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Search results for: BLOOD ANALYSIS
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A label-free graphene-based impedimetric biosensor for real-time tracing of the cytokine storm in blood serum; suitable for screening COVID-19 patients
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Influence of Intensity RAMP Incremental Test on Peak Power, Post-Exercise Blood Lactate, and Heart Rate Recovery in Males: Cross-Over Study
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Pilot Testing of Developed Multimodal Biometric Identity Verification System
PublicationThe bank client identity verification system developed in the course of the IDENT project is presented. The total number of five biometric modalities including: dynamic signature proofing, voice recognition, face image verification, face contour extraction and hand blood vessels distribution comparison have been developed and studied. The experimental data were acquired employing multiple biometric sensors installed at engineered...
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House dust as a source of analytical information on concentration of polybrominated diphenyl ethers (PBDEs) - first approach
PublicationPolybrominated diphenyl ethers (PBDEs), which are best recognized as flame retardants, were in 2001, by virtue of Stockholm Convention, listed in a group of Persistent Organic Compounds (POPs). Increasing concentration levels of PBDEs, reported in human tissues (e.g., blood, serum, breast milk, etc.) haverecently caught worldwide concern due to their potential tendency to disrupt thyroid hormones, neurobehavioral deficits and endocrine...
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TRNA-Leu (UUR) gene haplotypes observed in canine mammary gland tumours and its deleterious effect assessment according to the comparative analysis with TRNL1 human gene
Open Research DataThe aetiology and pathogenesis of many canine tumours are likely to be similar to cancers found in humans. This study aimed to present a plausible link between changes in tRNA-Leu (UUR) gene and the carcinogenesis process in dogs with mammary gland tumours. The whole mitochondrial DNA (mtDNA) isolated from blood and tumour tissues of 13 dogs with malig-nant...
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Radiation-induced Changes in Levels of Selected Proteins in Peripheral Blood Serum of Breast Cancer Patients as a Potential Triage Biodosimeter for Large-scale Radiological Emergencies
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Cardiovascular and Perceptual Responses to Resistance Training with Practical Blood Flow Restriction Induced by a Non-Elastic Band vs. Pneumatic Cuff: A Crossover Randomized Study
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Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial
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D-loop sequences retrieved from Canis lupus familiaris mitochondrial genome
Open Research DataCanine mitochondrial genome is built of 16727 bp. Non-coding control region (mtCR), called also D-loop, begins with 15458 nucleotide and ends with 16727 nucleotide. The length of this fragment is 1270 bp (Kim et al., 1998). D-loop region is responsible for replication and transcription of mitochondrial DNA. Mutations that occur within it may cause irregularity...
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Color-based Detection of Bleeding in Endoscopic Images
PublicationIn this paper a color descriptor designed for bleeding detection in endoscopic images is proposed. The development of the algorithm was carried out on a representative training set of 36 images of bleeding and 25 clear images. Another 38 bleeding and 26 normal images were used in the final stage as a test set. All of the considered images were extracted from separate endoscopic examinations. The experiments include color distribution...
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HRV and BPV indices in differentiating OSA patients from healthy controls
Open Research DataThe various HRV and BPV indices computed for the purpose of the analyses described in the paper “Differentiating patients with obstructive sleep apnea from healthy controls based on heart rate–blood pressure coupling quantified by entropy-based indices” by P. Pilarczyk, G. Graff, J.M. Amigó, K. Tessmer, K. Narkiewicz, and B. Graff.
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Identification of novel psychoactive substances 25B-NBOMe and 4-CMC in biological material using HPLC-Q-TOF-MS and their quantification in blood using UPLC–MS/MS in case of severe intoxications
PublicationThis paper describes cases of poisoning caused by new psychoactive substances such as: 25BNBOMe (2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine) and 4-CMC (1-(4-chlorophenyl)-2-(methylamino)-1-propanone). The analytical procedure includes rapid and selective method for the extraction and determination of 4-CMC and 25B-NBOMe in blood samples using UPLC–MS/MS technique. To the best of our knowledge,this is...
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Effects of renal sympathetic denervation on blood pressure and glycaemic control in patients with true resistant hypertension: results of Polish Renal Denervation Registry (RDN-POL Registry)
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Turmeric nanofiber-encapsulated natural product formulation act as a phytogenic feed additive—A study in broilers on growth performance, biochemical indices of blood, and E. coli in cecum
PublicationA phytogenic feed additive (PFA) formulation was prepared with bioactive molecules—curcuminoids, gingerol, and carvacrol by encapsulating in nanofiber isolated from turmeric spent (turmeric nanofiber, TNF). This formulation was completely characterized by scanning electron microscope, ultra performance liquid chromatography, and gas chromatography and evaluated for its efficacy. PFA-encapsulated TNF (PFA@TNF) considerably increased...
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Computed tomography indicators of cerebral microperfusion improve long term after carotid stenting in symptomatic patients
PublicationOBJECTIVES: We tested the hypothesis that computed tomography (CT) perfusion markers of cerebral microcirculation would improve 36 months after internal carotid artery stenting for symptomatic carotid stenosis while results obtained 6-8 weeks after the stenting procedure would yield a predictive value. METHODS: We recruited consecutive eligible patients with >70% symptomatic carotid stenosis with a complete circle of Willis and...
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Polyurethane porous scaffolds (PPS) for soft tissue regenerative medicine applications
PublicationTissue engineering requires suitable polymeric scaffolds, which act as a physical support for regenerated tissue. A promising candidate might be polyurethane (PUR) scaffold, due to the ease of the PUR properties design, which can be adjusted directly to the intended purpose. In this study, we report a successful fabrication of porous polyurethane scaffolds (PPS) using solvent casting/particulate leaching technique combined with...
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Preliminary evaluation of selected inflammatory cytokine gene expression in lymphocytes isolated from whole human blood infected with trans-anethole-treated Staphylococcus aureus Newman strain
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Quantification of key red blood cell folates from subjects with defined MTHFR 677C>T genotypes using stable isotope dilution liquid chromatography/mass spectrometry
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Genome-Wide DNA Methylation and Gene Expression in Patients with Indolent Systemic Mastocytosis
PublicationMastocytosis is a clinically heterogenous, usually acquired disease of the mast cells with a survival time that depends on the time of onset. It ranges from skin-limited to systemic disease, including indolent and more aggressive variants. The presence of the oncogenic KIT p. D816V gene somatic mutation is a crucial element in the pathogenesis. However, further epigenetic regulation may also affect the expression of genes that...
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Common methods for the chiral determination of amphetamine and related compounds II: Capillary electrophoresis and nuclear magnetic resonance
PublicationAmphetamine group and related ring-substituted substances are generally synthetic compounds, belonging to one of the most heavily abused drug groups in recent years. Some compounds in this class also originate from plants. Analysis of the enantiomers of AM-type compounds and metabolites is extremely important for a number of scientific disciplines. From studies of biological activity or mechanisms through determination of precursor...
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Effect of alcohol consumption on the levels of volatile organohalogen compounds in blood and urine = Wpływ spożywania alkoholu na poziom lotnych związków chlorowcoorganicznych w krwi i moczu ludzkim
PublicationW pracy przedstawiono wyniki oznaczania lotnych związków chlorowcoorganicznych w próbkach moczu i krwi pochodzących od dawców w różny sposób narażonych na ekspozycje lotnych związków chlorowcoorgnicznych (styl życia: palenie papierosów, picie alkoholu, przyjmowanie lekarstw czy rodzaj wykonywanej pracy). Do izolacji i wzbogacania analitów z próbek moczu i krwi, wykorzystano technikę analizy fazy nadpowierzchniowej nad cienką warstwą...
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Separation and determination of ciprofloxacin in seawater, human blood plasma and tablet samples using molecularly imprinted polymer pipette‐tip solid phase extraction and its optimization by response surface methodology
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Human Gb3/CD77 synthase reveals specificity toward two or four different acceptors depending on amino acid at position 211, creating Pk, P1 and NOR blood group antigens
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Impacts on human health in the Arctic owing to climate-induced changes in contaminant cycling – The EU ArcRisk project policy outcome
PublicationResults of the EU ArcRisk project on human health impacts in the Arctic owing to climate-induced changes in contaminant cycling are summarized in the context of their policy application. The question on how will climate change affect the transport of selected persistent organic pollutants (POPs) and mercury, both to and within the Arctic has been addressed, as well as the issue of human health impacts of these pollutants in the...
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HOPE-3, SPRINT, VALUE and a meta-analysis of trials in patients with diabetes support treatment of hypertension to a target below 140 mmHg
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Intensive blood pressure lowering prevents mild cognitive impairment and possible dementia and slows development of white matter lesions in brain: the SPRINT Memory and Cognition IN Decreased Hypertension (SPRINT MIND) study
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Identyfikacja parametrów zastępczego schematu elektrycznego krwiobiegu nerki na podstawie niepełnych danych pomiarowych : The parameters identification of the equivalent electric circuit of the kidney blood circulation basis on incomplete measuring date
PublicationW referacie przedstawiono metodę identyfikacji parametrów elektrycznego schematu zastępczego odwzorowującego przepływ krwi przez nerkę. Napięcie potraktowano jako sygnał wejściowy, któremu w hemodynamice odpowiada ciśnienie, natomiast prąd jako sygnał wyjściowy, któremu odpowiada przepływ krwi. Przebieg napięcia aproksymowano funkcją sklejaną w celu uproszczenia procedury pomiarowej i ograniczenia fluktuacji związanych z przebiegiem...
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Ontology groups representing angiogenesis and blood vessels development are highly up-regulated during porcine oviductal epithelial cells long-term real-time proliferation – a primary cell culture approach
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Social Differentiation of the Perception and Human Tissues Donation for Research Purposes.
PublicationThe willingness to donate human biological material for research purposes is shaped by socio-cultural factors; however, there is a lack of studies analysing the social perception of different human tissues, which may affect such willingness. This study aimed to distinguish different sociocultural categories of human tissues and types of potential donors based on their willingness to donate material. Quantitative research was...
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Wykorzystanie kamery termowizyjnej nowej generacji do oceny wpływu sił ortodontycznych na dziąsło = The application of a new-generation thermal imaging camera for the assessment of hemodynamic changes in gingiva during orthodontic treatment
PublicationIntroduction. One ot the most interesting modern methods of assessing microcirculation is thermovisiual examination. Thermovision cameras are commonly used in general medicine. As the periodontium is one of the most vascularized tissues in the human body, the application of high-sensitivity thermovision cameras may allow tor noninvasive asses- sment and early detection ot pathological changes in the gingiva by giving a complete...
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New, fast and cheap prediction tests for BRCA1 gene mutations identification in clinical samples.
PublicationDespite significant progress in cancer therapy, cancer is still the second cause of mortality in the world. The necessity to make quick therapeutic decisions forces the development of procedures allowing to obtain a reliable result in a quick and unambiguous manner. Currently, detecting predictive mutations, including BRCA1, is the basis for effectively treating advanced breast cancer. Here, we present new insight on gene mutation...
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Cross-talk Between the Heart and Arteries in Older 65+ Adults
PublicationRegulatory synchronization between the heart and the arterial walls is essential for optimal blood delivery to tissues. We investigated functional coherence between heart rhythm and aortic wall compliance in 30 volunteers aged 65 – 74. ECG and carotid and iliac pulse-wave were recorded and digitized at 2 kHz. Carotid-femoral pulse-wave transit time (cfTT) which reflex aortic compliance was assessed using the intersecting tangent...
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The potential interaction of environmental pollutants and circadian rhythm regulations that may cause leukemia
PublicationTumor suppressor genes are highly affected during the development of leukemia, including circadian clock genes. Circadian rhythms constitute an evolutionary molecular machinery involving many genes, such as BMAL1, CLOCK, CRY1, CRY2, PER1, PER2, REV-ERBa, and RORA, for tracking time and optimizing daily life during day-night cycles and seasonal changes. For circulating blood cells many of these genes coordinate their proliferation,...
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Molecular differences in mitochondrial DNA (mtDNA) genomes of dogs with malignant mammary tumours
Open Research DataThe aim of this study was to determine molecular defects in mitochondrial DNA with the use of large-scale genome analysis in malignant canine mammary gland tumours and indicate whether these changes were linked with the carcinogenesis process. With the use of the NGS technology, we sequenced 27 samples of mtDNA isolated from blood and tumours obtained...
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Znajomość własnego ciśnienia tętniczego i rozpowszechnienie nadciśnienia tętniczego w populacji wiejskiej - Program Kiełpino = The cognizance of patient's own blood pressure values and the hypertension prevalence among rural population - Kiełpino program
PublicationNadciśnienie tętnicze jest jedną z najczęstszych chorób przewlekłych występujących w Polsce. Nieleczone nadciśnienie tętnicze prowadzi do licznych powikłań, jest przyczyna przedwczesnej umieralności, wpływa na pogorszenie komfortu życia pacjenta i zwiększa koszty leczenia. Ocena znajomości własnego ciśnienia tętniczego krwi oraz rozpowszechnienia nadciśnienia tętniczego u pacjentów w wiejskiej praktyce lekarza rodzinnego - jest...
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The SPRINT study: Outcome may be driven by difference in diuretic treatment demasking heart failure and study design may support systolic blood pressure target below 140 mmHg rather than below 120 mmHg
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The non-invasive evaluation of heart function in patients with an acute myocardial infarction: The role of impedance cardiography
PublicationBackground: The purpose of this study was to analyze hemodynamic changes in patients treated with percutaneous coronary intervention (PCI) at an early stage of acute myocardial infarction (AMI) and at one-month follow-up. Methods: Patients with AMI (n = 27) who underwent PCI were analyzed using impedance cardiography (ICG). ICG data were collected continuously (beat by beat) during the whole PCI procedure and thereafter at every...
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Fluid structure interaction study of non-Newtonian Casson fluid in a bifurcated channel having stenosis with elastic walls
PublicationFluid–structure interaction (FSI) gained a huge attention of scientists and researchers due to its applications in biomedical and mechanical engineering. One of the most important applications of FSI is to study the elastic wall behavior of stenotic arteries. Blood is the suspension of various cells characterized by shear thinning, yield stress, and viscoelastic qualities that can be assessed by using non-Newtonian models. In this...
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Diagnostics of the Peripheral Artery Disease with use of Glucose Sensor - A Proof of Concept
PublicationIt is estimated that 13% of population over 50 years old suffer from symptomatic or asymptomatic peripheral artery disease (PAD). Ankle-brachial index (ABI) is viewed as a useful parameter in diagnostics of peripheral arterial disease, however screening tests with usage of this method are not advised. Hypoxia causes increase in lactate values and decrease in blood glucose. We hypothesize that the deficit in blood supply to the...
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Diagnostics of the Peripheral Artery Disease with use of Glucose Sensor - A Proof of Concept
PublicationIt is estimated that 13 % of population over 50 years old suffer from symptomatic or asymptomatic peripheral artery disease (PAD). Ankle-brachial index (ABI) is viewed as a useful parameter in diagnostics of peripheral arterial disease, however screening tests with usage of this method are not advised. Hypoxia causes increase in lactate values and...
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Haemocompatibility of Modified Nanodiamonds
PublicationThis study reports the interactions of modified nanodiamond particles in vitro with human blood. Modifications performed on the nanodiamond particles include oxygenation with a chemical method and hydrogenation upon chemical vapor deposition (CVD) plasma treatment. Such nanodiamonds were later incubated in whole human blood for different time intervals, ranging from 5 min to 5 h. The morphology of red blood cells was assessed along...
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Optoelectronic device for hematocrit measurements
PublicationAn optoelectronic system for measurements of hematocrit level (HCT) in the whole human blood is presented. Proposed system integrates a dedicated optoelectronic sensor, a microcontroller and a small LCD display in a low cost, battery-powered, handheld device. Chosen method for determining blood hematocrit level is based on optical properties of whole blood in visible and NIR wavelength range. Measurements with the use of proposed...
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Label‐free optical detection of cyclosporine in biological fluids
PublicationIn this paper, a spectroscopic method for determination of cyclosporine concentrations in biological fluids is presented. Blood plasma and hemoglobin solutions are chosen for the experiment. For various cyclosporine concentrations in blood plasma and hemoglobin, absorbance measurements in spectra range from 600 to 1100 nm are performed. The measurement results are analyzed by the use of a dedicated algorithm. The obtained data...
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Using wearable device for biomedical signal acquisition and processing
PublicationIn this paper we present the research conducted on synchronous measurements of biosignals. The experiment was conducted to evaluate the possibility of estimating vital signs based on eye tracking. Method: The eGlasses platform was used for acquisition of ECG, respiration rate, eye and pupil movement and blood pressure. Data were acquired in three 5 min. intervals during which a subject was performing certain tasks. The signals...
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Validation and modification of HPLC method for monitoring acetaminophen plasma concentrations in patients with chronic pancreatitis
PublicationBackground. Pancreatitis is the inflammation of the pancreas. The infl ammation may occur suddenly and resolve in a few days with the treatment in case of acute pancreatitis (AP). Chronic pancreatitis (CP) is a persistent inflammation of the pancreas that results in irreversible morphological changes and impairment of both exocrine and endocrine functions. Abdominal...
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Hydration of N-Hydroxyurea from Ab Initio Molecular Dynamics Simulations
PublicationN-Hydroxyurea (HU) is an important chemotherapeutic agent used as a first-line treatment in conditions such as sickle cell disease and β-thalassemia, among others. To date, its properties as a hydrated molecule in the blood plasma or cytoplasm are dramatically understudied, although they may be crucial to the binding of HU to the radical catalytic site of ribonucleotide reductase, its molecular target. The purpose of this work...
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Novel methods for diagnosis of pulmonary microangiopathy in diabetes mellitus
PublicationLung microangiopathy is a little known negative influence of diabetes mellitus on the functioning of the lungs. In current medical practice lung microangiopathy is diagnosed by comparing two measurements of lung diffusing capacity - one with the subject standing and one with the subject lying. The necessity to take two measurements is inconvenient. In lung microangiopathy we observe a reduction of diffusing capacity, lung flow...
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Obrazowanie perfuzji mózgu z wykorzystaniem modelowania parametrycznego danych DSC-MRI
PublicationPomiary DSC-MRI (Dynamic Susceptibility Contrast Magnetic Resonance Imaging) zostały wykorzystane w pracy do estymacji parametrów perfuzji mózgu: przepływu krwi mózgowej (cerebral blood flow, CBF), objętości krwi mózgowej (cerebral blood volume, CBV) oraz średniego czasu przejścia (mean transit time, MTT). Zaproponowano model trzykompartmentowy. Przedstawiono i porównano dwa podejścia do identyfikacji modelu na podstawie danych...
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Pulse Transit Time - Fiducial Points Accuracy Determination as Examined by Means of Synthetic Signals
PublicationThere are many approaches to non-invasively deter-mine blood pressure. Among them there are methods based on utilizing pulse transit time measured by means of photoplethys-mography. The variability of the blood pressure drop between two measurement sensors placed along the artery and its dependence on the selected parameters describing the cardiovascular system is presented in the paper. This pressure drop modifies the pressure...
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Brain perfusion imaging with the use of parametric modelling basing on DSC-MRI data
PublicationW pracy do estymacji parametrów perfuzji mózgu: przepływu krwi mózgowej (cerebral blood flow, CBF), objętości krwi mózgowej (cerebral blood volume, CBV) oraz średniego czasu przejścia (mean transit time, MTT) wykorzystano pomiary DSC-MRI (Dynamic Susceptibility Contrast Magnetic Resonance Imaging). W modelowaniu danych MRI zastoswoano model trzykompartmentowy. Przedstawiono i porównano dwa podejścia do identyfikacji modelu różniące...