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Search results for: IN VIVO EXPERIMENTATION
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In vivo study on borophene nanoflakes interaction with Tenebrio molitor beetle: viability of hemocytes and short-term immunity effect
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In vivo study on borophene nanoflakes interaction with Tenebrio molitor beetle: viability of hemocytes and short-term immunity effect
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In vivo evaluation of the antipsoriatic effect of hydrogel with lavandin essential oil and its main components after topical application
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Influence of two cultivars of persimmon on atherosclerosis indices in rats fed cholesterol-containing diets: investigation in vitro and in vivo
PublicationCelem badań było oszacowanie wpływu dwóch odmian śliwy daktylowej na niektóre parametry arteriosklerozy u szczurów karmionych dietą zawierającą cholesterol. W ramach badań in vitro badano owoce dwóch odmian śliwy daktylowej jako dodatku do diety szczurów na zawartość związków bioaktywnych (polifenole, flawonoidy, flawonole, taniny, kartenoidy i kwas askorbinowy) i na aktywność przeciwutleniającą. W trakcie badań in vivo różnych...
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Non-cytotoxic hydroxyl-functionalized exfoliated boron nitride nanoflakes impair the immunological function of insect haemocytes in vivo
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Full-field in vivo experimental study of the strains of a breathing human abdominal wall with intra-abdominal pressure variation
PublicationThe presented study aims to assess the mechanical behaviour of the anterior abdominal wall based on an in vivo experiment on humans. Full-field measurement of abdominal wall displacement during changes of intra-abdominal pressure is performed using a digital image correlation (DIC) system. Continuous measurement in time enables the observation of changes in the strain field during breathing. The understanding of the mechanical...
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New perspective on the in vivo use of cold stress dynamic thermography in integumental reconstruction with the use of skin-muscle flaps
PublicationAmong the problems encountered by plastic surgeons is the reconstruction of defects following tumors. One of the reconstructive options is TRAM flap. Despite that anatomy is well-explored, marginal flap necrosis may develop. To minimize complications imaging examinations was designed to determine the degree of flap perfusion. One of them is the thermographic examination.
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Correlation between in vitro and in vivo data on food digestion. What can we predict with static in vitro digestion models?
PublicationDuring the last decade, there has been a growing interest in understanding food's digestive fate in order to strengthen the possible effects of food on human health. Ideally, food digestion should be studied in vivo on humans but this is not always ethically and financially possible. Therefore, simple in vitro digestion models mimicking the gastrointestinal tract have been proposed as alternatives to in vivo experiments. Thus,...
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Complementation studies of the DnaK–DnaJ–GrpE chaperone machineries from Vibrio harveyi and Escherichia coli, both in vivo and in vitro
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Electrochemical Evaluation of the Compact and Nanotubular Oxide Layer Destruction under Ex Vivo Ti6Al4V ELI Transpedicular Screw Implantation
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Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C
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Antioxidant properties and bioactive constituents of some rare exotic thai fruits and comparison with conventional fruits. in vitro and in vivo studies
PublicationPrzedmiotem badań były ekstrakty uzyskane zarówno z egzotycznych owoców z terenu Tajlandii (durian, snake fruit, mangosteen) jak i owoców ''konwencjonalnych'' (mango, kiwi, awokado) w celu porównania zawartości związków bioaktywnych i aktywności przeciwutleniającej.Wyniki badań prowadzonych zarówno in vitro jak i in vivo mogą być wykorzystane przy opracowywaniu diety. W trakcie badań in vitro wykorzystano testy do określania potencjału...
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Expression of high affinity choline transporter during mouse development in vivo and its upregulation by NGF and BMP-4 in vitro
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In vivo creation of plasmid pCRT01 and its use for the construction of carotenoid-producing Paracoccus spp. strains that grow efficiently on industrial wastes
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Metabolic Profiling of Jasminum grandiflorum L. Flowers and Protective Role against Cisplatin-Induced Nephrotoxicity: Network Pharmacology and In Vivo Validation
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Hypericum alpestre extract exhibits in vitro and in vivo anticancer properties by regulating the cellular antioxidant system and metabolic pathway of L‐arginine
PublicationConventional treatment methods are not effective enough to fight the rapid increase in cancer cases. The interest is increasing in the investigation of herbal sources for the development of new anticancer therapeutics. This study aims to investigate the antitumor capacity of Hypericum alpestre (H. alpestre) extract in vitro and in vivo, either alone or in combination with the inhibitors of the L‐arginine/polyamine/nitric oxide...
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Micropatterning of BiVO 4 Thin Films Using Laser-Induced Crystallization
PublicationRelatively high temperatures even up to 500 °C are required to obtain bismuth vanadate (BiVO4) films with the scheelite monoclinic (s-m) structure that shows the highest photocatalytic activity. This requirement limits the possible choice of substrates. Moreover, high quality thin layers of crystalline BiVO4 cannot be prepared with current methods. In this study a light-induced crystallization approach is presented, which is a...
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Gas chromatography-olfactometry (GC-O), electronic noses (e-noses) and electronic tongues (e-tongues) for in vivo food flavour measurement
PublicationThe capter revies two types of artificial olfaction instrumentation, i.e. gas-chromatography-olfactometry (GC-O) and chemical sensor technologies (electronic nose and tongue), combined with multivariate data processing methods as promising approaches for rapid analysis of food. The chapter also includes examples of specific applications for the detection of food flavour and volatile components.
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Characteristics of blond and red star ruby jaffa graefruits (citrus paradisi):results of the studies in vitro, in vivo and on patients suffering from atherosclerosis
PublicationCelem projektu, którego wyniki opisano w pracy byly badania dwóch odmian (jasna i czerwona) owoców grejfruta (in vitro i in vivo) stosowanych jako suplement diety pacjentów cierpiących na arterioskleroze. Stwierdzono, że zawartość związków bioaktywnych a w szczególności zwiazakow fenolowych i lepsze właściwosci przeciwutelniajace wykazuja owoce jasnej odmiany grajfruta. Stosowanie diety z dodatkiem owoców czerownego grejfruta w...
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Mangiferin and Hesperidin Transdermal Distribution and Permeability through the Skin from Solutions and Honeybush Extracts (Cyclopia sp.)—A Comparison Ex Vivo Study
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In vivo evidence of ascorbate involvement in the generation of epigenetic DNA modifications in leukocytes from patients with colorectal carcinoma, benign adenoma and inflammatory bowel disease
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<p>In vivo Studies on Pharmacokinetics, Toxicity and Immunogenicity of Polyelectrolyte Nanocapsules Functionalized with Two Different Polymers: Poly-L-Glutamic Acid or PEG</p>
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Frontier education for a sustainable future - speculative design in architecture as a transdisciplinary experiment
PublicationIn this article, the authors propose the term frontier education referring to the well-established notion of frontier research - one, that through opening unexpected transdisciplinary perspectives, may offer new insights and create a fertile ground for new discoveries and ground-breaking concepts. In answer to the question of how to get rid of normative thinking and extend architectural experimentations, a speculative design architectural...
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Protective Effect of Morus alba Leaf Extract on N-Nitrosodiethylamine-induced Hepatocarcinogenesis in Rats
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TH-D-BRB-06: Assessment of Proton Beam In-Vivo Dose Verification by Directly Comparing Doses Measured in Tissue-Equivalent Polymer Gels to Proton-Activated Positron-Emission Distributions in the Gels Post Irradiation
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Games and play with light in architecture
PublicationThe paper deals with the issue of the influence of daylight on the creation of architecture in the view of designers` play with light in the architectural space. Using the examples of contemporary realizations of some art museums, the work demonstrates the impact of exploration and experimentation conducted by the creators of visual arts on the design styles and architectural solutions. It also reveals the historical continuity...
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Antitumor Activity of Triazine Mimic Antibiotics for DNA-binding Implications (Impressive Activity in Vitro Against a Variety of Tumor Types in the NCI-60 Screen): NSC 710607 To Fight HCT-116 Human Colon Carcinoma Cell Lines in Vivo Using the Hollow Fiber Assay and Xenograft Mouse Models
PublicationPurpose Successful clinical applications of DNA-directed selective cytotoxic agents disrupt the vital replication/transcription processes and ultimately lead to cancer cell death. This study aimed to examine the growth screen of two lead triazine compounds in a number of cell lines and xenografts and to develop anticancer agents with noncovalent binding affinity bringing fewer side effects. Methods The NCI initial hollow...
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A strategy towards the generation of testable adverse outcome pathways for nanomaterials
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Agile Media Management Approach – an analysis
PublicationThis article studies media management and demonstrates a fresh perspective on the new approach based on agile methodologies of project management. The analysis sequentially presents a literature overview of media and its management, the characteristics of media projects, agile project management, an analysis of agile approaches and media management along with the proposal of a...
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Advances in electrical impedance methods in medical diagnostics
PublicationOmówiono elektroimpedancyjne metody diagnostyczne i aparaturę pomiarową opracowane w Politechnikach - Gdańskiej i Warszawskiej.Przedyskutowano właściwości elektryczne różnych tkanek biologicznych, omówiono konstrukcję celek i elektrod do pomiarów in vivo oraz in vitro. Opisano konstrukcję wybranych systemów pomiarowych - pletyzmografów, kardiografów i tomografów elektroimpedancyjnych a także stosownego oprogramowania, np. rekonstrukcji...
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MRAS-Based Switching Linear Feedback Strategy for Sensorless Speed Control of Induction Motor Drives
PublicationThis paper presents a newly designed switching linear feedback structure of sliding mode control (SLF-SMC) plugged with an model reference adaptive system (MRAS) based sensorless fieldoriented control (SFOC) for induction motor (IM). Indeed, the performance of the MRAS depends mainly on the operating point and the parametric variation of the IM. Hence, the sliding mode control (SMC) could be considered a good control alternative...
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Inception and Propagation of Electrical Trees in the Presence of Space Charge in HVAC Extruded Cables
PublicationThis paper presents the space charge impact on the inception and propagation of electrical trees in cross-linked polyethylene (XLPE) insulation via simulations and experimentation. A 3D finite element analysis (FEA)-based modeling is proposed to simulate electrical trees via a needle embedded on the XLPE insulation. The proposed FEA model demonstrates the influence of the space charge magnitude and polarity on the initiation of...
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A probe for immittance spectroscopy based on the parallel electrode technique.
PublicationW pracy zaprezentowano konstrukcję sondy do spektroskopowych pomiarów immitancyjnych. Obliczono jej stałą, którą to wartość zweryfikowano eksperymentalnie. Pokazano przykładowe wyniki pomiarów in vivo.
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Numerical heat transfer model in skin burn depth simulations
PublicationW artykule przedstawiono numeryczny model wymiany ciepła zachodzącej w tkance skórnej . Wyniki symulacji na modelu zostały porównane z wynikami pomiarów In vivo na zwierzętach.
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Thermal imaging of skin burns. 9th European Congress of Thermology.
PublicationArtykuł przedstawia wyniki badań in-vivo diagnostyki oparzeń skóry z użyciem metod termograficznych. Wykazano iż na podstawie obrazu termograficznego możliwa jest klasyfikacja głębokości oparzenia.
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Tomografia elektroimpedancyjna
PublicationW opracowaniu przedstawiono podstawowe zagadnienia obrazowania elektroimpe-dancyjnego. Omówiono budowę aparatury i algorytmy rekonstrukcyjne. Przedsta-wiono przykładowe wyniki rekonstrukcji zarówno pomiarów eksperymentalnych iin vivo.
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Immunomodulation of macrophages activity in murine bacteremia model
PublicationZaprezentowano wyniki badań in vitro i in vivo połączeń muramylodipeptydu (MDP) z tetrapeptydem jakim jest tuftsyna. Otrzymane rezultaty pokazują, że badane związki modulują fagocytarne możliwości makrofagów w mysim modelu bakteryjnym.
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Thermal imaging and modelling of burned skin
PublicationW artykule przedstawiono wyniki eksperymentów in-vivo na zwierzętach w diagnostyce oparzeń z wykorzystaniem metod obrazowania termicznego w podczerwieni. Wyniki skorelowano z rezultatami otrzymanymi w symulacjach numerycznych tkanki skóry.
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The CDIO model in architectural education and research by design
PublicationArchitectural education has always been related to experimentation: that is, defining concepts, drawing sketches, working on models, then testing and modifying them. This activity mirrors the CDIO learning methods and objectives. Despite this, research studies into the applicability of the CDIO model in architectural curricula are scarce. In the discipline of architecture, hands-on experiences are associated not only with one of...
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Green analytical chemistry: Social dimension and teaching
PublicationGreen Analytical Chemistry (GAC) is the idea which every analytical chemist should be familiar of. Due to continuous improvement in the subject both from the aspects of theory and experimentation, the dynamic way analytical chemistry studies are evolving in the frame of chemistry degrees should not be surprising. Recently, many efforts have been made in order to include Green Chemistry principles to Education, also in the field...
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Double layer adhesive silicone dressing as a potential dermal drug delivery film in scar treatment
PublicationThe present studies focused on the evaluation of design of an adhesive silicone film intended for scar treatment. Developed silicone double layer film was examined in terms of its future relevance to therapy and applicability on the human skin considering properties which included in vitro permeability of water vapor and oxygen. In order to adapt the patches for medical use in the future there were tested such properties as...
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THE ART OF VIRTUAL INFORMATION EXCHANGE AND ITS INFLUENCE ON REAL CITY SPACE
PublicationThe paper investigates the impact of the new genres of contemporary public art based on the virtual information exchange in real spaces of the cities. On the basis of theoretical approaches, trans-disciplinary surveys and case studies, the paper focuses on the art that not only relies on the technological support but also refers to the new public sphere, where people are co-creators of the art object giving their personal input...
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Limitations of DSC-MRI for quantitative brain perfusion.
PublicationArtykuł przedstawia ograniczenia metody DSC-MRI w ilościowej ocenie przepływów mózgowych. W zakresie pięciu różnych grup zagadnień przeprowadzono testy symulacyjne oraz obliczenia na podstawie badań fantomowych i in-vivo. Pokazano i omówiono wyniki badań.
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Inhibitors of amino acids biosynthesis as antifungal agents
PublicationFungal microorganisms, including the human pathogenic yeast and filamentous fungi, are able to synthesize all proteinogenic amino acids, including nine that are essential for humans. A number of enzymes catalyzing particular steps of human-essential amino acid biosynthesis are fungi specific. Numerous studies have shown that auxotrophic mutants of human pathogenic fungi impaired in biosynthesis of particular amino acids exhibit...
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An interactive system for remote modeling and design validation of hybrid photovoltaic systems
PublicationAbstract: A multi-functional demonstrator of the interactive system is presented. The demostrator enables modeling, monitoring and design validation of hybrid photovoltaic systems assisted by fuel cells and thermoelectric generators, as well as experimentation and scientific research. A block diagram of the system is presented and the selection of its components is discussed. Availability of the system via Ethernet or GSM...
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Computer-Aided Greenery Design—Prototype Green Structure Improving Human Health in Urban Ecosystem
PublicationIncreasing population and urbanization, with climate change consequences, such as rising temperatures, influence public health and well-being. The search to improve the quality of life in cities becomes one of the priority objectives. A solution can be found in the role of greenery in an urban environment and its impact on human health. This opens a path toward experimentation on microclimate green structures that can be inserted...
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Combined anticancer therapy with imidazoacridinone analogue C‐1305 and paclitaxel in human lung and colon cancer xenografts—Modulation of tumour angiogenesis
PublicationThe acridanone derivative 5-dimethylaminopropylamino- 8- hydroxytriazoloacridinone (C-1305) has been described as a potent inhibitor of cancer cell growth. Its mechanism of action in in vitro conditions was attributed, among others, to its ability to bind and stabilize the microtubule network and subsequently exhibit its tumour- suppressive effects in synergy with paclitaxel (PTX). Therefore, the objective of the present study...
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Nutraceutical value of persimmon (Diospyros kaki Thunb.) and its influence on some indices of atherosclerosis in an experiment on rats fed cholesterol-containing diet
PublicationThe nutraceutic value of persimmon (Diospyros kaki Thunb. cv. Triumph) and its influence on some indices of atherosclerosis were studied in vitro and in experiment on rats fed cholesterol-containing diet. It was found that persimmon possesses a high nutraceutical value: it contains soluble fibers, total polyphenols and phe - nolic acids. The content of dietary fiberwas 1.83 ± 0.11, 0.69 ± 0.07 and 1.14 ± 0.12 g/100 g fresh weight...
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Synthesis and characterization of novel aliphatic polyurethanes for tissue engineering applications
PublicationSummarizing, in this thesis was described the synthesis of novel PUR system, which was obtained by using aliphatic diisocyanate (HDI), amorphous macrodiol (PEBA) and chain extender (BDO). This PUR system was established as suitable for TE purpose and successfully modified with AA, which as expected improved its biocompatibility. According to this, AA-modified HDI-based PURs is the PUR system ready for further studies including...
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SDN testbed for validation of cross-layer data-centric security policies
PublicationSoftware-defined networks offer a promising framework for the implementation of cross-layer data-centric security policies in military systems. An important aspect of the design process for such advanced security solutions is the thorough experimental assessment and validation of proposed technical concepts prior to their deployment in operational military systems. In this paper, we describe an OpenFlow-based testbed, which was...