, the Products of Glucosinolate Decomposition
PublikacjaThere is growing evidence that cancer chemoprevention employing natural, bioactive compounds may halt or at least slow down the different stages of carcinogenesis. A particularly advantageous effect is attributed to derivatives of sulfur-organic phytochemicals, such as glucosinolates (GLs) synthesized mainly in Brassicaceae plant family. GLs are hydrolysed enzymatically to bioactive isothiocyanates (ITC) and indoles, which exhibit strong...
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Rafał Janowicz dr hab. inż. arch.
OsobyRafał Janowicz jest adiunktem na wydziale Architektury Politechniki Gdańskiej w Katedrze Technicznych Podstaw Projektowania Architektonicznego od 2011 roku. Ukończył studia na kierunku Architektura i Urbanistyka na Wydziale Architektury Politechniki Gdańskiej w 2001 roku, a dwa lata później na kierunku Zarządzanie i Marketing na Wydziale Zarządzania i Ekonomii PG. W 2011 r. obronił pracę doktorską na Wydziale Architektury Politechniki...
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Analiza wrażliwości pierwszego i drugiego rzędu w problemach statyki prętów cienkościennych
PublikacjaAnaliza wrażliwości pierwszego rzędu jest wykorzystywana w wielu zagadnieniach teorii konstrukcji. Pomimo tego, że analiza wrażliwości drugiego rzędu pozwala na znaczną poprawę dokładności uzyskiwanych wyników, jest ona mniej popularna niż analiza pierwszego rzędu. W pracy wyznaczono drugą wariację zmiennych stanu zachowania się konstrukcji. Przyjęto klasyczne założenia teorii prętów cienkościennych. W przykładzie numerycznym wyznaczono...
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OTHER AN UNSPECIFIED FEMALE GENITAL ORGANS, Fallopian tube - Female, 33 - Tissue image [9160729581057011]
Dane BadawczeThis is the histopathological image of OTHER AN UNSPECIFIED FEMALE GENITAL ORGANS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Role of miR-15b/16–2 cluster network in endometrial cancer: An in silico pathway and prognostic analysis
PublikacjaEndometrial cancer (EC) is the second most common cancer in women. A large number of human cancers exhibit dysregulation of microRNA expression including EC. MiR-15b/16–2 is one of the best-known miRNA clusters that is expressed in many types of cancer tissues. Herein, we analyzed the expression of individual miR-15b/16–2 cluster members, its paralogues, and their target network analysis, as well as their prognostic significance...
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Pemphigoid - Female, 86 - Tissue image [6160730013048041]
Dane BadawczeThis is the histopathological image of SKIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Structural and dynamic changes adopted by EmrE, multidrug transporter protein—Studies by molecular dynamics simulation
PublikacjaEmrE protein transports positively charged aromatic drugs (xenobiotics) in exchange for two protons and thus provides bacteria resistance to variety of drugs. In order to understand how this protein may recognize ligands, the monomer and asymmetric apo-form of the EmrE dimer embedded in a heterogeneous phospholipid (POPE + POPG) membrane were studied by molecular dynamics simulations. Dimer is regarded as a functional form of the...
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Therapeutic Potential of Carnosine and Its Derivatives in the Treatment of Human Diseases
PublikacjaDespite significant progress in the pathogenesis, diagnosis, treatment, and prevention of cancer and neurodegenerative diseases, their occurrence and mortality are still high around theworld. The resistance of cancer cells to the drugs remains a significant problem in oncology today,while in the case of neuro-degenerative diseases, therapies reversing the process are still yet to be found. Furthermore, it is important to seek new...
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Biological and mechanical properties of bone cement with nanoarticles - in vitro and in vivo research
PublikacjaDespite antibiotic preventive treatment both before and after implant implementation, the risks of infection are real. These infections develop at the implant surface a few months after inserting them into the body. To prevent the development of bacteria and reduce the risk of infection, implants coated with nanoparticles are used. The Mechanical Department of the Technical University of Gdansk carries out research into using bone...
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Functionalized Peptide Fibrils as a Scaffold for Active Substances in Wound Healing
PublikacjaTechnological developments in the field of biologically active peptide applications in medicine have increased the need for new methods for peptide delivery. The disadvantage of peptides as drugs is their low biological stability. Recently, great attention has been paid to self-assembling peptides that can form fibrils. Such a formulation makes bioactive peptides more resistant to enzymatic degradation and druggable. Peptide fibrils...
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Improvement of opipramol base solubility by complexation with β-cyclodextrin
PublikacjaOpipramol (OPI), a tricyclic antidepressant and anxiolytic compound, is administered orally in the form of a dihydrochloride. Salt form of the drug has a higher solubility in water and hence bioavailability and stability. A similar effect can be achieved by closing the hydrophobic part of the drug molecule in the cyclodextrin cavity. The paper presents opipramol inclusion complexes with beta-cyclodextrin (β-CD) in 1:1 molar ratio....
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Polymer biodegradable coatings as active substance release systems for urological applications
PublikacjaCatheter-associated urinary tract infections are the result of catheterization of the bladder. The risk of infection is directly proportional to the length of the bladder catheterization. Bacteria cells have the ability to adhere and create the biofilm on the surface of catheter materials. Bacteria’s biofilm is an extremely beneficial environment of existence for microorganisms. Microorganisms that are an integral part of the biofilm...
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Synthesis of green benzamide-decorated UiO-66-NH2 for biomedical applications
PublikacjaMetal-organic frameworks (MOFs) biocompatible systems can host enzymes/bacteria/viruses. Herein we synthesized a series of fatty acid amide hydrolase (FAAH)-decorated UiO-66-NH2 based on Citrus tangerine leaf extract for drug delivery and biosensor applications. Five chemically manipulated FAAH-like benzamides were localized on the UiO-66-NH2 surface with physical interactions. Comprehensive cellular and molecular analyses were...
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CERVIX UTERI, Exocervix - Female, 35 - Cell image [4080730008365041]
Dane BadawczeThis is the histopathological image of CERVIX UTERI cell sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Determination of antibiotic residues in honey
PublikacjaHoney produced by honeybees is a valuable food product. The presence of xenobiotics in honey may harm its quality and constitute a danger to human health. Antibiotics are commonly applied by beekeepers to eliminate disease among honeybees. Moreover, ubiquitous administration of antibiotics may cause bacteria to become resistant to many drugs and spread antibioticresistant strains of bacteria. Appropriate sample preparation and...
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Epidemiologia udaru mózgu
PublikacjaUdar mózgu i choroba wieńcowa to główne przyczyny zgonu i niepełnosprawności. Choroby naczyń mózgowych są drugą przyczyną śmierci naświecie i trzecią przyczyną śmiertelności w krajach Europy Zachodniej.
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Wybrane Zagadnienia Kierunków Dyplomowania
Kursy OnlineCelem kursu jest przeprowadzenie sprawdzianu na zaliczenie przedmiotu. Zaliczenie odbędzie się 8.01.2021 o godz. 11.15. Drugi termin zaliczenia 12.01.2021 godz.9.15 - 10.00
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Magdalena Podwojewska dr inż. arch.
OsobyMagdalena Podwojewska jest starszym wykładowcą w Katedrze Architektury Miasta i Przestrzeni Nadwodnych Wydziału Architektury PG. Od 2016 r. pełni funkcję prodziekana ds. studenckich. Jest członkiem Pomorskiej Okręgowej Izby Architektów. Jej badania naukowe i publikacje dotyczą adaptacji obiektów infrastruktury kolejowej i poprzemysłowej związanej z transportem kolejowym, potencjałem historycznej tkanki budowlanej i układu komunikacyjnego....