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Search results for: FLUVIAL ECOLOGY
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The mechanisms of technological innovation in SMEs: a Bayesian Network Analysis of EU regional policy impact on Polish firms.
PublicationWe study the underlying mechanisms of technological innovation in SMEs in the context of ex-post evaluation of European Union’s regional policy. Our aim is to explain the observed change in firms’ innovativeness after receiving EU support for technological investment. To do so, we take an approach that is novel in innovation studies: a Bayesian Network Analysis to assess the effectiveness of EU policy instrument for technological...
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Origin of bitumen fractions in the Jurassic-early Cretaceous Vaca Muerta Formation in Argentina: insights from organic petrography and geochemical techniques
PublicationThis paper investigates chemical functional groups of the two extracted bitumen fractions in shales of the Jurassic to early Cretaceous Vaca Muerta Formation of the Neuquén Basin in Argentina, South America. The results indicate that Bitumen I is strongly aliphatic and appears to be genetically related to fluorescent amorphous organic matter. In contrast, Bitumen II consists of highly condensed, aromatic hydrocarbons, and has some...
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Molecular docking studies towards development of novel Gly-Phe analogs for potential inhibition of Cathepsin C (dipeptidyl peptidase I).
PublicationCathepsin C is a cysteine protease required for activation of various pro-inflammatory serine proteases and, essentially, is of interest as a therapeutic target. Cathepsin C coordinate system was employed as a model to study the interaction of some already available inhibitors of Cathepsin C. Compounds containing Gly-Phe fragment with functional groups at its ends were designed by knowledge based approach. Using AutoDock and...
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Assessment of TFP in European and American higher education institutions – application of Malmquist indices
PublicationIn this study we apply Malmquist methodology, based on the estimation of distance measures through Data Envelopment Analysis (DEA), to a sample of 500 universities (in 10 European countries and the U.S.) over the period 2000 to 2010 in order to assess and compare their productivity. On average, a rise in TFP is registered for the whole European sample (strongest for Dutch and Italian HEIs), while the productivity of American HEIs...
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Triazoloacridone C-1305 abrogates the restriction checkpoint in cells lacking functional p53 and promotes their accumulation in the G2/M phase of the cell cycle
PublicationTriazoloakrydon C-1305, nowy inhibitor topoizomerazy II, wykazuje wysoką aktywość cytotoksyczną wobec komórek wielu typów nowotworów. Komórki mysie pozbawione genu PARP-1 wykazywały nadwrażliwość na działanie tego związku. W pracy testowaliśmy działanie związku wobec dwóch różnych komóek nowotworowych różniących się statusem p53: komórkami białaczki myelocytarnej HL-60 i raka sutka MCF-7. Wykazaliśmy, że inkubacja ze związkiem...
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Dynamics of productivity in higher education. Cross-European evidence based on bootstrapped Malmquist indices
PublicationThis study presents patterns of productivity change in a large set of 266 public higher education institutions (HEIs) from 7 European countries across the time period 2001-2005. We adopt consistent bootstrap estimation procedures to obtain confidence intervals for Malmquist indices of HEI productivity and their components. Consequently, we are able to assess statistical significance of the changes in HEIs' productivity, efficiency...
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Antimicrobial molecular nanocarrier–drug conjugates
PublicationMany antimicrobial drugs are poorly active against pathogenic microbes causing intracellular infections, such as Mycobacterium tuberculosis or Plasmodium falciparum. On the other hand, several known antimicrobial agents are not effective enough because of their limited cellular penetration. A common feature of both challenges is the inability of an active agent to cross the biological membrane(s). One of the possible approaches...
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Influence of S-Oxidation on Cytotoxic Activity of Oxathiole-Fused Chalcones
PublicationSynthesis, in vitro cytotoxic activity, and interaction with tubulin of oxidized, isomeric 1-(5-alkoxybenzo[d] [1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-ones and 1-(6- alkoxybenzo[d][1,3]oxathiol-5-yl)-3-phenylprop-2-en-1- ones are described. Most of the compounds demonstrated cytotoxic activity at submicromolar concentrations. It was found that oxidation of sulfur atom of the oxathiole-fused chalcones strongly influenced activity...
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Synthesis and biological evaluation of fluorinated 3-phenylcoumarin-7-O-sulfamate derivatives as steroid sulfatase inhibitors
PublicationIn the present work, we report the initial results of our study on a series of 3-phenylcoumarin sulfamate-based compounds containing C-F bonds as a novel inhibitors of steroid sulfatase (STS). The new compounds are potent STS inhibitors, possessing more than 10 times higher inhibitory potency than coumarin-7-O-sulfamate. In the course of our investigation, compounds 2b and 2c demonstrated the highest inhibitory effect in the enzymatic...
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COMPUTER-AIDED DESIGN OF ORGANOPHOSPHORUS INHIBITORS OF UREASE
PublicationBased on the structure of the most potential inhibitor diamidophosphate, various novel groups of inhibitors were developed by knowledge-based design approach with covalent carbon-phosphorus or carbon-phosphorus-carbon bond to improve hydrolytic stability to inhibit the microbial ureases. Designed compounds were evaluated with 10 (LigScore1, LigScore2, PLP1, PLP2, JAIN, PMF, PMF04, LUDI_1, LUDI_2 and LUDI_3) different scoring functions...
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Docking simulations, Molecular properties and ADMET studies of novel Chromane6,7diol analogues as potential inhibitors of Mushroom tyrosinase
PublicationResearch on inhibition of tyrosinase enzyme has attained significant value, because tyrosinase inhibitors have potential applications in medicine, cosmetics (as whitening agents) and in agriculture (as bioinsecticides). Determination and elucidation of new tyrosinase inhibitors are not only beneficial for medical purposes, but their promising applications in improving food quality and nutritional...
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Molybdenum-uranium-vanadium geochemistry in the lower Paleozoic Alum Shale of Scandinavia: Implications for vanadium exploration
PublicationThis paper investigates the hyper-enrichments of molybdenum (Mo), uranium (U), and vanadium (V) in the lower Paleozoic, Alum Shale of Denmark, Sweden, Norway, and Estonia. Molybdenum and U are mainly associated with organic matter and the highest contents are found in the Furongian part of the Alum Shale. This Furongian hyper-enrichment of Mo and U commenced with the Steptoean Positive Carbon Isotope Excursion (SPICE) event. The...
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Elemental composition, environment of deposition of the Lower Carboniferous Emma Fiord Formation oil shale in Arctic Canada
PublicationThe sedimentary succession of 51-m consisting of a thin coal seam (1 m) and oil shale with a marlstone and carbonate-mudstone matrix of the Lower Carboniferous (Viséan) Emma Fiord Formation located on the Grinnell Peninsula, Devon Island, Arctic Canada was examined. The techniques used include reflected light microscopy, and instrumental neutron activation analysis (INAA) for elemental concentration, and inductively coupled plasma...
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The comparison of antioxidant properties and nutrigenomic redox-related activities of vitamin C, C-vitamers, and other common ascorbic acid derivatives
PublicationThe term ‘vitamin C’ describes a group of compounds with antiscorbutic activity of L-ascorbic acid (AA). Despite AA’s omnipresence in plant-derived foods, its derivatives have also been successfully implemented in the food industry as antioxidants, including the D-isomers, which lack vitamin C activity. This study aimed to determine the relationship between redox-related activities for five derivatives of AA using electrochemical,...
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The impact of institutions on innovation networks: empirical evidence from Poland
PublicationInnovation networks may accelerate and improve the innovation process, while institutional pathologies may hamper it. This study employs the Kruskal-Wallis H test and regression analysis to determine if the relationship between institutions and innovation networks does exist among the investigated variables. The purpose of the study was to find out whether cooperation with special local institutions influences the innovative behaviour...
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VALUATION OF EMBEDDED OPTIONS IN NON-MARKETABLE CALLABLE BONDS: A NEW NUMERICAL APPROACH
PublicationThe issue of how to price options embedded in callable bonds has attracted a lot of interest over the years. The usual bond valuation methods rely on yield curves, risk premium, and other parameters to estimate interest rates used in discounted cash flow calculations. The option to retire the bond is, however, neglected in the standard pricing models, causing a systematic overvaluation of callable bonds. In the event of a decline...
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Digital transformation and economic growth - DESI improvement and implementation
PublicationThe paper aims to improve the methodology of the Digital Economic and Society Index (DESI), the European Commission’s newest index to assess the development of the digital economy. In particular, we investigate whether methodological changes to the structure of DESI improve its ability to capture the digital transformation of EU economies. Using the sensitivity- based analysis, we check whether the selection of weights of individual...
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CONDITIONS OF THE GREEN TRANSFORMATION. THE CASE OF THE EUROPEAN UNION
PublicationThe main purpose of the paper is to identify the factors that determine the course of green transformation and to assess the current stage and possible directions of change in subsequent years in EU countries. The literature lacks comprehensive studies that show the impact of diverse types of factors on the course of green transformation. For this purpose, two perspectives of the research – economic and environmental – are usually...
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Investigating the disease- modifying properties of sclerotiorin in Alzheimer's therapy using acetylcholinesterase inhibition
PublicationAlzheimer's disease (AD) is a progressive neurodegenerative disorder caused due to the damage and loss of neurons in specific brain regions. It is the most common form of dementia observed in older people. The symptoms start with memory loss and gradually cause the inability to speak and do day-to-day activities. The cost of caring for those affected individuals is huge and is probably beyond most developing countries capability....
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A review on computer‐aided chemogenomics and drug repositioning for rational COVID ‐19 drug discovery
PublicationApplication of materials capable of energy harvesting to increase the efficiency and environmental adaptability is sometimes reflected in the ability of discovery of some traces in an environment―either experimentally or computationally―to enlarge practical application window. The emergence of computational methods, particularly computer-aided drug discovery (CADD), provides ample opportunities for the rapid discovery and development...
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Procognitive activity of nitric oxide inhibitors and donors in animal models
PublicationNitric oxide is a small gaseous molecule that plays important roles in the majority of biological functions. Impairments of NO-related pathways contribute to the majority of neurological disorders, such as Alzheimer’s disease (AD), and mental disorders, such as schizophrenia. Cognitive decline is one of the most serious impairments accompanying both AD and schizophrenia. In the present study, the activities of NO donors, slow (spermine...
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Interactions between bioactive components determine antioxidant, cytotoxic and nutrigenomic activity of cocoa powder extract
PublicationNumerous studies have shown, rather disappointingly, that isolated bioactive phytochemicals are not as biologically effective as natural plant products. Such a discrepancy may be explained by the concept of food synergy, which was verified in this research for cocoa extract versus its major components with regard to cancer chemoprevention. The evaluation embraced the relationship between redox properties evaluated in cell-free systems...
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Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitor
PublicationInositol requiring enzyme 1 alpha (IRE1α) is one of three signaling sensors in the unfolding protein response (UPR) that alleviates endoplasmic reticulum (ER) stress in cells and functions to promote cell survival. During conditions of irrevocable stress, proapoptotic gene expression is induced to promote cell death. One of the three signaling stressors, IRE1α is an serine/threonine-protein kinase/endoribonuclease (RNase) that...
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Conditions of Iranian international trade in terms of lifting the sanctions: A case study of Polish-Iranian trade perspectives
PublicationThe main aim of the paper is to identify the areas and determine the feasibility of trade between Polish and Iranian companies in relation to historical and cultural conditions. The authors describe the complexity of the issue of foreign trade, the determinants of relations between Poland and the Islamic Republic of Iran, and the Iranian economy – its features, strengths and weaknesses, and consequences of the recent UN, EU, and...
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Metody analizy energochłonności w przemyśle
PublicationBadania przeprowadzone w rozprawie doktorskiej pokazują nową ideę analitycznych metod analizy energochłonności w zastosowaniu do dużych odbiorców przemysłowych. Jej skuteczności dowodzono na przykładzie wybranego obiektu przemysłu spożywczego. Metoda ta jest rozwinięciem dotychczasowych metod wskaźnikowych. Autorską nowością jest wykorzystanie charakterystyk energetycznych procesów technologicznych do wyznaczania referencyjnych...
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Improving SBR Performance Alongside with Cost Reduction through Optimizing Biological Processes and Dissolved Oxygen Concentration Trajectory
PublicationAuthors of this paper take under investigation the optimization of biological processes during the wastewater treatment in sequencing batch reactor (SBR) plant. A designed optimizing supervisory controller generates the dissolved oxygen (DO) trajectory for the lower level parts of the hierarchical control system. Proper adjustment of this element has an essential impact on the efficiency of the wastewater treatment process as well...
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Determination of Pesticide Residues in Honeybees using Modified QUEChERS Sample Work-Up and Liquid Chromatography-Tandem Mass Spectrometry
PublicationIncreasing emissions of chemical compounds to the environment, especially of pesticides, is one of factors that may explain present honeybee colony losses. In this work, an analytical method employing liquid chromatography-tandem mass spectrometry (LC-MS/MS) was optimized for the simultaneous screening of 19 pesticides which have not been yet determined in honeybee samples from northern Poland (Pomerania). The sample preparation,...
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Model of the Internet mortgage market optimization
PublicationThe Internet mortgages are currently a fast growing market, allowing selling mortgages cheaper andfaster than in the traditional methods such as in bank departments.Given the specificity of selling mortgages in the Internet, banks try to sell more mortgages by spendingmore money on advertising and paying higher commission to the brokers selling their products. It is important tooptimise the amounts of money in both sectors (the...
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Impact of the Manufacturing Sector on the Export Competitiveness of European Countries – a Spatial Panel Analysis
PublicationThe purpose of this paper is to determine how changes in the export competitiveness of the EU economy (measured by exports and net exports) depend on changes in the competitiveness of processing industries, on the basis of manufacturing data from 19 EU countries over years 1995-2009 and using a spatial panel data model. The determinants of export competitiveness are selected in the light of predictions from international trade...
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Biobased Ultralow-Density Polyurethane Foams with Enhanced Recyclability
PublicationPolyurethane (PUR) foams are widely used in many engineering applications, but their efficient recycling has remained a major challenge for many years. This study presents a novel strategy of incorporating hydrolyzable ester units into the PUR structure to enhance PUR foam recyclability. The present ecodesign concept of PUR materials enables fully the replacement of petrochemical polyols with biobased alternatives and production...
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Improvement of ships seakeeping performance by application of the Full-scale CFD simulations – case study
PublicationThe ship’s fuel economy is increasingly important. The paper presents the effect of redesigning a case study ship for increasing seakeeping performance. Selected wave parameters reflects very difficult operational con-ditions existing on the North Sea and the Baltic Sea. The analyzed variants of a case study ship represent the latest developments of modern hull forms. The concepts similar to V-shaped bulbous bow, X-bow, X-aft,...
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Heavy duty vehicle fuel consumption modelling using artificial neural networks
PublicationIn this paper an artificial neural network (ANN) approach to modelling fuel consumption of heavy duty vehicles is presented. The proposed method uses easy accessible data collected via CAN bus of the truck. As a benchmark a conventional method, which is based on polynomial regression model, is used. The fuel consumption is measured in two different tests, performed by using a unique test bench to apply the load to the engine. Firstly,...
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Towards improved energy efficiency of future smart ships by application of advanced CFD simulations – case study
PublicationThe international trade plays crucial role in today’s globally developed world’s economy. Many people are unaware of the unimaginable volume of cargo being transported every year by oceans and seas. For most of the time invisible from land the shipping industry preserves its strong position of the most cost-efficient and environmental friendly mean of transport. However during last years the shipping industry is under great pressure...
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Modelling of the Polish Electricity Generation Subsystem in MARKAL Program with Emphasis on the EU Emissions Trading Scheme
PublicationThis paper addresses issues related to greenhouse gas emissions in the European Union and measures to reduce them, in particular the European Emissions Trading Scheme (EU ETS). A model of the Polish electricity generation subsystem, taking into account EU ETS mechanisms, has been developed using the MARKAL optimization package. Data collected on the basis of available projects, regulations and statistics were entered into the model....
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INTERNATIONALIZATION OF ENTERPRISES IN KAZAKHSTAN AS AN EXAMPLE OF INTERNATIONALIZATION PATTERNS IN THE AREA OF THE EURASIAN ECONOMIC UNION.
PublicationThe article aims to show the specificity of the internationalization of Kazakh enterprises, in particular, the pace, scope, intensity, and forms of their internationalization in the Eurasian Economic Union (EEU). The EEU is a relatively young grouping that was established in 2015 by the Republic of Armenia, the Republic of Belarus, the Republic of Kazakhstan, the Kyrgyz Republic and the Russian Federation. EEU creators try to give...
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Interdependence of Ratios in Banking Stability Pentagon
PublicationThe banking sector is one of the key sectors in every economy, therefore, the issue of stability is one of the main interests not only of researchers but also policy-makers. The stability of the banking sector is especially important during a process of transformation. The aim of this article is to present a new tool for estimating the stability of the banking sector as a whole. Although the tool can be used to estimate the level...
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Examination of fresh water chemistry in maritime Antarctica during austral summer 2017
PublicationDue to the fact that Antarctica is one of the least polluted places on Earth, it is a perfect place to observe the spread of global pollution. Therefore, research conducted on this continent is important due to the possibility of investigating the type of pollution and their way of transport. This work considers presence of organic contaminants in Maritime Antarctica in unexplored until now, Lions Rump headland. Qualitative and...
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An analysis of the characteristics of Japanese industrial sectors from 2005 through 2011
PublicationThe purpose of the current study is to analyze the characteristics of Japanese industrial sectors from 2005 through 2011. The study employs the analysis tools from the Input-Output (IO) analysis, namely the indices of the power of dispersion, and the sensitivity of dispersion. The study focuses on the thirteen industries. The characteristics are described by the quadrants of analyzed charts. The results show that industries 3 and...
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THE AGRI-HOOD AND SLOW-SUBURB CONCEPT IN THE CONTEXT OF AN IN-BETWEEN CITY (ZWISCHENSTADT)
PublicationThe concept of an “in-between-city” (Zwischenstadt) interprets the urban sprawl in Europe as a new, evolving model of urban development, taking the form of urbanized landscapes, which does not correspond with the traditional understanding of urban design. The actual shape of an in-between-city reflects the today’s technology and economy generating new lifestyles: global trends coexist with the locality in a strong relation. The...
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Thematic Areas in the Polish Countryside and Their Role in Local Development
PublicationThe article defines the phenomenon of space thematisation with regards to rural areas in Poland. The typology of thematic spaces and criteria of their comparative description have been proposed. Thematic villages, home gardens, amusement parks and housing estates have been distinguished. They have been compared in terms of spatial availability, the degree of user participation and the commercial vs. non-commercial creation purpose....
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Ultrasound assisted extraction
PublicationThe use of green and sustainable extraction techniques is very popular topic in the multidisciplinary area of chemistry, biology and technology. There is no doubt that extraction constitutes a very important step of analytical procedures of separation, detection, identification and determination of wide spectrum analytes from samples characterized by complex and very often nonhomogeneous composition of matrix. Traditional techniques...
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HOW EFFICIENT IS NOISE LABELING OF TIRES?
PublicationSince 2012 all new tires in Europe must be labeled. The label contains general information about tire performance concerning rolling resistance (that corresponds to fuel economy), noise emission and wet grip (only for passenger car tires). Measurements of noise performance of tires must be performed according to the Annex 3 of the Regulation No 117 of the Economic Commission for Europe of the United Nations. The regulation specifies...
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UNDECLARED WORK IN POLAND CHARACTERISTICS AND PREVALENCE
PublicationThis article aims to present the significance and prevalence of the phenomenon of undeclared work. First, we discuss the definitional issues of this phenomenon. Then, we present previous estimates on shadow economy and undeclared work in Poland, based on statistics provided by Central Statistical Office and other research entities. Our analysis covers the years 2000–2014. In the last part of the article, we use data from the Labour...
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Criteria for selection of working fluid in low-temperature ORC
PublicationThe economics of an ORC system is strictly linked to thermodynamic properties of the working fluid. A bad choice of working fluid could lead to a less efficient and expensive plant/generation unit. Some selection criteria have been put forward by various authors, incorporating thermodynamic properties, provided in literature but these do not have a general character. In the paper a simple analysis has been carried out which resulted...
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An intelligent cellular automaton scheme for modelling forest fires
PublicationForest fires have devastating consequences for the environment, the economy and human lives. Understanding their dynamics is therefore crucial for planning the resources allocated to combat them effectively. In a world where the incidence of such phenomena is increasing every year, the demand for efficient and accurate computational models is becoming increasingly necessary. In this study, we perform a revision of an initial proposal...
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Digestate Quality Originating from Kitchen Waste
PublicationThis paper examines the influence of biomass directed to anaerobic digestion on the quality of digestate, specifically focusing on the presence of undesirable substances, such as plastics, including biodegradable ones. It analyses the susceptibility of selected bioplastics to degradation and addresses the problem of reliable identification of microplastics in both feedstock—directed to anaerobic digestion—and produced digestate....
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Hydration of Simple Model Peptides in Aqueous Osmolyte Solutions
PublicationThe biology and chemistry of proteins and peptides are inextricably linked with water as the solvent. The reason for the high stability of some proteins or uncontrolled aggregation of others may be hidden in the properties of their hydration water. In this study, we investigated the effect of stabilizing osmolyte–TMAO (trimethylamine N-oxide) and destabilizing osmolyte–urea on hydration shells of two short peptides, NAGMA (N-acetyl-glycine-methylamide)...
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Assessment of the Feasibility of Energy Transformation Processes in European Union Member States
PublicationThe energy transition is now treated in most countries as a necessary condition for their long-term development. The process of energy transformation assumes the simultaneous implementation of the Sustainable Development Goals, which are a major challenge for modern economies and introduce significant restrictions in their functioning. Our study aims to group EU member states according to their ability to achieve energy transition...
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Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?
PublicationThe structure of B-DNA, the physiological form of the DNA molecule, has been a central topic in biology, chemistry and physics. Far from uniform and rigid, the double helix was revealed as a flexible and structurally polymorphic molecule. Conformational changes that lead to local and global changes in the helix geometry are mediated by a complex choreography of base and backbone rearrangements affecting the ability of the B-DNA...
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Entrepreneurship nests in a polish edge city
PublicationThe last two decades in Poland have been a period of both a dynamic development of the small and medium-sized enterprise sector and a transformation of the city surrounding territories. This development began during the economy transformation after 1989. Population migration and movement of economic entities away from central cities resulted in development of territorial structures within some Polish suburban areas, defined as...