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Search results for: Li2+ molecule
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Dissociative Electron Attachment to 5-Iodo-4-thio-2′-deoxyuridine: A Potential Radiosensitizer of Hypoxic Cells
PublicationIn the search for effective radiosensitizers for tumor cells, halogenated uracils have attracted more attention due to their large cross section for dissociation upon the attachment of low-energy electrons. In this study, we investigated dissociative electron attachment (DEA) to 5-iodo-4-thio-2'-deoxyuridine, a potential radiosensitizer using a crossed electron-molecule beam experiment coupled with quadrupole mass spectrometry....
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Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?
PublicationThe structure of B-DNA, the physiological form of the DNA molecule, has been a central topic in biology, chemistry and physics. Far from uniform and rigid, the double helix was revealed as a flexible and structurally polymorphic molecule. Conformational changes that lead to local and global changes in the helix geometry are mediated by a complex choreography of base and backbone rearrangements affecting the ability of the B-DNA...
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Expression of Deinococcus geothermalis Trehalose Synthase Gene in Escherichia coli and Its Enzymatic Properties
PublicationA novel trehalose synthase gene from Deinococcus geothermalis (DSMZ 11300) containing 1,692 bp reading-frame encoding 564 amino acids was amplified using PCR. The gene was ligated into pET30Ek/LIC vector and expressed after isopropyl alfa-D-thiogalactopyranoside induction in Escherichia coli BL21(DE3)pLysS. The recombinant trehalose synthase (DgeoTreS) containing a His6 tag at the C-terminus was purified by metal affinity chromatography...
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Evaluation and cellular responses of modulators of TRF1/TRF2 protein’s function as potential anticancer drugs interfering with telomeric shelterin’s function
PublicationA number of proteins that interact with telomeres have been identified in human cells, indicating the high plasticity of human nucleoprotein complex organization. The most important complex is the "shelterin" complex, which consists of six proteins: TRF1, TRF2, TIN2, POT1, TPP1. The TRF1 and TRF2 directly bind to telomeric double-stranded DNA and the TIN2 protein. The TIN2 protein also binds to the TPP1 protein, stabilizing the...
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The imidazoacridinone C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation
PublicationC-1311 is a small molecule, which has shown promise in a number of preclinical and clinical studies. However, the biological response to C-1311 exposure is complicated and has been reported to involve a number of cell fates. Here, we investigated the molecular signaling which determines the response to C-1311 in both cancer and non-cancer cell lines. For the first time we demonstrate that the tumor suppressor, p53 plays a key role...
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A. Computational analysis by molecular docking of thirty alkaloid compounds from medicinal plants as potent inhibitors of SARS-CoV-2 main protease(2020). Focused on analysis of the Medicinal plants that have potential therapeutic ability against COVID-19.
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Influence of pH and low-molecular weight organic compounds in solution on selected spectroscopic and analytical parameters of flowing liquid anode atmospheric pressure glow discharge (FLA-APGD) for the optical emission spectrometric (OES) determination of Ag, Cd, and Pb
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Maximizing Bio-Hydrogen and Energy Yields Obtained in a Self-Fermented Anaerobic Bioreactor by Screening of Different Sewage Sludge Pretreatment Methods
PublicationEgypt faces significant challenges in managing its sewage sludge generated in large quantities from wastewater treatment plants. This study investigates the feasibility of utilizing sewage sludge as a renewable resource for hydrogen production through anaerobic digestion at the 100 L bioreactor level. Hydrogen is considered a promising alternative energy source due to its high energy content and environmental benefits. To optimize...
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Studies on applicability of new solid-phase microextraction fibers for the selective extraction and determination of short - chain monocarboksylic acids
PublicationShort-chain monocarobxylic acids, sometimes referred to as volatile fatty acids (VFA), are a group of low molecular weight alkyl monocarboxylic acids that are widely distributed within the environment. These molecules contain any from 2 to 8 carbon atoms and originate from the anaerobic biodegradation of organic matter such as carbohydrates, proteins, and fats. These compounds are commonly found in the effluents from animal farming,...
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Aggregation of imidazoacridinones - spectroscopic and microcalorimetric approach
PublicationImidazoacridinones (IA) belong to a group of polycyclic heteroaromatic antitumor compounds. IA create the aggregated form in water solution. Self-association of substances is a very important phenomenon in many fields of applied chemistry. It is also fundamental model reaction of many kinds of molecular interactions such as the micelle formation of amphiphilic substances and the binding of small organic molecules to macromolecules....
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Effect of Acetylation and Beta‐Amylase Treatment on Complexation of Debranched Starch with Naringenin
PublicationStarch inclusion complexation has been shown to improve solubility of water insoluble molecules. Potato starch and Hylon VII are acetylated at two levels and then debranched alone or combined with β‐amylase hydrolysis, and its complexes with naringenin are prepared in aqueous conditions and characterized in this study. Both soluble and insoluble complexes are formed with the soluble complex present in the supernatant and the insoluble...
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Series of MI[Co(bpy)3][Mo(CN)8]·nH2O (MI = Li (1), K (2), Rb (3), Cs (4); n = 7−8) Exhibiting Reversible Diamagnetic to Paramagnetic Transition Coupled with Dehydration−Rehydration Process
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Local impedance imaging of boron-doped polycrystalline diamond thin films
PublicationLocal impedance imaging (LII) was used to visualise surficial deviations of AC impedances in polycrystalline boron-doped diamond (BDD). The BDD thin film electrodes were deposited onto the highly doped silicon substrates via microwave plasma-enhanced CVD. The studied boron dopant concentrations, controlled by the [B]/[C] ratio in plasma, ranged from 1 × 1016 to 2 × 1021 atoms cm−3. The BDD films displayed microcrystalline structure,...
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Intermolecular Interactions as a Measure of Dapsone Solubility in Neat Solvents and Binary Solvent Mixtures
PublicationDapsone is an effective antibacterial drug used to treat a variety of conditions. However, the aqueous solubility of this drug is limited, as is its permeability. This study expands the available solubility data pool for dapsone by measuring its solubility in several pure organic solvents: N-methyl-2-pyrrolidone (CAS: 872-50-4), dimethyl sulfoxide (CAS: 67-68-5), 4-formylmorpholine (CAS: 4394-85-8), tetraethylene pentamine (CAS:...
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A Highly Selective Biosensor Based on Peptide Directly Derived from the HarmOBP7 Aldehyde Binding Site
PublicationThis paper presents the results of research on determining the optimal length of a peptide chain to eectively bind octanal molecules. Peptides that map the aldehyde binding site in HarmOBP7 were immobilized on piezoelectric transducers. Based on computational studies, four Odorant Binding Protein-derived Peptides (OBPPs) with dierent sequences were selected. Molecular modelling results of ligand docking with selected peptides were...
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Unusual Influence of Fluorinated Anions on the Stretching Vibrations of Liquid Water
PublicationInfrared (IR) spectroscopy is a commonly used and invaluable tool in the studies of solvation phenomena in aqueous solutions. Concurrently, ab initio molecular dynamics (AIMD) simulations deliver the solvation shell picture at a molecular detail level and allow for a consistent decomposition of the theoretical IR spectrum into underlying spatial correlations. Here, we demonstrate how the novel spectral decomposition techniques...
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Integrate-and-fire models with an almost periodic input function
PublicationWe investigate leaky integrate-and-fire models (LIF models for short) driven by Stepanov and μ-almost periodic functions. Special attention is paid to the properties of the firing map and its displacement, which give information about the spiking behavior of the considered system. We provide conditions under which such maps are well-defined and are uniformly continuous. We show that the LIF models with Stepanov almost periodic...
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Total cross section measurements for electron scattering from tin(IV) chloride (SnCl4)
PublicationTotal cross section for electron scattering from SnCl4 molecules has been measured for energies from 0.6 to 300 eV. Obtained results have been compared with total cross sections for electron scattering from other tetrachloride molecules: XCl4 where X=C, Si, Ge.
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Foliate-Targeting Quantum Dots-β-Cyclodextrin Nanocarrier for Efficient Delivery of Unsymmetrical Bisacridines to Lung and Prostate Cancer Cells
PublicationTargeted drug delivery by nanocarriers molecules can increase the efficiency of cancer treatment. One of the targeting ligands is folic acid (FA), which has a high affinity for the folic acid receptors, which are overexpressed in many cancers. Herein, we describe the preparation of the nanoconjugates containing quantum dots (QDs) and β-cyclodextrin (β-CD) with foliate-targeting properties for the delivery of anticancer compound...
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The accretion of the new ice layer on the surface of hexagonal ice crystal and the influence of the local electric field on this process
PublicationThe process of creation of a new layer of ice on the basal plane and on the prism plane of a hexagonal ice crystal is analyzed. It is demonstrated that the ordering of water molecules in the already existing crystal affects the freezing. On the basal plane, when the orientations of water molecules in the ice block are random, the arrangement of the new layer in a cubic manner is observed more frequently — approximately 1.7 times...
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Overcoming carboxylic acid inhibition by granular consortia in high-load liquefied food waste fermentation for efficient lactate accumulation
PublicationGranular sludge, a self-aggregating spherical biofilm, possesses better stability compared to flocculent sludge under extreme conditions. This study compared the ability of anaerobic granular sludge (AnGS) and flocculent waste activated sludge (WAS) to convert food waste (FW) into highly-valuable optically active lactic acid (LA), a central and versatile intermediate platform molecule. Different loadings (30–60 g volatile suspended...
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Carbonic anhydrase inhibitors. Synthesis, and molecular structure of novel series N-substituted N'-(2-arylmethylthio-4-chloro-5- methylbenzenesulfonyl)guanidines and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII
PublicationA series of novel N-substituted N'-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)guanidines 9 e41 have been synthesized and investigated as inhibitors of four isoforms of zinc enzyme carbonic anhydrase (CA.EC 4.2.1.1), that is the cytosolic CA I and II, and cancer-associated isozymes CA IX and XII. Against the human CA I investigated compounds showed KI in the range of 87e6506 nM, toward hCA II ranging from 7.8 to 4500 nM,...
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Introduction to MIP synthesis, characteristics and analytical application
PublicationOne of the trends in analytical chemistry is associated with designing and developing new types of sample preparation techniques, which might significantly increase the efficiency and selectivity of the analytes isolation or/and preconcentration process. One of the most widely employed solutions are selective sorption materials, defined as molecularly imprinted polymers (MIPs), as well as the sorbents with the molecular fingerprint....
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To meet or to connect? Face-to-face contacts vs ICT in cluster organisations
PublicationThe main purpose of the paper is to explore how cluster organisations (COs) take advantage of direct (F2F) and indirect (ICT) contacts in fulfilling their main roles. The paper addresses the research question: “How important are Information and Communication Technologies at each level of advancement of cluster cooperation?” The research was conducted in 2016 in four purposefully selected cluster organisations representing metal...
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The Use of Information and Communication Technologies in Cluster Organizations
PublicationThe purpose of the paper is to explore how cluster organizations (COs) take advantage of Information and Communication Technologies (ICT). The paper addresses the research question: “How do cluster organizations take advantage of ICT in fulfilling their main roles?”. The research was carried out in the first half of 2016 in four purposefully selected cluster organizations. The main research strategy involved Grounded Theory; the...
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The Cluster Organization. Analyzing the Development of Cooperative Relationships
PublicationCluster organizations are becoming more and more popular, both in developing and developed countries. Considering the development of cluster policy and the related dynamic growth of cluster initiatives in the world, the lack of sufficient knowledge on the development of cooperation in cluster organizations inhibits their development and, in many cases, causes their complete disintegration. The book provides new important elements...
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Gospodarka cyfrowa a lokalizacja: wpływ ICT na funkcjonowanie klastrów
PublicationCelem niniejszego artykułu jest zaprezentowanie głównych możliwości, związanych z zastosowaniem nowoczesnych ICT w klastrach. Dodatkowo autorzy rozważają potencjalne zagrożenia dla funkcjonowania gron w we współczesnej gospodarce cyfrowej.
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Proximity and the Cluster Organization
PublicationIncluding the category of proximity in theoretical considerations and empirical analyzes in cluster organizations is an attempt to integrate existing approaches to understand and explain the specificity of inter-organizational cooperation developed in geographical proximity. The importance of geographical proximity to create a competitive advantage is emphasized in all theories on the establishment and development of industrial...
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Relationships Between Geographical and Virtual Proximity in Cluster Organisations
PublicationThe purpose of the paper is to explore the relationships between geographical and virtual proximity in cluster organizations (COs). The authors report the findings of a qualitative study conducted in four COs in Poland. The basic technique for collecting and analyzing data was an in-depth individual interview and qualitative content analysis. The research has shown that the relationships between geographical and virtual proximity...
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Otwarte innowacje w inicjatywach klastrowych
PublicationSpecyfika funkcjonowania inicjatyw klastrowych czyni z nich idealne podłoże do wcielania w życie idei open innovation – ułatwiają bowiem nawiązywanie kontaktów z innymi podmiotami, stawiają na otwartość swoich członków i budowę relacji opartych na zaufaniu, stanowią platformę wymiany zasobów (w tym przede wszystkim informacji i wiedzy) oraz wspólnego kreowania rozwiązań innowacyjnych. W artykule podjęto rozważania teoretyczne dotyczące...
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Diphosphinoboranes as Intramolecular Frustrated Lewis Pairs: P–B–P Bond Systems for the Activation of Dihydrogen, Carbon Dioxide, and Phenyl Isocyanate
PublicationHerein, we present the first example of the activation of small molecules by P-B-P bond systems. The reactivity study involves reactions of two selected diphosphinoboranes, (tBu2P)2BPh (1’) and (Cy2P)2BNiPr2 (2), that differ in terms of their structural and electronic properties for the activation of dihydrogen, carbon dioxide, and phenyl isocyanate. Diphosphinoborane 1’ activates H2 under very mild conditions in the absence of...
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An Improved Genetic Algorithm for Island Route Planning
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Saccharides
PublicationSaccharides are widely distributed in nature as the major component of fruits and vegetables (primarily monosaccharides), milk and malt (mainly disaccharides), and grains (mostly polysaccharides). They are an important source of energy, structural material, as well as flavor and taste factors. Molecules of this class of compounds contain mainly carbon, hydrogen, and oxygen atoms; however, most natural saccha- rides do not have...
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Superconductivity–Electron Count Relationship in Heusler Phases─the Case of LiPd2Si
PublicationWe report superconductivity in the full Heusler compound LiPd2Si (space group Fm3̅m, No. 225) at a critical temperature of Tc = 1.3 K and a normalized heat capacity jump at Tc, ΔC/γTc = 1.1. The low-temperature isothermal magnetization curves imply type-I superconductivity, as previously observed in LiPd2Ge. We show, based on density functional theory calculations and using the molecular orbital theory approach, that while LiPd2Si...
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Thermophysical study of the binary mixtures of triethyl phosphate with N-methylformamide, N,N-dimethylformamide and N,N-dimethylacetamide – Experimental and theoretical approach
PublicationDensities at (293.15, 298.15, 303.15 and 308.15) K, and viscosities and ultrasonic velocities at 298.15 K of binary liquid mixtures of triethyl phosphate with N-methylformamide, N,N-dimethylformamide and N,N-dimethylacetamide have been measured over the entire range of composition at p = 0.1 MPa. From the experimental data, values of excess molar volume, excess isentropic compressibility, viscosity deviation and excess Gibbs energy...
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Analysis of different tillage implements with respect to reduced fuel consumption, tractor operating speed and its wheel slippage
PublicationNowadays the prices of agricultural farm produced products are increasing with ant-speed and the prices of input for raising crops are increasing with rocket-speed. Therefore, there is a dire need to conduct some important studies to innovate the techniques which can lower the costs of crop production. In this context, this study was conducted to evaluate the consumption of fuel at different tillage implements, tractor operating...
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Experimental and Theoretical Insights into the Intermolecular Interactions in Saturated Systems of Dapsone in Conventional and Deep Eutectic Solvents
PublicationSolubility is not only a crucial physicochemical property for laboratory practice but also provides valuable insight into the mechanism of saturated system organization, as a measure of the interplay between various intermolecular interactions. The importance of these data cannot be overstated, particularly when dealing with active pharmaceutical ingredients (APIs), such as dapsone. It is a commonly used anti-inflammatory and...
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Klaster, inicjatywa klastrowa, powiązanie kooperacyjne - rozróżnienie pojęć
PublicationCelem niniejszego artykułu jest przedstawienie i omówienie podstawowych terminów używa-nych w praktyce gospodarczej, związanych z koncepcją klastrów: "inicjatywy klastrowej" i "po-wiązania kooperacyjnego". Terminy powyższe wymagają - zdaniem autorów - ciągłych refleksji ze względu na nierzadkie, niewłaściwe ich stosowanie. Autorzy artykułu odwołują się do powyż-szych pojęć, przedstawiają ich definicje i starają się w precyzyjny,...
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Klastry i inicjatywy klastrowe w gospodarce
PublicationNiniejszy artykuł stanowi naukową refleksję nad doprecyzowaniem podstawowych pojęć z problematyki klasteringu. Autorzy dokonują prze-glądu i próby strukturyzacji najważniejszych podejść teoretycznych doty-czących gron oraz proponują ustalenie granic i warunków poprawnej używalności pojęć "klaster" i "inicjatywa klastrowa". Zdaniem autorów koncepcja klastra wymaga dopracowania teoretycznego, a przede wszyst-kim jednoznacznego określenia...
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Factors that strengthen and weaken the identity of the cluster structures
PublicationThe main aim of this paper is the application of "identity" to the issues related to "clustering process" and particularly - to the cooperation in the clusters and the cluster initiatives. The authors distinguish these factors that have the greatest influence on the formation and maintenance of identity in mentioned networks of cooperation.
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Analiza kapitałów jako narzędzie konkurencyjności przedsiębiorstw w klastrze
PublicationNiniejszy artykuł stanowi refleksję nad zagadnieniem konkurencyjności przedsiębiorstw, a ściśle - nad nowym sposobem analizy potencjału firmy, opartym w swych teoretycznych założeniach na teorii kapitałów Pierre'a Bourdieu. Autorzy proponują aplikację koncepcji kapitałów do działań skierowanych na wykonanie analiz potencjału przedsiębiorstw funkcjonujących w klastrach.
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THE SCIENTIFIC CAPACITY AS AN INNOVATION DETERMINANT OF THE POLISH REGIONS
PublicationEvery Polish region (in the paper understood as a voivodship) is an inspiring ground for comparative studies on the national as well as European scale, i.e. with regard to the administrative units of the other European countries. The aim of the article is to advance the conclusions concerning the Regional Innovation Scoreboard – a European instrument applied to examine the innovation capacity of European regions – with the issues...
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The Factors Affecting Group Identity of Cluster Structures
PublicationThe paper provides a new approach to cluster analysis, basing on a sociologically rooted concept of identity. The authors state that identity in cluster structures is formed by two main groups of factors – uncontrollable or slightly controllable factors (identity mix) and factors that can be fully controlled by a cluster initiative (corporate identity mix). It means that the cluster coordinator is able to consciously build the...
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Być czy mieć? Hierarchia kapitałów w wybranych przedsiębiorstwach ICT na Pomorzu
PublicationPrezentowany artykuł stanowi podsumowanie pierwszej, początkowej fazy konstruowania koncepcji wykorzystującej przekształconą teorię kapitałów Pierre’a Bourdieu w analizie działań przedsiębiorstw. Jej sednem jest podział dostępnych przedsiębiorstwom zasobów na cztery podstawowe typy odpowiadające wyróżnionym typom kapitału, a więc: kapitałowi ekonomicznemu, społecznemu, kulturowemu i symbolicznemu oraz założenie, zgodnie z którym...
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Kulturowe determinanty zarządzania przedsiębiorstwami klastrowymi
PublicationCelem prezentowanego artykułu jest próba określenia swoistego kulturowego profilu zarządzania specyficznym rodzajem organizacji, jaką jest tzw. przedsiębiorstwo klastrowe, czyli podmiot gospodarczy wchodzący w skład formalnie wyodrębnionej z otoczenia „nadorganizacji” (lub po prostu organizacji wyższego rzędu), za jaką uważana jest inicjatywa klastrowa.
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Old Problems - New Solutions: Conversion of Capitals as a Tool for Shaping the Competitive Position in the Economic Field
PublicationThe acts and operations any social actor effectuates in each of the logically distinguished spheres of reality are conditioned by many factors, among which a reliable analysis of the strengths and weaknesses of an agent should be considered of utmost importance. The concept of capitals presented in this article divides the quantity of resources available to all acting agents into four main categories (which allows for determining...
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Zarządzanie kapitałami w klastrach: kapitał społeczny, kulturowy, ekonomiczny i symboliczny w strukturach klastrowych
PublicationCelem pracy było zaprezentowanie i poddanie pod dyskusję teoretycznej koncepcji analizy przedsiębiorstw klastrowych z wykorzystaniem zmodyfikowanej teorii kapitałów, metodyki badań, zgodnie z którą przeprowadzono pierwszą, empiryczną aplikację tejże koncepcji do grupy przedsiębiorstw składających się na wybrane struktury klastrowe oraz wyników tych badań (wspartych analizą statystyczną) dających pewien obraz istniejących kategorii...
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Tożsamość struktur klastrowych- rozważania teoretyczne i praktyczne implikacje
PublicationCelem niniejszego artykułu jest próba zastosowania pojęcia „tożsamości” do analizy zjawisk i procesów związanych z powstawaniem i funkcjonowaniem klastrów oraz inicjatyw klastrowych. Struktury klastrowe stanowią formę grupy społecznej, dlatego winny podlegać tym samym tendencjom, pod których wpływem pozostają wszystkie inne grupy społeczne. Za jedną z takich najistotniejszych prawidłowości (bezpośrednio powiązanych z tożsamością)...
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Old Problems - New Solutions: Conversion of Capitals as a Tool for Shaping the Competitive Position in the Economic Field
PublicationThe acts and operations any social actor effectuates in each of the logically distinguished spheres of reality are conditioned by many factors, among which a reliable analysis of the strengths and weaknesses of an agent should be considered of utmost importance. The concept of capitals presented in this article divides the quantity of resources available to all acting agents into four main categories (which allows for determining...
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Collision-induced luminescence spectra of pyridine bombarded by 1000 eV He+ cations
PublicationHere we show collision-induced luminescence spectra measured for collisions of the He+cations with thearomatic six-membered ring of the pyridine molecule (C5H5N). Distinct emission bands due to the CH(A2Δ→X2Πr;B2Σ+→X2Πr;C2Σ+→X2Πr), CN(B2Σ+→X2Σ+), C2(d3Πg→a3Πu), and NH(A3Π→X3Σ−) transitions, aswell as atomic H, He, and C lines have been observed. Apart from the He atoms, all the emitters arise from thefragmentation of the pyridine...