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Search results for: TRANSCRIPTOME PROFILING
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The use of RP-HPLC–Q-TOF–MS as a powerful tool for wastewater composition profiling and selection of water pollution marker specific to wastewater contamination
PublicationLimited drinking water resources and water pollution are one of the main worldwide problems. To reduce the consumption of fresh water resources, the use of treated wastewater has been proposed. The farmlands have been irrigated with wastewater for centuries, but the composition of used sewage has changed over the years. Recent research has revealed the presence of hundreds of new organic contaminants in many environmental waters,...
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Tourism Infrastructure Providing Access to Areas of Protected Landscape and Nature in Poland. Selected Examples
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Current state of a dual behaviour of antimicrobial peptides-Therapeutic agents and promising delivery vectors
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Comprehensive two-dimensional gas chromatography - promising technique for analysis of complex food matrices
PublicationThe present paper is focused on brief description of operational principle of comprehensive two-dimensional gas chromatography (GC×GC) technique, instrumentation and data processing. Furthermore, the examples of application in the field of food analysis, performed also in the author's laboratory, are given. The detailed discussion of GC×GC characterization and comparison of the volatile composition of berries of different blue...
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An integrated e-learning services management system providing HD videoconferencing and CAA services
PublicationIn this paper we present a novel e-learning services management system, designed to provide highly modifiable platform for various e-learning tools, able to fulfill its function in any network connectivity conditions (including no connectivity scenario). The system can scale from very simple setup (adequate for servicing a single exercise) to a large, distributed solution fit to support an enterprise. Strictly modular architecture...
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By-Products from Food Industry as a Promising Alternative for the Conventional Fillers for Wood–Polymer Composites
PublicationThe present paper describes the application of two types of food-industry by-products, brewers’ spent grain (BSG), and coffee silverskin (ŁK) as promising alternatives for the conventional beech wood flour (WF) for wood–polymer composites. The main goal was to investigate the impact of partial and complete WF substitution by BSG and ŁK on the processing, structure, physicochemical, mechanical, and thermal properties of resulting...
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Ground tire rubber functionalization as a promising approach for the production of sustainable adsorbents of environmental pollutants
PublicationWaste tires management and further utilization are currently one of the biggest concerns regarding the environment and human health protection. At present, shredding, grinding, or pulverization of waste tires are the most popular options for industrial recycling. Although many solutions for ground tire rubber (GTR) applications were checked and verified so far, their further implementation at an industrial scale is still very limited....
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Inhibiting activity of HIV-1: protease, reverse transcriptase and integrase all together by novel compounds using computational approaches (flexible and rigid docking)
PublicationAcquired immunodeficiency syndrome (AIDS), caused by human immunodeficiency virus type 1 (HIV-1) infection, is one of the most challenging diseases in recent decades. Nevertheless the shortcomings of chemical drugs such as toxicity, lack of curative effects, the search for more potent anti-HIV agents have been focused in our study. In current study, novel scaffold was designed having a benzyl and imidazole in it which are very...
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f-Cycles - a new approach to providing fast service recovery at low backup capacity overhead
PublicationW artykule zaproponowano klasowy algorytm doboru tras przeżywalnych, wykorzystujący autorską koncepcję f-Cykli ochronnych. Celem podejścia było zminimializowanie wartości czasu odtwarzania uszkodzonych strumieni ruchu. Cel ten został osiągnięty poprzez dostosowanie wielkości obszaru ochrony w zależności od klasy usług. Badania symulacyjne pokazały, że wykorzystując autorką koncepcję f-Cykli ochronnych, możliwe jest również jednoczesne...
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A novel class-based protection algorithm providing fast service recovery in IP/WDM networks
PublicationW artykule rozważa się warstwową strukturę sieci IP-MPLS/WDM. Węzły sieci mają funkcjonalność zarówno optycznych krotnic transferowych (OXC), jak i routerów IP. Dowolne dwa routery IP mogą być ze sobą połączone poprzez logiczne łącze IP realizowane przez ścieżkę optyczną WDM. Zaproponowano metodę klasową doboru tras przeżywalnych zapewniającą szybkie odtwarzanie uszkodzonych strumieni ruchu zarówno w warstwie WDM jak i IP-MPLS....
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Mucoadhesive Chitosan Delivery System with Chelidonii Herba Lyophilized Extract as a Promising Strategy for Vaginitis Treatment
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Bio-mitigation of organic pollutants using horseradish peroxidase as a promising biocatalytic platform for environmental sustainability
PublicationA wide array of environmental pollutants is often generated and released into the ecosystem from industrial and human activities. Antibiotics, phenolic compounds, hydroquinone, industrial dyes, and Endocrine-Disrupting Chemicals (EDCs) are prevalent pollutants in water matrices. To promote environmental sustainability and minimize the impact of these pollutants, it is essential to eliminate such contaminants. Although there are...
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Photosensitive and pH-dependent activity of pyrazine-functionalized carbazole derivative as promising antifungal and imaging agent
PublicationCarbazole skeleton plays a significant role as a structural scaffold of many pharmacologically active compounds. Pyrazine-functionalized carbazole derivative was constructed by coupling 2-amino-5-bromo-3-methylaminepyrazine (ABMAP) into 3 and 6 positions of the carbazole ring. Multi-experimental methods were used, e.g., potentiometric, spectroscopic (ATR, UV, XRD powder,1H and13C NMR), electrochemical (cyclic voltammetry), and...
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When Neural Networks Meet Decisional DNA: A Promising New Perspective for Knowledge Representation and Sharing
PublicationABSTRACT In this article, we introduce a novel concept combining neural network technology and Decisional DNA for knowledge representation and sharing. Instead of using traditional machine learning and knowledge discovery methods, this approach explores the way of knowledge extraction through deep learning processes based on a domain’s past decisional events captured by Decisional DNA. We compare our approach with kNN (k-nearest...
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Blue-berried honeysuckle a promising cancer preventing fruit; Polish genotypes as a source of bioactive phytochemicals
PublicationFrom the ancient times, plants containing health-oriented compounds in their matrices are used in the treatment of different complaints and diseases. One of these groups are plant secondary metabolites (PSM), especially phenolic compounds, terpenes and terpenoids. A large number of PSM exhibit cytotoxicity against a variety of tumor cells, as well as cancer preventive and anticancer efficacy in preclinical animal models. For this...
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Providing Public Space Continuities in Post-Industrial Areas through Remodelling Land/Water Connections
PublicationThis article examines the problem of urban transformation strategies applied in recent years which are based on the creation of new water areas and modification of existing ones. The research is an attempt to prove that modifications of plans of water areas and forms of their borders may play an important role in achieving the best quality public spaces in post-industrial territories. The basis for demonstrating the importance...
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Łączna kalibracja profili poborów wody i parametrów modelu systemu wodociągowego
PublicationW artykule przedstawiono propozycję etapowego podejścia do kalibracji modeli systemów wodociągowych (SW). Zaprezentowana metoda kalibracji, w odróżnieniu od dotychczas proponowanych, oparta jest na wyznaczeniu profili poboru wody oraz rezystancji połączeń w postaci przedziałowej. Problem kalibracji został sformułowany w postaci zagadnień programowania liniowego mieszanego, co gwarantuje uzyskanie globalnych rozwiązań optymalnych....
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Klasyfikator rozmyty użyteczny we wstępnym doborze profili łopatkowych turbin parowych
PublicationW artykule przedstawiona została próba stworzenia wstępnego modelu klasyfikatora rozmytego użytecnego we wstępnym doborze profili łopatkowych turbin parowych. Dobór odpowiedniego rozwiązania dokonywany jest na podstawie parametrów przepływu czynnika przez wieńce turbiny. Tego typu narzędzie decyzyjne może okazać się przydatne zarówno w przypadku modernizacji istniejących już obiektów, w których zdiagnozowane uszkodzenia wymuszają...
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“Biological Adhesion” is a Significantly Regulated Molecular Process during Long-Term Primary In Vitro Culture of Oviductal Epithelial Cells (Oecs): A Transcriptomic and Proteomic Study
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Discovery of small-molecule regenerative drugs using a model of complex tissue injury in mice. Transcriptomic responses of neurodevelopmental genes during pharmacologically induced regeneration
PublicationDespite significant development in regenerative medicine, there is a deficit of effective therapies for wound healing and tissue regeneration. Research performed using animal wound models allows for a better understanding of this complex process, searching for compounds with pro-regenerative properties, and assessing their efficacy and safety. Unfortunately, the lack of adequate preclinical models proves to be an issue as no animal...
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Tiliroside Combined with Anti-MUC1 Monoclonal Antibody as Promising Anti-Cancer Strategy in AGS Cancer Cells
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Novel Quaternary TlGaSn2Se6 Single Crystal as Promising Material for Laser Operated Infrared Nonlinear Optical Modulators
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In vitro and in vivo evaluation of sandwich-like mesoporous silica nanoflakes as promising anticancer drug delivery system
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Promising Nanoparticle-Based Heat Transfer Fluids—Environmental and Techno-Economic Analysis Compared to Conventional Fluids
PublicationProviding optimal operating conditions is one of the major challenges for effective heating or cooling systems. Moreover, proper adjustment of the heat transfer fluid is also important from the viewpoint of the correct operation, maintenance, and cost efficiency of these systems. Therefore, in this paper, a detailed review of recent work on the subject of conventional and novel heat transfer fluid applications is presented. Particular...
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Meconium analysis as a promising diagnostic tool for monitoring fetal exposure to toxic substances: Recent trends and perspectives
PublicationPrenatal exposure to toxic substances is an important public health problem. Many biological specimens obtained from the fetus or mother are used for biomonitoring. Each material reflects exposure in a specific time period and has different advantages and disadvantages in terms of accuracy, time window of detection and cost/benefit ratio. Recently, meconium has become the matrix of choice in toxicology screening for detecting exposure...
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Effects of dispersion on predicting longitudinal concentration profiles in activated sludge reactors
PublicationW pracy przedstawiono wpływ dyspersji na prognozowanie stężeń azotu amonowego w komorach osadu czynnego w oczyszczalni ścieków Gdańsk-Wschód. W tym celu wykorzystano jednowymiarowe równanie adwekcji-dyspersji z członem źródłowym (szybkością nitryfikacji). Współczynnik dyspersji został wyznaczony na podstawie pomiarów znacznika fluoroscencyjnego. Model został zweryfikowany w oparciu o pomiary stężeń azotu w 6 sekcjach komory tlenowej...
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Genes involved in angiogenesis and circulatory system development are differentially expressed in porcine epithelial oviductal cells during long-term primary in vitro culture – a transcriptomic study
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Co-free triple perovskite La1.5Ba1.5Cu3O7±δ as a promising air electrode material for solid oxide fuel cells
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INTER-LAYER SHARING OF BACKUP PATH CAPACITIES PROVIDING FAST SERVICE RECOVERY IN IP-MPLS/WDM NETWORKS
PublicationIn this paper, we investigate the issue of providing the transmission continuity in IP-MPLS/WDM networks in the presence of failures of nodes/links. Special focus is put on assuring fast restoration of flows affected after a failure in a scenario assuming sharing the backup path capacities in order to decrease the overall bandwidth consumption. In particular, we propose a new approach to inter-layer sharing of link capacity reserved...
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A new approach to inter-layer sharing providing differentiated protection services in survivable IP-MPLS/WDM networks
PublicationArtykuł omawia zagadnienie ochrony transmisji o charakterze połączeniowym w sieciach wielowarstwowych IP-MPLS/WDM. W szczególności prezentuje nową metodę współdzielenia międzywarstwowego zasobów ścieżek zabezpieczających gwarantującą szybkie odtwarzanie uszkodzonych połączeń (nawet o 40% szybciej w porównaniu z powszechnie stosowaną metodą).
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Recent progress in the development of steroid sulfatase inhibitors – examples of the novel and most promising compounds from the last decade
PublicationThe purpose of this review article is to provide an overview of recent achievements in the synthesis of novel steroid sulfatase (STS) inhibitors. STS is a crucial enzyme in the biosynthesis of active hormones (including estrogens and androgens) and, therefore, represents an extremely attractive molecular target for the development of hormone-dependent cancer therapies. The inhibition of STS may effectively reduce the availability...
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AOP173 key event associated pathway predictor – online application for the prediction of benchmark dose lower bound (BMDLs) of a transcriptomic pathway involved in MWCNTs-induced lung fibrosis
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Salinity enhances high optically active L-lactate production from co-fermentation of food waste and waste activated sludge: Unveiling the response of microbial community shift and functional profiling
PublicationLactic acid (LA), a versatile platform molecule, can be fermented from organic wastes, such as food waste and waste activated sludge. In this study, an efficient approach using salt, a component of food waste as an additive, was proposed to increase LA production. The LA productivity was increased at 10 g NaCl/L and optical pure L-lactate was obtained at 30 g NaCl/L. The enhancement of LA was in accordance with the increased solubilization...
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Diazepinoporphyrazines Containing Peripheral Styryl Substituents and Their Promising Nanomolar Photodynamic Activity against Oral Cancer Cells in Liposomal Formulations
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In vitro studies of antimicrobial activity of Gly-His-Lys conjugates as potential and promising candidates for therapeutics in skin and tissue infections
PublicationWe presented in vitro studies of antimicrobial activity of Gly-His-Lys conjugates that are important point in preliminary biological evaluation of their potential application in skin and tissue therapy. The novel compounds include the conjugation of fatty acids with a modification of the amino acid sequence in the primary structure of Gly-His-Lys.
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Facile synthesis and characterization of graphene and N-doped graphene by CVD method from liquid precursors for promising electrode materials
PublicationIn this study, high-quality and few-layered graphene was synthesized using the chemical vapor deposition (CVD) method from liquid sources. Two different liquid carbon sources, pyridine, and benzene, were used and deposited on nickel foam under heat conditions using a bubbler in a quartz tube. X-ray diffraction (XRD) and Raman analysis confirmed the crystalline properties of graphene and N-doped graphene, demonstrating the high...
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Whether Carbon Nanotubes Are Capable, Promising, and Safe for Their Application in Nervous System Regeneration. Some Critical Remarks and Research Strategies
PublicationCarbon nanotubes are applied in or considered for different fields of medicine. Among them is the regeneration or rebuilding of nervous system components, which still lack substantial progress; this field is supported by carbon nanotubes to a great extent as the principal material. The limited research on this issue has involved PU/silk/MWCNTs, PCL/silk/MWCNTs, PCL/PGS/CNTs, chitin/CNTs, PGF/CNTs, CNTs/PGFs/PLDLA,MWCNTs chitosan,MWCNTs/PPy,...
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Effects of different hydraulic models on predicting longitudinal profiles of reactive pollutants in activated sludge reactors
PublicationW pracy przedstawiono wpływ dyspersji na prognozowanie stężeń azotu amonowego w komorach osadu czynnego w oczyszczalni ścieków Gdańsk-Wschód. W tym celu wykorzystano jednowymiarowe równanie adwekcji-dyspersji z członem źródłowym (szybkością nitryfikacji). Współczynnik dyspersji został wyznaczony na podstawie pomiarów znacznika fluoroscencyjnego. Model został zweryfikowany w oparciu o pomiary stężeń azotu w 6 sekcjach komory tlenowej...
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Dobór parametrów pomiaru cyfrowego profili i jego następstwa w analizie amplitudowo-częstotliwościowej nierówności powierzchni
PublicationAnaliza pomiaru cyfrowych nierówności profili jest złożonym problemem interdyscyplinarnym, którego parametry powinny uwzględniać ich charakter i cele postawione dla badanych nierówności powierzchni. Normatywne wysokościowe ujęcia nierówności oraz długościowe, punktowe i inne parametry nie oddają jednoznacznie cech powierzchni, dlatego też poznawcze i badawcze analizy profili powinny być prowadzone funkcjami amplitudowo-częstotliwościowymi...
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Promising Photocytotoxicity of Water-Soluble Phtalocyanine against Planktonic and Biofilm Pseudomonas aeruginosa Isolates from Lower Respiratory Tract and Chronic Wounds
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New Molecular Markers Involved in Regulation of Ovarian Granulosa Cell Morphogenesis, Development and Differentiation during Short-Term Primary In Vitro Culture—Transcriptomic and Histochemical Study Based on Ovaries and Individual Separated Follicles
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Could spray-dried microbeads with chitosan glutamate be considered as promising vaginal microbicide carriers? The effect of process variables on the in vitro functional and physicochemical characteristics
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Promising effects of xanthine oxidase inhibition by allopurinol on autonomic heart regulation estimated by heart rate variability (HRV) analysis in rats exposed to hypoxia and hyperoxia
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Porównanie wyników datowania metodami luminescencji (TL i OSL) próbek z wybranych profili lessowych Polski SE i Ukrainy NW
PublicationPrzeprowadzono datowanie dla wybranych pięciu profili lessowych, trzy pochodziły z Polski a dwa z Ukrainy. Datowaniu podlegało 89 próbek, przeprowadzono je metodami TL i OSL. W pracy zostały przedstawione statystyczne relacje między wspomnianymi metodami oraz między profilami glebowymi występującymi w danych okresach geologicznych.
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In silico design of telomerase inhibitors.
PublicationTelomerase is a reverse transcriptase enzyme involved in DNA synthesis at the end of linear chromosomes. Unlike in most other cells, telomerase is reactivated most cancerous cells and, therefore, has become a promising new anticancer target. Despite extensive research, direct telomerase inhibitors have yet not been introduced to the clinics because of the complexity of this enzyme. Structures of this protein from simple organisms...
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Opinia o innowacyjności w odniesieniu do planowanego efektu prac badawczo – rozwojowych nad nowymi rodzajami profili ciężkich wraz z akcesoriami komplementarnymi
PublicationOpinia o innowacyjności w odniesieniu do planowanego efektu prac badawczo – rozwojowych nad nowymi rodzajami profili ciężkich wraz z akcesoriami komplementarnymi. Opinia związana z wystąpieniem o środki na dofinansowanie innowacyjnej technologii produkcji. Mocowania, pomosty, belki, konstrukcje skręcane.
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Regulacja epigenetyczna a potencjał regeneracyjny ssaków. Badania globalnych profili metylacji w tkankach dorosłej myszy MRL/MpJ i w sercach noworodków myszy C57BL/6J.
PublicationW pracy tej otrzymano genomowe profile metylacji DNA dla dwóch modeli regeneracji u ssaków: (i) dorosłej myszy MRL/MpJ, która jest zdolna do zamykania otworów w małżowinie usznej oraz wykazuje podwyższone zdolności regeneracyjne w wielu innych narządach oraz (ii) sercach noworodków myszy, u których zachodzi regeneracja rozległych uszkodzeń lewej komory serca. Zidentyfikowano szereg odmiennie metylowanych regionów DNA, regionów DMR,...
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Anticancer Imidazoacridinone C-1311 is Effective in Androgen-Dependent and Androgen-Independent Prostate Cancer Cells
PublicationAndrogen receptor (AR) plays a crutial role in prostate cancer (PCa) development and metastasis. Here, we reported potent anti-PCa activity of a small molecule imidazoacridinone C-1311. In AR-positive PCa cells, C-1311 was found to inhibit the transcriptional activity of AR uncovering a novel mechanism that may be relevant for its anticancer effect. Mechanistically, C-1311 decreased AR binding to prostate-specific antigen (PSA)...
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Changes in gene methylation patterns in neonatal murine hearts: Implications for the regenerative potential
PublicationBackground The neonatal murine heart is able to regenerate after severe injury; this capacity however, quickly diminishes and it is lost within the first week of life. DNA methylation is an epigenetic mechanism which plays a crucial role in development and gene expression regulation. Under investigation here are the changes in DNA methylation and gene expression patterns which accompany the loss of regenerative potential. Results The...
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Projektowanie profili maszyn wirnikowych przy zastosowaniu kryterium mini- mum dyssypacji.**2002, 122 s. 126 rys. 2 tab. bibliogr. 35 poz. maszyn. Rozprawa doktorska /2002.06.25/. PG, Wydz. Mechaniczny. Promotor: Prof. dr hab. inż. R. Puzyrewski.
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