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Search results for: COMMON CARP
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Determination of BRAF V600E (VE1) protein expression and BRAF gene mutation status in codon 600 in borderline and low-grade ovarian cancers
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Chemopreventive activity of bioactive fungal fractions isolated from milk-supplemented cultures of Cerrena unicolor and Pycnoporus sanguineus on colon cancer cells
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The induction of autophagy in human colon wt p53 and p53-null HCT116 cells by 4-methyl-1-nitroacridine derivative C-1748
PublicationPrzeprowadzone badania miały na celu określenie zdolności pochodnej 4-metylo-1-nitroakrydyny C-1748 do uruchomienia autofagii komórek ludzkiego raka okrężnicy HCT116 posiadających dziki gen p53 oraz podlinii nie posiadającej tego genu. Wszystkie eksperymenty przeprowadzone zostały przy stężeniu hamującym proliferację komórek nowotworowych w 90%. Wykazano, że indukowana przez C-1748 autofagia w komórkach raka okrężnicy jest zależna...
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Cellular Effects of Selected Unsymmetrical Bisacridines on the Multicellular Tumor Spheroids of HCT116 Colon and A549 Lung Cancer Cells in Comparison to Monolayer Cultures
PublicationMulticellular tumor spheroids are a good tool for testing new anticancer drugs, including those that may target cancer stem cells (CSCs), which are responsible for cancer progression, metastasis, and recurrence. Therefore, we applied this model in our studies of highly active antitumor unsymmetrical bisacridines (UAs). We investigated the cellular response induced by UAs in 2D and 3D cultures of HCT116 colon and A549 lung cancer...
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Authors’ response to Dr Finsterer's comment “Exclude differentials before diagnosing SARS-CoV-2-associated acute hemorrhagic necrotizing encephalitis” (THEIJID-D-22-00008)
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Imidazoacridinone derivative C-1311 (SymadexTM) induces apoptosis, mitotic catastrophe or senescence in human colon carcinoma HCT116 cells depending on p53 status
PublicationPrzeprowadziliśmy badania zmierzające do wyjaśnienia odpowiedzi komórek ludzkiego raka jelita grubego HCT116 traktowanych C-1311 w zależności od statusu białka p53. Wykazaliśmy, że pochodna imidazoakrydonu C-1311 w stężeniach biologicznie istotnych indukuje przejściowy blok w fazie G2M komórek HCT116 p53-/- oraz blok w fazie G1 i G2M komórek HCT116 p53+/+. W komórkach z niefunkcjonalnym białkiem p53 imidazoakrydon indukował katastrofę...
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Pro-apoptotic action of protein-carbohydrate fraction isolated from coelomic fluid of the earthworm Dendrobaena veneta against human colon adenocarcinoma cells
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The cellular response of human colon carcinoma HCT116 cells to 4-methyl-1-nitroacridine derivative C-1748 treatment depending on p53 status
PublicationWykazano, że pochodna C-1748 indukuje apoptozę w komórkach linii ludzkich raków jelita grubego HCT116 p53+/+ i p53-/- w sposób zależny od czasu inkubacji i stężenia związku. Wskazują na to: pojawienie się frakcji komórek sub-G1, charakterystyczne zmiany w morfologii jąder komórkowych, zmiany w strukturze błony plazmatycznej. Ponadto, pod wpływem badanego związku komórki HCT116 p53+/+ wykazują większą podatność do ulegania apoptozie...
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Improved cytotoxicity and preserved level of cell death induced in colon cancer cells by doxorubicin after its conjugation with iron-oxide magnetic nanoparticles
PublicationA promising strategy for overcoming the problem of limited efficacy in antitumor drug delivery and in drug release is the use of a nanoparticle-conjugated drug. Doxorubicin (Dox) anticancer chemotherapeutics has been widely studied in this respect, because of severe cardiotoxic side effects. Here, we investigated the cytotoxic effects, the uptake process, the changes in cell cycle progression and the cell death processes in the...
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Sklepy typu pop-up – od Guerilla Stores marki Comme de Garcons przez unikalne doświadczenie zakupowe Bikini Berlin do ... ?
PublicationObiekty, sklepy typu pop- up pojawiały się w miastach ponad dziesięć lat temu. Otwierane są na krótki okres czasu w celu promocji marki i nawiązania bezp o- średniego kontaktu z odbiorcą. Pop -up’y różnią się od tradycyjnych, stacjona r- nych sklepów rodzajem prowadzonej w nich działalności, mającym na celu przede wszystkim promocję marki. Pierwsze tymczasowe obiekty, tzw. Guerilla stores , stworzone zostały w 2004 roku...
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Does the community-based combined Meeting Center Support Programme (MCSP) make the pathway to day-care activities easier for people living with dementia? A comparison before and after implementation of MCSP in three European countries
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Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints
PublicationOur previous studies have shown that murine fibroblast cells, in which PARP-1 gene was inactivated by gene disruption, are extremely sensitive to triazoloacridone compound C-1305, an inhibitor of DNA topoisomerase II with unusual properties. Here, we show that pharmacological inhibition of PARP-1 activity by its inhibitor compound NU1025, sensitizes human cervical carcinoma HeLa cells to compound C-1305 compared to treatment with...
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Metodologia badania zaworów hamulcowych
PublicationArtykuł opisuje metodologię statycznego i dynamicznego badania zaworów hamulcowych. Stanowisko badawcze zaprojektowano i zbudowano na Politechnice Gdańskiej jako część projektu badawczo-rozwojowego pt.: „Zaprojektowanie i zbadanie innowacyjnych podsystemów ładowarek kołowych firmy Hydro-Metal”, dofinansowanego przez PARP w ramach programu „Bon na innowacje”. Ponadto przedstawiono szczegóły konstrukcyjne i funkcje najczęściej spotykanych zaworów...
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Antitumor potential of new low molecular weight antioxidative preparations from the white rot fungus Cerrena unicolor against human colon cancer cells
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Reply to “Comment on ‘Crystal Structure Prediction by Global Optimization as a Tool for Evaluating Potentials: Role of the Dipole Moment Correction Term in Successful Predictions'” by B. P. van Eijck and J. Kroon
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Pain assessment and management in children in the postoperative period: A review of the most commonly used postoperative pain assessment tools, new diagnostic methods and the latest guidelines for postoperative pain therapy in children
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Selected Aspects of Pavement Texture Influence on Tire Rolling Resistance
PublicationTire rolling resistance has a significant influence on fuel consumption in cars and trucks and on CO2 emissions. Rolling resistance depends on the tire construction, pavement texture and stiffness, as well as environmental and traffic conditions. This article presents a pilot study on the impact of pavement texture on the rolling resistance of passenger car tires. Reasons why Mean Profile Depth is not a good descriptor of pavement...
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Generalized access control in hierarchical computer network
PublicationThe paper presents the design of the security layer for a distributed system located in the multizone hierarchical computer network. Depending on the zone from which a client’s request comes to the system and the type of the request, it will be either authorized or rejected. There is one common layer for the access to all the business services and interactions between them. Unlike the commonly used RBAC model, this system enforces...
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The relationship between 8-oxo-7,8-dihydro-2′-deoxyguanosine level and extent of cytosine methylation in leukocytes DNA of healthy subjects and in patients with colon adenomas and carcinomas
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4-methyl-1-nitroacridine derivative C-1748 induces apoptosis, mitotic catastrophe or senescence in human colon carcinoma HCT116 cells depending on p53 status
PublicationPrzeprowadzone badania miały na celu określenie zdolności pochodnej 4-metylo-1-nitroakrydyny C-1748 do uruchomienia apoptozy, katastrofy mitotycznej lub procesu starzenia komórek ludzkiego raka okrężnicy HCT116 posiadających dziki gen p53 oraz podlinii nie posiadającej tego genu. Wykazano, że pochodna C-1748 indukuje apoptozę w komórkach obu linii HCT116 w sposób zależny od czasu inkubacji, przy czym komórki HCT116 p53+/+ wykazują...
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Wpływ kierowcy na opór toczenia samochodu
PublicationW pracy omówiono wpływ zachowań kierowcy na opory toczenia pojazdu w ruchu drogowym. Można tu wyróżnić styl jazdy kierowcy oraz jego dbałość o pojazd. Przedstawiono wzrost oporu toczenia w aspekcie dynamicznego przyspieszania oraz szybkiej jazdy na zakręcie. Przeanalizowano także wpływ na opór toczenia takich czynników jak: ciśnienie w ogumieniu obciążenie promieniowe, zbieżność kół jezdnych samochodu oraz zużycie ogumienia.
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Zespół wypalenia zawodowego i zmęczenie w kontekście pracy zmianowej i stresu zawodowego wśród pielęgniarek chirurgicznych
PublicationTwo aspects of work-related consequences among surgery nurses are discussed: burnout syndrome and fatigue, having an impact on the quality of medical care and safety of patients. Siegrist's effort-reward imbalance model has been adopted as a concept of occupational stress. The organization of working time, i.e. the length of shifts and their rotation, was considered. Nurses on twelve-hour shifts worked much harder, were more tired...
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Computer Aided Telediagnostics System for Stoma Patients
PublicationStoma surgery may concern patients with colorectal cancer and inflammatory bowel disease. More than half of patients diagnosed with colon cancer present at an advanced stage, and palliative treatment may involve stoma formation. This type of surgery may change the patient’s life strongly, therefore they should receive special medical care. The paper presents the assumptions, concept, and architecture of the Stoma-Alert diagnosis...
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The idea of the heat storage in heat accumulator for car engine preheating before start = Koncepcja wykorzystania ciepła zakumulowanego w cieczy chłodzącej do wstępnego podgrzania silnika samochodu przed kolejnym rozruchem
PublicationSposób eksploatacji samochodów osobowych w miastach charakteryzuje się krótkimi przejazdami, a w przypadku pojazdów kurierów i pojazdów dostawczych również krótkimi postojami z zatrzymaniem silnika. Nowoczesne układy chłodzenia z pompą cieczy chłodzącej z napędem niezależnym od silnika stwarzają możliwość schładzania lub podgrzewania silnika zatrzymanego. Wpływ stanu cieplnego podczas rozruchu na parametry eksploatacyjne był rozważany...
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Mechanical properties of polyester reinforced PVC coated fabric subjected to biaxial loading of creep type
PublicationThe goal of the current study is to analyze the basic mechanical properties of the architec-tural fabric VALMEX, which is a composite material built of reinforcing polyester thread families and both sides PVC coated. The material was firstly subjected to biaxial loading of creep type for about 48 hours. The stress levels of the creep loading in two main or-thogonal directions of the fabric (commonly called the warp and fill directions)...
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The exposure to UV filters: Prevalence, effects, possible molecular mechanisms of action and interactions within mixtures
PublicationSubstances that can absorb sunlight and harmful UV radiation such as organic UV filters are widely used in cosmetics and other personal care products. Since humans use a wide variety of chemicals for multiple purposes it is common for UV filters to co-occur with other substances either in human originating specimens or in the environment. There is increasing interest in understanding such co-occurrence in form of potential synergy, antagonist,...
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Phage therapy as a novel strategy in the treatment of urinary tract infections caused by E. coli
PublicationUrinary tract infections (UTIs) are regarded as one of the most common bacterial infections affecting millions of people, in all age groups, annually in the world. The major causative agent of complicated and uncomplicated UTIs are uropathogenic E. coli strains (UPECs). Huge problems with infections of this type are their chronicity and periodic recurrences. Other disadvantages that are associated with UTIs are accompanying complications...
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INFLUENCE OF TEMPERATURE ON THE TYRE ROLLING RESISTANCE
PublicationTemperature is a very important factor controlling rolling resistance of road vehicle tyres. There are at least three different temperatures that may be considered as important factors controlling thermal conditions of the rolling tyre. The most common measure of the thermal conditions during tyre rolling is ambient air temperature. The other two are: pavement temperature and “tyre” temperature. Tyre temperature is the most difficult...
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The influence of small amount of substances present in tissue on the optical spectrum of immunosuppressive drug
PublicationIn this paper, we describe how commonly present in tissue substances - sodium chloride and glucose - affect the optical spectrum of an immunosuppressive drug (Cyclaid® by Apotex). Prepared samples were investigated using the spectrophotometer in the spectrum range from 250 nm to 1100 nm. The maximum wavelength shift calculated on the basis of measurement results is not bigger than the measurement wavelength step. So, it can be...
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Review of intelligent software architectures for the development of an intelligent decision support system for design process planning in concurrent engineering
PublicationW artykule poddano dogłębnej analizie szereg inteligentnych technik miękkie-go modelowania pod katem ich przydatności w obszarze wspomagania procesówplanowania dla inżynierii współzadaniowej. Skoncentrowano się na wspomaganiujednego z najważniejszych obszarów inżynierii współzadaniowej, a mianowicieprocesu projektowania. W wyniku analizy zaproponowano architekturę wspomaga-nia opartą na tablicowej bazie wiedzy modelującej wnioskowanie...
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Segmentation of academic community for the purposes of mobility plan development – case study of Gdansk University of Technology
PublicationThe objective of the paper is to analyse the structure of academic community for its transport behaviour and attitudes using the example of the Gdansk University of Technology (the GUT) in Poland. Once understood, the group can be divided into homogenous sub-groups and studied for their potential and ways to influence their behaviour, attitudes and transport patterns. The results may be used to develop dedicated actions designed...
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The problem of infections associated with implants – an overview
PublicationImplant-associated infections are serious and relatively common complication that leads to implant loss. The purpose of this paper is to gather knowledge about this issue. A literature review of the epidemiology, risk factors and pathogenesis of infections related to implants was carried out. This position collects data on commonly used implants and infections associated with them from various fields of medicine and contains classifications...
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Panax quinquefolium L. Ginsenosides from Hairy Root Cultures and Their Clones Exert Cytotoxic, Genotoxic and Pro-Apoptotic Activity towards Human Colon Adenocarcinoma Cell Line Caco-2
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The Efficiency of Post‐Communist Countries’ Health Systems
PublicationHealth‐care costs are a major financial burden for the transition economies, which have experienced rapidly increasing demand for health‐care services. The former communist countries of the Central and Eastern Europe and Central Asia needed to reform the financing of their health‐care systems and make efforts to strengthen the role of primary care while limiting the role of hospital care. The growing health needs and, consequently,...
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Landscape as the tool of coherence in the land management of rural communes
PublicationEconomic and social transformation of rural areas in Poland after 1990 reveals itself through disintegration of previous spatial order. Building a new pattern requires a vision, which would counteract complex causes of disintegration. The latter belong to institutional domain of planning strategies and the area of common practices. Therefore, agreement on aims and means between spatial policy strategies and tactics of space users...
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Spectral Methods for Modelling of Wave Propagation in Structures in Terms of Damage Detection—A Review
PublicationModern methods of detection and identification of structural damage direct the activities of scientific groups towards the improvement of diagnostic methods using for example the phenomenon of mechanical wave propagation. Damage detection methods that use mechanical wave propagation in structural components are extremely effective. Many different numerical approaches are used to model this phenomenon, but, due to their universal...
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Pedestrian detection in low-resolution thermal images
PublicationOver one million people die in car accidents worldwide each year. A solution that will be able to reduce situations in which pedestrian safety is at risk has been sought for a long time. One of the techniques for detecting pedestrians on the road is the use of artificial intelligence in connection with thermal imaging. The purpose of this work was to design a system to assist the safety of people and car intelligence with the use...
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Organizacja systemu opieki nad seniorami wyzwaniem dla samorządów lokalnych
PublicationA significant part of the activities undertaken so far under the senior policy, also at the local level, have been focused on seniors’ social (physical and educational) activation. The growing number of the oldest seniors, with limited independence, living alone in single‑person households, away from their families, will force the policy priorities to be reoriented in such a way as to develop efforts to provide different types...
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Tire/Road Noise On Poroelastic Road Surfaces - Results Of Laboratory Measurements
PublicationTire/road noise is the most important part of traffic noise for medium and high speed driving both in the case of passenger cars and trucks. The potential to make modification of tires that significantly reduce tire/road noise in nearly over, at least for conventional tires so the only promising action is to improve road pavements. One of the innovative solutions is poroelastic road pavement (PERS) that reduces airflow related...
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Multiresidue Methods for Determination of Currently Used Pesticides in Fruits and Vegetables Using QuECHERS Technique
PublicationApplied all over the world, pesticides are some of the most common pollutants of the environment because of their stability, mobility, their consequent long-term adverse effects on living organisms in general and human health in particular. For these reasons it is essential to monitor and analyse pesticide residues in the fruits and vegetables. The analysis of food samples for the presence of pesticides causes a lot of difficulties...
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Comprehensive two dimensional gas chromatography coupled with mass spectrometry as tool for characterization of the main pollutants present in atmospheric air in Gdansk
PublicationNowadays, the technique that is commonly used to identify and quantify the chemical compounds in gas sample is gas chromatography. The separation resolution in gas chromatography can be improved by applying the modulation technique. In this paper present is the most important information regarding the pollutants present in atmospheric air. The areas in which the tests were carried out are one of the largest industrial zones in...
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Noise Generated by Tyres Designet for Electric Vehicles - Results of Laboratory Experiments
PublicationA few years ago, electric and hybrid vehicles were rarely seen on public roads and were considered more as exotic curiosities or even as a sign of extravagance than a practical means of transport. Nowadays the situation has changes significantly. This was caused both by the technical development and legislative actions, as well as the organizational nature promoting the purchace and use of low emission vehicles. Electric vehicles...
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Building Confidence and Trust in Ireland's National Maternity Services Workforce –What matters most and how?
PublicationNational surveys on care experiences are increasingly adopted as regulatory mechanisms for improving care quality and increasing public trust in healthcare services. Based on data collected as part of Ireland's 2020 National Maternity Experience Survey, this study investigates care-related factors that contribute most to confidence and trust in the professional workforce (or carers) within Irish maternity services. The survey covered...
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Information Extraction from Polish Radiology Reports using Language Models
PublicationRadiology reports are vital elements of directing patient care. They are usually delivered in free text form, which makes them prone to errors, such as omission in reporting radiological findings and using difficult-to-comprehend mental shortcuts. Although structured reporting is the recommended method, its adoption continues to be limited. Radiologists find structured reports too limiting and burdensome. In this paper, we propose...
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LOW NOISE TIRES FOR HYBRID AND ELECTRIC VEHICLES
PublicationLow Emission Vehicles that are hybrid and electric cars may benefit from specially designed tires that are optimized for driving conditions typical for such vehicles. It is possible that in the future Low Emission Vehicles, especially passenger cars, will substitute conventional vehicles in all applications, however for the time being they are mostly used in urban and suburban areas. Urban traffic has a rather low demand for grip...
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Integrating heterogeneous systems with high-dependability requirements by means of web services
PublicationWeb services are commonly used on boundaries of heterogeneous components in Service Oriented Architecture (SOA) as they provide a universal communication channel not bound to any particular programming language or run-time platform. This paper describes how web services can be used to integrate heterogeneous systems which serve purposes requiring high dependability, reliability and availability. Examples of such systems include...
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Reply to the ‘Comment on “Spectroscopic properties and location of the Ce3+ energy levels in Y3Al2Ga3O12 and Y3Ga5O12 at ambient and high hydrostatic pressure”’ by Y. Wang, M. Głowacki, M. Berkowski, A. Kamińska and A. Suchocki, Phys. Chem. Chem. Phys., 2019, 21, DOI: 10.1039/C8CP06154H
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Viability of decisional DNA in robotics
PublicationThe Decisional DNA is an artificial intelligence system that uses prior experiences to shape future decisions. Decisional DNA is written in the Set Of Experience Knowledge Structure (SOEKS) and is capable of capturing and reusing a broad range of data. Decisional DNA has been implemented in several fields including Alzheimer’s diagnosis, geothermal energy and smart TV. Decisional DNA is well suited to use in robotics due to the...
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A MEASUREMENT SYSTEM FOR MONITORING CARDIOVASCULAR EVENTS IN SYNCOPE PATIENTS
PublicationSyncope phenomena is an abrupt and transient loss of consciousness leading to interruption of awareness of one’s surroundings and falls with risk of injury. Syncope is often followed by complete and usually rapid spontaneous recovery. It is said that half of all individuals experience syncopal event at least once during their life. The condition can occur at any age and happens in people with and without other medical problems....
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The influence of accumulation area and the length of pedestrian route on functioning of roundabouts with traffic signals
Publicationtraffic volumes. This kind of intersection is commonly used in the centres of Polish cities on multilane roads and fairly common in the case of tram lines running through a central island. The increase of traffic flow volumes on left turn and U-turn has made this type of roundabout difficult to operate. Small storage areas around central islands are critical places that significantly influence the capacity of this kind of intersection....