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Search results for: GRANULAR CELL TUMORS AND ALVEOLAR SOFT PART SARCOMAS
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Metastasis of the testicular germ cell tumors to the parotid gland
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Germ cell-like telomeric length homeostasis in nonseminomatous testicular germ cell tumors
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Process control strategy deployment with part measuring activity in a flexible machining cell
PublicationRozwinięto zintegrowany model planowania i sterowania przebiegu procesu w rzeczywistym, zrobotyzowanym elastycznym gnieździe obróbki (EGO) ze współrzędnościową maszyną pomiarową, realizującą funkcje pomiarowo-kontrolne wytwarzanych przedmiotów. Analizowano współzależności wybranych heurystycznych planów kontroli przedmiotów oraz strategii szeregowania operacji procesów technologicznych, z zastosowaniem programowalnych modeli symulacyjnych...
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Performance of the PEM fuel cell module. Part 2. Effect of excess ratio and stack temperature
PublicationThe paper describes a fuel cell based system performance under different thermal conditions. The system could be fed with bottled hydrogen or with very high purity hydrogen obtained from reforming of methanol. The system is based on two fuel cell units (1.2 kW each, produced by Ballard Power Systems Inc. and called Nexa), DC/DC converter, DC/AC inverter, microprocessor control unit, load unit, bottled hydrogen supply system and...
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Copper(i) complexes with phosphine derived from sparfloxacin. Part III: multifaceted cell death and preliminary study of liposomal formulation of selected copper(i) complexes
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Soft Tissue Retraction Maneuver in Cone Beam Computed Tomography Prior to Crown-Lengthening Procedure—A Technical Note
PublicationBackground: An accurate determination of the biological width and the relationship of the cemento-enamel junction with the border of the alveolar bone is crucial during a clinical crown-lengthening (CCL) procedure. The aim of this study was to present a technical note about the retraction techniques in cone beam computed tomography (CBCT) prior to CCL, highlighting the significant enhancement in procedural accuracy and predictability...
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Novel therapeutic compound acridine–retrotuftsin action on biological forms of melanoma and neuroblastoma
PublicationPURPOSE: As a continuation of our search for anticancer agents, we have synthesized a new acridine-retrotuftsin analog HClx9-[Arg(NO2)-Pro-Lys-Thr-OCH3]-1-nitroacridine (named ART) and have evaluated its activity against melanoma and neuroblastoma lines. Both tumors develop from cells (melanocytes, neurons) of neuroectodermal origin, and both are tumors with high heterogeneity and unsatisfactory susceptibility to chemotherapies....
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Inhibition of T-type calcium channel disrupts Akt signaling and promotes apoptosis in glioblastoma cells.
PublicationGlioblastoma multiforme (GBM) are brain tumors that are exceptionally resitant to both radio- and chemotherapy regimens and novel approaches to treatment are needed. T-type calcium channels are one type of low voltage-gated channel (LVCC) involved in embryonic cell proliferation and differentiation; however they are often over-expressed in tumors, including GBM. In this study, we found that inhibition of T-type Ca channels in GBM...
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Enhancing Renal Tumor Detection: Leveraging Artificial Neural Networks in Computed Tomography Analysis
PublicationRenal cell carcinoma is one of the most common cancers in Europe, with a total incidence rate of 18.4 cases per 100 000 population. There is currently significant overdiagnosis (11% to 30.9%) at times of planned surgery based on radiological studies. The purpose of this study was to create an artificial neural network (ANN) solution based on computed tomography (CT) images as an additional tool to improve the differentiation of...
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The imidazoacridinone C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation
PublicationC-1311 is a small molecule, which has shown promise in a number of preclinical and clinical studies. However, the biological response to C-1311 exposure is complicated and has been reported to involve a number of cell fates. Here, we investigated the molecular signaling which determines the response to C-1311 in both cancer and non-cancer cell lines. For the first time we demonstrate that the tumor suppressor, p53 plays a key role...
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Chloroacridine derivatives as potential anticancer agents which may act as tricarboxylic acid cycle enzyme inhibitors
PublicationThe chloroacridines affect biological forms of melanoma in different ways. Amelanotic (Ab) melanoma (with inhibited melanogenesis and higher malignancy) was particularly sensitive to the action of the chloroacridines. The Ab melanoma cells died through apoptosis and through death without caspase activation. Diminished activity of TAC enzymes was noticed among Ab melanoma cells together with ATP/NAD depletion, especially in the...
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Throughput-Coverage Characteristics for Soft and Partial Frequency Reuse in the LTE Downlink
PublicationThe paper presents results of simulation and evaluation of throughput-coverage characteristics for the OFDMA-based LTE network with Soft Frequency Reuse or Partial Frequency Reuse. Firstly, simulation results of throughput characteristics for a single user connection are presented, which allow the evaluation of the stability and availability of bit rate achieved in different areas of a cell. Secondly, the capacity characteristics...
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Production activity control in a flexible machining cell considering part measuring condition. W: Computer integrated manufacturing. Advanced design and management. Ed.: B. Skołud, D. Krenczyk. Warszawa: Wydaw. Nauk.-Tech. **2003 s. 494-501, 6 rys. 1 tabl. bibliogr. 9 poz. Sterowanie procesu produkcyjnego w elastycznym gnieździe obróbkowym z uwzg- lędnieniem funkcji kontroli wytwarzanych przedmiotów.
PublicationPrzedstawiono modele struktur organizacyjnych przebiegu procesu organizacyj-nego w rzeczywistym zrobotyzowanym elastycznym gnieździe obróbki (EGO) z udziałem współrzędnościowej maszyny pomiarowej CNC. Badano eksperymentalnie występujące współzależności pomiędzy analizowanymi planami kontroli przed-miotów wytwarzanych i strategiami szeregowania operacji procesu technologi-cznego obróbki, z wykorzystaniem zintegrowanych modeli...
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Generation and Characterization of a DNA-GCN4 Oligonucleotide-Peptide Conjugate: The Impact DNA/Protein Interactions on the Sensitization of DNA
PublicationRadiotherapy, the most common therapy for the treatment of solid tumors, exerts its effects by inducing DNA damage. To fully understand the extent and nature of this damage, DNA models that mimic the in vivo situation should be utilized. In a cellular context, genomic DNA constantly interacts with proteins and these interactions could influence both the primary radical processes (triggered by ionizing radiation) and secondary reactions,...
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Metabolic Profiles of New Unsymmetrical Bisacridine Antitumor Agents in Electrochemical and Enzymatic Noncellular Systems and in Tumor Cells
PublicationNew unsymmetrical bisacridines (UAs) demonstrated high activity not only against a set of tumor cell lines but also against human tumor xenografts in nude mice. Representative UA compounds, named C-2028, C-2045 and C-2053, were characterized in respect to their physicochemical properties and the following studies aimed to elucidate the role of metabolic transformations in UAs action. We demonstrated with phase I and phase II enzymes...
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Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers
PublicationMultidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism of drug resistance. Here, we show that MDR cells display a marked increase in lysosome number. We further demonstrate that imidazoacridinones (IAs), which are cytotoxic fluorochromes,...
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Using an IEEE1149.1 Test Bus for Fault Diagnosis of Analog Parts of Electronic Embedded Systems
PublicationThe new solution of a BIST called the JTAG BIST for self-testing of analog parts of electronic embedded systems is presented in the paper. The JTAG BIST consists of the BCT8244A and SCANSTA476 integrated circuits of Texas Instruments controlled via the IEEE 1149.1 bus. The BCT8244A is a scan test device with octal buffers, and the SCANSTA476 is a 12-bit ADC with 8 analog input channels. Self-testing approach is based on the fault...
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Antitumor DNA-Damaging C-1748 is a New Inhibitor of Autophagy that Triggers Apoptosis in Human Pancreatic Cancer Cell Lines
PublicationDespite the enormous progress that has been made over the past decades in diagnosis, treatment and prevention of many types of tumors, survival rates in pancreatic cancer still remain poor. Pancreatic cancer is one of the most malignant and chemoresistant tumors and the profound mechanism supporting these phenomena is the constitutively activated prosurvival autophagy. The antitumor 1-nitroacridine derivative C-1748 belongs to...
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A method of self-testing of an analog circuit terminated by an ADC in electronic embedded systems controlled by microcontrollers
PublicationA new self-testing method of analog parts terminated by an ADC in electronic embedded systems controlled by microcontrollers is presented. It is based on a new fault diagnosis method based on on-line (i.e. during measurement), transformations of voltage samples of the time response of a tested part to a square pulse - onto localization curves placed in the measurement space. The method can be used for fault detection and single...
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In vitro biological evaluation of a novel folic acid-targeted receptor quantum dot−β−cyclodextrin carrier for C-2028 unsymmetrical bisacridine in the treatment of human lung and prostate cancers
PublicationTraditional small-molecule chemotherapeutics usually do not distinguish tumors from healthy tissues. However, nanotechnology creates nanocarriers that selectively deliver drugs to their site of action. This work is the next step in the development of the quantum dot−β−cyclodextrin−folic acid (QD−β−CD−FA) platform for targeted and selected delivery of C−2028 unsymmetrical bisacridine in cancer therapy.Herein, we report an initial...
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c-Myc inhibition and p21 modulation contribute to unsymmetrical bisacridines-induced apoptosis and senescence in pancreatic cancer cells
PublicationBackground Pancreatic cancer (PC) is one of the most aggressive cancers and is the seventh leading cause of cancer-related death worldwide. PC is characterized by rapid progression and resistance to conventional treatments. Mutations in KRAS, CDKN2A, TP53, SMAD4/DPC4, and MYC are major genetic alterations associated with poor treatment outcomes in patients with PC. Therefore, optimizing PC therapy is a tremendous challenge. Unsymmetrical...
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Influence of the grains shape on the mechanical behavior of granular materials
PublicationDiscrete Element Method is a numerical method suitable for modeling geotechnical problems concerning granular media. In most cases simple forms of grains, like discs or spheres, are used. But these shapes are capable of soil behavior modeling up to a certain point only, they cannot reflect all of the features of the medium (large shear resistance and large volumetric change). In order to reflect the complex behavior of the real...
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Post-match recovery profile of leukocyte cell subsets among professional soccer players
PublicationThis study assessed the impact of cumulative match time on the distribution of CD45+ cell subtests in the capillary blood of professional soccer players. Twenty-two males (aged 18–30 years) took part in the 36-week study. Participants playing up to 540 in cumulative match time and less than 30 min in each single match during the observation period formed the control group. White blood cell (WBC) phenotyping and creatine kinase...
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SUBSOIL CHARACTERISTICS OF THE VISTULA RIVER DIKES
PublicationThe results of CPTU tests are used to determine the strength parameters of a dike subsoil. Stress state and stress history of the subsoil under the flood embankment was evaluated with CPTU and DMT tests. Normally consolidated soil was found under the central part of the dike, while the subsoil near the dike toe is found to be overconsolidated. Due to consolidation the undrained shear strength of the subsoil under the central part...
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Electrochemical simulation of enzymatic transformations studied for the selected antitumor acridine derivatives
PublicationThe elucidation of the metabolic pathways and the biotransformation mechanisms of potential drugs is a crucial point in drug development. It allows to know the activation routes of the new biologically active compounds, especially in respect to their possible toxicity. Generally, in vivo or in vitro experiments with liver microsomes or hepatocytes are performed. However, these testing schemes are tedious, time consuming and of...
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Electrochemistry meets enzymes: Investigation of the biotransformation pathway of C-1311 based on electrochemical simulation in comparison to in vitro methods.
PublicationThe knowledge of the metabolic pathways and the biotransformation of new drugs is one of the major challenges in pharmaceutical research. It is crucial for elucidation of degradation routes of the new biologically active compounds, especially in the area of possible toxicity. Conventional in vitro drug metabolism studies are based on incubating drug candidate with e.g. hepatocytes or, most importantly, liver cell microsomes and...
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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublicationThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
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Voltammetric and biological studies of folate-targeted non-lamellar lipid mesophases
PublicationFolate-targeted lipid nanostructures are promising strategies for the development of biocompatible drug delivery systems. The objective of this study was to evaluate the efficacy of drug delivery to cancer cells by folate-targeted lipid mesophases, cubosomes (CUB) and hexosomes (HEX), loaded with doxorubicin (DOX). Three cancer-derived cell lines (KB, HeLa, T98G) exhibiting different expressional levels of folate receptor protein...
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Design, synthesis and high antitumor potential of new unsymmetrical bisacridine derivatives towards human solid tumors, specifically pancreatic cancers and their unique ability to stabilize DNA G-quadruplexes
PublicationNew promising unsymmetrical bisacridine derivatives (UAs), have been developed. Three groupsincluding 36 compounds were synthesized by the condensation of 4-nitro or 4-methylacridinone, imi-dazoacridinone and triazoloacridinone derivatives with 1-nitroacridine compounds linked with anaminoalkyl chain. Cytotoxicity screening revealed the high potency of these compounds against severaltumor cell lines. Particularly, imidazoacridinone-1-nitroacridine...
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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublicationThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
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Study on deformed steel columns subjected to impact load due to soft-storey failure in buildings during earthquakes
PublicationThe so called soft-storey failure is one of the most typical types of damage induced in buildings as the result of earthquake excitation. It has been observed during ground motions that the failure of an upper soft storey of a structure results in large vertical impact load acting on the lower floors. If the resistance of the structural members of the lower storeys is not sufficient it may further lead to progressive collapse of...
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Analysis of pounding between adjacent buildings founded on different soil types
PublicationEarthquake-induced pounding was experienced in many previous earthquakes and it was found to be a critical issue. This study investigates the effect of pounding between buildings founded on the same and different soil types. Three 3-D buildings with 4, 6 and 8 storeys were considered in this study. Three pounding scenarios were taken into account, i.e. pounding between 4-storey and 6-storey buildings, between 4-storey and 8-storey...
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Towards 5G — Cloud-based Radio Access Networks
PublicationIn the paper a general concept of the 5G network architecture is presented as well as system requirements having impact on innovative solutions in the 5G network are highlighted. A major part of the paper is both presentation and discussion of the problem of Cloud Radio Access Network introduction for public networks in which the cell and resource virtualisation will be implemented. On the other hand, the problem of resource virtualization...
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Self-Testing of Analog Parts Terminated by ADCs Based on Multiple Sampling of Time Responses
PublicationA new approach for self-testing of analog parts terminated by analog-to-digital converters in mixed-signal electronic microsystems controlled by microcontrollers is presented. It is based upon a new fault diagnosis method using a transformation of the set of voltage samples of the time response of a tested analog part to a square impulse into localization curves placed in a multidimensional measurement space. The method can be used...
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Designing a High-sensitivity Microscale Triple-band Biosensor based on Terahertz MTMs to provide a perfect absorber for Non-Melanoma Skin Cancer diagnostic
PublicationNon-melanoma skin cancer (NMSC) is among the most prevalent forms of cancer originating in the top layer of the skin, with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) being its primary categories. While both types are highly treatable, the success of treatment hinges on early diagnosis. Early-stage NMSC detection can be achieved through clinical examination, typically involving visual inspection. An alternative,...
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Modulated crystal structures - periodicity in more than three dimensions
PublicationThe initial definition of a crystal was that it is an object with flat faces. When diffraction studies were developed it turned out that crystal consists of a highly ordered particles and it is possible to isolate a small unique part of their structure - a unit cell - and the definition has been changed to rely on this fact. Nowadays by a crystal we mean any solid having an essentially discrete diffraction diagram. It is because...
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Microbial and chemical quality assessment of the small rivers entering the South Baltic. Part II: Case study on the watercourses in the Puck Bay catchment area
PublicationDue to its location, Puck Bay is an area particularly vulnerable to pollution of anthropogenic origin. The aim of the study was to assess the water quality of small watercourses entering the inner part of Puck Bay. The paper presents the results of chemical and microbiological analyses of 10 rivers and canals at their estuaries located on the western shore of the internal Puck Bay. The following environmental parameters were analyzed:...
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Seismic gap between buildings founded on different soil types experiencing pounding during earthquakes
PublicationSeveral formulas have been suggested in the literature to evaluate the minimum seismic gap that would prevent collisions between adjacent buildings during earthquakes, including those based on the absolute sum of the peak displacements (ABS), square root of the sum of the squares (SRSS), the double difference method (DDC), Australian code, and approach proposed by Naderpour et al. The aim of the present study is to evaluate the...
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Optimization of hydrodynamic vortex separator for removal of sand particles from storm water by computational fluid dynamics
PublicationStorm water treatment has been gradually acknowledged for the removal of pollutants from urban areas using the hydro cyclone separation technique. The separation efficiency of the hydrodynamic vortex separator (HDVS) is a complex phenomenon. With the aim enhance the separation potency of HDVS for storm runoff to get rid of sand particles, the HDVS with different structural configurations was studied by computational fluid dynamics....
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Induction of G2/M phase arrest and apoptosis of human pancreatic cancer BxPC-3 cells by potenet antitumor 1-nitroacridine derivative C-1748
PublicationPancreatic ductal adenocarcinoma (PDA) is among the most lethal human cancers, in part because it is insensitive to many chemotherapeutic drugs. Gemcitabine still remains the best chemotherapeutic agent available for the treatment of advanced pancreatic cancer. However, gemcitabine treatment results in only a marginal survival advantage. Thus, there is a strong need for the continuous development of novel therapeutic agents...
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Microbial and chemical quality assessment of the small rivers entering the South Baltic. Part I: Case study on the watercourses in the Baltic Sea catchment area
PublicationThe area of the Coastal Landscape Park (CLP) due to its location is extremely attractive touristic area. In the summer season, a significant increase in population density is observed, which influences surface water quality. Large numbers of tourists generate an increased amount of municipal wastewater, being treated in local treatment plants and discharged into rivers and streams. The paper presents preliminary research from summer...
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Naturally-derived hydrogels for 3D pancreatic tumor models: A short review
PublicationStatistics suggest a high proportion of mortality rate by pancreatic cancer, which is a solid tumor characterized by high heterogeneity and the presence of a complex extracellular matrix. The very low effectiveness of pancreatic cancer treatment roots in the high metastatic potential and drug resistance of this tumor. Therefore, the quest for efficient cellular models enabling precise mimicking in vivo conditions, and anticancer...
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Experimental and numerical study on deformed steel columns subjected to impact load during earthquakes
PublicationThe soft-storey failure is one of the most typical types of damage observed in buildings during earthquakes. The failure of an upper soft storey of a structure results in large impact load acting on the lower floors and if the resistance of the structural members of the lower storeys is not sufficient it may further lead to progressive collapse of the whole building. The aim of the present paper is to investigate the dynamic behaviour...
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Analysis of floor-to-column pounding of buildings founded on different soil types
PublicationThe aim of this study is to investigate the effect of the soil type on buildings experiencing floor-to-column pounding during earthquakes. Five buildings with 4-storeys, 6-storeys, and 7-storeys were considered. Three types of the 4-storey building with different total heights were taken into account which leads to floor-to-column pounding at 1/3, 1/2 and 2/3 of the height of the impacted column. Two pounding scenarios were considered,...
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Ionic liquids for nano- and microstructures preparation. Part 1: Properties and multifunctional role
PublicationIonic liquids (ILs) are a broad group of organic salts of varying structure and properties, used in energy conversion and storage, chemical analysis, separation processes, as well as in the preparation of particles in nano- and microscale. In material engineering, ionic liquids are applied to synthesize mainly metal nanoparticles and 3D semiconductor microparticles. They could generally serve as a structuring agent or as a reaction...
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l-ascorbic acid modified poly(ester urethane)s as a suitable candidates for soft tissue engineering applications
PublicationIn this paper we created novel poly(ester urethane)s (PESUs) designed specifically for tissue engineering. The PESUs were derived from oligomeric α,ω-dihydroxy(ethylene-butylene adipate) (dHEBA), 1,4-butanediol (BDO) and aliphatic 1,6-hexamethylene diisocyanate (HDI) and modified with l-ascorbic acid to improve their biocompatibility. In addition, we determined their mechanical properties (such as tensile strength, elongation at...
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Utilizing Genome-Wide mRNA Profiling to Identify the Cytotoxic Chemotherapeutic Mechanism of Triazoloacridone C-1305 as Direct Microtubule Stabilization
PublicationRational drug design and in vitro pharmacology profiling constitute the gold standard in drug development pipelines. Problems arise, however, because this process is often dicult due to limited information regarding the complete identification of a molecule’s biological activities. The increasing aordability of genome-wide next-generation technologies now provides an excellent opportunity to understand a compound’s diverse eects...
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Biocompatibility and potential functionality of lanthanum-substituted cobalt ferrite spinels
PublicationBulk and nanostructurized lanthanum-cobalt spinels have attracted a lot of interest from researchers, due to their unique physical and chemical properties as well as functionalities, which are interesting for biomedical and electronic industries. In this manuscript we show that introducing small lanthanum (La3+) content can tune magnetic, electronic and cytotoxic properties of the CoFe2− xLaxO4 system (x ≤ 0.1). The mechanisms...
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The Effect of Full-Cell Impregnation of Pine Wood (Pinus sylvestris L.) on Changes in Electrical Resistance and on the Accuracy of Moisture Content Measurement Using Resistance Meters
PublicationThe impact of the full-cell impregnation of pine wood was investigated with respect to changes in electrical resistance and the accuracy of moisture content measurement. This study compared the resistance of impregnated and untreated pine timber harvested from the northern part of Poland (Pomeranian region). The wood was impregnated by the vacuum-pressure method. The preservative (TANALITH E 3475) and coloring (TANATONE 3950) agents...
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Superconductivity of Ta-Hf and Ta-Zr alloys: Potential alloys for use in superconducting devices
PublicationThe electronic properties relevant to superconductivity are reported for bulk Ta-Hf and Ta-Zr body centered cubic alloys, in a large part to determine whether their properties are suitable for potential use in superconducting qbits. The body centered cubic unit cell sizes increase with increasing alloying. The results of magnetic susceptibility, electrical resistivity, and heat capacity characterization are reported. While elemental...