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Search results for: BREAST CANCER DIAGNOSTICS
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cDNA sequencing improves the detection of P53 missense mutations in colorectal cancer
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Myotilin, a New Topotecan Resistant Protein in Ovarian Cancer Cell Lines
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EUROPEAN JOURNAL OF CANCER
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Application of Bayesian Networks in risk diagnostics arising from the degree of urban regeneration area degradation
PublicationUrban regeneration as a complex project, generates many extremely specific threats affecting the increase of investment risk. Its unique nature causes that probability parameter, normally applied in the process of risk quantification, is extremely difficult to estimate. Due to lack of historical data urban regeneration related activities are therefore associated with uncertainty. According to the authors, a useful tool for resolving...
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An inherited NBN mutation is associated with poor prognosis prostate cancer
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The presence of prostate cancer at biopsy is predicted by a number of genetic variants
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Nondestructive methods complemented by FEM calculations in diagnostics of cracks in bridge approach pavement
PublicationNondestructive methods of road pavement diagnostics are an alternative to traditional approach to pavement failure investigation. The article presents a detailed multidisciplinary inspection carried out using ground-penetrating radar (GPR), laser scanning technology and finite element method (FEM) calculations. It was done in order to assess the factors that contributed to occurrence of premature cracks of a bridge approach pavement....
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Antitumor 1-nitroacridine derivative C-1748 induces significant apoptosis in pancreatic cancer cells.
PublicationPancreatic cancer is the fifth leading cause of cancer death and has the lowest survival rate of any solid cancer in the industrial countries. The poor prognosis of pancreatic cancer results from its tendency for late presentation, aggressive invasion, early metastasis, and resistance to chemotherapy. Gemcitabine still remains the best chemotherapeutic agent available for the treatment of advanced pancreatic cancer. However, gemcitabine...
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Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition
PublicationHeterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based...
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Caffeine Inhibits Differentiation Of Lung Cancer Stem Cells By Modulating Their Respiratory Metabolism
PublicationIt is ell established that many tumor types contain a fraction of cells, with stem cell-like properties, called cancer stem cells (CSCs), that are resistant to apoptosis induced by therapeutic agents. The presence of CSCs may explain why a standard anticancer treatment, that eliminates only differentiated cancer cells, does not lead to cancer cure.We previously showed the existence of caffeine-sensitive mechanism that controls...
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Metabolism of antitumour agent 1-nitroacridine derivative, C-1748 in pancreatic cancer cell lines
PublicationPancreatic cancer has the highest mortality rate of all major cancers because of limited treatment options. Surgical removal of the tumour is possible only in its early stage, nevertheless the asymptomatic development very often makes unable an accurate diagnose. In the case of metastatic pancreatic cancer only chemotherapy, mainly with gemcitabine, can be offered to patients. However, common resistance towards gemcitabine imposes...
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Towards Cancer Patients Classification Using Liquid Biopsy
PublicationLiquid biopsy is a useful, minimally invasive diagnostic and monitoring tool for cancer disease. Yet, developing accurate methods, given the potentially large number of input features, and usually small datasets size remains very challenging. Recently, a novel feature parameterization based on the RNA-sequenced platelet data which uses the biological knowledge from the Kyoto Encyclopedia of Genes and Genomes, combined with a classifier...
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GPR simulations for diagnostics of a reinforced concrete beam
PublicationThe most popular technique for modelling of an electromagnetic field, the finite difference time domain (FDTD) method, has recently become a popular technique as an interpretation tool for ground penetrating radar (GPR) measurements. The aim of this study is to detect the size and the position of damage in a reinforced concrete beam using GPR maps. Numerical simulations were carried out using the finite differ-ence time domain...
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Current measurement and analysis for induction motor diagnostics
PublicationPrzedstawiono sposób diagnozowania łożysk tocznych w silnikach indukcyjnych z wykorzystaniem pomiarów i analizy prądu zasilającego silnik. Zaprezentowano metodę pomiarową i opracowania danych diagnostycznych. Uzyskano zgodność częstotliwości składowych widma prądu otrzymanych z badań teoretycznych i eksperymentalnych.Podano wyniki badań łożysk o róznych uszkodzeniach i prawdopodobieństwa poprawnych diagnoz.
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Diagnostics of high-voltage varistors by acoustic emission
PublicationWarystory, szeroko stosowane w ogranicznikach przepięć, powinny być testowane na końcowym etapie ich wytwarzania. Stosowane metody testowania wymagają użycia wysokich napięć i prądów o dużych natężeniach, co jest nidogodne, destrukcyjne i wymaga poboru relatywnie dużych pocy. W artykule zaproponowano zastosowanie analizy sygnału emisji akustycznej do predykcji jakości struktury warystora. Opisano system przygotowany do tej aplikacji,...
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Technical diagnostics and monitoring of traction current collectors
PublicationNew evaluation methods of the technical condition of rolling stock current collectors are proposed in this paper. The method of automatic measurement of the pantograph static force characteristic, realized when the vehicle runs through the test section of the track with especially prepared overhead line height distribution, has been practically implemented by the Polish Railways. The method of testing the slipper spring suspension...
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Modelling and diagnostics of a traction transformer - a case study
PublicationW niniejszym artykule przedstawiono wyniki badań w dziedzinie diagnostyki kolei elektrycznych. Zostały one przeprowadzone przez międzynarodowe przemysłowo-akademickie konsorcjum w ramach projektu europejskiego (6-go programu ramowego). Skupiono się na modelowaniu transformatora trakcyjnego z myślą o rozwinięciu nieinwazyjnej metody diagnostycznej w czasie rzeczywistym. Model przeznaczony do badań finalnych został rozwinięty w oparciu...
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THE VIBRATION BASED DIAGNOSTICS OF SHIP PROPULSION SYSTEMS
PublicationThe article has been worked out on the basis of the report devoted to the conducted diagnostic investigations of the ship main propulsion unit’s mechanical system. Gdansk University of Technology has been ordered with such investigations by the repair Shipyard carrying out the ship’s overhaul. Diagnostic tests involved measurements and analyses of the vibration signals generated in selected constructional kinematic pairs of the...
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Implementation of Active Dynamic Thermography in medical diagnostics
PublicationW pracy przedstawiono wyniki badań wdrożeniowych Aktywnej Termografii Dynamicznej w diagnostyce wybranych chorób.
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Diagnostics of zno varistors by means of nondestructive testing
PublicationStandard industrial testing of high-voltage varistors for surge arresters demands application of high voltages and intensive currents. Nondestructive methods for varistor quality and endurance evaluation have been proposed and described. They rely on the application of resonant ultrasound spectroscopy, electro-ultrasonic spectroscopy, noise measurement and nonlinearity testing at voltages lower than continuous operating range....
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A method of verification diagnostics for functional safety analysis
PublicationProblemy analizy bezpieczeństwa zostały zapoczątkowane w lotnictwie i energetyce jądrowej, a obecnie wprowadzane są szeroko do różnych gałęzi przemysłu, jak przemysł chemiczny, mechaniczny, etrochemiczny, spożywczy, itp. W analizie bezpieczeństwa funkcjonalnego względem przyjętego poziomu SIL wyznacza się prawdopodobieństwa nie wypełnienia określonej funkcji na żądanie (PDF). Do tego celu stosuje się różne metody analityczne, wykorzystuje...
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International Conference on Diagnostics of Processes and Systems 2022
PublicationWydarzenie stanowiło 15 ogniwo cyklu organizowanego od 1996 roku, naprzemiennie przez Politechnikę Warszawską, Uniwersytet Zielonogórski oraz Politechnikę Gdańską. Tegoroczna edycja konferencji została objęta patronatem JM Rektora Politechniki Gdańskiej, prof. Krzysztofa Wilde, Komitetu Automatyki i Robotyki Polskiej Akademii Nauk, Towarzystwa Konsultantów Polskich (FSNT-NOT) oraz Polskiego Stowarzyszenia Pomiarów Automatyki i...
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Guided waves for nondestructive diagnostics of embedded waveguides
PublicationThe thesis concentrates on comprehensive theoretical, numerical and experimental analysis of guided wave propagation in bars embedded in concrete or mortar. The investigations are focused on a particular type of objects representing a laboratory model of a ground anchor. Complex description of wave propagation phenomena in partially embedded bars is given and its application in...
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Neural nets application in diagnostics of industrial robots
PublicationPrzedstawiono wyniki wstępnych badań nad możliwością zastosowania sztucznych sieci neuronowych w procesie diagnozowania stanu technicznego robotów przemysłowych z napędem elektrycznym. Omówiono proces projektowania sieci neuronowych, za pomocą których realizowano liniową predykcję zmian dokładności pozycjonowania jednokierunkowego robota IRB 6 powstających przy różnych obciążeniach i prędkościach manipulatora podczas pracy z celowo...
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Advances in electrical impedance methods in medical diagnostics
PublicationOmówiono elektroimpedancyjne metody diagnostyczne i aparaturę pomiarową opracowane w Politechnikach - Gdańskiej i Warszawskiej.Przedyskutowano właściwości elektryczne różnych tkanek biologicznych, omówiono konstrukcję celek i elektrod do pomiarów in vivo oraz in vitro. Opisano konstrukcję wybranych systemów pomiarowych - pletyzmografów, kardiografów i tomografów elektroimpedancyjnych a także stosownego oprogramowania, np. rekonstrukcji...
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Quantumness in Diagnostics of Marine Internal Combustion Engines and Other Ship Power Plant Machines
PublicationThe article provides proof that the diagnostics of marine internal combustion engines and other ship power plant machines should take into account the randomness and unpredictability of certain events, such as wear, damage, the variations of mechanical and thermal loads, etc., which take place during machine operation. In the article, the energy E, like the other forms (methods) that it can be converted into (heat and work), is...
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European Journal of Breast Health
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Iranian Journal of Breast Diseases
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Role of size scale of ZnO nanoparticles and microparticles on toxicity toward bacteria and osteoblast cancer cells
PublicationThe specific role of size scale, surface capping, and aspect ratio of zinc oxide (ZnO) particles on toxicity toward prokaryotic and eukaryotic cells was investigated. ZnO nano and microparticles of controlled size and mor- phology were synthesized by wet chemical methods. Cytotoxicity toward mammalian cells was studied using a human osteoblast cancer cell line and antibacterial activity using Gram-negative bacteria (Escherichia...
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Nuclear Magnetic Resonance Metabolomics Reveals Qualitative and Quantitative Differences in the Composition of Human Breast Milk and Milk Formulas
PublicationCommercial formula milk (FM) constitutes the best alternative to fulfill the nutritional requirements of infants when breastfeeding is precluded. Here, we present the comparative study of polar metabolite composition of human breast milk (HBM) and seven different brands of FM by nuclear magnetic resonance spectroscopy. The results of the multivariate data analysis exposed qualitative and quantitative differences between HBM and...
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Severe oxidatively damaged DNA after cisplatin treatment of cancer patients
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Comparison of 2D and 3D culture models in the studies of the biological response induced by unsymmetrical bisacridines in cancer cells
PublicationMulticellular tumor spheroids are a good tool for testing new anticancer drugs, including those that may target cancer stem cells (CSCs), responsible for cancer progression, metastasis, and recurrence. Therefore, following the initial evaluation of the impact of antitumor unsymmetrical bisacridines (UAs) on lung and colon cancer cells using traditional monolayer cultures, I extended my investigations and applied the spherical model....
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Non-Destructive Diagnostics of Concrete Beams Strengthened with Steel Plates Using Modal Analysis and Wavelet Transform
PublicationExternally bonded reinforcements are commonly and widely used in civil engineering objects made of concrete to increase the structure load capacity or to minimize the negative effects of long-term operation and possible defects. The quality of adhesive bonding between a strengthened structure and steel or composite elements is essential for effective reinforcement; therefore, there is a need for non-destructive diagnostics of adhesive...
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Novel chalcone-derived pyrazoles as potential therapeutic agents for the treatment of non-small cell lung cancer
PublicationLung cancer is considered to account for approximately one-fifth of all malignant tumor-related deaths worldwide and is therefore one of the most lethal malignancies. Pyrazole scaffold possesses a wide range of biological and pharmacological activities, which play important roles in medicinal chemistry. The present study reports the synthesis and in vitro biological characterization of nine pyrazoles derived from chalcones as potential...
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EXHAUST GAS TEMPERATURE MEASUREMENTS IN DIAGNOSTICS OF TURBOCHARGED MARINE INTERNAL COMBUSTION ENGINES PART II DYNAMIC MEASUREMENTS
PublicationThe second part of the article describes the technology of marine engine diagnostics making use of dynamic measurements of the exhaust gas temperature. Little-known achievements of Prof. S. Rutkowski of the Naval College in Gdynia (now: Polish Naval Academy) in this area are presented. A novel approach is proposed which consists in the use of the measured exhaust gas temperature dynamics for qualitative and quantitative assessment...
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Thermal Images Analysis Methods using Deep Learning Techniques for the Needs of Remote Medical Diagnostics
PublicationRemote medical diagnostic solutions have recently gained more importance due to global demographic shifts and play a key role in evaluation of health status during epidemic. Contactless estimation of vital signs with image processing techniques is especially important since it allows for obtaining health status without the use of additional sensors. Thermography enables us to reveal additional details, imperceptible in images acquired...
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CANCER-AM CANCER SOC
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Low prevalence of CDKN2A/ARF mutations among early-onset cancers of breast, pancreas and malignant melanoma in Poland
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Serum lipid profile discriminates patients with early lung cancer from healthy controls
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BMC CANCER
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Conditions for increasing the recognition of degradation in thermal-flow diagnostics, taking into account environmental legal aspects
PublicationThe ever-increasing demand for electricity and the need for conventional sources to cooperate with renewable ones generates the need to increase the efficiency and safety of the generation sources. Therefore, it is necessary to find a way to operate existing facilities more efficiently with full detection of emerging faults. These are the requirements of Polish, European and International law, which demands that energy facilities...
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Cytochromes P450 and Skin Cancer: Role of Local Endocrine Pathways
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Role of miR-15b/16–2 cluster network in endometrial cancer: An in silico pathway and prognostic analysis
PublicationEndometrial cancer (EC) is the second most common cancer in women. A large number of human cancers exhibit dysregulation of microRNA expression including EC. MiR-15b/16–2 is one of the best-known miRNA clusters that is expressed in many types of cancer tissues. Herein, we analyzed the expression of individual miR-15b/16–2 cluster members, its paralogues, and their target network analysis, as well as their prognostic significance...
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Plasma free amino acid profiling as metabolomic diagnostic and prognostic biomarker in paediatric cancer patients: a follow‑up study
PublicationAmino acids (AAs) play a crucial role in cancer cell metabolism. Levels of 22 plasma AAs at the time of diagnosis and after treatment were established among 39 pediatric cancer patients and 33 healthy children. Glutamic acid levels decreased and tryptophan levels increased during treatment. Cancer patients presented significantly lower levels of glutamine and leucine post-treatment while levels of 12 other AAs were higher comparing...
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CDKN2A common variant and multi-organ cancer risk—a population-based study
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Germline mutations in theCHEK2 kinase gene are associated with an increased risk of bladder cancer
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A personalised approach to prostate cancer screening based on genotyping of risk founder alleles
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RAGE as a Novel Biomarker for Prostate Cancer: A Systematic Review and Meta-Analysis
PublicationThe receptor for advanced glycation end-products (RAGE) has been implicated in driving prostate cancer (PCa) growth, aggression, and metastasis through the fueling of chronic inflammation in the tumor microenvironment. This systematic review and meta-analysis summarizes and analyzes the current clinical and preclinical data to provide insight into the relationships among RAGE levels and PCa, cancer grade, and molecular effects....
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Self diagnostics using smart glasses - preliminary study
Publicationn this preliminary study we analyzed the possibility of the reliable measurement of biomedical signals with some potential hardware extensions of smart glasses. Using specially designed experimental prototypes four category of biomedical signals were measured: electrocardiograms, electromyograms, electroencephalograms and respiration waveforms. Experi- ments with volunteers proved that using even simple construc- tion of sensors...
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Quantum issues in diagnostics of marine energy machines and devices
PublicationW artykule podjęto zagadnienie możliwości uwzględniania części dorobku mechaniki kwantowej w diagnostyce okrętowych urządzeń energetycznych. Wykazano, że są zbieżne spostrzeżenia mechaniki kwantoweji diagnostyki technicznej uzyskane w obszarze wiedzy z zakresu badań empirycznych. Uzasadniono konieczność wykonywania podczas badań empirycznych, nie tylko rachunku błędów, lecz także określania niedokładności wyników badań (pomiarów)...