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Wyniki wyszukiwania dla: biological system modeling
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Power System Stabilizer as a Part of a Generator MPC Adaptive Predictive Control System
PublikacjaIn this paper, a model predictive controller based on a generator model for prediction purposes is proposed to replace a standard generator controller with a stabilizer of a power system. Such a local controller utilizes an input-output model of the system taking into consideration not only a generator voltage Ug but also an additional, auxiliary signal (e.g., α, Pg, or ωg). This additional piece of information allows for taking...
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System sejsmiki refleksyjnej do poszukiwania morskich złóż węglowodorowych
PublikacjaW poszukiwaniu morskich złóż węglowodorowych wykorzystywane są różne metody zaliczane do tzw. sejsmiki refleksyjnej. Jedną z nich jest wykorzystanie systemu sejsmiki refleksyjnej holowanego za statkiem specjalistycznym przeznaczonym do badań sejsmicznych. Jest to złożony ruchomy układ techniczny składający się z wielu elementów składowych, takich jak: system wzbudzania fal akustycznych, system rejestracji odbijanych fal akustycznych...
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Procognitive activity of nitric oxide inhibitors and donors in animal models
PublikacjaNitric oxide is a small gaseous molecule that plays important roles in the majority of biological functions. Impairments of NO-related pathways contribute to the majority of neurological disorders, such as Alzheimer’s disease (AD), and mental disorders, such as schizophrenia. Cognitive decline is one of the most serious impairments accompanying both AD and schizophrenia. In the present study, the activities of NO donors, slow (spermine...
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Detection and Model of Thermal Traces Left after Aggressive Behavior of Laboratory Rodents
PublikacjaAutomation of complex social behavior analysis of experimental animals would allow for faster, more accurate and reliable research results in many biological, pharmacological, and medical fields. However, there are behaviors that are not only difficult to detect for the computer, but also for the human observer. Here, we present an analysis of the method for identifying aggressive behavior in thermal images by detecting traces...
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Application 2D Descriptors and Artificial Neural Networks for Beta-Glucosidase Inhibitors Screening
PublikacjaBeta-glucosidase inhibitors play important medical and biological roles. In this study, simple two-variable artificial neural network (ANN) classification models were developed for beta-glucosidase inhibitors screening. All bioassay data were obtained from the ChEMBL database. The classifiers were generated using 2D molecular descriptors and the data miner tool available in the STATISTICA package (STATISTICA Automated Neural...
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Pathways of nitrogen compounds depletion in hybrid constructed wetlands
PublikacjaHybrid Constructed Wetlands are composed of two or more filters with mixed flow direction of sewage. Apparently in the HCWS the benefits of both types of bed are merged, resulting in better effluent quality (organic and nitrogen componds removal). Such heterogeneous environment creates possibilities for different ways of nitrogen "disappearing". The objective of the present study was to compare the removal of nitrogen with accompanying...
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Degradation of xylose using a microbial fuel cell
PublikacjaIt is generally known, that many kind of microorganisms are capable of using carbohydrates as a source of carbon and energy in an environment. The biodegradation process of monosaccharides from pentoses (in this case- racemic mixture of D - and L – xylose) is an immense opportunity for an entire reduction of biological contamination to neutral compounds through MFC. The process is occurred in a single-chamber MFC, which is contained...
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Operation of multistage constructed wetlands systems in temporary climate
PublikacjaThe investigation were carried out at two different hybrid constructed wetlands, which treated municipal sewage after mechanical treatment from small villages in Pomeranian Region. In all facilities first step of biological treatment were horizontal flow beds. The main difference concern configuration of the facilities and sewage distributions systems into vertical flow beds. The measurement period was divided into vegetation...
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Common methods for the chiral determination of amphetamine and related compounds II: Capillary electrophoresis and nuclear magnetic resonance
PublikacjaAmphetamine group and related ring-substituted substances are generally synthetic compounds, belonging to one of the most heavily abused drug groups in recent years. Some compounds in this class also originate from plants. Analysis of the enantiomers of AM-type compounds and metabolites is extremely important for a number of scientific disciplines. From studies of biological activity or mechanisms through determination of precursor...
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H2AX phosphorylation, its role in DNA damage response and cancer therapy
PublikacjaDouble-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired, may have severe consequences for cell survival, as they lead to chromosome aberrations, genomic instability, or cell death. Various physical, chemical, and biological factors are involved in DSB induction. Cells respond to DNA damage by activating the so-called DNA damage response (DDR), a complex molecular mechanism developed to detect...
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Mercury concentrations in marine biota with special focus on grey and ringed seals
PublikacjaMarine organisms are exposed and sensitive to effects of environmental contamination by heavy metals including different forms of mercury. Baltic seals as the top predators of the marine ecosystem are even more endangered due to (considerable) longevity as well as a long biological half-time of toxin elimination. The concentrations of mercury in seals from the Baltic is poorly known, thus the aim of this work is to determine and...
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Silver-modified titania with enhanced photocatalytic and antimicrobial properties under UV and visible light irradiation
PublikacjaCommercial titania photocatalysts were modified with 2 wt% of silver by photodeposition. The properties of the samples were characterized by DRS, XPS, XRD, FE-SEM and STEM. The modified samples exhibited activity under visible light and enhanced activity under UV irradiation for 2-propanol and acetic acid oxidation, respectively. The time-resolved microwave conductivity (TRMC) analysis indicated that enhanced activity (2.5–8-fold...
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Reliability and Validity of Optoelectronic Method for Biophotonical Measurements
PublikacjaReliability and validity of measurements is of utmost importance when assessing measuring capability of instruments developed for research. In order to perform an experiment which is legitimate, used instruments must be both reliable and valid. Reliability estimates the degree of precision of measurement, the extent to which a measurement is internally consistent. Validity is the usefulness of an instrument to perform accurate...
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Application of safirinium N-hydroxysuccinimide esters to derivatization of peptides for high-resolution mass spectrometry, tandem mass spectrometry, and fluorescent labeling of bacterial cells
PublikacjaMass spectrometry methods are commonly used in the identification of peptides and biomarkers. Due to a relatively low abundance of proteins in biological samples, there is a need for the development of novel derivatization methods that would improve MS detection limits. Hence, novel fluorescent N-hydroxysuccinimide esters of dihydro-[1,2,4]triazolo[4,3-a]pyridin-2-ium carboxylates (Safirinium P dyes) have been synthesized. The...
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Preconcentration and Analytical Methods for Determination of Methyl Tert-Butyl Ether and Other Fuel Oxygenates and Their Degradation Products in Environment: A Review
PublikacjaFuel oxygenates (FOs) are mainly ethers or alcohols which are added to gasoline either to boost the octane number or to make the fuel burning process more "cleaner" with increasing the oxygen content, or to obtain a combination of both effects. FOs are water soluble with high mobility in the environment which presence even at very low concentrations lower the quality of water making it unsafe or unpleasant due to their objectionable...
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To Survive in a CBRN Hostile Environment: Application of CAVE Automatic Virtual Environments in First Responder Training
PublikacjaThis paper is of a conceptual nature and focuses on the use of a specific virtual reality environment in civil-military training. We analyzed the didactic potential of so-called CAVE automatic virtual environments for First Responder training, a type of training that fills the gap between First Aid training and the training received by emergency medical technicians. Since real training involves live drills based on unexpected situations,...
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The imidazoacridinone C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation
PublikacjaC-1311 is a small molecule, which has shown promise in a number of preclinical and clinical studies. However, the biological response to C-1311 exposure is complicated and has been reported to involve a number of cell fates. Here, we investigated the molecular signaling which determines the response to C-1311 in both cancer and non-cancer cell lines. For the first time we demonstrate that the tumor suppressor, p53 plays a key role...
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Endocrine disrupting compounds in the baby's world - A harmful environment to the health of babies
PublikacjaGlobally, there has been a significant increase in awareness of the adverse effects of chemicals with known or suspected endocrine-acting properties on human health. Human exposure to endocrine disrupting compounds (EDCs) mainly occurs by ingestion and to some extent by inhalation and dermal uptake. Although it is difficult to assess the full impact of human exposure to EDCs, it is well known that timing of exposure is of importance...
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Mangiferin Affects Melanin Synthesis by an Influence on Tyrosinase: Inhibition, Mechanism of Action and Molecular Docking Studies
PublikacjaMangiferin is a strong antioxidant that presents a wide range of biological activities. The aim of this study was to evaluate, for the first time, the influence of mangiferin on tyrosinase, an enzyme responsible for melanin synthesis and the unwanted browning process of food. The research included both the kinetics and molecular interactions between tyrosinase and mangiferin. The research proved that mangiferin inhibits tyrosinase...
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Evaluating Gelatin-Based Films with Graphene Nanoparticles for Wound Healing Applications
PublikacjaIn this study, gelatin-based films containing graphene nanoparticles were obtained. Nanoparticles were taken from four chosen commercial graphene nanoplatelets with different surface areas, such as 150 m2/g, 300 m2/g, 500 m2/g, and 750 m2/g, obtained in different conditions. Their morphology was observed using SEM with STEM mode; porosity, Raman spectra and elemental analysis were checked; and biological properties, such as hemolysis...
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Synthesis, molecular structure, and metabolic stability of new series of N' -(2-alkylthio-4-chloro-5-methylbenzenesulfonyl)-1-(5-phenyl-1 H -pyrazol-1-yl)amidine as potential anti-cancer agents
PublikacjaA series of new N'-(2-alkylthio-4-chloro-5-methylbenzenesulfonyl)-1-(5-phenyl-1H-pyrazol-1-yl)amidine derivatives have been synthesized and evaluated in vitro by MTT assays for their antiproliferative activity against cell lines of colon cancer HCT-116, cervical cancer HeLa and breast cancer MCF-7. The studied compounds display selective activity mainly against HCT-116 and HeLa cells. Thus, five compounds show selective cytotoxic...
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Application potential of dummy molecularly imprinted polymers as solidphase extraction sorbents for determination of low-mass polybrominated diphenyl ethers in soil and sediment samples
PublikacjaDespite the introduction of restrictive regulations in the USA and the European Union, polybrominated diphenyl ethers (PBDEs) are still found in various types of environmental and biological samples at significant concentration levels. The presence of these persistent organic pollutants in the environment raises important issues because of their negative impact on immunological and neurological systems, and on the hormonal balances...
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Bacterial presence in polar regions associated with environment modification by chemical compounds including contaminants
PublikacjaMicrobes are omnipresent and diverse members of all biological communities. In marine and freshwater ecosystems, microorganisms form the base of the food chain supporting higher trophic levels. Even though, microbes generally are thought to live in warm regions of Earth, many of them develop in cold climates. Polar regions remain relatively protected from widespread anthropogenic disturbances, which is a consequence of its remoteness...
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Investigation of the Effect of the Rocket's Suborbital Flight on Biofilm, Enzymes and Biosynthesis on Autonomous, Modular and Scalable Platforms For Conducting Experiments of an Astrobiotechnological Nature
PublikacjaWith new incentives for human space exploration, biotechnological experiments in orbit became imperative. Answering this need, we build an autonomous, modular, and scalable platform that enables those experiments on rockets. We called it AMBER. The aim of the payload of the R6 suborbital rocket is to perform an experiment to study the influence of rocket flights on biofilm, molecular biology enzymes and biosynthesis using our platform....
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Age Prediction from Low Resolution, Dual-Energy X-ray Images Using Convolutional Neural Networks
PublikacjaAge prediction from X-rays is an interesting research topic important for clinical applications such as biological maturity assessment. It is also useful in many other practical applications, including sports or forensic investigations for age verification purposes. Research on these issues is usually carried out using high-resolution X-ray scans of parts of the body, such as images of the hands or images of the chest. In this...
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Adaptive stochastic and hybrid nonlinear optimization algorithms for improving the effectiveness of the biological processes at WWTP
PublikacjaWastewater treatment plays an important factor in the modern world. Insufficient treatment may result in environmental pollution which can further lead to disasters and diseases. However, processes that take place inside wastewater treatment plants (WWTP) are highly complex in nature, therefore it is difficult to design an efficient, optimal control system. The problem regarding biochemical reactions inside Sequential Batch Reactor...
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Web based training system TeleCAD. Teleworkers training for CAD system users
PublikacjaW artykule zaprezentowano internetowy system dostarczania kursów do nauczania na odległość. System został opracowany w ramach projektu Leonardo da Vinci TeleCAD (1998-2001). Pokazano jak system wykorzystywany jest obecnie oraz możliwość wykorzystania w projekcie CURE (Research Framework Programme5, 2003-2005).
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Understanding the Ukrainian Migrants Challenges in the EU: A Topic Modeling Approach
PublikacjaConfronted with the aggression against Ukraine in 2022, Europe faces one of the most important humanitarian challenges - the migration of war refugees from Ukraine, most of them women with children and the elderly. Both international institutions such as the European Union and the United Nations, but also national governments and, above all, local governments, which are the main providers of services and resources for refugees,...
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The Air and Sewage Pollutants from Biological Waste Treatment
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Thymus vulgaris Essential Oil and Its Biological Activity
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Behavior of lipids in biological wastewater treatment plant processes
PublikacjaLipidy (oleje, smary, tłuszcze oraz długołańcuchowe kwasy tłuszczowe) są istotnym składnikiem ścieków. Ich ilość np. w ściekach komunalnych stanowi około 30-40% ogólnej wartości ChZT. Przemiany lipidów w procesach biologicznego oczyszczania są obiektem wielu badań, mimo to nie są do końca poznane i zrozumiane. W pracy przedstawiono przegląd literatury dotyczący przemian lipidów w trakcie tlenowego i beztlenowego oczyszczania ścieków...
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Biological hazards in low noise, poroelastic road surfaces
PublikacjaDrainage pavements as well as poroelastic pavements ("PERS") are a very efficient way to decrease traffic noise by reducing tire/road noise at the source as well as noise propagation over the road surface. Many noise generating mechanisms at the tire/road interface are very much reduced by road porosity (pipe resonance, "air pumping", Helmholtz resonance and the horn effect). A well-designed porous or poroelastic road surface may...
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The biological activity of new tuftsin derivatives - induction of phagocytosis
PublikacjaFagocytoza odgrywa ważną rolę w ochronie organizmu przed różnymi mikroorganizmami. Proces ten może być indukowany przez różne czynniki np. endogenny immunomodulator jakim jest tuftsyna czy muramylo-dipeptyd (MDP), najmniejszy syntetyczny glikopeptyd bakteryjnej ściany komórkowej. Zsyntetyzowano nowe analogi MDP i nor-MDP z tuftsyną i retro-tuftsyną, które są zdolne do indukowania fagocytozy. Najbardziej obiecujące okazały się dwa...
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GaMRed – adaptive filtering of high-throughput biological data
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In Vitro Biological Evaluation of Aprepitant Based 177Lu-Radioconjugates
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Biological Inspirations: Iron Complexes Mimicking the Catechol Dioxygenases
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Synthesis and biological activity of tricyclic aryloimidazo-, pyrimido-, and diazepinopurinediones
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Biological Activity of Tea-Chokeberry and Chokeberry Fermented Beverages
PublikacjaFermented beverages, such as kombucha are gaining more and more popularity due to their beneficial effects on human health. These products are obtained by the fermentation of tea infusion using so called tea fungus. This microbial consortium can also be used to prepare fermented fruit beverages. Therefore, the aim of this study was to determine the changes in the antioxidant profile of tea-chokeberry and chokeberry beverages...
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Investigation of biological and photochemical treatment of municipal landfill leachates
PublikacjaW pracy przedstawiono rezultaty badań charakterystyki oraz efektywności foto- oraz biodegradacji odcieków z dwóch składowisk komunalnych w północnej Polsce. Celem pracy było zbadanie efektywności oczyszczania w systemie UV, UV/H2O2 oraz możliwości biologicznego oczyszczania odcieków metodą osadu czynnego. Stosowanie metody kombinowanej (UV/H2O2/osad czynny) pozwoliło na uzyskanie lepszej efektywności oczyszczania (98% spadek wartości...
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Biological activity of conjugates of muramyl dipeptides with batracylin derivatives
PublikacjaW artykule opisano aktywność biologiczną koniugatów muramylo-dipeptydów z batracyliną lub pochodnymi batracyliny. Badania przeprowadzone w Akademii Medycznej w Gdańsku miały na celu oznaczenie immunomodulacyjnych właściwości tych koniugatów wobec subpopulacji leukocytów krwi obwodowej hodowanych w obecności komórek nowotworowych (K562, WEHI164, Ab melanoma). Leukocyty izolowane były z krwi obwodowej uzyskanej od zdrowych ochotników....
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An analysis of pesticides and polychlorinated biphenyls in biological samples and foods.
PublikacjaPestycydy i polichlorowane bifenyle występują w środowisku w małych ilościach, ale ulegając kumulacji, stanowią zagrożenie dla ludzi i zwierząt. Najbardziej zagrożony jest człowiek stojący na szczycie łańcucha pokarmowego. Świadomość niebezpieczeństw jakie niesie ze sobą postępujące zanieczyszczenie środowiska w połączeniu z nowoczesnymi środkami zaradczymi powinna zmniejszyć do minimum możliwość występowania zatruć u ludzi i powstania...
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Fluctuation-Enhanced Sensing for Biological Agent Detection and Identification
PublikacjaPrzedstawiono wcześniejsze wyniki badań dotyczące trzech różnych sposobów wykrywania obecności substancji biologicznych za pomocą zjawisk fluktuacyjnych: 1) wirusów wnikających do komórek, 2) zapachów emitowanych przez mikroby, 3) rozkładu widma i wartości chwilowych szumów podczas rozpraszania światła używanego do wykrywania zarodników na podstawie wyznaczenia współczynnika dyfuzji opisująceo ich ruch.We survey and show our earlier...
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Reporter Fluorescent Molecules in Biological Systems: The Current Overview
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Solid Phase Synthesis and Biological Activity of Tuftsin Conjugates
PublikacjaNew tuftsin/retro-tuftsin conjugates were designed and synthesized using a classical fluorenylmethoxycarbonyl (Fmoc) solid phase procedure. All the peptide conjugates were divided into three series: 1,4-dihydroxyanthraquinone (type A), 1-nitroacridine (type B), and 4-carboxyacridone (type C) derivatives. In type A conjugates, the N-terminal group of the peptide chain is directly connected to the anthraquinone ring at C1 (Scheme...
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Disturbances of biological N-removal processes in the presence of sulphonamides
PublikacjaBadano podatność na biodegradację oraz wpływ na efektywność nitryfikacji wybranych sulfonamidów (sulfanilamidu SA, sulfacetamidu SCM oraz p-toluenosulfonamidu p-TSA). Podatnośc na biodegradację badano przy użyciu testu OECD 301D (test zamkniętej butelki). Efektywność nitryfikacji miarzono zgodnie z ISO 9509:1989. Stwierdzono, że wszystkie badane związki wykazują bardzo słabą podatność na biodegradację oraz mają wyraźny wpływ na...
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Biological activity of conjugates of muramyl dipeptides with batracylin derivatives
PublikacjaZaprezentowano immunomodulacyjne właściwości nowych koniugatów batracyliny (BAT) z pochodnymi muramylodipeptydów wobec subpopulacji leukocytów krwi obwodowej hodowanych w obecności komórek linii nowotworowych. Leukocyty izolowane były z krwi obwodowej uzyskanej od zdrowych ochotników. Zbadane koniugaty MDP lub nor-MDP z batracyliną wykazały silniejsze własności hamujące proliferację komórek wybranych linii nowotworowych (K562,...
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On Inadequacy of Sequential Design of Experiments for Performance-Driven Surrogate Modeling of Antenna Input Characteristics
PublikacjaDesign of contemporary antennas necessarily involves electromagnetic (EM) simulation tools. Their employment is imperative to ensure evaluation reliability but also to carry out the design process itself, especially, the adjustment of antenna dimensions. For the latter, traditionally used parameter sweeping is more and more often replaced by rigorous numerical optimization, which entails considerable computational expenses, sometimes...
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Information System for Drivers Within the Integrated Traffic Management System - TRISTAR
PublikacjaAdvanced traveler information systems (ATIS) for drivers are a very important element of modern traffic management. In recent years ITS infrastructure is being developed also in Poland. It allows for delivering to drivers information related to the conditions in the road network through, inter alia, dedicated Variable Message Signs (VMS). Such information enables drivers to take decisions, contributing to improving the efficiency...
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Dynamic Modeling of COVID-19 Disease with Impact of Lockdown in Pakistan and Malaysia
PublikacjaBeing researchers, it is an utmost responsibility to provide insight on social issues thus, this work addresses the dynamic modeling of first and most contagious disease named as COVID-19 caused by coronavirus. The first case of COVID-19 appeared in Pakistan was on 26th February 2020 and in Malaysia on 27th February 2020; both patients had foreign travel history. In the paper, the number of total affected cases and total deaths...
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Comparative study of neural networks used in modeling and control of dynamic systems
PublikacjaIn this paper, a diagonal recurrent neural network that contains two recurrent weights in the hidden layer is proposed for the designing of a synchronous generator control system. To demonstrate the superiority of the proposed neural network, a comparative study of performances, with two other neural network (1_DRNN) and the proposed second-order diagonal recurrent neural network (2_DRNN). Moreover, to confirm the superiority...