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Mechanism of recognition of parallel G-quadruplexes by DEAH/RHAU helicase DHX36 explored by molecular dynamics simulations
PublikacjaBecause of high stability and slow unfolding rates of G-quadruplexes (G4), cells have evolved specialized helicases that disrupt these non-canonical DNA and RNA structures in an ATP-dependent manner. One example is DHX36, a DEAH-box helicase, which participates in gene expression and replication by recognizing and unwinding parallel G4s. Here, we studied the molecular basis for the high affinity and specificity of DHX36 for parallel-type...
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Systems, environments, and soliton rate equations: A non-Kolmogorovian framework for population dynamics
PublikacjaSoliton rate equations are based on non-Kolmogorovian models of probability and naturally include autocatalytic processes. The formalism is not widely known but has great unexplored potential for applications to systems interacting with environments. Beginning with links of contextuality to non- Kolmogorovity we introduce the general formalism of soliton rate equations and work out explicit examples of subsystems interacting with...
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Fabrication of exfoliated graphite reinforced silicone rubber composites - Mechanical, tribological and dielectric properties
PublikacjaThe effect of exfoliated graphite (EG) on the mechanical, tribological and dielectric properties of the silicone rubber (QM) composites has been systematically investigated and analysed. Morphological analysis of the composites helps to understand the interfacial interaction between the filler and the rubber matrix as well as wear mechanism respectively. An enhancement in the mechanical, tribological and dielectric properties was...
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Fabrication of exfoliated graphite reinforced silicone rubber composites - Mechanical, tribological and dielectric properties
PublikacjaThe effect of exfoliated graphite (EG) on the mechanical, tribological and dielectric properties of the silicone rubber (QM) composites has been systematically investigated and analysed. Morphological analysis of the composites helps to understand the interfacial interaction between the filler and the rubber matrix as well as wear mechanism respectively. An enhancement in the mechanical, tribological and dielectric properties was...
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Linking music data in executable documents
PublikacjaThis paper presents the application of Interactive Open Document Architecture (IODA) to music and video data. This architecture was design to create multilayer documents which consist of many files. The paper shows the method of creating media documents on the basis of IODA. These kind of documents were called IODA Media Documents (IMD). IMD have links that connect many different kinds of files containing music and video data....
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Correlation between charge density waves and antiferromagnetism in Nd1−xGdxNiC2 solid solutions
PublikacjaWe report a study on the evolution of a charge density wave and antiferromagnetism in the series of the polycrystalline solid solution Nd1−xGdxNiC2 (0 _ x _ 1) by means of magnetic and transport properties measurements. The experimental results reveal the violation of the de Gennes law and a strong correlation between the Peierls, Néel, and Curie-Weiss temperatures, which strongly suggests a cooperative interaction between the...
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Gaze tracking in multi-display environment
PublikacjaThis paper presents the basic ideas of eye and gaze tracking in multiple-display environment. The algorithm for display detection and identification is described as well as the rules for gaze interaction in multi display environment. The core of the method is to use special LED markers and eye and scene tracking glasses. Scene tracking camera registers markers position which is then represented as a cloud of points. Analyzing the...
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Analysis of Reconstituted Tripartite Complex Supports Avidity-based Recruitment of Hsp70 by Substrate Bound J-domain Protein
PublikacjaHsp70 are ubiquitous, versatile molecular chaperones that cyclically interact with substrate protein(s). The initial step requires synergistic interaction of a substrate and a J-domain protein (JDP) cochaperone, via its J-domain, with Hsp70 to stimulate hydrolysis of its bound ATP. This hydrolysis drives conformational changes in Hsp70 that stabilize substrate binding. However, because of the transient nature of substrate and JDP...
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Longitudinal drug synergy assessment using convolutional neural network image-decoding of glioblastoma single-spheroid cultures
PublikacjaAbstract Background In recent years, drug combinations have become increasingly popular to improve therapeutic outcomes in various diseases, including difficult to cure cancers such as the brain cancer glioblastoma. Assessing the interaction between drugs over time is critical for predicting drug combination effectiveness and minimizing the risk of therapy resistance. However, as viability readouts of drug combination experiments...
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Elastic waves in the railroad track substructures and its surroundings analyzed with non-classical operational methods
PublikacjaWe analyze the propagation of the waves generated by the rolling stock and the interaction of those waves on the medium and its surroundings. We use non-classical operational methods for monitoring construction of the railway infrastructure and for noise damping.
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The influence of image masks definition onsegmentation results of histopathological imagesusing convolutional neural network
PublikacjaAbstract—In the era of collecting large amounts of tissue materials, assisting the work of histopathologists with various electronic and information IT tools is an undeniable fact. The traditional interaction between a human pathologist and the glass slide is changing to interaction between an AI pathologist with a whole slide images. One of the important tasks is the segmentation of objects (e.g. cells) in such images. In this...
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Chalcogen bonding interactions in a series of aromatic selenocyanates
PublikacjaSelenium atoms in aromatic selenocyanates are characterized by the occurrence of two σ-holes, a stronger one in the prolongation of the NC–Se bond and a weaker one in the prolongation of the Ar–Se bond. The crystal structures of several bis(selenocyanato) derivatives, prepared by a method originally developed for ortho bis-substituted derivatives, illustrate very well this difference, with a short NC–Se⋯NC ChB interaction organizing...
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Application of Survey Simulator for Museums
Publikacja“Virtual Museum” is currently a very popular form of presenting museums’ collections of artefacts as well as an approach to archaeological research [1], [2], [3]. The term “virtual” can be understood in many ways – from a simple collection of on-line photographs, through multidirectional viewable panorama pictures, to complete interactive models of the real world, including 3-dimensional (3D) geometry, physical properties and many...
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Molecular docking studies towards development of novel Gly-Phe analogs for potential inhibition of Cathepsin C (dipeptidyl peptidase I).
PublikacjaCathepsin C is a cysteine protease required for activation of various pro-inflammatory serine proteases and, essentially, is of interest as a therapeutic target. Cathepsin C coordinate system was employed as a model to study the interaction of some already available inhibitors of Cathepsin C. Compounds containing Gly-Phe fragment with functional groups at its ends were designed by knowledge based approach. Using AutoDock and...
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Characterization of CaTi0.9Fe0.1O3/La0.98Mg0.02NbO4 composite
PublikacjaA composite of CaTi0.9Fe0.1O3 and electrolyte material, i.e. magnesium doped La0.98Mg0.02NbO4 was prepared and studied. The phase content and the sample microstructure was examined by an X-ray diffraction method and scanning electron microscopy. EDS measurements were done both for composite samples and the diffusion couple. The electrical properties were studied by four terminal DC method. The Ahigh-temperature interaction between...
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Directed pulse dynamics
PublikacjaIntroducing a projection method into a one-dimensional model of a pulse propagation in isotropic media, we derive and investigate a system of equation describing dynamics ultrashort pulses of opposite directions ofpropagation and ones with interaction of directed pulses with different polarization.
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Evaluation of citric acid corrosion inhibition efficiency and passivation kinetics for aluminium alloys in alkaline media by means of dynamic impedance monitoring
PublikacjaA novel approach is proposed for constructing the adsorption isotherm in corrosion studies, based on a well-known interaction between citric acid and aluminium in alkaline electrolytes. Our approach utilizes the instantaneous impedance measurements via Dynamic Electrochemical Impedance Spectroscopy in galvanostatic mode (g-DEIS). Unlike other common tools, g-DEIS delivers exact information about the concentration required for full...
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Sleep apnea: epidemiology, pathophysiology, and relation to cardiovascular risk
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How does institutional and natural social support shape the beliefs about psychological help among policemen?
PublikacjaEffectiveness of social support mechanisms results from interacting subjective factors (beliefs about help from others) and context (social network available). Organized institutional support and perception of natural support reduce barriers in obtaining psychological help.
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Editor's note and 2018 reviewers
PublikacjaPrzedmiotem pracy jest odniesienie do prac opublikowanych w 2018 roku, jak również do serii artykułów w ramach specjalnego wydania: Special Issue on Augmented and Participatory Sound and Music Interaction Using Semantic Audio.
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Blended Learning in Teaching Safety of Electrical Installations
PublikacjaBlended learning becomes more commonly used in teaching information technology or other subjects, which involve practice in computer laboratories. In case of subjects with no access to computer rooms blended learning supports lecturing and teaching classes e.g. interactive lessons. The article presents the use of blended learning forms in Gdansk University of Technology in teaching the subject of Safety of Electrical Installations....
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Distance learning trends: introducing new solutions to data analysis courses
PublikacjaNowadays data analysis of any kind becomes a piece of art. The same happens with the teaching processes of statistics, econometrics and other related courses. This is not only because we are facing (and are forced to) teach online or in a hybrid mode. Students expect to see not only the theoretical part of the study and solve some practical examples together with the instructor. They are waiting to see a variety of tools, tutorials,...
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Local Texture Pattern Selection for Efficient Face Recognition and Tracking
PublikacjaThis paper describes the research aimed at finding the optimal configuration of the face recognition algorithm based on local texture descriptors (binary and ternary patterns). Since the identification module was supposed to be a part of the face tracking system developed for interactive wearable computer, proper feature selection, allowing for real-time operation, became particularly important. Our experiments showed that it is...
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Low-energy positron scattering from DNA nucleobases: the effects from permanent dipoles
PublikacjaAb initio quantum calculations for low-energy positron scattering from gas-phase isolated molecular nucleobases which are part of the DNA structure are presented and discussed over the range of 1 eV to 25 eV. The calculations report the integral cross sections (ICSs) and the momentum-transfer cross sections (MTCSs) for Adenine, Guanine, Thymine and Cytosine. The calculations show very clearly the important role of the dominant...
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Ultrasonic spectroscopy of silicon single crystal
PublikacjaSpecimens of Si single crystals with different crystal orientation [100] and [110] were studied by the electro-ultrasonic spectroscopy (EUS) and Resonant Ultrasonic Spectroscopy (RUS). A silicon single crystal is an anisotropic crystal, so its properties are different in different directions in the material relative to the crystal orientation. EUS is based on interaction of two signals: electric AC signal and ultrasonic signal,...
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Comparative molecular modelling of biologically active sterols
PublikacjaMembrane sterols are targets for a clinically important antifungal agent – amphotericin B. The relatively specific antifungal action of the drug is based on a stronger interaction of amphotericin B with fungal ergosterol than with mammalian cholesterol. Conformational space occupied by six sterols has been defined using the molecular dynamics method to establish if the conformational features correspond to the preferential interaction...
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Ultrashort Opposite Directed Pulses Dynamics with Kerr Effect and Polarization Account
PublikacjaWe present the application of projection operator methods to solving the problem of the propagation and interaction of short optical pulses of different polarizations and directions in a nonlinear dispersive medium. We restrict ourselves by the caseof one-dimensional theory, taking into account material dispersion and Kerr nonlinearity. The construction of operators is delivered in two variants: for the Cauchy problem and for the...
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Pączkowanie - metoda rozwoju interoperacyjnych komponentów dla systemów rozproszonych = Budding – the software development method of interoperable components for distributed systems
PublikacjaPrzedstawiono 2 współczesne metody wytwarzania oprogramowania: iteracyjno-przyrostową oraz techniki zwinne, ich zalety i wady w kontekście budowy interoperacyjnych platform i środowisk rozproszonych. Zaprezentowano metodę rozwoju oprogramowania przez pączkowanie, jej założenia, zalety i wady. Przedstawiono technologie, na bazie których działa metodologia wytwarzania oprogramowania przez pączkowanie: Software Product Line, Enterprise...
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Systems of boundary value problems of advanced differential equations
PublikacjaThis paper considers the existence of extremal solutions to systems of advanced differential equations with corresponding nonlinear boundary conditions. The monotone iterative method is applied to obtain the existence results. An example is provided for illustration.
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Modelowanie i symulacja dynamiki ruchu trakcyjnego odbieraka prądu
PublikacjaW artykule przedstawiono dwa modele matematyczne kolejowych odbieraków prądu. Model podstawowy opracowano na podstawie analizy konstrukcji odbieraka ze stopniami swobody w ruchu obrotowym i postępowym. Drugi tzw. model zastępczy ma obydwa stopnie swobody w ruchu postępowym. Przedstawiono prosty sposób wyznaczenia wartości parametrów modelu zastępczego na podstawie wyników symulacji modelu odbieraka podstawowego. Model zastępczy,...
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Quasi-solutions for generalized second order differential equations with deviating arguments
PublikacjaThis paper deal with boundary value problems for generalized second order differential equations with deviating arguments. Existence of quasi-solutions and solutions are proved by monotone iterative method. Examples with numerical results are added.
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Semantic rules representation in controlled natural language in FluentEditor
PublikacjaThis paper presents a way of representation of semantic rules (SWRL) in controlled English in order to facilitate understanding the rules by humans interacting with a machine. This approach (implemented in FluentEditor) may be applied in many domains, where the understandability of the rules used to support a decision process is of great importance.
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S09-4 The development of the Physical Activity Environment Policy Index (PA-EPI): a tool for monitoring and benchmarking government policies and actions to improve physical activity
PublikacjaBackground Insufficient physical activity (PA) is a global issue for health. A multifaceted response, including government action, is essential to improve population levels of PA. The purpose of this study was to develop the ‘Physical Activity Environment Policy Index’ (PA-EPI) monitoring framework to assess government policies and actions for creating a healthy PA environment. Methods An iterative process was undertaken. This...
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The Physical Activity Environment Policy Index for monitoring government policies and actions to improve physical activity
PublikacjaBackground A multifaceted response, including government action, is essential to improve population levels of physical activity (PA). This article describes the development process of the ‘Physical Activity Environment Policy Index’ (PA-EPI) monitoring framework, a tool to assess government policies and actions for creating a healthy PA environment. Methods An iterative process was undertaken. This involved a review of policy...
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Image simulation and annotation for color blinded
PublikacjaIn this paper methods for image simulation as seen by a color blinded and a method for constructing images of perceived color difference are presented. The work is also focused on the interactive color description of an image contents. As a result, the individuals having problems with color discrimination can identify colors in an image.W artykule prezentowane są metody symulacji kolorów w obrazach postrzeganych przez osoby ze...
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Thermal Buckling Analysis of Circular Bilayer Graphene sheets Resting on an Elastic Matrix Based on Nonlocal Continuum Mechanics
PublikacjaIn this article, the thermal buckling behavior of orthotropic circular bilayer graphene sheets embedded in the Winkler–Pasternak elastic medium is scrutinized. Using the nonlocal elasticity theory, the bilayer graphene sheets are modeled as a nonlocal double–layered plate that contains small scale effects and van der Waals (vdW) interaction forces. The vdW interaction forces between the layers are simulated as a set of linear springs...
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Instantaneous impedance monitoring of synergistic effect between cavitation erosion and corrosion processes
PublikacjaThe most common method of determination of cavitation erosion resistance as well as the magnitude of erosion-corrosion synergistic interaction is based on the weight loss measurements. Nondestructive characterization of installations elements is in most cases impossible to perform. Also, such a measurement does not include local types of failure or alteration of operating conditions. There is an urge to elaborate a method for monitoring...
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OrphaGPT: An Adapted Large Language Model for Orphan Diseases Classification
PublikacjaOrphan diseases (OD) represent a category of rare conditions that affect only a relatively small number of individuals. These conditions are often neglected in research due to the challenges posed by their scarcity, making medical advancements difficult. Then, the ever-evolving medical research and diagnosis landscape calls for more attention and innovative approaches to address the complex challenges of rare diseases and OD. Pre-trained...
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The Sustainable Link - the Haze of the Past in the Future
PublikacjaThe aim of the topic is to explore the site by focusing on historical elements and life cycle thinking. The history and sustainability will thereby be the core approach and method during the ongoing design process. These themes will encourage the interdisciplinary and iterative design process.
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Stateczność i niezawodność pełnomorskich platform wiertniczych
PublikacjaW pracy przedstawiono wieloletnie doświadczenia Autora w zakresie wybranych aspektów numerycznej analizy pełnomorskich platform wiertniczych, w szczególności stacjonarnych platform stalowych poddanych działaniu fal wiatrowych i wiatru. W opisie zachowania się platform uwzględniono współoddziaływanie trzech ośrodków: materiału konstrukcji, morskich fal wiatrowych i podłoża gruntowego. Przyjęcie do opisu stochastycznych właściwości...
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Facial Feature extraction from a monochromatic picture
PublikacjaFace pose determination represents an important area of research in Human Machine Interaction. In this paper, I describe a new method of extracting facial feature locations from a single monochromatic monocular camera for the purpose of estimating and tracking the three dimensional pose of human face and eye-gaze direction.
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Facial feature extraction from a monochromatic picture.
PublikacjaFace pose determination represents an important area of research in Human Machine Interaction. In this paper, I describe a new method of extracting facial feature locations from a single monochromatic monocular camera for the purpose of estimating and tracking the three dimensional pose of human face and eye-gaze direction.
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A Biofeedback System that Uses the Game to Study Electrical Muscle Activity
PublikacjaThe aim of this project was to design a system that will allow performing repetitive muscle exercises using a biofeedback device. It is supposed to enhance the motivation and attractiveness of the performed tasks thanks to an interactive game developed for mobile devices with the Android operating system. The built-in calibration mechanisms enable the users to play a game that is independent of their abilities which evens out the...
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Non-compulsory practical education programme for modernist heritage
PublikacjaA non-compulsory programme for students of architecture that contains more specialised topics beyond the basic subjects is an important educational tool. The advantages include classes in smaller groups, the possibility of practical exercises in real field conditions and the benefits of meeting professional practitioners. This type of programme is particularly useful for teaching architectural heritage of the 20th Century, its...
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Możliwości integracji projektów sztuki nowych mediów w procesy odnowy przestrzeni miejskiej
PublikacjaZadaniem badawczym podjętym w rozprawie było wykazanie możliwość integracji projektów sztuki nowych mediów w procesy odnowy przestrzeni miejskiej. Wyodrębniono cztery etapy procesów odnowy miast: diagnozę, planowanie, realizację oraz ewaluację. Wskazano, że na etapie diagnozy sztuka nowych mediów może między innymi wspierać proces zbierania i wizualizacji danych, informować mieszkańców o stanie środowiska miejskiego. Na etapie...
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Boundary problems for fractional differential equations
PublikacjaIn this paper, the existence of solutions of fractional differential equations with nonlinear boundary conditions is investigated. The monotone iterative method combined with lower and upper solutions is applied. Fractional differential inequalities are also discussed. Two examples are added to illustrate the results.
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Smooth least absolute deviation estimators for outlier-proof identification
PublikacjaThe paper proposes to identify the parameters of linear dynamic models based on the original implementation of least absolute deviation estimators. It is known that the object estimation procedures synthesized in the sense of the least sum of absolute prediction errors are particularly resistant to occasional outliers and gaps in the analyzed system data series, while the classical least squares procedure unfortunately becomes...
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Enhanced Remote Control Providing Medical Functionalities
PublikacjaThis paper presents the enhanced remote control and its role in pervasive healthcare in the home. The device was equipped with health-related measurement modules and a message-processing unit. Preliminary results are presented for monitoring of a pulse, hand tremors, grip forces, and for self evaluation procedures. The interaction of the device with the smart environment is presented and discussed.
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Charge dependence of fragmentation process induced by ion collisions with furan molecule
PublikacjaThe goal of this work is to describe the system evolution after ion-molecule interaction. We combine different quantum chemistry and statistical mechanics approaches in order to give extended description of the process. Herein we report on a recent study of the fragmentation mechanism of neutral, singly- and doubly-ionized furan molecule in the gas phase.
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Fractional equations of Volterra type involving a Riemann Liouville derivative
PublikacjaIn this paper, we discuss the existence of solutions of fractional equations of Volterra type with the Riemann Liouville derivative. Existence results are obtained by using a Banach fixed point theorem with weighted norms and by a monotone iterative method too. An example illustrates the results.