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Search results for: active pharmaceutical ingredients
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Antibacterial evaluation of bioactive modifiers of bone cements: antibiotics, nanometals and chitosan
PublicationModern biomaterials in addition to their basic tasks, can serve as carriers of active substance. The release of a bioactive particles allows to locally fight infection or its prevent it. Bone cements additionally to their basic applications in orthopedic surgery can also serve to deliver locally active substances. Currently, only antibiotics are routinely used as modifiers for bone cements. Bioactive bone cements constitute...
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Antioxidant Interactions between Major Phenolic Compounds Found in 'Ataulfo' Mango Pulp: Chlorogenic, Gallic, Protocatechuic and Vanillic Acids
PublicationPhenolic compounds are known to have antioxidant capacity; however, there is little information about molecular interactions between particular phenolics found in fruits at different developmental stages. Therefore, the total antioxidant capacity of the phenolic compounds of a fruit may not correspond to the sum of individual antioxidant capacity given by antioxidants from that tissue. In this study, individual antioxidant capacity...
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Arabinoxylans: A review on protocols for their recovery, functionalities and roles in food formulations
PublicationArabinoxylans (AXs) are compounds with high nutritional value and applicability, including prebiotics or supplementary ingredients, in food manufacturing industries. Unfortunately, the recovery of AXs may require advanced separation and integrated strategies. Here, an analysis of the emerging techniques to extract AXs from cereals and their by-products is discussed. This review covers distinct methods implemented over the last...
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Chronic viral hepatitis B without delta-agent - Male, 41 - Tissue image [4090730007938341]
Open Research DataThis is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Chronic viral hepatitis B without delta-agent - Male, 41 - Tissue image [4090730007934111]
Open Research DataThis is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Jednofazowy falownik napięcia z aktywnym obwodem odsprzęgającym
PublicationZnanym zagadnieniem w jednofazowych falownikach napięcia jest pobieranie ze źródła napięcia stałego składowej przemiennej o częstotliwości dwukrotnie większej od częstotliwości generowanej przez falownik. Jednym z rozwiązań problemu jest stosowanie dużej baterii kondensatorów elektrolitycznych, lecz lepszym sposobem z punktu widzenia niezawodności i gęstości mocy przekształtnika jest stosowanie aktywnych układów odsprzęgania mocy....
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Ancillary services to grids provided with distributed generation
PublicationThe paper introduces system for utilization of the customer-side generated energy. Additionally system can secure some ancillary services to grids. Those services include: current active filtering, load voltage stabilization and in case of grid voltage faults - uninterruptible load supplying (possible with energy storage device). Presented experimental results confirm flexibility of this arrangement in processes of power delivery...
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Thermal self-action effects of acoustic beam in a vibrationally relaxing gas
PublicationThermal self-action of acoustic beam in a molecular gas with excited internal degrees of molecules’ freedom, is studied. This kind of thermal self-action differs from that in a Newtonian fluid. Heating or cooling of a medium takes place due to transfer of internal vibrational energy. Equilibrium and non-equilibrium gases, which may be acoustically active, are considered. A beam in an acoustically active gas is self-focusing unlike...
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A robust 18-pulse diode rectifier with coupled reactors
PublicationThe article presents the principle of operation and selected results of simulation and laboratory tests of the 18-pulse rectifier system with coupled reactors and small series active power filter. The presented system makes it possible to reduce, especially in distribution supply networks, undesired higher current harmonics. The 18-pulse nature of operation of the rectifier is reached using a set of coupled three-phase network...
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Augmenting digital documents with negotiation capability
PublicationActive digital documents are not only capable of performing various operations using their internal functionality and external services, accessible in the environment in which they operate, but can also migrate on their own over a network of mobile devices that provide dynamically changing execution contexts. They may imply conflicts between preferences of the active document and the device the former wishes to execute on. In the...
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Power electronic transformer based on cascaded H-bridge converter
PublicationIn this paper the control strategy of power electronic transformer (PET) is proposed. The analyzed structure of PET uses two seven-level cascaded H-bridge (CHB) rectifiers. The electrical power of PET is transferred between DC-links of CHB converters using dual-active-bridges (DABs) and low voltage high frequency transformers. The roposed solution allows for controlling the active and reactive power with a low level of harmonic...
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The effect of morphology and crystalline structure of Mo/MoO3 layers on photocatalytic degradation of water organic pollutants
PublicationMolybdenum oxide layers were formed by anodization of the Mo metallic foil in a water/ethylene glycol-based electrolyte containing fluoride ions. The as-prepared, amorphous samples were annealed in air at different temperatures in a range from 100 �C to 700 �C. The crystal phase and morphology of anodized and annealed MoO3 layers were investigated using X-ray diffraction, Raman spectroscopy, and scanning electron microscopy. The...
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Nanoparticles: Synthesis, characteristics, and applications in analytical and other sciences
PublicationNanoparticles (NPs) are widely employed in different research areas, ranging from analytical chemistry and environmental science to medicine, the agriculture and pharmaceutical industry. This is mainly due to the unique characteristics of NPs and the novelty they introduce in such applications. In analytical chemistry, the role of NPs can differ depending on the nature of the steps involved in analytical process. NPs are probably...
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Analytical procedures for quality control of pharmaceuticals in terms of residual solvents content: Challenges and recent developments
PublicationResidual solvents play an important role in the synthesis of drugs and in product formulations. In addition, they pose a serious problem, that is toxicity, as many of them exhibit toxic or environmentally hazardous properties. Therefore, constant monitoring of quality control is needed. In this study, we present an overview of regulatory and general methods described by various pharmacopoeias. Then, the most commonly used methodologies...
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Environmentally Oriented Models and Methods for the Evaluation of Drug x Drug Interaction Effects
PublicationThis detailed review compares known and widely used methods for drug interaction estimation, some of which now have historical significance. Pharmaceutical application has been noted as far back as several thousand years ago. Relatively late in the 20th century, however, researchers became aware that their fate and metabolism, which still remain a great challenge for environmental analysts and risk assessors. For the patient’s...
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Smart acoustic band structures
PublicationSmart acoustic band structures exhibit very interesting and non-standard physical properties due to the periodic nature of their certain characteristic on different scale levels. They manifest mostly in their frequency spectra as socalled frequency band-gaps or stop-bands, what has a great impact on the behaviour of these structures in relation to the propagation of vibro-acoustic signals that can be transmitted through the structures...
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Progress, Challenge, and Perspective of Bimetallic TiO2-Based Photocatalysts
PublicationBimetallic TiO2-based photocatalysts have attracted considerable attention in recent years as a class of highly active catalysts and photocatalysts under both UV and Vis light irradiation. Bimetallic noble metal structures deposited on TiO2 possess the ability to absorb visible light, in a wide wavelength range (broad LSPR peak), and therefore reveal the highest level of activity as a result of utilization of a large amount of...
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Application of TMS320c67xx signal processors for SONIC-self-optimizing narrowband interference canceler
PublicationThe paper presents a laboratory system for testing active control algorithms of acoustics noise in ducts. An applied algorithm - self-optimizing narrowband interference canceller (SONIC), allows one to remove narrowband disturbances of constant or slowly time-varying frequencies. Example experimental results of using the laboratory system for supression of sinusoidal disturbance are described. An electronic part of the system was...
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A two dimensional approach for modelling of pennate muscle behaviour
PublicationThe purpose of this study was to elaborate a two-dimensional approach for unipennate and bipennate striated skeletal muscle modelling. Behavior of chosen flat pennate muscle is modelled as a rheological system composed of serially linked passive and active fragments having different mechanical properties. Each fragment is composed of three elements: mass element, elastic element and viscous element. Each active fragment furthermore...
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Squamous cell carcinoma, metastatic, NOS - Female, 53 - Tissue image [9090729594408831]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Squamous cell carcinoma, metastatic, NOS - Female, 53 - Tissue image [9090729594409841]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Squamous cell carcinoma, metastatic, NOS - Female, 53 - Tissue image [9090729594409921]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Chronic viral hepatitis B without delta-agent - Male, 41 - Tissue image [40907300079361]
Open Research DataThis is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Chronic viral hepatitis B without delta-agent - Male, 41 - Tissue image [4090730007936601]
Open Research DataThis is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Squamous cell carcinoma, metastatic, NOS - Female, 53 - Tissue image [9090729594405561]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Squamous cell carcinoma, metastatic, NOS - Female, 53 - Tissue image [9090729594404251]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Electrochemistry meets enzymes: Investigation of the biotransformation pathway of C-1311 based on electrochemical simulation in comparison to in vitro methods.
PublicationThe knowledge of the metabolic pathways and the biotransformation of new drugs is one of the major challenges in pharmaceutical research. It is crucial for elucidation of degradation routes of the new biologically active compounds, especially in the area of possible toxicity. Conventional in vitro drug metabolism studies are based on incubating drug candidate with e.g. hepatocytes or, most importantly, liver cell microsomes and...
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Marek Szelągowski dr
PeopleMarek Szelągowski has participated in the creation and implementation of IT solutions in the fields of accounting, human resources management, production, IT infrastructure management, etc. As the CIO of the BUDIMEX Group in 2000–2008 he was responsible for the accommodation of informatization strategies to the changing needs of the business sector. He was managing and participating in analyses and optimizations of business processes...
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Using Minimum Actuators to Control Shape and Stress of a Double Layer Spherical Model Under Gravity and Lateral Loadings
PublicationSpherical domes are picturesque structures built in developed countries to attract tourists. Due to horizontal and vertical overloading, the structures’ attractive shapes may be disturbed, and some members' stress may exceed the elastic level. In this paper, the shape and stress of a deformed double-layer spherical numerical model due to simultaneous lateral and vertical loadings are controlled, meanwhile, the number of actuators...
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Flow cytometric approach to evaluate the impact of hydro-technical concrete compounds’ release to the freshwater microbiome
PublicationThe aim of this research was to test the potential of applying a flow cytometric procedure to evaluate the impact of concrete compounds’ release to the freshwater microbiome. Cells from the collected samples were stained with a fluorogenic redox indicator dye that measures the redox potential of microbial cells. This novel approach was combined with the assessment of microorganisms’ penetration into the internal structures of concrete...
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Analysis of AC/DC/DC Converter Modules for Direct Current Fast-Charging Applications
PublicationThe paper is a comprehensive laboratory comparison study of two galvanic isolated solution off-board battery chargers: (1) Si-based cost-effective case, and (2) SiC-bidirectional ready for vehicle to grid concept case. All circuits are modular, and in both cases the DC/DC converter can be replaced according to the end user requirements (the coupled transformer remains the same and is constructed based on 12xC100 cores to avoid...
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Code development of a DSP-FPGA based control platform for power electronics applications
PublicationThis paper focuses on the implementation of power electronics algorithms in control platforms based on DSP-FPGA. Today’s power electronics technology demands high power computation with high speed interfacing at the same time. The most popular configuration is a DSP for the former and a FPGA for the latter. The main goal of this work was to develop a generic control system for power electronics application, but it is explained...
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Forced Degradation Studies of Ivabradine and In Silico Toxicology Predictions for Its New Designated Impurities
PublicationAll activities should aim to eliminate genotoxic impurities and/or protect the API against degradation. There is a necessity to monitor impurities from all classification groups, hence ivabradine forced degradation studies were performed. Ivabradine was proved to be quite durable active substance, but still new and with insufficient stability data. Increased temperature, acid, base, oxidation reagents and light were found to cause...
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Inspired by Nature: The Use of Plant-derived Substrate/Enzyme Combinations to Generate Antimicrobial Activity in situ
PublicationThe last decade has witnessed a renewed interest in antimicrobial agents. Plants have received particular attention and frequently rely on the spontaneous enzymatic conversion of an inactive precursor to an active agent. Such two-component substrate/enzyme defence systems can be reconstituted ex vivo. Here, the alliin/alliinase system from garlic seems to be rather effective against Saccharomyces cerevisiae, whilst the glucosinolate/myrosinase...
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Extended duration running and impulse loading characteristics of an acoustic bearing with enhanced geometry
PublicationThis paper presents performance during prolonged running of the acoustic bearing when PZTs are switched off and when they are switched on. The effect of active PZT on shaft’s displacements in X and Y directions is clearly demonstrated. Performance of the acoustic bearing was also assessed when an impulse force was applied to the running shaft at speed. Once again the benefits of having PZTs active are beyond doubt. The instability...
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Magnetic deep eutectic solvents – Fundamentals and applications
PublicationMagnetic deep eutectic solvents (MDES), a relatively new subclass of conventional deep eutectic solvents (DES) containing additional paramagnetic components in their structure. MDES exhibit a strong response toward external magnetic fields, thus they can improve many industrial and analytical applications. In addition, this new group of solvents present unique physicochemical properties that can be easily tuned by selecting the...
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Magnetic and infrared thermography methods in detection of antipersonnel landmines
PublicationIn this paper the two alternative methods of antipersonnel landmine detection are shown: the magnetic method and the active infrared thermography. The experimental results of the detection of selected, plastic mines using both methods are also presented.
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Electrochemical simulation of metabolic reduction and conjugation reactions of unsymmetrical bisacridine antitumor agents, C-2028 and C-2053
PublicationElectrochemistry (EC) coupled with analysis techniques such as liquid chromatography (LC) and mass spectrometry (MS) has been developed as a powerful tool for drug metabolism simulation. The application of EC in metabolic studies is particularly favourable due to the low matrix contribution compared to in vitro or in vivo biological models. In this paper, the EC(/LC)/MS system was applied to simulate phase I metabolism of the representative...
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Rapid and simple multi-analyte LC–MS/MS method for the determination of benzodiazepines and Z-hypnotic drugs in blood samples: Development, validation and application based on three years of toxicological analyses
PublicationBenzodiazepines (BZDs) and Z-drugs have been particularly important treatments for sleeping and anxiety disorders for many years. However, recently, a number of new benzodiazepines (named designer benzodiazepines, DBZDs) were synthesised, but some of them have never been used in the clinic; they reached the black drug market as new psychoactive substances and are used for recreational purposes. The abuse of these substances has...
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Formulation, characterisation and in vitro studies of doxorubicin-loaded silica–polydimethylsiloxane granules
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Propensity of salicylamide and ethenzamide cocrystallization with aromatic carboxylic acids
PublicationThe cocrystallization of salicylamide (2-hydroxybenzamide, SMD) and ethenzamide (2-ethoxybenzamide, EMD) with aromatic carboxylic acids was examined both experimentally and theoretically. The supramolecular synthesis taking advantage of the droplet evaporative crystallization (DEC) technique was combined with powder diffraction and vibrational spectroscopy as the analytical tools. This led to identification of eleven new cocrystals...
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Comparison of hydrophilic interaction and reversed phase liquid chromatography coupled with tandem mass spectrometry for the determination of eight artificial sweeteners and common steviol glycosides in popular beverages
PublicationHydrophilic interaction liquid chromatography (HILIC) coupled with tandem mass spectrometry (MS/MS) was used to separate artificial and natural sweeteners approved for use in European Union (EU). Among three tested HILIC columns (BlueOrchid PAL-HILIC, Ascentis Express Si and Acclaim™ Trinity™ P2) the last one was selected for the development of HILIC method due to the best results obtained with it. Early eluting and coeluting compounds...
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The determination of elements in herbal teas and medicinal plant formulations and their tisanes
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Understanding element composition of medicinal plants used in herbalism—A case study by analytical atomic spectrometry
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Structure–bioavailability relationship study of genistein derivatives with antiproliferative activity on human cancer cell
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Silylation of acetaminophen by trifluoroacetamide-based silylation agents
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Selected analytical challenges in the determination of pharmaceuticals in drinking/marine waters and soil/sediment samples
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A new pH/organic modifier gradient RP HPLC method for convenient determination of lipophilicity and acidity of drugs as applied to established imidazoline agents
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Quantitative structure-(chromatographic) retention relationship models for dissociating compounds
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Combined pH/organic solvent gradient HPLC in analysis of forensic material
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