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Ridged horn antenna for ground penetrating radar
PublikacjaOmówiono modyfikację tuby grzbietowej polegającą na jej wypełnieniu dielektrykiem, w celu wykorzystania do układu pozwalającego na poszukiwanie obiektów znajdujących się pod ziemią. Omówiono badania, które doprowadziły do opracowania konstrukcji anteny z wypełnieniem dielektrycznym. Przedstawiono wyniki testu takiej anteny w układzie do detekcji obiektu metalowego umieszczonego pod ziemią.
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Cell-penetrating peptides – mechanism of transduction and synthesis – short review
PublikacjaPotential antimicrobial agents may be effective if they are delivered efficiently to their site of action. In many cases, lack of permeability through the cell membrane is the main problem. One of the possible solutions could be a novel intracellular delivery system involving cell-penetrating peptides (CPPs), which may improve the efficiency of many new biophar-maceuticals. Among other things, CPPs are capable of trans-porting...
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A novel heterogeneous model of concrete for numerical modelling of ground penetrating radar
PublikacjaThe ground penetrating radar (GPR) method has increasingly been applied in the non-destructive testing of reinforced concrete structures. The most common approach to the modelling of radar waves is to consider concrete as a homogeneous material. This paper proposes a novel, heterogeneous, numerical model of concrete for exhaustive interpretation of GPR data. An algorithm for determining the substitute values of the material constants...
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High frequency impulse ground penetrating radar application in assessment of interlayer connections
PublikacjaGround Penetrating Radar (GPR) technique is commonly used in the nondestructive evaluation of pavement structures. In particular, this method is used to estimate thicknesses of pavement layers as well as it can be utilized in advanced studies of pavement structures. The device presented in this paper comprise the high frequency impulse antennas that allow for investigating the interlayer zones in terms of their electromagnetic...
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The Effect of Conjugation with Octaarginine, a Cell-Penetrating Peptide on Antifungal Activity of Imidazoacridinone Derivative
PublikacjaAcridine cell-penetrating peptide conjugates are an extremely important family of compounds in antitumor chemotherapy. These conjugates are not so widely analysed in antimicrobial therapy, although bioactive peptides could be used as nanocarriers to smuggle antimicrobial compounds. An octaarginine conjugate of an imidazoacridinone derivative (Compound 1-R8) synthetized by us exhibited high antifungal activity against reference...
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Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity
PublikacjaSeven conjugates composed of well-known fluoroquinolone antibacterial agents, ciprofloxacin (CIP) or levofloxacin (LVX), and a cell-penetrating peptide transportan 10 (TP10-NH2) were synthesised. The drugs were covalently bound to the peptide via an amide bond, methylenecarbonyl moiety, or a disulfide bridge. Conjugation of fluoroquinolones to TP10-NH2 resulted in congeners demonstrating antifungal in vitro activity against human...
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Buried Object Characterization Using Ground Penetrating Radar Assisted by Data-Driven Surrogate-Models
PublikacjaThis work addresses artificial-intelligence-based buried object characterization using 3-D full-wave electromagnetic simulations of a ground penetrating radar (GPR). The task is to characterize cylindrical shape, perfectly electric conductor (PEC) object buried in various dispersive soil media, and in different positions. The main contributions of this work are (i) development of a fast and accurate data driven surrogate modeling...
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Penetrating Biological Tissue Using Light-Emitting Diodes with a Highly Efficient Near-Infrared ScBO3:Cr3+ Phosphor
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Scrutiny of power grids by penetrating PV energy in wind farms: a case study of the wind corridor of Jhampir, Pakistan
PublikacjaThis study examines the problems caused by intermittent renewable energy sources, especially wind farms, and suggests a different solar energy penetration strategy to improve their loading capacity. The study uses real-time data from a wind farm in Jhampir, Pakistan, to analyse and assess various aspects of grid stations connected to wind farms. Electrical Transient Analyzer Program is used to validate the results by linking...
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Scrutiny of power grids by penetrating PV energy in wind farms: a case study of the wind corridor of Jhampir, Pakistan
PublikacjaThis study examines the problems caused by intermittent renewable energy sources, especially wind farms, and suggests a different solar energy penetration strategy to improve their loading capacity. The study uses real-time data from a wind farm in Jhampir, Pakistan, to analyse and assess various aspects of grid stations connected to wind farms. Electrical Transient Analyzer Program is used to validate the results by linking these...
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Historic bridge modelling using laser scanning, ground penetrating radar and finite element methods in the context of structural dynamics
PublikacjaPraca dotyczy modelowania MES zabytkowej konstrukcji mostowej przy użyciu danych geometrycznych pochodzących ze skanowania laserowego oraz georadaru. Z uwagi na brak badań materiału budujcego most, przeprowadza się analize wrażliwości konstrukcji na zmiany modułu sprężystości granitu.
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Applying ground penetrating radar to tracking of ancient architectural transformations: the case of the monastery St. Peter on the Island of Rab (Croatia)
PublikacjaThe ground-penetrating radar (GPR) method has been used for many years in archaeological research. However, thismethod is still not widely used in studies of past architecture. The biggest problem with the implementation of the GPRmethod at such sites is usually connected with extensive debris layers, plant cover and standing relics of walls and otherfeatures that restrict the available measurement area. Despite of these, properly...
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3-D finite-difference time-domain modelling of ground penetrating radar for identification of rebars in complex reinforced concrete structures
PublikacjaThis paper presents numerical and experimental investigations to identify reinforcing bars using the ground penetrating radar (GPR) method. A novel element of the paper is the inspection of different arrangements of reinforcement bars. Two particular problems, i.e. detection of few adjacent transverse bars and detection of a longitudinal bar located over or under transverse reinforcement, have been raised. An attention was also...
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Non-destructive Diagnostics of the Floor in the Gdańsk Crane Using Ground Penetrating Radar = Diagnostyka nieniszcząca posadzki w gdańskim Żurawiu z zastosowaniem metody georadarowej
PublikacjaThis paper presents the results of a ground penetrating radar (GPR) survey carried out at the Crane in Gdańsk. The measurements were conducted on the floor of the southern and northern towers. The aim of the experiment is to assess the possibility of detecting anomalies beneath the floor. The surveys were carried out in a non-destructive manner, using a georadar unit with 2 GHz and 400/900 MHz antennas. This paper compares the...
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Peptydy penetrujące – rodzaje i mechanizmy przenikania przez błony komórkowe
PublikacjaPeptydy penetrujące z pewnością są wyjątkową i ciekawą grupą związków peptydowych. Zostały odkryte ponad dwadzieścia lat temu, ale wiedza na ich temat wciąż jest rozbudowywana. Liczne badania nad mechanizmami ich przenikania do wnętrza komórek pozwalają zrozumieć jakie cechy strukturalne warunkują ich zdolność do penetracji komórek. Wiedza ta pozwala na projektowanie nowych, bardziej efektywnych peptydów penetrujących., które mogą...
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Adenocarcinoma, NOS - Female, 66 - Tissue image [6210730043063991]
Dane BadawczeThis is the histopathological image of RECTOSIGMOID JUNCTION tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Cavity-expansion approximation for projectile impact and penetration into sand
PublikacjaA one-dimensional problem of a spherical cavity expanding at a constant velocity from zero initial radius in an infinite granular medium, which has the first-kind self-similar solution, is considered. We are solving this dynamic spherical cavity-expansion problem to model rigid spheres penetrating into a granular media. Elastic–plastic deformation of the granular media is described in a barotropic approximation, using the high-pressure...
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Increasing the lifetime of engineering structures through the use of composite laggings
PublikacjaThe use of composite laggings prevents concrete (chemical and biological) corrosion. Columns coated with composite or reinforced composite are more resistant to negative environmental impact on concrete or steel. The mechanical properties of the reinforced casing also cause that these types of columns are more resistant to lateral forces. The applied casing limits carbonization of concrete and cyclical freezing and thawing with...
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Application of gpr method in diagnostics of reinforced concrete structures
PublikacjaThis paper presents an application of the ground penetration method (GPR) for diagnostics of reinforced concrete structures. In situ measurements were conducted for three civil engineering structures: the ground floor structure, the abutment of the railway viaduct and the concrete well. The dual polarized ground penetrating radar with the antenna operating at a center frequency of 2 GHz was used for GPR surveys. Three different...
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GPR simulations for diagnostics of a reinforced concrete beam
PublikacjaThe most popular technique for modelling of an electromagnetic field, the finite difference time domain (FDTD) method, has recently become a popular technique as an interpretation tool for ground penetrating radar (GPR) measurements. The aim of this study is to detect the size and the position of damage in a reinforced concrete beam using GPR maps. Numerical simulations were carried out using the finite differ-ence time domain...
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Numerical modeling of GPR field in damage detection of a reinforced concrete footbridge
PublikacjaThe paper presents a study on the use of the ground penetrating radar (GPR) method in diagnostics of a footbridge. It contains experimental investigations and numerical analyses of the electromagnetic field propagation using the finite difference time domain method (FDTD). The object of research was a reinforced concrete footbridge over a railway line. The calculations of the GPR field propagation were performed on a selected cross-section...
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A concept of heterogeneous numerical model of concrete for GPR simulations
PublikacjaThe Ground Penetrating Radar (GPR) method, which is increasingly being used in the non-destructive diagnostics of reinforced concrete structures, often needs more accurate interpretation tools for analysis of experimental data. Recently, there has been growing interest in developing of various numerical models for exhaustive understanding of GPR data. This paper presents the concept of a heterogeneous numerical model of concrete,...
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Typology, current state and non-destructive testing of timber roof trusses of historic churches in the West Vistula Delta, Poland
PublikacjaThis paper presents the current state of conservation of historic roof churches located in the Żuławy of Gdańsk (Poland). It also describes the architecture of these temples, the region itself and old carpentry techniques for constructing roof trusses. Interdisciplinary tests were carried out in six churches. The geometry of the load bearing structures, the moisture content and the carpentry technique were specified. The field...
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Diagnostics of pillars in St. Mary’s Church (Gdańsk, Poland) using the GPR method
PublikacjaThe main goal of this study was non-destructive evaluation of pillars in the St. Mary’s Church (Gdańsk, Poland) using the ground penetrating radar (GPR) technique. The GPR inspection was conducted on four brick masonry pillars and five pillars strengthened by reinforced concrete jacketing. Data were acquired with a 2 GHz antenna along longitudinal and transverse profiles. The study involved the estimation of the electromagnetic...
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Synthetic strategies in construction of organic low molecular-weight carrier-drug conjugates
PublikacjaInefficient transportation of polar metabolic inhibitors through cell membranes of eukaryotic and prokaryotic cells precludes their direct use as drug candidates in chemotherapy. One of the possible solutions to this problem is application of the ‘Trojan horse’ strategy, i.e. conjugation of an active substance with a molecular carrier of organic or inorganic nature, facilitating membrane penetration. In this work, the synthetic...
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Interpolation methods in GPR tomographic imaging of linear and volume anomalies for cultural heritage diagnostics
PublikacjaThis paper presents results of a ground penetrating radar (GPR) survey conducted in St. Joseph’s Church in Gdańsk, Poland. The aim of the study was to produce tomographic imaging of a renovated floor as well as the objects buried under the floor to detect linear and volume inclusions. The assumed track spacing was meaningfully greater than the single signal spacing in each track, which induced the need for interpolation methods...
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Inhibitors of glucosamine-6-phosphate synthase as potential antimicrobials or antidiabetics – synthesis and properties
PublikacjaGlucosamine-6-phosphate synthase (GlcN-6-P synthase) is known as a promising target for antimicrobial agents and antidiabetics. Several compounds of natural or synthetic origin have been identified as inhibitors of this enzyme. This set comprises highly selective L-glutamine, amino sugar phosphate or transition state intermediate cis-enolamine analogues. Relatively low antimicrobial activity of these inhibitors, poorly penetrating...
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Realizacja eksplozyjnego niszczenia opon wieloosiowego pojazdu specjalnego
PublikacjaRealizacja programu badań nad zachowaniem się pojazdów w warunkach eksplozyjnego uszkodzenia opon pojazdów kołowych wymaga aby proces utraty ciśnienia będący rezultatem lokalnego zniszczenia ścian bocznych, lub bieżnika opony przebiegał bardzo gwałtownie. Postulat ten może być zrealizowany na kilka sposobów. Najważniejsze z nich to: zniszczenie mechaniczne za pomocą noża lub penetratora, zniszczenie za pomocą "pocisku" miotanego...
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Antimicrobial molecular nanocarrier–drug conjugates
PublikacjaMany antimicrobial drugs are poorly active against pathogenic microbes causing intracellular infections, such as Mycobacterium tuberculosis or Plasmodium falciparum. On the other hand, several known antimicrobial agents are not effective enough because of their limited cellular penetration. A common feature of both challenges is the inability of an active agent to cross the biological membrane(s). One of the possible approaches...
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An integrated geoarchaeological approach to late Iron Age settlement at Kaštelina hillfort (Lopar, Island of Rab, Croatia) using Amplitude Data Comparison (ADC) method and trial excavation
PublikacjaGeophysical prospection and small-scale archaeological excavation were undertaken on the site of Kaštelina, a Late Iron Age hillfort settlement located on the Stolac promontory in the northern part of Rab island (Kvarner Gulf, Croatia). Within the frame of the “Archaeological topography of the island of Rab” program, a Polish–Croatian team applied a series of multidisciplinary methods to study the occupational history of the...
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Radar technique in application of interlayer identification connections
PublikacjaOne of important issues in pavement construction is to ensure that layers applied directly one on top of the other make up a continuous whole and form an integral construction complex. An appropriate interlayer connection plays here significant role ensuring proper transmission of distortions generated by wheels of vehicles to lower layers and preventing water penetration between the layers. In case of damaged pavements where lack...
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MARSTRUCT benchmark study on nonlinear FE simulation of an experiment of an indenter impact with a ship side-shell structure
PublikacjaThis paper presents a benchmark study on collision simulations that was initiated by the MARSTRUCT Virtual Institute. The objective was to compare assumptions, finite element models, modelling techniques and experiences between established researchers within the field. Fifteen research groups world-wide participated in the study. An experiment involving a rigid indenter penetrating a ship-like side structure was used as the case...
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Integrated Application of GPR and Ultrasonic Testing in the Diagnostics of a Historical Floor
PublikacjaThe paper presents the results of integrated ground penetrating radar (GPR) and ultrasonic testing (UT) measurements conducted on a historical floor in St. Nicholas’ Church, Gdańsk, Poland. The described inspection was the first stage of the technical state assessment of the building. The aim of the study was the detection of underfloor air gaps, which were observed in a few trial pits. The condition of the ground under the floor...
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Non-destructive Testing of Wooden Elements
PublikacjaExamining the condition of wooden elements is crucial from the perspective of proper structure performance. If the deterioration in the internal wood condition, which displays no symptoms visible from the outside, is detected, the further spread of the deterioration can be prevented. Test results often point to the necessity of conducting repairs and, renovations, replacing the structure of wooden beams, or even substituting a...
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Insights into oral microbiome and colorectal cancer – on the way of searching new perspectives
PublikacjaMicrobiome is a keystone polymicrobial community that coexist with human body in a beneficial relationship. These microorganisms enable the human body to maintain homeostasis and take part in mechanisms of defense against infection and in the absorption of nutrients. Even though microbiome is involved in physiologic processes that are beneficial to host health, it may also cause serious detrimental issues. Additionally, it has been...
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PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke
PublikacjaIschemic stroke is a disturbance in cerebral blood flow caused by brain tissue ischemia and hypoxia. We optimized a multifactorial in vitro model of acute ischemic stroke using rat primary neural cultures. This model was exploited to investigate the pro-viable activity of cell-penetrating peptides: arginine-rich Tat(49–57)-NH2 (R49KKRRQRRR57-amide) and its less basic analogue, PTD4 (Y47ARAAARQARA57-amide). Our model included glucose...
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The application of non-destructive methods in the diagnostics of the approach pavement at the bridges
PublikacjaThe article presents the possibility of using non-destructive methods of road pavement diagnostics as an alternative to traditional means to assess the reasons for premature cracks adjacent to bridge objects. Two scanning methods were used: laser scanning to measure geometric surface deformation and ground penetrating radar (GPR) inspection to assess the road pavement condition. With the use of a laser scanner, an effective tool...
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„Civis Polonus. Hostem Moscoviensem” – Rosja Maurycego Mochnackiego
PublikacjaCzym było obywatelstwo polskie Mochnackiego i jakie przesłanki miała jego wrogość wobec Moskwy – to pytania, które podejmuje artykuł. Przedstawia on postać najwybitniejszego krytyka literackiego doby romantyzmu. Omawia znaczenie w jego biografii wychowania na prowincji, nieograniczonego kontaktu z naturą i ludowością, udziału w antycarskiej konspiracji, rosyjskiego więzienia, zniewolenia cenzurą, udziału w wojnie z Rosją, Wielkiej...
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Nondestructive methods complemented by FEM calculations in diagnostics of cracks in bridge approach pavement
PublikacjaNondestructive methods of road pavement diagnostics are an alternative to traditional approach to pavement failure investigation. The article presents a detailed multidisciplinary inspection carried out using ground-penetrating radar (GPR), laser scanning technology and finite element method (FEM) calculations. It was done in order to assess the factors that contributed to occurrence of premature cracks of a bridge approach pavement....
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New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets
PublikacjaInfections of Candida spp. etiology are frequently treated with azole drugs. Among azoles, the most widely used in the clinical scenario remains fluconazole (FLC). Promising results in treatment of dangerous, systemic Candida infections demonstrate the advantages of combined therapies carried out with combinations of at least two different antifungal agents. Here, we report five conjugates composed of covalently linked FLC and...
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Dual-Activity Fluoroquinolone-Transportan 10 Conjugates offer alternative Leukemia therapy during Hematopoietic Cell Transplantation
PublikacjaHematopoietic cell transplantation (HCT) is often considered a last resort leukemia treatment, fraught with limited success due to microbial infections, a leading cause of mortality in leukemia patients. To address this critical issue, we explored a novel approach by synthesizing antileukemic agents containing antibacterial substances. This innovative strategy involves conjugating fluoroquinolone antibiotics, such as ciprofloxacin...
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Finite element models used in diagnostics of transverse cracks in bridge approach pavement
Dane BadawczeTransverse cracks in the asphalt pavement were observed on bridge structures next to single-module expansion joints with a 5 meter approach slab set at the depth of 1 m. The finite element (FE) models of the approach pavement were created to investigate the reasons of premature cracking and crack initiation mechanism over the back edge of the abutment...
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Zastosowanie metody georadarowej do badań konstrukcji żelbetowych
PublikacjaW pracy przedstawiono zastosowanie metody georadarowej do diagnostyki konstrukcji żelbetowych. Metoda GPR (z ang. ground penetrating radar) należy do grupy badań nieniszczących NDT (z ang. nondestructive testing). Jest ona powszechnie stosowana m. in. w archeologii, geologii i budownictwie. Dzięki tej metodzie możliwa jest identyfikacja warstw geologicznych, podziemnej infrastruktury a także zbrojenia i potencjalnych uszkodzeń...
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Buried Object Characterization by Data-Driven Surrogates and Regression-Enabled Hyperbolic Signature Extraction
PublikacjaThis work addresses artificial-intelligence-based buried object characterization using FDTD-based electromagnetic simulation toolbox of a Ground Penetrating Radar (GPR) to generate B-scan data. In data collection, FDTD-based simulation tool, gprMax is used. The task is to estimate geophysical parameters of a cylindrical shape object of various radii, buried at different positions in the dry soil medium simultaneously and independently...
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Architektura a dekonstrukcja. Przypadek Petera Eisenmana i Bernarda Tschumiego
PublikacjaArchitecture and Deconstruction Case of Peter Eisenman and Bernard Tschumi Introduction Towards deconstruction in architecture Intensive relations between philosophical deconstruction and architecture, which were present in the late 1980s and early 1990s, belong to the past and therefore may be described from a greater than...