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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublikacjaThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
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Intencje przedsiębiorcze studentów – analiza międzynarodowa oparta na rozszerzonym modelu Ajzena
PublikacjaPoszukiwanie czynników wpływających na rozpoczęcie działalności gospodarczej doczekało się opisu w wielu publikacjach. Nie ma wątpliwości, że czynnikiem kluczowym w procesie przedsiębiorczym są intencje, a dzięki pracom I. Ajzena wiadomo także, jakie grupy czynników wpływają na intencje. Jednak jego teoria planowanego zachowania wydaje się być niewystarczająca. Celem rozdziału było opracowanie propozycji rozszerzenia teorii Ajzena....
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Innovative investment funds and stability of financial systems: Nonparametric study of exchange-traded funds in Europe
PublikacjaThe main aim of the paper is investigation of the potential contribution of exchange-trade funds (ETFs) to the instability of the European financial systems. The paper begins with presentation of the key theoretical concepts with regard to ETFs and financial stability. We discuss the key attributes of ETFs as the innovative category of investment funds, their hypothesized impact on the financial stability as well as briefly describe...
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Impact of information systems (IS) infusion on Open Government Data (OGD) adoption
PublikacjaPurpose – This study aims to underline the possible influence of the moderator, information systems (IS) infusion, on Open Government Data (OGD) adoption and usage. Design/methodology/approach – Using the partial least squares-structural equation modeling methodological approach, the adapted unified theory of acceptance and use of technology (UTAUT) model has been used for understanding the role of themoderating variable, namely,...
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Aktywna metoda testowania bezpieczeństwa aplikacji webowych httpvalider oraz ocena jej skuteczności
PublikacjaW rozdziale omówiono zagadnienia oceny bezpieczeństwa aplikacji webowych, w szczególności podejście pasywnego i aktywnego testowania bezpieczeństwa. Przedstawiono metodę aktywnego testowania HttpValider obejmującą generowanie żądań HTTP pozwalające na identyfikację 13 luk bezpieczeństwa. Dla opracowanej metody zaprojektowano i zaimplementowano narzędzie wspierające automatyczne przeprowadzenie testów dla scenariusza użycia testowanej...
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Zarządzanie zaufaniem w bezprzewodowych sieciach czujników - studium przypadku
PublikacjaW artykule przedstawiono studium przypadku dotyczące zastosowania bezprzewodowej sieci czujników do wspomagania pacjenta z nadwagą w jego środowisku domowym. Przyjęto, że sieć wykorzystuje metodę rozproszonego zarządzania zaufaniem i pokazano, że metoda ta umożliwia wykrycie i izolację czujników realizujących działania sprzeczne z polityką sieci. Ilościowe oszacowanie czasu niezbędnego do wykrycia takich...
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Trust management in WSN - case study evaluation
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Using trust management model for detection of faulty nodes in Wireless Sensor Networks
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Assessing the time effectiveness of trust management in fully synchronised wireless sensor networks
PublikacjaThe paper presents the results of the time effectiveness assessment of the distributed WSN Cooperative Trust Management Method - WCT2M in a fully synchronized Wireless Sensor Network (WSN). First we introduce some basic types of synchronization patterns in WSN based on the idea of sleep scheduling. Then we explain how WCT2M works in the network applying the fully synchronized sleep scheduling pattern. Such networks were subjected...
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A METHOD OF TRUST MANAGEMENT IN WIRELESS SENSOR NETWORKS
PublikacjaThe research problem considered in this paper is how to protect wireless sensor networks (WSN) against cyber-threats by applying trust management and how to strengthen network resilience to attacks targeting the trust management mechanism itself. A new method, called WSN Cooperative Trust Management Method (WCT2M), of distributed trust management in multi-layer wireless sensor networks is proposed and its performance is evaluated....
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In silico approaches for better understanding cysteine cathepsin-glycosaminoglycan interactions
PublikacjaCysteine cathepsins constitute the largest cathepsin family, with 11 proteases in human that are present primarily within acidic endosomal and lysosomal compartments. They are involved in the turnover of intracellular and extracellular proteins. They are synthesized as inactive procathepsins that are converted to mature active forms. Cathepsins play important roles in physiological and pathological processes and, therefore, receive...
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New technologies and diffusion of innovative financial products: Evidence on exchange-traded funds in selected emerging and developed economies
PublikacjaExchange-traded funds (ETFs) are one of the most rapidly-expanding categories of innovative financial products that have been introduced on many financial markets, in both emerging and developed economies. Our research contributes to the present state of knowledge by examining factors, including information and communication technologies (ICTs), influencing the diffusion of ETFs. In our research, we consider also the impact of...
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Differences in sequences between HBV-relaxed circular DNA and covalently closed circular DNA
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Immunization with whole cell but not acellular pertussis vaccines primes CD4 T RM cells that sustain protective immunity against nasal colonization with Bordetella pertussis
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A new assay for simultaneous identification and differentiation of Klebsiella oxytoca strains
PublikacjaBacterial strain typing, or identifying bacteria at the strain level, is particularly important for diagnosis, treatment, and epidemiological surveillance of bacterial infections. This is especially the case for bacteria exhibiting high levels of antibiotic resistance or virulence, and those involved in nosocomial or pandemic infections. Strain typing also has applications in studying bacterial population dynamics.
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Massive Open Online Courses (MOOCs) in hospitality and tourism
PublikacjaThe tourism industry, interesting and challenging, faces structural human resource problems such as skills shortages and staff turnover, seasonality and a high percentage of small to medium enterprises whose employees have limited time for training or education. Large tourism enterprises often span countries and continents, such as hotel chains, airlines, cruise companies and car rentals, where the employees need similar training...
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Optimization of Hydrogen - Evolving Photochemical Molecular Devices
PublikacjaA molecular photocatalyst consisting of a RuII photocenter, a tetrapyridophenazine bridging ligand, and a PtX2 (X=Cl or I) moiety as the catalytic center functions as a stable system for light-driven hydrogen production. The catalytic activity of this photochemical molecular device (PMD) is significantly enhanced by exchanging the terminal chlorides at the Pt center for iodide ligands. Ultrafast transient absorption spectroscopy...
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Charge separation control in organic photosensitizers for photocatalytic water splitting without sacrificial electron donors
PublikacjaPhotocatalytic hydrogen evolution reaction (photoHER) is one of the most promising approaches towards production of “green” hydrogen. Currently, the state-of-the-art photoHER systems require the use of sacrificial electron donors (SED), because of inefficient charge separation in photosensitizers and thermodynamically challenging water oxidation by the same catalyst. Here, we present a molecular design approach for all-organic...
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AutoCAD: Examination of Factors Influencing User Adoption
PublikacjaThe primary purpose of the research is to examine and validate determinants of user intention to use AutoCAD software, utilising the constructs from prior studies in a more integrated model. The paper proposes a revised Technology Acceptance Model (TAM) for measuring the adoption of AutoCAD. In the study, a latent construct PPA (perceived physical accessibility) was added to the proposed research model as a new determinant of AutoCAD...
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First report on echinocandin resistant Polish Candida isolates
PublikacjaPurpose: Candida spp. are ranked as one of the four major causative agents of fungal infections. The number of infections caused by Candida species resistant to fluconazole, which is applied as the first line drug in candidiasis treatment, increases every year. In such cases the application of echinocandin is necessary. Echinocandin susceptibility testing has become a routine laboratory practice in many countries due to the increasing...
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ANALIZA FUNKCJONOWANIA POLSKIEGO RYNKU ENERGII ELEKTRYCZNEJ W OKRESIE WPROWADZENIA STOPNI ZASILANIA W 2015 ROKU
PublikacjaW artykule przedstawiono opis sytuacji, która doprowadziła do wprowadzenia wysokich stopni zasilania w KSE w sierpniu 2015 r. Omówiono przyczyny i konsekwencje wprowadzenia stopni zasilania, na podstawie analizy zapotrzebowania na moc w KSE. Przedstawiono analizę cen i obrotów na Rynku Bilansującym w tym okresie. Opisano wpływ nietypowej sytuacji na Giełdę Energii oraz na ceny na rynku „spotowym” i rynkach terminowych.
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Poszukiwanie nowych leków immunosupresyjnych (Quest for new immunosuppressive drugs)
PublikacjaTransplantology is getting more and more important in medicine. Development of surgical techniques and immunosuppressive treatment enabled to establish successful transplantations with various organs and tissues. However, allografts are recognized as foreign tissues and stimulate rejection, i.e. a strong immunological response which, if not stopped, results in complete destruction of the transplanted tissue. In order to prevent...
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Chitosan-protein scaffolds loaded with lysostaphin as potential antistaphylococcal wound dressing materials.
PublikacjaAIMS: The development of technology for preparing chitosan-protein scaffolds loaded with lysostaphin, which potentially could be used as dressing for wound treatment and soft tissue infections caused by Staphylococcus aureus. METHODS AND RESULTS: The unique technology of chitosan solubilization using gaseous CO(2) instead of organic or inorganic acids was used for the incorporation of lysostaphin, the enzyme that exhibits bactericidal...
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Schronienie – poszukiwanie formuły dla domu wpisanego w relacje środowiskowe
PublikacjaKonieczność schronienia i potrzeba zamieszkiwania wymagają przestrzeni, które współcześnie zazwyczaj zabezpieczają obiekty architektoniczne. Jednak często zauważamy niedobory wartości w przestrzeni zamieszkiwania. Pomysłem zaradczym w tej sytuacji jest powrót do punktu wyjścia. Do zapewnienia schronienia. Jeśli będzie ono wpisane w relacje środowiskowe i ukształtowane w zgodzie z potrzebą zachowania ciągłości kulturowej, ma szansę...
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Manifesto [Intellectual Output 5] for High-quality Baukultur in the Digital Age
PublikacjaThe aim of the Manifesto is to extract the most important messages of the work on the BuildDigiCraft project and to translate them into a public declaration of views, intentions and policy recommendations directed at the academic, professional and policy-making community responsible for the shaping of the built environment (on local, regional, national and European/international level). With the BuildDigiCraft Manifesto the project...
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Distributed Trust Management Model for Wireless Sensor Networks
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Skłonność do rywalizacji a intencje przedsiębiorcze – o różnicach międzypłciowych
PublikacjaAccording to the person-environment fit model people are more inclined to choose particular careers paths over other depending on their individual characteristics. They are also more likely to be satisfied with a career path that matches their characteristics and less likely to experience negative consequences including strain. In previous research several characteristics of entrepreneurs which differentiate them from non-entrepreneurs...
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PCR detection of Scopulariopsis brevicaulis
PublikacjaScopulariopsis brevicaulis is known as a most common etiological factor of the mould toenail infections. There are also reports indicating that S. brevicaulis could cause organ and disseminated infections. Nowadays microscopic observations from the direct sample and culture are crucial for the appropriate recognition of the infection. In this paper is presented a PCR-based method for S. brevicaulis detection. The specificity of...
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Gender differences in entrepreneurship myths
PublikacjaThe article presents the research results related to the most popular entrepreneurship myths in a group of business students. The author focused on gender differences in myth intensity, credibility and importance based on subject literature. The statistic analysis does not confirm any significant differences between male and female groups in case of the majority of myths, however women’s entrepreneurial intentions proved to be...
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Exploring the approaches towards support of academic entrepreneurship: evidence from an emerging market
PublikacjaOver the past three decades, an exponentially growing body on elements and actors of the concept of an entrepreneurial university has emerged. Compared to its western European counterparts, however, the idea of the third role of the university has only recently been implemented in Central and Eastern European countries, and thus both research and entrepreneurial practice grapple with empirical results. In this paper, we attempt...
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Exploring the relationship between investment choices, cognitive abilities risk attitudes and financial literacy
PublikacjaPurpose The main purpose of this study is to investigate the investment choices' relationship with cognitive abilities, risk aversion, risky investment intentions, subjective financial literacy and objective financial literacy. Design/methodology/approach To examine the relationship, two investment choices were given to 256 subjects from Pakistan. Questionnaire had total 20 questions for measuring five variables. To review this...
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What makes them dream big? Determinants of business growth aspirations among Polish students
PublikacjaThe objective of the article is to explore the concept of business growth aspirations and identify its determinants at an early stage of the entrepreneurial process. In this exploratory study, I focused on the underexplored approach to entrepreneurial process i.e. to study the growth aspirations and its determinants alongside entrepreneurial intentions. Studying growth aspirations and their determinants provides valuable insights...
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Examination of 5G NR, LTE, and NB-IoT Radio Interfaces and Their Vulnerabilities to Interference
PublikacjaModern cellular wireless communication systems of the fourth (4G) and fifth generation (5G) face a problem of various types of interference or intentional jamming. Consequently, a degradation of the services provided and an incorrect network operation may occur. In this paper, configuration of the networks’ physical layer is investigated, with the said investigation preceded by the measurement of parameters of commercial networks...
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Regulation of LPS assembly via controlled proteolysis and sensing of LPS stress in Escherichia coli
PublikacjaLipopolysaccharide (LPS) is a complex glycolipid, essential for the bacterial viability and along with phospholipids, it constitutes the major amphiphilic component of outer membrane (OM) in most of the Gram-negative bacteria, including Escherichia coli. LPS molecules confer an effective permeability barrier to the OM and play a crucial role in bacteria-environment and -host interactions. The synthesis and accumulation of this...
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Instytucjonalny kontekst intencji rozwojowych przedsiębiorstw na Pomorzu
PublikacjaLiteratura dotycząca wzrostu małych firm podkreśla wagę kontekstu instytucjonalnego w tworzeniu warunków ich wzrostu. Mówiąc o instytucjach należy odróżniać zarówno aspekt obiektywny jak i subiektywny. Artykuł porusza oba aspekty: jakość instytucji jak i ich postrzeganie przez przedsiębiorców. Ten drugi aspekt został opisany w oparciu o wyniki badań Pomorskiego Obserwatorium Gospodarczego. W konkluzji zawarto wniosek iż postrzeganie...
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New PCR test for detection of Candida glabrata based on the molecular target chosen by the RAPD technique
PublikacjaRapid, reliable diagnosis is a necessary condition for the successful treatment of infections. Such diagnostic assays are continually being developed. #e paper presents a method for selecting the molecular target for PCR-based diagnostics based on the comparison of RAPD patterns. A sequence encoding Candida glabrata CBS138 hypothetical protein was selected. The limit of detection for PCR and real-time PCR reactions with DNA extracted...
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Discrimination of hospital isolates of Acinetobacter baumannii using repeated sequences and whole genome alignment differential analysis
PublikacjaAn optimized method for bacterial strain differentiation, based on combination of Repeated Sequences and Whole Genome Alignment Differential Analysis (RS&WGADA), is presented in this report. In this analysis, 51 Acinetobacter baumannii multidrug-resistance strains from one hospital environment and patients from 14 hospital wards were classified on the basis of polymorphisms of repeated sequences located in CRISPR region, variation...
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Molecular targets for antifungals in amino acid and protein biosynthetic pathways
PublikacjaFungi cause death of over 1.5 million people every year, while cutaneous mycoses are among the most common infections in the world. Mycoses vary greatly in severity, there are long-term skin (ringworm), nail or hair infections (tinea capitis), recurrent like vaginal candidiasis or severe, life-threatening systemic, multiorgan infections. In the last few years, increasing importance is attached to the health and economic problems...
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PANTOGRAPH AS AN EXAMPLE OF THE USE OF GEOMETRIC TRANSFORMATIONS IN CONSTRUCTING OF OLD DRAWING INSTRUMENTS = PANTOGRAF JAKO PRZYKŁAD ZASTOSOWANIA PRZEKSZTAŁCEŃ GEOMETRYCZNYCH W KONSTRUOWANIU DAWNYCH PRZYRZĄDÓW KREŚLARSKICH
PublikacjaThe article describes the pantograph, considered to be the ancestor of today's photocopier. This instrument draws the copies, enlarges or reduces any figure. The author presents its genesis, the scope of application in the past, explains the structure and geometrical transformations used during its action. Based on a specific example, the work illustrates practical application of geometry in the past inventions for designing.
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Wpływ postrzeganego ryzyka oraz czynników wizerunkowych na zamiar zakupu marek własnych sieci handlowych
PublikacjaCelem przeprowadzonych badań była analiza wpływu wizerunku sklepu, postrzeganego ryzyka oraz wizerunku cenowego marek własnych na zamiar ich zakupu. Dokonano replikacji modelu zaproponowanego przez M.F. Diallo i w jej ramach zastosowano technikę wywiadu realizowanego za pośrednictwem Internetu (CAWI) i przeprowadzono analizy z wykorzystaniem modelu równań strukturalnych (SEM) przy pomocy oprogramowania AMOS. Stwierdzono, że zamiar...
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‘Acridines’ as New Horizons in Antifungal Treatment
PublikacjaFrequent fungal infections in immunocompromised patients and mortality due to invasive mycosis are important clinical problems. Opportunistic pathogenic Candida species remain one of the leading causes of systemic mycosis worldwide. The repertoire of antifungal chemotherapeutic agents is very limited. Although new antifungal drugs such as lanosterol 14α-demethylase and β-glucan synthase inhibitors have been introduced into clinical...
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Biobójcze wykończenie tkanin
PublikacjaThe problem of nosocomial infections is nothing new. In places, where people, whose immune system is weakened, are gathered and subjected to various kinds of treatments, the risk of infection increases considerably. The use of textiles with biocidal finishing, which contains nanoAg and nanoCu, may give an additional protection against nosocominal infections. This article presents the latest information regarding various methods...
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Chitosan pyrolysis in the presence of a ZnCl2/NaCl salts for carbons with electrocatalytic activity in oxygen reduction reaction in alkaline solutions
PublikacjaThe one-step carbonization of low cost and abundant chitosan biopolymer in the presence of salt eutectics ZnCl2/NaCl results in nitrogen-doped carbon nanostructures (8.5 wt.% total nitrogen content). NaCl yields the spacious 3D structure, which allows external oxygen to easily reach the active sites for the oxygen reduction reaction (ORR) distinguished by their high onset potential and the maximum turnover frequency of 0.132 e...
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Bariery natury systemowej, organizacyjnej i społecznej w tworzeniu i rozwoju akademickich spółek
PublikacjaIn the literature on the subject, many studies can be found on the barriers they face in creating and developing their entrepreneurial activity in Poland. Among them, mainly those that concern all entrepreneurs, and thus also spin-off companies, are described. However, these companies are burdened with specific barriers that are significant only to them. The study drew particular attention to them, but also referred to the others,...
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Application of Diffusion Models in the Analysis of Financial Markets: Evidence on Exchange Traded Funds in Europe
PublikacjaExchange traded funds (ETFs) are financial innovations that may be considered as a part of the index financial instruments category, together with stock index derivatives. The aim of this paper is to explore the trajectories and formulates predictions regarding the spread of ETFs on the financial markets in six European countries. It demonstrates ETFs’ development trajectories with regard to stock index futures and options that...
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Improved jamming resistance using electronically steerable parasitic antenna radiator
PublikacjaThis paper presents an idea of using an Electronically Steerable Parasitic Antenna Radiator (ESPAR) for jamming suppression in IEEE 802.11b networks. Jamming (intentional interference) attacks are known to be effective and easy to perform, which may impose connectivity problems in applications concerning Internet of Things (IoT). In our paper, theoretical considerations are presented and the results of experiments performed in...
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Biofilm bakteryjny uropatogennych szczepów E. coli Dr+ jako czynnik indukujący przewlekłość zakażeń dróg moczowych ograniczający ich leczenie
PublikacjaZakażenia dróg moczowych (ZUM) stanowią jedne z najczęściej występujących infekcji bakteryjnych, dotykających każdego roku miliony osób na świecie. Problematyka tych zakażeń wynika z ich przewlekłości i nawrotów, pomimo stosowania terapii antybiotykowej oraz ciągle wzrastającej lekooporności uropatogenów je wywołujących. Dominującym czynnikiem etiologicznym ZUM są uropatogenne szczepy E. coli (UPECs), wykazujące zdolność do adhezji,...
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The New Klebsiella pneumoniae ST152 Variants with Hypermucoviscous Phenotype Isolated from Renal Transplant Recipients with Asymptomatic Bacteriuria-Genetic Characteristics by WGS.
PublikacjaKlebsiella pneumoniae (Kp) is one of the most important etiological factors of urinary tract infections in renal transplant (RTx) recipients. We described the antimicrobial susceptibility phenotypes and genomic features of two hypermucoviscous (HM) Kp isolates recovered from RTx recipients with asymptomatic bacteriuria (ABU). Using whole genome sequencing (WGS) data, we showed that the strains belong to the ST152 lineage with the...
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Comparative modeling of shear localization in granular bodies with FEM and DEM
PublikacjaThe intention of the paper is to compare the calculations of shear zones in granular bodies using two different approaches: a continuum and a discrete one. In the first case, the FEM based on a micro-polar hypoplastic constitutive law was used. In the second case, the DEM was taken advantage of, where contact moments were taken into account to model grain roughness. The comparative calculations were performed for a passive case...
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Peptidoglycan hydrolases - potential weapons against Staphylococcus aureus
PublikacjaBacteria of the genus Staphylococcus are common pathogens responsible for a broad spectrum of human and animal infections and belong to most important etiological factors causing food poisoning. Because of rapid increase in prevalence of isolation of staphylococci resistant to many antibiotics, there is an urgent need for development of new alternative chemotherapeutics. A number of studies have recently demonstrated the strong...