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Search results for: DRUG DESIGN, ANTICANCER COMPOUNDS, ANTIFUNGAL COMPOUNDS, MOLECULAR TARGETS
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New heterometallic Co/Zn, Ag/Co, and Ag/Zn imidazolates: structural characterization and catalytic activity in the oxidation of organic compounds
PublicationNanocrystalline powders of monometallic and bimetallic imidazolates of Co, Zn, and Ag were produced by a reaction carried out in water. The powders were characterized by powder X-ray diffraction and the crystal structures of new compounds Ag2ZnIm4 and Ag2CoIm4 (Im = imidazolate) were solved. Heterometallic Co/Zn imidazolates showed the standard ZIF-8 crystal structure while Ag/Zn and Ag/Co systems were isostructural with the copper...
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Chemical characterization of wild populations of Brassica oleracea complex species (n=9) for the content of their bioactive compounds
PublicationThe wild species belonging to Brassica oleracea complex species (n=9) are widespread in the Mediterranean basin and represent the relative species of several vegetable crops, such as broccoli, cauliflower, kale, cabbage. They are characterized by the high level of bioactive compounds, such as glucosinolates (GLSs), known for their benefits for human health. Four accessions were evaluated: B. macrocarpa (BM) from Favignana (Trapani),...
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The estimation of total volatile organic compounds emissions generated from peroxide cured natural rubber/polycaprolactone blends
PublicationNatural rubber (NR)/polycaprolactone (PCL) blends at the ratio of 90/10% wt. (NR/PCL90/10) and 70/30% wt. (NR/PCL70/30), with a constant amount of dicumyl peroxide, were prepared by compounding in an internal mixer. Obtained NR/PCL bio-based blends were cured at three different temperatures (150 °C, 160 °C and 170 °C). The total content of volatile organic compounds (TVOC) as a function of the NR/PCL blends ratio, and their curing...
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Anticancer properties of low molecular weight oat beta-glucan – An in vitro study
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Fruit Pomace as a Component Shaping the Content of Bioactive Compounds and Nutritional, Health-Promoting (Anti-Diabetic and Antioxidant) of Shortcrust Pastries Sweetened with Sucrose and Erythritol
Open Research DataIn this study, an attempt was made to develop shortcrust pastries containing different amounts of chokeberry, apple and blackcurrant pomace (0%, 10%, 30%, 50%), modulating their degree of sweetness via the application of sucrose or erythritol. The obtained products were assessed for their nutritional value (energy value, protein, fats, dietary fibre,...
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Pilot scale degradation study of 16 selected volatile organic compounds by hydroxyl and sulfate radical based advanced oxidation processes
PublicationThe studies of effective technologies for complete degradation of the volatile organic compounds (VOCs), are very important due to the high biotoxicity of the VOCs which makes the biological technologies ineffective. It also increases the risk of VOCs emission instead of their treatment when using open air biological technologies. In the present study, different types of Advanced Oxidation Processes (AOPs) were investigated for...
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Flow cytometric approach to evaluate the impact of hydro-technical concrete compounds’ release to the freshwater microbiome
PublicationThe aim of this research was to test the potential of applying a flow cytometric procedure to evaluate the impact of concrete compounds’ release to the freshwater microbiome. Cells from the collected samples were stained with a fluorogenic redox indicator dye that measures the redox potential of microbial cells. This novel approach was combined with the assessment of microorganisms’ penetration into the internal structures of concrete...
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A. Computational analysis by molecular docking of thirty alkaloid compounds from medicinal plants as potent inhibitors of SARS-CoV-2 main protease(2020).
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Molecular Structures of the Phospha-Wittig Reaction Intermediate: Initial Step in the Synthesis of Compounds with a C═P–P Bond as Products in the Phospha-Wittig Reaction
PublicationThe phospha-Wittig reactivity ofβ-diketiminate titanium(III) complexes with phosphanylphosphido ligands was investigated. The reactions of [MeNacNacTi(Cl){η2-P(SiMe3)-PtBu2}] and [MeNacNacTi(Cl){η2-P(SiMe3)-P(Ph)tBu}] with acetone conducted in toluene solution under mild conditions led to the phospha-Wittig intermediates [{(ArN=C(Me)CHC(Me)=NAr)(C(Me)2O}Ti(Cl){PtBu2-P(SiMe3)C(Me)2O}] (1) and [{(ArN=C(Me)CHC(Me)=NAr) (C-(Me)2O}Ti(Cl){P(Ph)tBu-P(SiMe3)C(Me)2O}]...
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The strategies of nutrient removal compounds from wastewater by using aquatic plants in the Green deal implementation
PublicationThe aim of the study was to determine the efficiency of wastewater treatment from nitrogen compounds - ammonium, nitrite, nitrate, and phosphate - using Lemna minor and Spirogyra sp. in the context of the strategies toward Green Deal Implementation. Meanwhile, the various biological treatment methods of nutrients according to the value-added and application prospects were also discussed as a future solution in the Circular Economy...
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Real-time monitoring of the emission of volatile organic compounds from polylactide 3D printing filaments
PublicationEstablishing the emission profile of volatile organic compounds generated during fused deposition modeling 3D printing using polymer filaments is important in terms of both understanding the processes taking place during thermal degradation of thermoplastics, and assessing the user's exposure to potentially harmful volatiles. However, obtaining detailed, real-time qualitative and quantitative results poses a challenge. In this...
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Characterization of volatile compounds, structural, thermal and physico-mechanical properties of cross-linked polyethylene foams degraded thermo-mechanically at variable times
PublicationWaste cross-linked polyethylene foam (wXLPE) was thermo-mechanically degraded at variable time using internal batch mixer. The progress of wXLPE degradation has been investigated by using a simultaneous thermogravimetric/differential scanning calorimetry analyzer coupled with Fourier transform infrared spectroscopy, swelling measurements, tensile tests and scanning electron microscopy. Volatile organic compounds generated during...
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Simultaneous Determination of Indolic Compounds in Plant Extracts by Solid-Phase Extraction and High-Performance Liquid Chromatography with UV and Fluorescence Detection
PublicationA high-performance liquid chromatographic method with UV and fluorescence detection (HPLC-DAD-FLD) was developed for simultaneous determination of indolic compounds in plant material. Indole-3-carbinol (I3C), indole-3-acetic acid (I3AA), indole-3-acetonitrile (I3ACN), and 3,3′-diindolylmethane (DIM) were used as representative compounds that cover a wide spectrum of indole structures occurring in nature. For concentration and purification...
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Fast-response optoelectronic detection of explosives’ residues from the nitroaromatic compounds detonation: field studies approach
PublicationWe are presenting an application of optoelectronic nitrogen dioxide (NO2) analyzer based on cavity enhanced absorption spectroscopy in the detection of traces of explosives after detonation. It has been shown that the analyzer using blue-violet laser is able to detect explosive residues after the detonation of various amounts of nitroaromatic compounds (75g-1kg) with higher efficiency than the HPLC soil sample testing equipment,...
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Modeling hydrolysis of slowly biodegradable organic compounds in biological nutrient removal activated sludge systems
PublicationHydrolysis is an important process in biological wastewater treatment and is known to be the ratelimiting step in organic carbon removal from municipal or industrial wastewater. The influence of the readily biodegradable chemical oxygen demand fraction in biological wastewater treatment systems has been extensively investigated, but little is known about the effects of slowly biodegradable substrate (XS) on denitrification and...
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Thromboelastometric Analysis of Anticancer Cerrena unicolor Subfractions Reveal Their Potential as Fibrin Glue Drug Carrier Enhancers
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Strain improvement and immobilization technique for enhanced production of the anticancer drug paclitaxel by Aspergillus fumigatus and Alternaria tenuissima
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Sandwich-like mesoporous silica flakes for anticancer drug transport—Synthesis, characterization and kinetics release study
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In vitro and in vivo evaluation of sandwich-like mesoporous silica nanoflakes as promising anticancer drug delivery system
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Discovery of the anticancer drug vinblastine from the endophytic Alternaria alternata and yield improvement by gamma irradiation mutagenesis
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Natural/bio-based sorbents as greener extractive materials for endocrine disrupting compounds in samples of different matrix composition
PublicationEndocrine-disrupting compounds (EDCs) are a group of chemicals that interfere with the endocrine system, leading to adverse effects on human health and the environment. Increasing concerns over the EDCs presence in various environmental compartments has driven the search for greener extraction materials. Recently, the use of polymers of natural origin (biopolymers) has been demonstrated to be an effective and promising research...
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A review on computer‐aided chemogenomics and drug repositioning for rational COVID ‐19 drug discovery
PublicationApplication of materials capable of energy harvesting to increase the efficiency and environmental adaptability is sometimes reflected in the ability of discovery of some traces in an environment―either experimentally or computationally―to enlarge practical application window. The emergence of computational methods, particularly computer-aided drug discovery (CADD), provides ample opportunities for the rapid discovery and development...
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Seasonal changes in organotin compounds in water and sediment samples from the semi-closed Port of Gdynia
PublicationThe effect of seasonal changes on the distribution of organotin compounds (OTC) in the sediments and seawaterfrom the docks of the Port of Gdynia was investigated. Sediment and seawater samples were collectedfrom four industrial docks in February (winter) and June (summer) in 2009. The samples were analyzed forbutyltin, phenyltin, octyltin, and tricyclohexyltin (total of 9 OTC derivatives). The fine fraction (b0.063 mm)accumulated...
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Piperine Targets Different Drug Resistance Mechanisms in Human Ovarian Cancer Cell Lines Leading to Increased Sensitivity to Cytotoxic Drugs
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How do sterols determine the antufungal activitiy of amphotericin B? Free energy of binding between the drug and its membrane targets.
PublicationAmphotericin B (AmB) is a well-known polyene antibiotic used to treat systemic fungal infections. It is commonly accepted that the presence of sterols in the membrane is essential for the AmB biological activity, that is, for the formation of transmembrane ion channels. The selective toxicity of AmB for fungal cells is attributed to the fact that it is more potent against fungal cell membranes containing ergosterol than against...
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Understanding the early-stage release of volatile organic compounds from rapeseed oil during deep-frying of tubers by targeted and omics-inspired approaches using PTR-MS and gas chromatography
PublicationDuring deep-frying, a plethora of volatile products is emitted with the fumes. These compounds could act as oil quality indicators and change the indoor air composition leading to health risks for occupants. The presented experiments focus on deep-frying of different tubers in rapeseed oil at different frying temperatures. Here, two scenarios for real-time monitoring of volatile organic compounds (VOCs) using proton transfer reaction...
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Fermi-liquid behavior of binary intermetallic compounds Y3 M (M = Co, Ni, Rh, Pd, Ir, Pt)
PublicationA series of polycrystalline samples of Y3 M (M = Co, Ni, Rh, Pd, Ir, Pt), intermetallic binary compounds were synthesized by the arc-melting method. Powder x-ray diffraction (pXRD) confirmed the orthorhombic cementite-type crystal structure and allowed for the estimation of the lattice parameters. Physical properties were investigated by means of electrical resistivity and heat capacity measurements between 1.9 K and 300 K. All...
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Structural, spectral and magnetic properties of Ni(II), Co(II) and Cd(II) compounds with imidazole derivatives and silanethiolate ligands
PublicationA series of new metal heteroleptic complexes have been obtained in simple reactions of 1-(3-aminopropyl)-imidazole (api) and 1,4-bis(imidazol-1-yl)-butane (bbi) ligands with metal silanethiolates or acetylacetonates. The obtained complexes are the coordination polymers [Ni{SSi(tBuO)3}2(μ-api)]n1, [Co{SSi(tBuO)3}2(μ-api)]n2, [Cd{SSi(tBuO)3}2(μ-api)·2CH3OH]n3, [Cd{SSi(tBuO)3}2(μ-bbi)·CHCl3]n4 and the dimer [Co{SSi(tBuO)3}2(μ-bbi)·3CH3OH]25....
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Molecular mechanism of the enzymatic oxidation investigated for imidazoacridinone antitumor drug C-1311.
PublicationPraca miala na celu określenie molekularnego mechanizmu enzymatycznej utleniającej aktywacji wymienionego związku przeciwnowotworowego w takim układzie modelowym, w którym wcześniej wykazano jego kowalencyjne wiązanie się do DNA. Badania struktur chemicznych produktów enzymatycznej aktywacji wykazały, że dwa z nich powstają w wyniku dealkilacji łańcucha bocznego cząsteczki, natomiast dwa inne w wyniku aktywacji pierścienia imidazoakrydonu....
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Versatile method employing basic techniques of genetic engineering to study the ability of low molecular weight compounds to bind covalently with DNA in cell free systems.
PublicationMechanizm działania większości leków przeciwnowotworowych oraz związków rakotwórczych polega na ich kowalencyjnym wiązaniu z DNA. Poziom tego wiązania jest zazwyczaj bardzo niski, co powoduje, że potrzebne są niezwykle czułe metody aby kowalencyjna modyfikacja mogła być w ogóle wykryta. My podjęliśmy próbę zastosowania w tym celu prostych, szybkich i sprawdzonych technik inżynierii genetycznej: metody PCR do uzyskania fragmentu...
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The removal of biogenic compounds and suspended solids in a constructed wetland system
PublicationW celu ochrony ujęcia powierzchniowego wody pitnej dla m. Gdańska w 1997 roku został wybudowany obiekt hydrofitowy na cieku spływającym ze wsi Bielkowo. System hydrofitowy jest zbiornikiem retencyjnym złożonym z dwóch części: - część ''mokra'' tzn. stale wypełniona wodą stanowiąca system grobli z wewnętrznym drenażem, która miała pełnić rolę oczyszczających złóż korzeniowych, - część ''sucha'' wypełniająca się wodą okresowo i przeznaczona...
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IT Support for the Optimization of the Epoxidation of Unsaturated Compounds on the Example of the TOPSIS Method
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Enthalpy of formation of intermetallic compounds from the Li–Si system
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Heterogeneous Oxidation of Phenolic Compounds with Photosensitizing Catalysts Incorporated into Chitosan
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The use of fungi in biofiltration to remove hydrophobic volatile organic compounds
PublicationThe growing importance placed on air quality by environmental regulations and public opinion necessitate the minimization and removal of volatile organic compound emissions (VOCs), including odours. The removal of hydrophobic VOCs from the air by biological methods remains a major technical challenge (despite its importance in the shift to green engineering). A potential solution to this challenge is the use of fungi in biofiltration....
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Moderately Reactive Molecules Forming Stable Ionic Compounds with Superhalogens
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Chiral phonons in the honeycomb sublattice of layered CoSn-like compounds
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Isolation and determination of phenolic compounds from freshwater Cladophora glomerata
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Separation of volatile compounds from fermentation broth by membrane distillation
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New Phenolic Compounds from the Roots of Lentil (Lens culinaris)
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Thermal decomposition of surface compounds for the generation of small quantities of acetaldehyde
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Generation of standard gaseous mixtures by thermal decomposition of surface compounds
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Quantitative structure-(chromatographic) retention relationship models for dissociating compounds
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Sorption Properties of Polydivinylbenzene Polymers towards Phenolic Compounds and Pharmaceuticals
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Marinating and Salting of Herring, Nitrogen Compounds’ Changes in Flesh and Brine
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Magnetic composite adsorbents of phenolic compounds with superior corrosion resistance
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Environmental fate of endocrine disrupting compounds - analytical problems and challenges
PublicationNarażenie na substancje wykazujące się aktywnością hormonów płciowych może negatywnie wpływać na układ endokrynny i rozrodczy u ludzi i innych organizmów żywych. Badania wykazały że obserwowane są znaczne wzrosty przypadków występowania nowotworów piersi, prostaty i jąder. Inne zaś wykazały obniżoną liczbę plemników w nasieniu mężczyzn i wydłużenie czasu oczekiwania na poczęcie. Odkrycia te znajdują potwierdzenie w badaniach polowych...
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Concentration of bioactive compounds in mussels Mytilus galloprovincialis as an indicator of pollution
PublicationOznaczano zawartość związków cynoorganicznych oraz ksenobiotyków z grupy PCB i WWA w tkankach małży pochodzących z obszarów zanieczyszczonych i niezanieczyszczonych z regionu Mokpo Bay (Korea).Wyżej wymienione związki mogą być traktowane jako wskaźniki antropopresji.
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Identification of volatile compounds in raw spirits of different organoleptic quality
PublicationGłównym celem prezentowanych badań było określenie składu lotnej frakcji destylatów rolniczych, a następnie wyodrębnienie profili zapachowych destylatów rolniczych różniących się właściwościami sensorycznymi ocenionymi na podstawie klasycznej analizy sensorycznej. Profile zapachowe tworzono z wykorzystaniem kapilarnej chromatografii gazowej połączonej ze spektrometrią mas (GC-MS). Do ekstrakcji lotnych związków zastosowano technikę...
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Identification of volatile compounds based on the electrocatalytic gas sensor responses
PublicationMeasured response in case of electrocatalytic gas sensors is in form of a voltamperometric characteristic. Current-voltage (I-V) response shape depends on the gas type and its concentration. Such response contains significantly more information comparing with typical electrochemical sensors, but is quite difficult to analyze. When I-V curve contains current peaks, position of such peaks can be used...