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Wyniki wyszukiwania dla: antibiotic resistance genes
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Hydroxyl and sulfate radical-based degradation of ciprofloxacin using UV-C and/or Fe2+-catalyzed peroxymonosulfate: Effects of process parameters and toxicity evaluation
PublikacjaCiprofloxacin (CIP) is a valuable antibiotic and discharged in huge quantities in aquatic environment. Different •OH and SO4•−-based advanced oxidation technologies (AOTs), e.g., Fe2+/PMS, UV-C/PMS, and UV-C/Fe2+/PMS are developed for treatment of CIP. The removal of CIP by Fe2+/PMS, UV-C/PMS and UV-C/Fe2+/PMS was 63, 77, and 87 %, respectively, under identical conditions which showed better performance of UV-C/Fe2+/PMS. The UV-C/Fe2+/PMS...
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Chitosan-Based Membranes as Gentamicin Carriers for Biomedical Applications — Influence of Chitosan Molecular Weight
PublikacjaOver the past decade, much attention has been paid to chitosan as a potential drug carrier because of its non-toxicity, biocompatibility, biodegradability and antibacterial properties. The effect of various chitosan characteristics on its ability to carry different antibiotics is discussed in the literature. In this work, we evaluated the influence of the different molecular weights of this polymer on its potential as an antibacterial...
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Differential expression profile between amygdala and blood during chronic lithium treatment in a rat model of depression – a pilot study
PublikacjaLithium is a mood stabilizer widely used in the pharmacotherapy of bipolar disorder and treatment‑resistant depression. Taking into account dysregulated inflammatory activity in depression and the immunomodulatory role of lithium, we hypothesized that genes associated with inflammatory responses may be potential biomarkers of lithium action. We aimed to compare gene expression changes between the brain and the periphery after...
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Population-based case-control study of alpha 1-antitrypsin and SLC11A1 in Crohn's disease and ulcerative colitis.
PublikacjaBackground: Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases of the digestive tract. Genetic factors and an abnormal immune response to infections are suspected to be involved in inflammatory bowel diseases. Methods: In the present study 300 blood samples from CD patients (n 100), UC patients (n 100), and healthy controls (n 100) were taken from a population-based case-control study. PCR assays...
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Novel single-stranded DNA-binding protein from psyvhrophilic bacterium Psychrobacter arcticus
PublikacjaTo study the biochemical properties of SSB from Psychrobacter arcticus (ParSSB), we have cloned the ssb genes obtained by PCR and have developed Escherichia coli overexpression systems. The gene consists of an open reading frame of 642 nucleotides encoding SSB protein of 213 amino acids with a calculated molecular mass of 22.8 kDa. The amino-acid sequence of ParSSB exhibits 49% identity and 57% similarity to Escherichia coli SSB....
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DNA methylation in cancer development, diagnosis and therapy-multiple opportunities for genotoxic agents to act as methylome disruptors or remediators
PublikacjaThe role of DNA methylation and recently discovered hydroxymethylation in the function of the human epigenome is currently one of the hottest topics in the life sciences. Progress in this field of research has been further accelerated by the discovery that alterations in the methylome are not only associated with key functions of cells and organisms, such as development, differentiation and gene expression, but may underlie a number...
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Epigenetic inhibitor zebularine activates ear pinna wound closure in the mouse
PublikacjaBackground:Most studies on regenerative medicine focus on cell-based therapies and transplantations.Small-molecule therapeutics, though proved effective in different medical conditions, have not been extensivelyinvestigated in regenerative research. It is known that healing potential decreases with development and devel-opmental changes are driven by epigenetic mechanisms, which suggests epigenetic repression of regenerativecapacity.Methods:We...
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Checkpoints that regulate balanced biosynthesis of lipopolysaccharide and its essentiality in Escherichia coli
PublikacjaThe outer membrane (OM) of Gram-negative bacteria, such as Escherichia coli, is essential for their viability. Lipopolysaccharide (LPS) constitutes the major component of OM, providing the permeability barrier, and a tight balance exists between LPS and phospholipids amounts as both of these essential components use a common metabolic precursor. Hence, checkpoints are in place, right from the regulation of the first committed step...
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A vector-enzymatic DNA fragment amplification-expression technology for construction of artificial, concatemeric DNA, RNA and proteins for novel biomaterials, biomedical and industrial applications
PublikacjaA DNA fragment amplification/expression technology for the production of new generation biomaterials for scientific, industrial and biomedical applications is described. The technology enables the formation of artificial Open Reading Frames (ORFs) encoding concatemeric RNAs and proteins. It recruits the Type IIS SapI restriction endonuclease (REase) for an assembling of DNA fragments in an ordered head-to-tail-orientation. The...
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Immunophenotyping and transcriptional profiling of in vitro cultured human adipose tissue derived stem cells
PublikacjaAdipose-derived stem cells (ASCs) have become an important research model in regenerative medicine. However, there are controversies regarding the impact of prolonged cell culture on the ASCs phenotype and their differentiation potential. Hence, we studied 10 clinical ASCs replicates from plastic and oncological surgery patients, in six-passage FBS supplemented cultures. We quantified basic mesenchymal cell surface marker transcripts...
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imPlatelet classifier: image‐converted RNA biomarker profiles enable blood‐based cancer diagnostics
PublikacjaLiquid biopsies offer a minimally invasive sample collection, outperforming traditional biopsies employed for cancer evaluation. The widely used material is blood, which is the source of tumor-educated platelets. Here, we developed the imPlatelet classifier, which converts RNA-sequenced platelet data into images in which each pixel corresponds to the expression level of a certain gene. Biological knowledge from the Kyoto Encyclopedia...
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Platelet RNA Sequencing Data Through the Lens of Machine Learning
PublikacjaLiquid biopsies offer minimally invasive diagnosis and monitoring of cancer disease. This biosource is often analyzed using sequencing, which generates highly complex data that can be used using machine learning tools. Nevertheless, validating the clinical applications of such methods is challenging. It requires: (a) using data from many patients; (b) verifying potential bias concerning sample collection; and (c) adding interpretability...
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Analysis of sloping brace stiffness influence on stability and load bearing capacity of a truss
PublikacjaThe paper is focused on the numerical study of stability and load bearing capacity of a truss with side elastic braces. The structure is made in reality. The rotational and sliding brace stiffnesses were taken into account. Linear buckling analysis and non-linear static analysis with geometric and material nonlinearity were performed for the beam and shell model of the truss with respect to the angle of sloping braces. As a result...
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Improved performance of LaNi0.6Fe0.4O3 solid oxide fuel cell cathode by application of a thin interface cathode functional layer
PublikacjaIn this work, novel functional layers were prepared by a low temperature spray pyrolysis method on the oxygen side of the solid oxide cells. Thin layers of Ce0.8Gd0.2O2 and LaNi0.6Fe0.4O3 are prepared between the electrolyte and the porous oxygen electrode. Additionally the influence of the sprayed ceria barrier layer on the zirconia based electrolyte with the new layers is evaluated. Impedance spectroscopy results show improvement...
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Investigation of polyurethane elastomer–steel joints using glass lacquer as an adhesive agent
PublikacjaThis article describes an innovative method of coupling polyurethane elastomer (based on polyurethane glycolysate) with constructional steel, by implementation of a Glaspur®—glass lacquer containing latent polyurethanes and monosilane adhesion promoters. The commonly applied coupling agent is Cilbond® 45SF glue or its derivatives. Additionally, glycolysate was synthesised from polyurethane waste and 1,3-propylene glycol in 6:1...
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Scientific research in the Department of Machine Design and Automotive Engineering
PublikacjaShort descriptions of various research subjects taken up at the Department of Machine Design and Automotive Engineering are included in the paper. The subjects cover a wide range of bearing systems and tribology research and the research on tires and road surfaces. A third field of activity is biomedical engineering – with the attempts to improve methods of modelling biological materials in FEM calculations. The Department has...
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Dynamics of Ice Jam Formation and Release
PublikacjaThe numerical model DynaRICE and its application to ice jam formation and release is presented. The model is a two-dimensional coupled flow and ice dynamic model. The ice dynamic component, which includes both the internal ice resistance and boundary friction on ice motion, uses a Lagrangian SPH method. The hydrodynamic component of the model uses a streamline upwind finite element method, which is capable of simulating trans-critical...
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Effect of polymer fibres reinforcement on selected properties of asphalt mixtures
PublikacjaThe paper presents selected results of the research program concerning fibre reinforced asphalt concrete. Aramid-polyalphaolefin fibres was used in this study. Selected properties responsible for low temperature cracking and resistance to permanent deformation are presented in this paper. Low temperature cracking susceptibility was evaluated with the results obtained from bending test of rectangular beams with constant rate of...
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Stability of an imperfect truss loaded by wind
PublikacjaThe present paper is devoted to the numerical research of stability of a truss loaded by wind and stiffened by elastic supports located at the top chord. The lateral braces or lateral and torsional braces were taken into account. In this paper, the linear buckling analysis re- sults for the beam and shell model were presented. Two different shapes of initial geometric imperfections were considered in the non-linear static analysis...
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Accurate electrothermal modelling of high frequency DC-DC converters with discrete IGBTs in PLECS software
PublikacjaIn the paper, a novel, improved method of the IGBT junction temperature computations in the PLECS simulation software is presented. The developed method aims at accuracy of the junction temperature computations in PLECS by utilising a more sophisticated model of transistor losses, and by taking into account variability of transistor thermal resistance as a function of its temperature. A detailed description of the proposed method,...
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Damage Development on the Surface of Nickel Coating in the Initial Period of Erosion
PublikacjaThe common occurrence of the phenomenon of cavitation in many industries and the multitude of factors affecting the resistance to cavitation erosion of used materials contribute to the search for methods and appropriate parameters of coating application that are able to minimize the effects of erosion. To determine the validity of the developed application parameters and the method used, cavitation studies and microscopic observations...
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Measurement methods for assessing insulation condition of underground pipelines
PublikacjaThe paper discusses the most frequently applied measurement methods for assessing the quality of external insulation along pipelines and detecting defect locations in the protective coating. The quality of coating along a given pipeline section under investigation is assessed by determining unitary resistance of the coating, which is calculated on the basis of measurement results obtained along a pipeline subjected to cathodic...
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Uncertainty estimation of loop impedance measurement determined by the vector method
PublikacjaThis article presents a detailed analysis of uncertainty estimation of loop impedance measurement determined by the vector method. The analysis includes the following estimates: resistance variance, voltage variance and time measurement variance. This paper presents a methodology for estimating the combined standard uncertainty of loop impedance by the vector method. The vector method allows to determine loop impedance based on...
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Experimental investigations on pressure drop during the condensation in flow of HFE7000 in vertical minichannel
PublikacjaIn the work presented in the paper authors focused attention on the issues of flow resistance and pressure drop during condensation in the flow. The case of the descending flow through a cylindrical single-channel of 2.3 mm inner diameter was carefully analyzed. In the course of investigations a new working fluid HFE 7000 has been scrutinised which has a strongly differing properties in comparison to the other fluids that are commonly...
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Effect of native air-formed oxidation on the corrosion behavior of AA7075 aluminum alloys
PublikacjaThe microstructure of aluminum alloys plays a key role in their corrosion resistance. In particular, the presence of intermetallic precipitates differing in the potential from the alloy matrix induces local corrosion. The study presents the effect of native air-formed oxidation on the corrosion behavior of AA 7075 aluminum alloy. Various microscopic and spectroscopic techniques were used to examine the changes occurring in the...
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Investigations of Titanium Implants Covered with Hydroxyapatite Layer
PublikacjaTo reduce unfavorable phenomena occurring after introducing an implant into human body various modifications of the surface are suggested. Such modifications may have significant impact on biocompatibility of metallic materials. The titanium and it's alloys are commonly used for joint and dental implants due to their high endurance, low plasticity modulus, good corrosion resistance as well as biocompatibility. Special attention...
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Glucose metabolism disorders in patients with non-functioning adrenal adenomas — single-centre experience
PublikacjaIntroduction: The presence of glucose metabolism disorders and their possible correlation with degree of cortisol secretion were evaluated in patients with non-functioning adrenal incidentalomas (NFAIs). Material and methods: The study group consisted of 131 patients with hormonally inactive adrenal incidentalomas....
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Influence of grain shape on the mechanical behaviour of granular materials
PublikacjaWe performed series of numerical vertical compression tests on assemblies of 2D granular material using a Discrete Element code and studied the results in regard to the grain shape. The samples consist of 5000 grains made either of 3 overlapping discs (clump - grain with concavities) or of six-edged polygons (convex grain). These two types of grains have a similar external envelope, ruled with a geometrical parameter α. In the...
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Modal Analysis of a Steel Radial Gate Exposed to Different Water Levels
PublikacjaWith the increase in water retention needs and planned river regulation, it might be important to investigate the dynamic resistance of vulnerable elements of hydroelectric power plants, including steel water locks. The most frequent dynamic loads affecting hydroengineering structures in Poland include vibrations caused by heavy road and railway traffic, piling works and mining tremors. More destructive dynamic loads, including...
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Influence of CeO2 and TiO2 Particles on Physicochemical Properties of Composite Nickel Coatings Electrodeposited at Ambient Temperature
PublikacjaThe Ni-TiO2 and Ni-CeO2 composite coatings with varying hydrophilic/hydrophobic characteristics were fabricated by the electrodeposition method from a tartrate electrolyte at ambient temperature. To meet the requirements of tight regulation by the European Chemicals Agency classifying H3BO3 as a substance of very high concern, Rochelle salt was utilized as a buffer solution instead. The novelty of this study was to implement a...
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Development and experimental validation of a novel double-stage yield steel slit damper-buckling restrained brace
PublikacjaThis research is focused on the development and experimental validation of a novel double-stage yield steel slit damper-buckling restrained brace (SSD-DYB) system designed for seismic resistance of steel structures. The SSD-DYB integrates the energy dissipation capability of a steel slit damper (SSD) in its initial segment, enhancing performance in the case of lower seismic intensities levels while employing a larger segment for...
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Zastosowanie audytu wewnętrznego u operatorów produkcyjnych w zapobieganiu kryzysom-studium przypadku
PublikacjaGłównym tematem artykułu była analiza badań przeprowadzonych u producenta farb proszkowych przedsiębiorstwa X, w zakresie zastosowania audytu wewnętrznego, jako metody pozwalającej na zapobieganie pojawienia się kryzysu. Właściwa współpraca operatorów produkcyjnych z menedżerami ma kluczowe zna-czenie dla budowy właściwej pozycji audytu wewnętrznego w przedsiębiorstwie X. Brak należytej współpracy na etapie badań, przy braku...
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СИСТЕМА КОНТРОЛЯ СОСТОЯНИЯ ИЗОЛЯЦИИ ЭЛЕКТРОПРИВОДОВ В СЕТЯХ С ГЛУХОЗАЗЕМЛЕННОЙ НЕЙТРАЛЬЮ (System of insulation status monitoring for electric drives in networks with a dead-earth neutral)
PublikacjaПредложен метод контроля изоляции частотно-регулируемых электроприводов в сетях с глухозаземленной нейтралью. Система контроля изоляции включается в момент остановки электропривода. Ключи инвертора коммутируются по специальному закону, и с помощью сигнала трансформатора тока, который изме- ряет ток во всех трех фазах привода одновременно, определяется ток утечки. Рассмотрена схема датчика тока утечки и приведены экспериментальные...
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Improvement of Fingerprinting Method based on Hill Cipher by using Frequency Domain
PublikacjaThe main goal of this paper is to present the advantages of a digital fingerprinting in a frequency domain over a pixel domain, in case of VoD services (Video on Demand). The paper presents basic issues of a multimedia data protection by digital fingerprinting. It also describes threats to embedded fingerprints from both collusion attacks and from a transmission itself. Possible solution was presented on the example of the DCT...
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Stability and limit load analysis of a cold-formed channel section column
PublikacjaThe paper presents stability and limit load analysis of a steel column 1440 mm high of a cold-formed channel section, subjected to a combination of compression and bending. Experimental results were compared to the resistance of a code procedure and to the outcome of numerical non-linear analysis. Comparison was made of numerical solutions by means of static (Riks) and dynamic (Explicit and Implicit) methods. Perfectly elastic...
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Properties comparison of rubber and three layer PTFE-NBR-bronze water lubricated bearings with lubricating grooves along full bush circumference based on experimental tests
PublikacjaWater lubricated bearings have been in industrial use for well over a century. During the last decade their traditional range has been expanded with new, modern products. Despite that fact, certain solutions continue to employ the standard rubber bearing with lubricating grooves located along entire bush circumference. The work presents experimental research conducted on comparable sliding bearings with lubrication grooves along...
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Biocompatibility and Bioactivity of Load-Bearing Metallic Implants
PublikacjaThe main objective of here presented research is to develop the titanium (Ti) alloy base composite materials possessing better biocompatibility, longer lifetime and bioactivity behaviour for load-bearing implants, e.g. hip joint and knee joint endoprosthesis. The development of such materials is performed through: modeling the material behaviour in biological environment in long time and developing of new procedures for such evaluation;...
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NANOCRYSTALLINE CATHODES FOR SOLID OXIDE FUEL CELLS MADE OF NOBLE METALS
PublikacjaCathodes for solid oxide fuel cells prepared by the infiltration method at 600 °C are presented. The infiltration method allows to produce stable, nanostructured electrodes. Cathodes were prepared using gold, platinum, La2NiO4+δ (L2N) and La0.6Sr0.4Co0.2Fe0.8O3 δ (LSCF). Symmetrical cathode/electrolyte/cathode samples were prepared and examined with SEM microscopy and electrochemical impedance spectroscopy. Despite successful deposition...
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Cavitation erosion degradation of Belzona® coatings
PublikacjaIn hydrocarbon and maritime industry there is a constant need of materials and coatings withstanding severe conditions. One of adverse phenomena present there is cavitation erosion. The paper presents evaluation of cavitation resistance of three different steel coatings. Belzona 2141 (ACR-Fluid Elastormer), 1321 (Ceramic S-Steal) and 5831 (ST-Barrier) were deployed on P110 steel and subjected to ultrasound cavitation in distilled...
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Secured wired BPL voice transmission system
PublikacjaDesigning a secured voice transmission system is not a trivial task. Wired media, thanks to their reliability and resistance to mechanical damage, seem an ideal solution. The BPL (Broadband over Power Line) cable is resistant to electricity stoppage and partial damage of phase conductors, ensuring continuity of transmission in case of an emergency. It seems an appropriate tool for delivering critical data, mostly clear and understandable...
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UWB-Based Indoor Navigation in a Flexible Manufacturing System Using a Custom Quadrotor UAV
PublikacjaA novel solution for indoor navigation of a transportation drone in flexible manufacturing is presented in this paper. To address the challenges of accurate and robust drone navigation in occluded environments, an ultra-wideband (UWB) navigation system has been integrated with a commercially available open source control platform. The system offers high accuracy (± 20 mm), low power consumption, resistance to electronic interference,...
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Effect of the let-through energy of overcurrent protective devices on the temperature of conductors during short-circuits
PublikacjaThe scope of the verification of low-voltage systems covers the earth fault loop impedance measurement. This measurement is usually performed with the use of low-value current meters, which force a current many times lower than the one occurring during a real short-circuit. Therefore, the international standard recommends consideration of the increase of resistance of conductors with the increase of temperature, which may occur...
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Fluctuation enhanced gas sensing with WO3-based nanoparticle gas sensors modulated by UV light at selected wavelengths
PublikacjaThe sensitivity and selectivity of WO3-based gas sensors can be enhanced by UV-irradiation-induced modulation, especially if different wavelengths are employed. We used fluctuation-enhanced gas sensing, based on measurements of resistance fluctuations in the gas sensor, to study the effects of such modulation on the noise intensity for ambient atmospheres of synthetic air without and with additions of small amounts of ethanol,...
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Ocena stanu technicznego konstrukcji zgarniaczy będących na wyposażeniu osadników wstępnych Grupowej Oczyszczalni Ścieków „DĘBOGÓRZE
PublikacjaOsadniki wstępne typu DORRA – 4 szt., o pojemności 1830 m3, wyposażone są w elementy mechaniczne do kierunkowego przemieszczania się osadu w kierunku leja centralnego. Celem pracy jest ocena stany technicznego części mechanicznej, a w szczególności: - konstrukcji zespołu zgarniania części pływających oraz osadu. - zespołu napędu i sterowania, - zespołu napędu i jazdy. Pierwsze dwa zespoły będą oceniane również z punktu widzenia...
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Wpływ błędów parametrów modelu maszyny indukcyjnej na działanie rozszerzonego obserwatora prędkości
PublikacjaW artykule opisano metodę odtwarzania prędkości wirnika maszyny indukcyjnej przy wykorzystaniu rozszerzonego obserwatora prędkości. Zbadano wpływ błędów parametrów modelu maszyny indukcyjnej na właściwości dynamiczne obserwatora poprzez porównanie macierzy stanu obserwatora obarczonego oraz nieobarczonego błędami parametrów. Zbadany został także wpływ błędów parametrów na jakość odtwarzania zmiennych maszyny w stanie ustalonym.
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On the Possibility of the Amphotericin B-Sterol Complex Formation in Cholesterol- and Ergosterol-Containing Lipid Bilayers: A Molecular Dynamics Study
PublikacjaAmphotericin B (AmB) is a well-known membrane-active antibiotic that has been used to treat systemicfungal infections for more than 45 years. Therapeutic application of AmB is based on the fact that it is moreactive against ergosterol-containing membranes of fungal cells than against mammalian membranes withcholesterol. In this paper, we examine the hypothesis according to which the selectivity of the AmB's membraneaction originates...
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Influence of several biodegradable components added to pure and nanosilver-doped PMMA bone cements on its biological and mechanical properties
PublikacjaAcrylic bone cements (BC) are wildly used in medicine. Despite favorable mechanical properties, processability and inject capability, BC lack bioactivity. To overcome this, we investigated the effects of selected biodegradable additives to create a partially-degradable BC and also we evaluated its combination with nanosilver (AgNp). We hypothesized that using above strategies it would be possible to obtain bioactive BC. The Cemex...
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Polysaccharide nanocomposites in wastewater treatment: A review
PublikacjaIn modern times, wastewater treatment is vital due to increased water contamination arising from pollutants such as nutrients, pathogens, heavy metals, and pharmaceutical residues. Polysaccharides (PSAs) are natural, renewable, and non-toxic biopolymers used in wastewater treatment in the field of gas separation, liquid filtration, adsorption processes, pervaporation, and proton exchange membranes. Since addition of nanoparticles...
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Stability of a truss under upward wind loading
PublikacjaThe present paper is devoted to the numerical investigations of stability of a truss under upward wind load. The truss is braced at its the upper cord. A structural variant including lateral braces, or lateral and torsional braces is considered. The research presents the problems of linear buckling and non-linear static analysis of the truss shell and beam model with geometric and material non-linearity are presented. The initial...
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Degradation of reference tyres used for CPX measurements
PublikacjaMeasurements of tyre/road noise using the Close Proximity Method are based on reference tyres that are described in ISO/TS 11819-3. The standard specifies two tyres, namely "P1" and "H1" that should be used during measurements. To be used for measurements each tyre must fulfill certain conditions that are listed in the standard. The conditions are related to the tread pattern depth and rubber hardness. During experiments performed...