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Wyniki wyszukiwania dla: ANDROGEN RECEPTOR
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Deep eutectic solvents based highly efficient extractive desulfurization of fuels – Eco-friendly approach
PublikacjaThe developed process is based on alternative, green and cheap solvents for efficient desulfurization of fuels. Several deep eutectic solvents (DESs) were successfully synthesized and studied as extraction solvents for desulfurization of model fuel containing thiophene (T), benzothiophene (BT) and dibenzothiophene (DBT). The most important extraction parameters (i.e. kind of DES, DES: fuel volume ratio, hydrogen bond acceptor:...
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Hydrophobic deep eutectic solvents in microextraction techniques–A review
PublikacjaOver the past decade, deep eutectic solvents (DES) have been widely studied and applied in sample preparation techniques. Until recently, most of the synthesized DES were hydrophilic, which prevented their use in the extraction of aqueous samples. However, after 2015 studies on the synthesis and application of hydrophobic deep eutectic solvents (HDES) has rapidly expanded. Due to unique properties of HDES i.e. density, viscosity,...
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Effect of temperature and composition on physical properties of deep eutectic solvents based on 2-(methylamino)ethanol – measurement and prediction
PublikacjaNovel deep eutectic solvents were synthesized using 2-(methylamino)ethanol as hydrogen bond donor with tetrabutylammonium bromide or tetrabutylammonium chloride or tetraethylammonium chloride as hydrogen bond acceptors. Mixtures were prepared at different molar ratios of 1:6, 1:8 and 1:10 salt to alkanolamine and then Fourier Transform Infrared Spectroscopy measurements were performed to confirm hydrogen bonds interactions between...
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First deep eutectic solvent-based (DES) stationary phase for gas chromatography and future perspectives for DES application in separation techniques
PublikacjaThe paper presents the first application of deep eutectic solvents (DES) as stationary phases for gas chromatography. DES obtained by mixing tetrabutylammonium chloride (TBAC) as a hydrogen bond acceptor (HBA) with heptadecanoic acid being a hydrogen bond donor (HBD) in a mole ratio of HBA:HBD equal to 1:2 was characterized by its ability to separate volatile organic compounds (VOCs). The Rohrschneider – McReynolds constants determined...
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Design, engineering, and performance of nanorod-Fe2O3@rGO@LaSrFe2-Co O6 (n = 0, 1) composite architectures: The role of double oxide perovskites in reaching high solar to hydrogen efficiency
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The hydrogen bond network structure within the hydration shell around simple osmolytes: Urea, tetramethylurea, and trimethylamine-N-oxide, investigated using both a fixed charge and a polarizable water model
PublikacjaDespite numerous experimental and computer simulation studies, a controversy still exists regarding the effect of osmolytes on the structure of surrounding water. There is a question, to what extent some of the contradictory results may arise from differences in potential models used to simulate the system or parameters employed to describe physical properties of the mixture and interpretation of the results. Bearing this in mind,...
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The hydrogen bond network structure within the hydration shell around simple osmolytes: Urea, tetramethylurea, and trimethylamine-N-oxide, investigated using both a fixed charge and a polarizable water model
PublikacjaDespite numerous experimental and computer simulation studies, a controversy still exists regarding the effect of osmolytes on the structure of surrounding water. There is a question, to what extent some of the contradictory results may arise from differences in potential models used to simulate the system or parameters employed to describe physical properties of the mixture and interpretation of the results. Bearing this in mind,...
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Wpływ obecności i struktury warstwy azotowanej oraz stanu naprężeń na niszczenie wodorowe stali = Effect of presence and structure of nitrided layer, and stress state on hydrogen degradation of steels
PublikacjaPrzedstawiono wyniki badań wpływu azotowania według dwóch technologii na niszczenie wodorowe stali stopowej, oceniane w próbach powolnego rozciągania. Różną podatność na niszczenie wodorowe przypisano różnej mikrostrukturze warstw azotowanych oraz stanom naprężeń, wpływającym na dyfuzję i pułapkowanie wodoru.
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Biologically active compounds based on the carbazole scaffold - synthetic and mechanistic aspects
PublikacjaDoctoral dissertation is divided into three main parts: introduction, results and discussion and experimental. The introduction is divided into four main parts which describe: 5-hydroxytryptamine receptors, the most popular antidepressants, new compounds based on the carbazole structure with affinity for serotonin receptors, telomeres and telomerase with their functions, telomerase inhibition strategies, carbazoles approved in...
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Ultrasound-Assisted Dispersive Liquid-Liquid Microextraction Using Deep Eutectic Solvents (DESs) for Neutral Red Dye Spectrophotometric Determination
PublikacjaDeep eutectic solvents (DES), which have low toxicity and are low cost, biodegradable, and easily synthesized, were used for the extraction of neutral red (NR) dye before its spectrophotometric analysis. DES, containing choline chloride as a hydrogen bond acceptor and phenol as a hydrogen bond donor with a molar ratio of 1:2, was used for the extraction of NR dye from aqueous media. The possible interaction of different DESs with...
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Analogue GPS repeater
PublikacjaThis article concerns the problem of difficulty in correct indoor Global Positioning System (GPS) signals reception due to attenuation. Radio signal repeaters are proposed as means to solve this problem. Firstly, the GPS signal characteristics are described, emphasizing their low power in the point of reception. In the second part, various applications of GPS signal repeater, where indoor GPS signals reception is required, are...
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AMCA to TAMRA long range resonance energy transfer on a flexible peptide
PublikacjaFörster resonance energy transfer between 7-amino-4-methyl-3-coumarinylacetic acid, (AMCA, donor) and 5- carboxytetramethylrhodamine, (TAMRA, acceptor) bound to Lys(AMCA)-Gly-Pro-Arg-Ser-Leu-Ser-Gly-Lys (TAMRA)-NH2 peptide is demonstrated by various spectroscopic techniques in glycerol at room temperature. In particular, nonexponential character of fluorescence intensity decay evidences the distance distribution between the donor...
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Comparative study of a combined heat and power plant retrofitted by CO2 capture during the combustion of syngas from sewage sludge gasification versus zero-emission combustion of hydrogen produced using renewables
PublikacjaWith ecological requirements aimed at limiting the production of CO2, it is necessary to produce all, or most of the energy from RES. During the transformation process, ecological and highly efficient combustion power plants will be needed. The classic cycle of combined heat and power (CCGT) with green improvements will continue to be one of the most suitable technologies for this task. This article presents the modernization of...
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Co w architekturze piszczy? Dźwiękowy wymiar przestrzeni / What’s the buzz in architecture? – The sonic aspect of space
PublikacjaThe article presents a debate on the dividing line between architecture and the sound sciences. It sketches out the theoretical and practical aspects of space development in the context of its sonic reception. The analysis is based on examples of projects combining architecture and art in public space and their consequences for the reception of this space. The projects relate to the use of art in urban space with special emphasis...
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Determination of long-chain aldehydes using a novel quartz crystal microbalance sensor based on a biomimetic peptide
PublikacjaThere is an increasingly popular trend aimed at improvement of fundamental metrological parameters of sensors via implementation of materials mimicking biological olfactory systems. This study presents investigation on usefulness of the peptide mimicking HarmOBP7 region as a receptor element of the piezoelectric sensor for selective analysis of long-chain aldehydes. Identification of odorant binding proteins creates new possibilities...
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Development and Assessment of Regeneration Methods for Peptide-Based QCM Biosensors in VOCs Analysis Applications
PublikacjaCleaning a quartz crystal microbalance (QCM) plays a crucial role in the regeneration of its biosensors for reuse. Imprecise removal of a receptor layer from a transducer’s surface can lead to unsteady operation during measurements. This article compares three approaches to regeneration of the piezoelectric transducers using the electrochemical, oxygen plasma and Piranha solution methods. Optimization of the cleaning method allowed...
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Biowodór, „paliwo przyszłości”, dotychczasowe metody otrzymywania , porównanie metod otrzymywania
PublikacjaWodór jest ważnym pierwiastkiem w przemyśle chemicznym. Biowodór wydaje się być użytecznym odnawialnym nośnikiem energii, który mógłby zastąpić paliwa kopalne. Największym problemem wodoru jest jego rzadkie występowanie w czystej formie molekularnej H 2 . Dlatego otrzymanie biowodoru w objętościach opłacalnych ja ko surowiec czy biopaliwo wiedzie przez bioodpady „przesycone” wodorem. Każdy związek...
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Structure-function analysis of decay-accelerating factor: identification ofresidues important for binding of the Escherichia coli Dr adhesin and complement regulation
PublikacjaZidentyfikowano ważne dla wiązania adhezyny Dr uropatogennych Escherichiacoli reszty aminokwasowe w ludzkim receptorze DAF SCR-3.
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Atmospheric emissions of POPs in Europe - a discussion of existing data and data need
PublikacjaZaproponowano, aby schematy inwentaryzacji i raportowania emisji w przyszłości były tak dobrane, aby zaspokajały potrzeby zarówno administracji odpowiedzialnej za strategię redukcji emisji jak i naukowców wykorzystujących inwentaryzację emisji na potrzeby dalszych badań naukowych. Stan obecny inwentaryzacji emisji POP oszacowany został jako niezadowalający a dalsze usprawnienia są konieczne dla poprawienia wiarygodności wyników...
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Simplified AutoDock force field for hydrated binding sites
Publikacjahas been extracted from the Protein Data Bank and used to test and recalibrate AutoDock force field. Since for some binding sites water molecules are crucial for bridging the receptor-ligand interactions, they have to be included in the analysis. To simplify the process of incorporating water molecules into the binding sites and make it less ambiguous, new simple water model was created. After recalibration of the force field on...
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Design, synthesis, and molecular docking of new 5-HT reuptake inhibitors based on modified 1,2-dihydrocyclopenta[b] indol-3(4H)-one scaffold
PublikacjaA new group of serotonin reuptake inhibitors containing 1,2-dihydrocyclopenta[b]indol-3(4H)-one scaffoldwas synthesized, starting from indole 5-((1H-indol-3-yl)(1,3-dioxane-4,6-diones as a key intermediates. Following three transformations including intramolecular cyclization and formation of imines, a series of new ligand for human serotonin transporter was obtained. The ability of these ligands to inhibit human TS3 serotonin transporter...
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High order of nongeminate recombination in organic bulk heterojunction solar cells
PublikacjaWe analyze high order of nongeminate recombination in organic donor–acceptor bulk heterojunction solar cells. The model of recombination where an exciton annihilates on an electron–hole Langevin bound pair near donor–acceptor interface has been applied in our studies. We obtained satisfactory agreement between experimental results and theoretical calculations for the concentration dependences of several parameters characterizing...
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Wodór jako paliwo cz. 2
PublikacjaW artykule scharakteryzowano aktualne i przyszłościowe metody wytwarzania wodoru. Przedstawiono problem związany z przechowywaniem wodoru oraz ukazano aktualne i przyszłościowe rozwiązania dotyczące magazynowania wodoru.
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Transcriptomic Effects of Estrogen Starvation and Induction in the MCF7 Cells. The Meta-analysis of Microarray Results
PublikacjaEstrogen is one of the most important signaling molecules which targets a number of genes. Estrogen levels regulate cell proliferation and a plethora of metabolic processes, which may interfere with a range of medical conditions and drug metabolism. The MCF7 breast cancer cell line, expressing the estrogen receptor α, is a well-studied model of cellular answer to estrogen. The aim of this study was to characterize transcriptomic...
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Synthesis, Chemical Characterization and Multiscale Biological Evaluation of a dimericcRGD Peptide for Targeted Imaging of αVβ3 Integrin Activity
PublikacjaCyclic peptides containing the Arg-Gly-Asp (RGD) sequence have been shown to specifically bind the angiogenesis biomarker α V β3 integrin. We report the synthesis, chemical characterization, and biological evaluation of two novel dimeric cyclic RGD-based molecular probes for the targeted imaging of α V β3 activity (a radiolabeled version, 64Cu-NOTA-PEG4-cRGD2, for PET imaging, and a fluorescent version, FITC-PEG4-cRGD2, for in...
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Anion–cation interactions in a series of salts with substituted Hphen, Hbpy and H2bpy cations and [W(CN)8]4− anion: polymer with “super-short” N–H⋯N hydrogen bridges containing exclusively anions and H+
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Trialkoksysilanotiolany amoniowe. Anion silanotiolanowy jako akceptor w wiązaniu wodorowym N-H..S.**2004, 161 s. 74 rys. 48 tab. bibliogr. 148 poz. maszyn. Rozprawa doktorska /24.03.2004/Wydz. Chemiczny PG Promotor: dr hab. inż. Barbara Becker
Publikacja.
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Respiratory signal of bathing person - preliminary study
PublikacjaThe scope of this paper is analysis of applicability of modern biomedical acquisition system installed in bathtub towards reception of respiratory signals of bathing person. An analysis of the possibility of such measurement is shown as well as preliminary results.
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Organic electroluminescence from singlet and triplet exciplexes: Exciplex electrophosphorescent diode
PublikacjaW pracy zaobserwowano po raz pierwszy elektroluminescencję z trypletowych stanów ekscypleksowych w układzie dwuamina TPD (donor) -organiczny kompleks gadolinu (akceptor). Opsano konstrukcję elektrofosforescencyjnej diody ekscypleksowej.
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Recognition and sensing of anions
PublikacjaMolecular ion recognition is one of the most intensively studied areas of supramolecular technology. The reason for this is the essential role that ions play in many biological as well as industrial processes. On the other hand, however, it has been proved that ions can have a negative impact on human health and the environment. For these reasons, it is extremly important to develop rapid and simple methods allowing the determination...
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Filozofia społeczna Jana Pawła II (krótkie wprowadzenie)
PublikacjaW artykule przedstawiono zarys antropologii filozoficznej oraz główne tezy filozofii społecznej Jana Pawła II wyłożone w encyklikach: ''Redemptor hominis'', ''Laborem exercens'', ''Sollicitudo rei socialis'' i ''Centesimus annus''.
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Creation of Hydrogen Bonded 1D Networks by Cocrystallization of N,N`-bis(2-pyridyl) aryldiamines with Dicarboxylic Acids.Tworzenie 1D sieci krystalicznych poprzez kokrystalizację N,N` -bis(2-piry- dylo) arylodiamin z kwasami dikarboksylowymi.
PublikacjaZsyntetyzowano szereg N,N`-bis(2-pirydylo) arylodiamin, a następnie otrzymano serię kompleksów w/w amin z kwasami dikarboksylowymi oraz kwasem kwadratowym w postaci monokryształów. Jednostki N,N`-bis(2-pirydylo) arylodiamin i kwasy dikarboksylowe oddziaływują ze sobą poprzez wiązania wodorowe tworząc ośmioczłonowy cykliczny układ. W kompleksach 1:1 cząsteczki układają się w jedno-wymiarową sieć krystaliczną tworzoną przy udziale...
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Modeling the electrical characteristics of P3HT:PCBM bulk heterojunction solar cells: Influence of the interface recombination
PublikacjaThe interface recombination of charge carriers located in the material with lower permittivity (Szmytkowski 2009 Chem.Phys.Lett. 470 123) has been implemented for the first time to calculate the electrical characteristics of the donor-acceptor P3HT:PCBM bulk heterojunction solar cell. In order to estimate the photocurrent density in this system, a simple analytical formula has been derived. We have obtained a very good agreement...
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Toward mechanosynthesis of diamondoid structures: vii. simple strategy of building atomically perfect spm tip through attachment of c60 molecule to commercial silicon tip by controlled hydrogen atom desorption from tip asperity si(111) silicon surface
PublikacjaZaproponowano strategię unieruchomienia cząsteczki c60 na ostrzu chandlowego czujnika spm zbudowanego z krzemu. strategia składa się z czterech prostych etapów i prowadzi do ostrza spm o atomowo zdefiniowanej budowie. modelowanie właściwości ostrza sugeruje, że mogło by ono mieć zastosowanie w mechanosyntezie.
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Voltammetric and biological studies of folate-targeted non-lamellar lipid mesophases
PublikacjaFolate-targeted lipid nanostructures are promising strategies for the development of biocompatible drug delivery systems. The objective of this study was to evaluate the efficacy of drug delivery to cancer cells by folate-targeted lipid mesophases, cubosomes (CUB) and hexosomes (HEX), loaded with doxorubicin (DOX). Three cancer-derived cell lines (KB, HeLa, T98G) exhibiting different expressional levels of folate receptor protein...
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Insightful studies of AuCu nanostructures deposited on Ti platform: Effect of rapid thermal annealing on photoelectrochemical activity supported by synchrotron radiation studies
PublikacjaIn this work, we present the influence of annealing atmospheres during rapid thermal annealing (40◦C/s) on nanostructured Ti platforms modified by 10 nm layer of AuCu alloy obtained via magnetron sputtering. The AuCu/Ti platform annealed under hydrogen atmosphere exhibits the best photoelectrochemical activity under visible light, i.e. 27 times higher photocurrent than for pure Ti dimpled platform, and the lowest reflectance with minimum...
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Charge photogeneration effect on the exciplex emission from thin organic films
PublikacjaZaobserwowano silne wygaszenie fluorescencji i fosforescencji ekscypleksowej w układzie dwuamina TPD (donor elektronu): pochodna fenantroliny BPT (akceptor elektronu) w zewnętrznym polu elektrycznym. Efekt ten przypisano wygaszaniu molekularnych ekscytonów singletowych TPD na elektronach akceptorów BPT.
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Detection of some volatile degradation products released during photoexposition of ranitidine in a solid state
PublikacjaRanitidine (RAN) is on top of the list of prescribed drugs, due to its popularity as a selective H2-receptor antagonist, which efficiently decreases the amount of acid produced in the stomach. RAN is not stable both in a solid state and in a solution, which creates manufacturing problems, requires appropriate storage conditions, and results in a short drug shelf-life. The aim of this work was to study the emission of volatile...
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Application of vibrational spectroscopy, thermal analyses and X-Ray diffraction in the rapid evaluation of the stability in solid-state of ranitidine, famotidine and cimetidine
PublikacjaThis paper reports the study on applicability of Fourier transform infrared (FTIR), near-infrared (NIR) and Raman spectroscopy, differential scanning calorimetry (DSC) and X-ray diffraction (XRD) for the estimation of the chemical stability and photostability of histamine H2-receptor antagonist substances. Ranitidine hydrochloride (RAN), famotidine (FAM) and cimetidine (CIM) were tested and differences in sensitivity were measured...
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Wnikanie wodoru z paliwa i oleju do stali stopowych 26h2mf i 34hnm oraz jego oddziaływanie z defektami struktury = The hydrogen entry from fuel and oil to the 26h2mf and 34hnm alloy steels, and its interaction with structure defects
PublikacjaWykonano badania skłonności do korozji naprężeniowej przy rozciąganiu próbek ze stałą małą prędkością 10-6s-1, przy obciążeniu cyklicznie zmiennym w środowisku gorącego paliwa kotłowego i gliceryny oraz badania absorpcji wodoru dla stali stopowych 26H2MF i 34HNM w paliwie kotłowym, przepracowanym oleju mineralnym oraz glicerynie jako środowisku referencyjnym. Wykazano największą wrażliwość stali przy obciążeniach zmiennych oraz...
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Highly efficient exciplex phosphorescence from organic light-emitting diodes
PublikacjaW pracy badano fluorescencję ekscypleksową w układzie dendrymer aminowy m-MTDATA(donor elektronu):fenantrolina BPT (akceptor) oraz fosforescencję ekscypleksową w układzie m-MTDATA:organiczny kompleks platyny PtL2Cl. Opisano konstrukcję dwuwarstwowej diody elektrofosforescencyjnej o kwantowej (użytecznej) wydajności świecenia 2.4%.
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Targeting of FLT3-ITD kinase contributes to high selectivity of imidazoacridinone C-1311 against FLT3-activated leukemia cells
PublikacjaDrugs targeting receptor tyrosine kinase FLT3 are of particular interest since activating FLT3-internal tandem duplication (ITD) mutations abundantly occur in fatal acute myeloid leukemias (AMLs). Imidazoacridinone C-1311, a DNA-reactive inhibitor of topoisomerase II, has been previously shown to be a potent and selective inhibitor of recombinant FLT3. Here, we expand those findings by studying its effect on leukemia cells with...
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The Efficacious Benefit of 25-Hydroxy Vitamin D to Prevent COVID-19: An In-Silico Study Targeting SARS-CoV-2 Spike Protein
PublikacjaThe environment has rapidly looked at proven specialist task forces in the aftermath of the COVID-19 pandemic to build public health policies and measures to mitigate the effects of emerging coronaviruses. According to the researchers, taking 10 μg of 25-hydroxy vitamin D daily is recommended to keep us safe. There have been several studies recently indicating that there is a reduced risk of contracting Coronavirus by 25-hydroxy...
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STUDENTS' PERCEPTION OF E-GRADING: INFORMATICS COURSE CASE STUDY
PublikacjaUsing computers for grading can simplify work for teachers. However it is a sensitive part of their work and must be performed carefully. More information is required on students' reception and opinions about e-grading. This paper is a case study of e-grading used in Informatics course and discusses results obtained from surveying the students after being graded by a teacher and a computer.
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Feasibility Study of Biohydrogen Production from Acid Cheese Whey via Lactate-Driven Dark Fermentation
PublikacjaThe high loading of lactic acid bacteria (LAB) present in cheese whey still limits its use as hydrogen feedstock. This study aims to investigate the feasibility of producing hydrogen from acid cheese whey via lactate-driven dark fermentation (LD-DF). Mesophilic batch fermentations were performed with delipidated acid cheese whey at a fixed pH of 5.8 and driven by an acidogenic bacterial culture containing LAB and lactate-oxidizing...
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Modelling of dark fermentation of glucose and sour cabbage
PublikacjaIn the article, modified Anaerobic Digestion Models 1 (ADM-1) was tested for modelling dark fermentation for hydrogen production. The model refitting was done with the Euler method. The new model was based on sets of differential equations. The model was checked for hydrogen production from sour cabbage in batch and semi-batch in 5 g VSS (volatile solid suspension)/L and at the semi-batch process from glucose at 5 and 10 g VSS/L....
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Bioreactors and biophoton-driven biohydrogen production strategies
PublikacjaGiven the current issues with global warming and rising greenhouse gas emissions, biohydrogen is a viable alternative fuel option. Technologies to produce biohydrogen include photo fermentation, dark fermentation, direct and indirect bio-photolysis, and two-stage fermentation. Biological hydrogen generation is a green and promising technique with mild reaction conditions and low energy consumption compared to thermochemical and...
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Deep eutectic solvent-based shaking-assisted extraction for determination of bioactive compounds from Norway spruce roots
PublikacjaPolyphenolic compounds play an essential role in plant growth, reproduction, and defense mechanisms against pathogens and environmental stresses. Extracting these compounds is the initial step in assessing phytochemical changes, where the choice of extraction method significantly influences the extracted analytes. However, due to environmental factors, analyzing numerous samples is necessary for statistically significant results,...
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Research and Analysis of High-Speed Data Transmission Radio Link Designed for Maritime Environment
PublikacjaIn these article, the realization of digital radio link for high-speed data transmission was presented. Its concept and practical realization, using USRP devices from National Instruments, were described. Developed software for generation and reception of digital signals in baseband, including description of modulation types, and time and frequency synchronization mechanisms, was presented. Moreover, an operation of designed radio...
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Research and analysis of high-speed data transmission radio link designed for maritime environment
PublikacjaIn these article the realization of digital radio link for high-speed data transmission was presented. Its concept and practical realization, using USRP devices from National Instruments, were described. Developed software for generation and reception of digital signals in baseband, including description of modulation types, and time and frequency synchronization mechanisms, was presented. Moreover, an operation of designed radio...