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Search results for: DNA DAMAGE RESPONSE,NON-SMALL-CELL LUNG CANCER, PHARMACEUTICS, TARGET IDENTIFICATION
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Analysis of the effect of the seismic gap on the response of buildings experiencing pounding during earthquakes
PublicationThe aim of this paper is to investigate the effect of the seismic gap on the dynamic response of buildings experiencing earthquake-induced pounding. Three buildings have been analysed, which are 5-storey, 7-storey and 9-storey structures. Three possible pounding scenarios have been considered, which are pounding between 5-storey and 7-storey buildings, pounding between 5-storey and 9-storey buildings and pounding between 7-storey...
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Survival time prognosis under a Markov model of cancer development
PublicationIn this study we look at a breast cancer data set of women from Pomerania region collected in year 1987-1992 in the Medical University of Gdańsk. We analyze the clinical risk factors in conjunction with Markov model of cancer development. We evaluate Artificial Neural Network (ANN) survival time prediction via a simulation study.
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PCR and real-time PCR approaches to the identification of Arthroderma otae species Microsporum canis and Microsporum audouinii/Microsporum ferrugineum
PublicationObjectives The identification of species in the Arthroderma otae complex is essential to determine the origin of infection and to eliminate the risk of transmission. Microsporum canis is a zoophilic species, whereas Microsporum audouinii and Microsporum ferrugineum are anthropophilic species. In this paper, we propose alternative methods that permit species-specific identification of both anthropophilic and zoophilic members of...
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Unraveling the Interplay between DNA and Proteins: A Computational Exploration of Sequence and Structure-Specific Recognition Mechanisms
PublicationMy PhD dissertation focused on DNA-protein interactions and the recognition of specific DNA sequences and structures. I discovered that acidic amino acid residues (Asp/Glu) play a crucial role by exhibiting a preference for cytosine. Their contribution to binding affinity depends on nearby cytosines, balancing electrostatic repulsion with specific interactions. Acidic residues act as negative selectors, discouraging non-cytosine...
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CELL
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Modal parameters identification with Particle Swarm Optimization
PublicationThe paper presents method of the modal parameters identification based on the Particle Swarm Optimization (PSO) algorithm [1]. The basic PSO algorithm is modified in order to achieve fast convergence and low estimation error of identified parameters values. The procedure of identification as well as algorithm modifications are presented and some simple examples for the SISO systems are provided. Results are compared with the results...
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Identification of models and signals robust to occasional outliers
PublicationIn this paper estimation algorithms derived in the sense of the least sum of absolute errors are considered for the purpose of identification of models and signals. In particular, off-line and approximate on-line estimation schemes discussed in the work are aimed at both assessing the coefficients of discrete-time stationary models and tracking the evolution of time-variant characteristics of monitored signals. What is interesting,...
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Identification of models and signals robust to occasional outliers
PublicationIn this paper estimation algorithms derived in the sense of the least sum of absolute errors are considered for the purpose of identification of models and signals. In particular, off-line and approximate on-line estimation schemes discussed in the work are aimed at both assessing the coefficients of discrete-time stationary models and tracking the evolution of time-variant characteristics of monitored signals. What is interesting,...
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Identification of hydroacoustic wave sources of ship in motion
PublicationThis paper deals with results of identification tests of acoustic field spectrum of underwater noise generated by ship in motion. The field is connected with acoustic activity of ship mechanisms and devices in operation. Vibration energy generated by the mechanisms and devices is transferred through ship structural elements to surrounding water where it propagates in the form of acoustic waves of a broad band of frequencies. In...
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Modulation of immune response to Toxoplasma gondii in sheep by immunization with a DNA vaccine encoding ROP1 antigen as a fusion protein with ovine CD154
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The changes of antioxidant defense system caused by quercetin administration do not lead to DNA damage and apoptosis in the spleen and bone marrow cells of rats
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Seismic damage diagnosis in adjacent steel and RC MRFs considering pounding effects through improved wavelet-based damage-sensitive feature
PublicationThis paper aims to propose complex Morlet (cmorfb-fc) wavelet-based refined damage-sensitive feature (rDSF) as a new and more precise damage indicator to diagnose seismic damages in adjacent steel and Reinforced Concrete (RC) Moment Resisting Frames (MRFs) assuming pounding conditions using acceleration responses. The considered structures include 6- and 9-story steel and 4- and 8-story RC benchmark...
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Framework for Product Innovation Using SOEKS and Decisional DNA
PublicationProduct innovation always requires a foundation based on both knowledge and experience. The production and innovation process of products is very similar to the evolution process of humans. The genetic information of humans is stored in genes, chromosomes and DNA. Similarly, the information about the products can be stored in a system having virtual genes, chromosomes and decisional DNA. The present paper proposes a framework for...
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Termodynamiczne aspekty oddziaływania niskocząsteczkowych ligandów z DNA
PublicationKwasy nukleinowe są celem biologicznym dla wielu antybiotyków oraz leków przeciwnowotworowych i przeciwwirusowych. Dlatego podczas tworzenia nowych farmaceutyków ważna jest dokładna wiedza na temat sposobu wiązania się leku do DNA.Oddziaływanie ligand-DNA można podzielić na dwie grupy: 1. wiązanie kowalencyjne, które często prowadzi do utworzenie trwałych wiązań pomiędzy nićmi DNA, 2. fizykochemiczne wiązanie, które może być podzielone...
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Decreased integrity of exercise-induced plasma cell free nuclear DNA – negative association with the increased oxidants production by circulating phagocytes
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Decreased integrity of exercise-induced plasma cell free nuclear DNA – negative association with the increased oxidants production by circulating phagocytes
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Repeated bouts of exhaustive exercise increase circulating cell free nuclear and mitochondrial DNA without development of tolerance in healthy men
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A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA
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International Journal of Applied Pharmaceutics
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Immunological response of sheep to injections of plasmids encoding Toxoplasma gondii SAG1 and ROP1 genes
PublicationInfection with the intracellular protozoan parasite Toxo¬plasma gondii (T. gondii) causes health problems to both humans and livestock and has a large economic impact worldwide. The immune response in sheep following infection with T. gondii was evaluated using six different combinations of plasmid DNA, recombinant antigen and adjuvant. Sheep were generally vaccinated twice by intramuscular injection with plasmid DNA containing...
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Amplification of c-myc gene and overexpression of c-Myc protein in breast cancer and adjacent non-neoplastic tissue
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Raman spectroscopic study of Ni2+-DNA interactions in aqueous systems
PublicationMetodą ramanowskich widm różnicowych określono sposób oddziaływania jonu Ni2+ z DNA(CT) w układach wodnych. Kation Ni(II) koordynuje w pozycjach N7 guaniny (G) i adeniny (A) w powtarzających się sekwencjach GG, AA i GA cząsteczki DNA. Jednocześnie Ni2+ oddziałuje zewnątrz sferowo poprzez cząsteczki wody z grupami fosforanowymi DNA.
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Red Kale (Brassica oleracea L. ssp. acephala L. var. sabellica) Induces Apoptosis in Human Colorectal Cancer Cells In Vitro
PublicationThis article presents the results of studies investigating the effect of red kale (Brassica oleracea L. ssp. acephala L. var. sabellica) extract on cancer cells (HT-29). The cytotoxicity of the red kale extract was assessed using MTT and LDH assays, while qRT-PCR was employed to analyze the expression of genes associated with the p53 signaling pathway to elucidate the effect of the extract on cancer cells. Furthermore, HPLC-ESI-QTOF-MS/MS...
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Targeting DNA Topoisomerase II in Antifungal Chemotherapy.
PublicationTopoisomerase inhibitors have been in use clinically for the treatment of several diseases for decades. Although those enzymes are significant molecular targets in antibacterial and anticancer chemotherapy very little is known about the possibilities to target fungal topoisomerase II (topo II). Raising concern for the fungal infections, lack of effective drugs and a phenomenon of multidrug resistance underlie a strong need to expand...
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Damage Development on the Surface of Nickel Coating in the Initial Period of Erosion
PublicationThe common occurrence of the phenomenon of cavitation in many industries and the multitude of factors affecting the resistance to cavitation erosion of used materials contribute to the search for methods and appropriate parameters of coating application that are able to minimize the effects of erosion. To determine the validity of the developed application parameters and the method used, cavitation studies and microscopic observations...
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Maritime heritage of small port towns of the Polish coast
PublicationThe article describes problems of the gradual disappearance of real maritime heritage in small Polish port cities. The maritime heritage of small port cities was shaped by coastal processes and urban historical conditions what has led to creation of specific types of landscapes. Special architectural objects of the post-port heritage of small ports of the Polish coast are hydrotechnical constructions (i.e. breakwaters, quays),...
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Heart Lung and Vessels
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EXPERIMENTAL LUNG RESEARCH
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Heart Lung and Circulation
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Damage Detection in the Wind Turbine Blade Using Root Mean Square and Experimental Modal Parameters
PublicationThe paper presents results of an experimental study related to a non-destructive diagnostic technique used for preliminary determination the location and size of delamination in composite coatings of wind turbine blades. The proposed method of damage detection is based on the analysis of the ten first mode shapes of bending vibrations, which correspond to displacements of rotor blades perpendicular to the rotor plane. Modal parameters...
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Shaping the competence of future spatial policymakers for small- and medium-sized towns
PublicationIn this article, the authors aim to present issues addressed within the framework of the architecture and spatial development courses offered by the Faculty of Architecture at Gdańsk University of Technology (FA-GUT), Gdańsk, Poland. These issues concern competence in the education of future spatial planners and their readiness to deal with the development challenges facing small- and medium-sized towns. Within the article, the...
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Non-Linear Analysis of Inter-Story Pounding between Wood-Framed Buildings during Ground Motion
PublicationPounding between adjacent buildings during ground motion may result in structural damage or lead to total destruction of structures. The research on the phenomenon has recently been much advanced; however, the analyses have been carried out only for concrete, steel, and masonry structures, while pounding between wooden buildings has not been studied so far. The aim of this paper is to show the results of detailed non-linear seismic...
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Osteoblast and bacterial cell response on RGD peptide‐functionalized chitosan coatings electrophoretically deposited from different suspensions on Ti13Nb13Zr alloy
PublicationMetallic materials for long-term load-bearing implants still do not provide high antimicrobial activity while maintaining strong compatibility with bone cells. This study aimed to modify the surface of Ti13Nb13Zr alloy by electrophoretic deposition of a chitosan coating with a covalently attached Arg-Gly-Asp (RGD) peptide. The suspensions for coating deposition were prepared in two different ways either using hydroxyacetic acid...
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European Multicenter Evaluation of High-Density DNA Probe Arrays for Detection of Hepatitis B Virus Resistance Mutations and Identification of Genotypes
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Identification and characterization of single-stranded-DNA-binding proteins from Thermus thermophilus and Thermus aquaticus - new arrangement of binding domains
PublicationOkreślono molekularne właściwości białek SSB-podobnych z Thermus thermophi-lus i T. aquaticus. Zbadano aktywność białek oraz termostabilność. Ponadto, dowiedziono homodimeryczność obu białek i ustalono minimalną sekwencję wiążącą ssDNA.
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Application of decisional DNA in web data mining
PublicationPrzedstawiono pilotową koncepcję i aplikację integracji reprezentacji wiedzy opartej na decyzyjnym DNA oraz systemów pozyskiwania wiedzy i danych z Internetu. Wskazano na zalety proponowanej integracji oraz przedstawiono kierunki przyszłych badań w tym zakresie.
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Higher platelet counts correlate to tumour progression and can be induced by intratumoural stroma in non-metastatic breast carcinomas
PublicationBackground Platelets support tumour progression. However, their prognostic significance and relation to circulating tumour cells (CTCs) in operable breast cancer (BrCa) are still scarcely known and, thus, merit further investigation. Methods Preoperative platelet counts (PCs) were compared with clinical data, CTCs, 65 serum cytokines and 770 immune-related transcripts obtained using the NanoString technology. Results High normal...
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Adding Intelligence to Cars Using the Neural Knowledge DNA
PublicationIn this paper we propose a Neural Knowledge DNA based framework that is capable of learning from the car’s daily operation. The Neural Knowledge DNA is a novel knowledge representation and reasoning approach designed to support discovering, storing, reusing, improving, and sharing knowledge among machines and computing devices. We examine our framework for drivers' classification based on their driving behaviour. The experimental...
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Catalytic topoisomerase II inhibitors in cancer therapy.
PublicationDNA topoizomeraza II jest jednym z głównych celów molekularnych dla leków stosowanych w terapii przeciwnowotworowej. Wszystkie inhibitory tego enzymu są zdolne do zakłócania w jeden z etapów cyklu katalitycznego topoizomerazy II. Związki, które stabilizują kowalencyjny kompleks DNa i topoizomerazy II (znany jako kompleks rozszczepialny) są nazywane truciznami topoizomerazy, inne związki, które hamują aktywność enzymu na innych...
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Decisional DNA based embedded systems: a new perspective
PublicationOmówiono nowe kierunki i perspektywy badań w zakresie systemów podporządkowanych opartych na decyzyjnym DNA.
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RAGE as a Novel Biomarker for Prostate Cancer: A Systematic Review and Meta-Analysis
PublicationThe receptor for advanced glycation end-products (RAGE) has been implicated in driving prostate cancer (PCa) growth, aggression, and metastasis through the fueling of chronic inflammation in the tumor microenvironment. This systematic review and meta-analysis summarizes and analyzes the current clinical and preclinical data to provide insight into the relationships among RAGE levels and PCa, cancer grade, and molecular effects....
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A non-linear direct peridynamics plate theory
PublicationIn this paper a direct non-local peridynamics theory for thin plates is developed. Peridynamic points are assumed to behave like rigid bodies with independent translation and finite rotation degrees of freedom. The non-local mechanical interaction between points is characterized by force and moment vectors. The balance equations including the linear momentum, the angular momentum and the energy are presented. Peridynamic deformation...
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Detection of MGMT, RASSF1A, p15INK4B, and p14ARF promoter methylation in circulating tumor-derived DNA of central nervous system cancer patients
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Application of nonmetallic frustrated cations in the activation of small molecules
PublicationThe concept of nonmetallic frustrated cations has been used in small molecule activation. The in situ generated ambiphilic phosphinoborinium cation activated phenyl isocyanate, diisopropylcarbodiimide, and acetonitrile under very mild conditions without any catalyst, yielding single-, double-, or mixed-activation products. Furthermore, the mechanisms of the reactions of the phosphinoborinium cation with small molecules were elucidated...
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Soft modes of the dielectric response in the twist–bend nematic phase and identification of the transition to a nematic splay bend phase in the CBC7CB dimer
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Prevention of resonance oscillations in gear mechanisms using non-circular gears
PublicationOne of the main disadvantages of gear mechanisms is the occurrence of noise and vibrations. This study investigated the applicability of non-circular gears for preventing resonance oscillations in gear mechanisms. The influence of a small deviation of the gear centrodes from the nominal circles on kinematic and oscillatory characteristics was analysed. It was shown that a larger deviation results in a smaller resonance amplitude...
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Decisional DNA digitral TV: concept and initial experiments
PublicationPrzedstawiono pierwsze wyniki eksperymentalnej integracji telewizji cyfrowej z decyzyjnym DNA reprezentujacym wiedze o odbiorcy programow.
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Pedestrian on footbridges, vertical loads and response
PublicationThe paper is a synthesis of the experimental and theoretical investigations on dynamics of pedestrian bridges under vertical load The subject is divided into four issues.1) The pedestrian as a vertical dynamic load on footbridges, theoretic load function for walking and crouching.2) Crowd walking on the footbridge - pedestrian flow.3) Vertical lock-in effect.4) Response of the footbridge - numeric and side test results, -...
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An image processing approach for fatigue crack identification in cellulose acetate replicas
PublicationThe cellulose acetate replication technique is an important method for studying material fatigue. However, extracting accurate information from pictures of cellulose replicas poses challenges because of distortions and numerous artifacts. This paper presents an image processing procedure for effective fatigue crack identification in plastic replicas. The approach employs thresholding, adaptive Gaussian thresholding, and Otsu binarization...
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Synthesis, molecular structure, and metabolic stability of new series of N' -(2-alkylthio-4-chloro-5-methylbenzenesulfonyl)-1-(5-phenyl-1 H -pyrazol-1-yl)amidine as potential anti-cancer agents
PublicationA series of new N'-(2-alkylthio-4-chloro-5-methylbenzenesulfonyl)-1-(5-phenyl-1H-pyrazol-1-yl)amidine derivatives have been synthesized and evaluated in vitro by MTT assays for their antiproliferative activity against cell lines of colon cancer HCT-116, cervical cancer HeLa and breast cancer MCF-7. The studied compounds display selective activity mainly against HCT-116 and HeLa cells. Thus, five compounds show selective cytotoxic...