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Wyniki wyszukiwania dla: ANTI CARCINOGENIC ACTIVITY
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Assessment of anti‐SARS‐CoV‐2 antibodies level in convalescents plasma
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Modus operandi of Qatar Resistance Policy against “Anti-Terror Quartet”
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Investigation of Anti-Lock Braking System failures using wavelet analysis
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Anti-inflammatory Potential of Flavonoids from the Aerial Parts of Corispermum marschallii
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Determination of Flavonoids in Selected Scleranthus Species and Their Anti-Collagenase and Antioxidant Potential
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Serum Anti-Müllerian Hormone Levels in Patients with Epithelial Ovarian Cancer
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Coefficients for Assessing the Visibility of Materials Used in Anti-Smog Face Masks
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Cultural Beliefs About Manhood Predict Anti-LGBTQ+ Attitudes and Policies
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Active Polylactide-poly(ethylene glycol) Films Loaded with Olive Leaf Extract for Food Packaging—Antibacterial Activity, Surface, Thermal and Mechanical Evaluation
PublikacjaAs the demand for sustainable and innovative solutions in food packaging continues to grow, this study endeavors to introduce a comprehensive exploration of novel active materials. Specifically, we focus on characterizing polylactide-poly(ethylene glycol) (PLA/PEG) films filled with olive leaf extract (OLE; Olea europaea) obtained via solvent evaporation. Examined properties include surface structure, thermal degradation and mechanical...
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Physicochemical and Volatile Compounds Analysis of Fruit Wines Fermented with Saccharomyces cerevisiae: FTIR and Microscopy Study with Focus on Anti-Inflammatory Potential
PublikacjaThe growing trend in fruit wine production reflects consumers’ interest in novel, diverse drinking experiences and the increasing demand for healthier beverage options. Fruit wines made from kiwi, pomegranates, and persimmons fermented using S. bayanus Lalvin strain EC1118 demonstrate the versatility of winemaking techniques. Kiwifruit, persimmon, and pomegranate wines were analyzed using HPLC and GC-TOFMS analyses to determine...
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Anti-Cancer Agents in Medicinal Chemistry
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Activity and discrimination against women in the labour market in the countries of Baltic Sea Region
PublikacjaAn increasing participation of women in the labour market seem to be a key to overcome the problems of the EU labour market and to achieve the objectives of Strategy Europe 2020. Therefore, the objective of this paper is to identify differences in the situation of women in the labour market in selected countries such as those in the Baltic Sea region and to attempt to verify the hypothesis of the existence of discrimination against...
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Sport-related concussion alters cerebral hemodynamic activity during controlled respiration
PublikacjaThis study investigated cerebral hemodynamic activity following sport-related concussion. Prefrontal cortex oxygenation was assessed by near-infrared spectroscopy (NIRS) during a controlled breathing protocol. Wavelet transformation of the NIRS signals showed significant decreases in HbO2 and HbD amplitude at the respiratory frequency interval (0.10–0.6 HZ) from preseason baseline to acute concussion. These results suggest a decreased...
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Jaw biomechanics: Estimation of activity of muscles acting at the temporomandibular joint
PublikacjaThe aim of this study was to elaborate a method of estimation of activity of surface muscles acting at the temporomandibular joint of the healthy subjects by using a surface electromyography (EMG). The scope of this study involved testing chosen jaw motions (open, close, lateral deviation) and process of mastication occurring during eating food with different toughness (chewing gum, cereal and carrot) by using mixed sides, right...
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The influence of cultivation conditions on the myrosinase activity and glucosinolate content in white cabbage
PublikacjaIn the process of biofumigation typically natural compounds present in Brassicaceae family are used to combat pests and protect crops. Glucosinolates, sulfur-containing secondary metabolites found in Brassica plants, are hydrolized by the enzyme myrosinase (β-thioglucosidase, EC 3.2.3.1) with the liberation of degradation products such as isothiocyanates, nitriles, thiocyanates and epithionitriles. Isothiocyanates are the most...
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Electrical Stimulation Modulates High Gamma Activity and Human Memory Performance
PublikacjaDirect electrical stimulation of the brain has emerged as a powerful treatment for multiple neurological diseases, and as a potential technique to enhance human cognition. Despite its application in a range of brain disorders, it remains unclear how stimulation of discrete brain areas affects memory performance and the underlying electrophysiological activities. Here, we investigated the effect of direct electrical stimulation...
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Honey antibacterial activity: A neglected aspect of honey quality assurance as functional food
PublikacjaBackground Honey is considered as a functional food with health-promoting properties. Its potent antibacterial and antibiofilm effects are the major attributes of so called ‘medical-grade honey’ which is topically used for the treatment of burns, wounds and skin disorders. Nevertheless, the current set of honey quality parameters adopted in the European Union do not include its biological properties. Furthermore, in light of the...
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The Effect of Conjugation with Octaarginine, a Cell-Penetrating Peptide on Antifungal Activity of Imidazoacridinone Derivative
PublikacjaAcridine cell-penetrating peptide conjugates are an extremely important family of compounds in antitumor chemotherapy. These conjugates are not so widely analysed in antimicrobial therapy, although bioactive peptides could be used as nanocarriers to smuggle antimicrobial compounds. An octaarginine conjugate of an imidazoacridinone derivative (Compound 1-R8) synthetized by us exhibited high antifungal activity against reference...
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Investigations on the immunosuppressive activity of derivatives of mycophenolic acid in immature dendritic cell
PublikacjaThe main activity of mycophenolic acid (MPA) and its analogs is the inhibition of proliferation of T cells. Here, we hypothesized that MPA and its conjugates inhibits also the activity of antigen-presenting cells (APC) including dendritic cells (DCs). We tested the effect of novel amino acid derivatives of MPA and conjugates of MPA with acridines/acridones on DCs by flow cytometry, ELISA and MLR assay. Both acridines/acridone derivatives...
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Characteristic and specificity of protease activity of thermophilic bacteria Meiothermus ruber
PublikacjaThe primary purpose of research was to establish the possibility of using thermophilic bacteria Meiothermus ruber as a source of proteolytic enzymes. The main reason of searching new proteases is their commercial value especially in production of detergents, food, pharmaceuticals, leather, diagnostics or waste management. The development of this type processes will be possible by utilization of enzymes which have unique characteristics...
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The impact of cooking method on the phenolic composition, total antioxidant activity and starch digestibility of rice (Oryza sativa L.)
PublikacjaThis study investigated changes in the phenolic composition, total antioxidant activity (TAA) and starch digestibility in white and brown rice due to three different cooking procedures, and subsequent reheating of cooked rice after storage. Among the analyzed samples, brown rice showed the highest TAA and phenolic content (622.5 mg kg-1 DW). All cooking methods resulted in significant decrease of phenolic content and TAA of rice...
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Transcriptional activity of epigenetic remodeling genes declines in keratinocytes after in vitro expansion
PublikacjaPURPOSE: In vitro expansion is an invaluable method to obtain keratinocytes in amounts necessary for effective transplantation therapies. In vitro cell culturing provokes questions concerning potential epigenetic alterations occurring in expanded cells in the context of usefulness for transplantation and safety. The purpose of this study was to investigate as to whether keratinocyte expansion is associated with changes in the activity...
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Real-Time Sensor-Based Human Activity Recognition for eFitness and eHealth Platforms
PublikacjaHuman Activity Recognition (HAR) plays an important role in the automation of various tasks related to activity tracking in such areas as healthcare and eldercare (telerehabilitation, telemonitoring), security, ergonomics, entertainment (fitness, sports promotion, human–computer interaction, video games), and intelligent environments. This paper tackles the problem of real-time recognition and repetition counting of 12 types of...
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Synthesis and biological activity of mycophenolic acid-amino acid derivatives
PublikacjaIn search of new immunosuppressants, mycophenolic acid (MPA) was coupled with amino acid methyl esters followed by hydrolysis to analogs bearing free carboxylic groups. The obtained compunds were tested in vitro as growth inhibitors of lymphoid cell line (Jurkat) and human peripheral blood mononuclear cells (PBMC) from healthy donors. According to obtained results recovering of free carboxylic group increased their activity. Additionally,...
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Changes in enzymatic activity of fish and slaughter animals meat after high pressure treatment at subzero temperatures
PublikacjaThe aim of this study was to determine changes in the activity of proteolytic enzymes and transglutaminase of fish and mammal meat after pressurization at subzero temperatures. The activity was measured at the optimal pHs determined for enzymes from particular types of tested meat. It was found that increasing the pressure in the range of 60–193 MPa, did not change significantly the activity of acidic proteases of cod flesh, while...
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The structure of revenues of non-public universities in 2010 from didactic activity by sources of financing (in%)
Dane BadawczeIncome from teaching activities of non-public universities accounted for almost 1/5 of income from teaching activities of all types of universities. Non-public universities generated the highest revenues from fees for teaching classes, which accounted for over half of the revenues from this title in relation to all universities.The average cost of education...
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Amygdalin: Toxicity, Anticancer Activity and Analytical Procedures for Its Determination in Plant Seeds
PublikacjaAmygdalin (D-Mandelonitrile 6-O--D-glucosido--D-glucoside) is a natural cyanogenic glycoside occurring in the seeds of some edible plants, such as bitter almonds and peaches. It is a medically interesting but controversial compound as it has anticancer activity on one hand and can be toxic via enzymatic degradation and production of hydrogen cyanide on the other hand. Despite numerous contributions on cancer cell lines, the clinical...
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Activating Public Space: How to Promote Physical Activity in Urban Environment
PublikacjaPhysical activity is an essential component of a healthy lifestyle. The quality and equipment of urban public space plays an important role in promoting physical activity among people (residents, tourists). In order for recreation and sports activities to be undertaken willingly, in a safe and comprehensive manner, certain spatial conditions and requirements must be met. The distinctive feature of contemporary large cities is the...
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Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity
PublikacjaSeven conjugates composed of well-known fluoroquinolone antibacterial agents, ciprofloxacin (CIP) or levofloxacin (LVX), and a cell-penetrating peptide transportan 10 (TP10-NH2) were synthesised. The drugs were covalently bound to the peptide via an amide bond, methylenecarbonyl moiety, or a disulfide bridge. Conjugation of fluoroquinolones to TP10-NH2 resulted in congeners demonstrating antifungal in vitro activity against human...
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The added value of using the HEPA PAT for physical activity policy monitoring: a four-country comparison
PublikacjaBackground Public policy is increasingly recognized as an important component of physical activity promotion. This paper reports on the current status of physical activity policy development and implementation in four European countries based on the Health-Enhancing Physical Activity Policy Audit Tool (HEPA PAT) developed by WHO. It compares the findings to previous studies and discusses the general utility of this tool and its...
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Are the short cationic lipopeptides bacterial membrane disruptors? Structure-Activity Relationship and molecular dynamic evaluation
PublikacjaShort cationic lipopeptides are amphiphilic molecules that exhibit antimicrobial activity mainly against Grampositives. These compounds bind to bacterial membranes and disrupt their integrity. Here we examine the structure-activity relation (SAR) of lysine-based lipopeptides, with a prospect to rationally design more active compounds. The presented study aims to explain how antimicrobial activity of lipopeptides is affected by...
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S09-4 The development of the Physical Activity Environment Policy Index (PA-EPI): a tool for monitoring and benchmarking government policies and actions to improve physical activity
PublikacjaBackground Insufficient physical activity (PA) is a global issue for health. A multifaceted response, including government action, is essential to improve population levels of PA. The purpose of this study was to develop the ‘Physical Activity Environment Policy Index’ (PA-EPI) monitoring framework to assess government policies and actions for creating a healthy PA environment. Methods An iterative process was undertaken. This...
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Xanthone synthetic derivatives with high anticandidal activity and positive mycostatic selectivity index values
PublikacjaWith the current massive increases in drug-resistant microbial infection as well as the significant role of fungal infections in the death toll of COVID-19, discovering new antifungals is extremely important. Natural and synthetic xanthones are promising derivatives, although only few reports have demonstrated their antifungal mechanism of action in detail. Newly synthetized by us xanthone derivative 44 exhibited strong antifungal...
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Silybum marianum glycerol extraction for the preparation of high-value anti-ageing extracts
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Effect of the Sorption Layer on the Protection Time Provided by Anti-Smog Half-Masks
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Milky Sap of Greater Celandine (Chelidonium majus L.) and Anti-Viral Properties
PublikacjaThe milky juice of the greater celandine herb has been used in folk medicine and in homeopathy for treatment of viral warts for years. However, classical medicine fails to use properties of celandine herbs in treatment of diseases induced by papilloma viruses. Nevertheless, dermatological outpatient clinics are regularly visited by patients reporting efficacy of milky sap isolated from celandine herb in treatment of their own...
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Fabrication of anti-corrosion nitrogen doped graphene oxide coatings by electrophoretic deposition
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Parallel in vitro and in silico investigations into anti-inflammatory effects of non-prenylated stilbenoids
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Developing electrochemical measurements in order to assess anti-corrosive coatings more effectively
PublikacjaCelem pracy było sprawdzenie powtarzalności wyników uzyskanych metodą pomiaru szumu (Electrochemical Noise method - ENM) elektrochemicznego wykonanych na powłokach organicznych w konfiguracji bez połączenia z podłożem metalowym (NOCS - No Connection to the Substrate). NOCS polega na wykonaniu pomiarów na trzech teoretycznie takich samych obszarach badanego układu. W takim układzie nie jest wymagane połączenie elektryczne z metalowym...
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SYNTHESIS OF PHOSPHORUS TACRINE ANALOGUES AS A NEW POTENTIAL ANTI-ALZHEIMER’S DISEASE AGENTS
PublikacjaA series of novel phosphorus tacrine derivatives was obtained in three steps, including synthesis of 9-chlorotacrine, connection of 9-chlorotacrine with hexamethylenediamine, 1,8-diaminooctane and 1,12-diaminododecane linkers and reaction of obtained tacrine diamine analogues with corresponding acid ester to give nine tacrine organophosphorus compounds. All of the obtained final structures were characterized by 1H NMR, 13C NMR,...
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Glucose oxidase as an important yet overlooked factor determiningthe antibacterial activity of bee pollen and bee bread
PublikacjaBee pollen (BP) and bee bread (BB) have attracted great attention due to their biological activities including antibacterial activity. However, the mechanism of antibacterial activity is largely unknown. Therefore, we aimed to characterise the antibacterial effect of BP and BB aqueous extracts against bacterial pathogens (Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis and Enterococcus faecalis)...
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Elderly persons professional activity - substantive issues and methodological challenges
PublikacjaPopulation ageing in Europe and mass withdrawal from professional activity leads to a number of adverse phenomena, such as increased public spending, reduced consumer demand and the growing problem of social exclusion. The study focuses on the problems of population ageing in Europe as well as on the feasible steps that may be taken with a view to professional activation of the elderly. The first part is concerned with the trends...
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Structure-activity relationship studies on the antimicrobial activity of novel edeine a and d analogues
PublikacjaOpisano syntezę 4 nowych analogów peptydowego antybiotyku, edeiny a i d z wykorzystaniem klasycznej syntezy w roztworze. Stosowano metodę estrów aktywnych oraz metodę azydową do tworzenia wiązań peptydowych. Zbadano także aktywność przeciwgrzybową i przeciwbakteryjną opisanych połączeń.
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Novel 5-Substituted 2-(Aylmethylthio)-4-chloro-N-(5-aryl-1,2,4-triazin-3-yl)benzenesulfonamides: Synthesis, Molecular Structure, Anticancer Activity, Apoptosis-Inducing Activity and Metabolic Stability
PublikacjaA series of novel 5-substituted 2-(arylmethylthio)-4-chloro-N-(5-aryl-1,2,4-triazin-3-yl) benzenesulfonamide derivatives 27–60 have been synthesized by the reaction of aminoguanidines with an appropriate phenylglyoxal hydrate in glacial acetic acid. A majority of the compounds showed cytotoxic activity toward the human cancer cell lines HCT-116, HeLa and MCF-7, with IC50 values below 100 M. It was found that for the analogues 36–38...
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Emerging anticancer activity of candidal glucoseamine-6-phosphate synthase inhibitors upon nanoparticle-mediated delivery
PublikacjaNumerous glutamine analogues have been reported as irreversible inhibitors of the glucosamine-6-phosphate (GlcN-6-P) synthase in pathogenic Candida albicans in the last 3.5 decades. Among the reported inhibitors, the most effective N3-(4-methoxyfumaroyl)-L-2,3- diaminopropanoic acid (FMDP) has been extensively studied in order to develop its more active analogues. Several peptide−FMDP conjugates were tested to deliver FMDP to its...
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Comparison of the content of phenolic compounds and antioxidant activity of white, red and black currants (Ribes sp.) extracts
PublikacjaThe aim of this study was to compare the content of antioxidant compounds and the antioxidant activity of extracts from white, red and black currants (Ribes sp.). The chemical properties verified included determinations of anthocyanins and other phenols by HPLC-DAD-MS, total antioxidant activity by standard spectrophotometric tests (ABTS, DPPH and FCR), and profiles of antioxidants by TLC with visualization reagents (ABTS, DPPH,...
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Study of proapoptotic activity of anthraquinone derivatives towards H226 cancer cells using flow cytometry
Dane BadawczeThis study presents the fluorescence intensity of Annexin V/7AAD and caspase 3/7 which correspond to the proapoptotic activity of anthraquinone derivatives towards H226 cancer cells.
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Study of proapoptotic activity of anthraquinone derivatives towards A549 cancer cells using flow cytometry
Dane BadawczeThis study presents the fluorescence intensity of Annexin V/7AAD and caspase 3/7 which correspond to the proapoptotic activity of anthraquinone derivatives towards A549 cancer cells.
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INFLUENCE OF TEMPERATURE ON THE ACTIVITY OF ANAMMOX GRANULAR BIOMASS - SHORT AND LONG-TERM ASPECT
PublikacjaThe aim of this study was to determine a short-term and long-term effect of temperature on the anammox process rate and determination of temperature coefficients in the Arrhenius and Ratkowski equations. The short-term effects of temperature on the anammox biomass were investigated in batch tests at ten different temperatures in the range of 10-55 ̊C. The maximum rate 1.3 gN (gVSS·d)-1 observed at 40 ̊C. The minimum rate, close...
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Anna Zielińska-Jurek prof. dr hab. inż.
OsobyResearch work on photocatalysis by Prof. Anna Zielinska-Jurek started in 2006 at Gdansk University of Technology (Poland), including 3-month research stay at Hokkaido University, Training School “Environmental Applications of TiO2 Photocatalysis” at the University of Oulu in Finland granted by COST Program and Training School “NanoBiophotonics” at the Beckmann Institute, Urbana-Champaign in the USA granted by University of Illinois....