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Wyniki wyszukiwania dla: IMPURITIES IN PHARMACEUTICAL PRODUCTS
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Selection of effective cocrystals former for dissolution rate improvement of active pharmaceutical ingredients based on lipoaffinity index
PublikacjaNew theoretical screening procedure was proposed for appropriate selection of potential cocrystal formers possessing the ability of enhancing dissolution rates of drugs. The procedure relies on the training set comprising 102 positive and 17 negative cases of cocrystals found in the literature. Despite the fact that the only available data were of qualitative character, performed statistical analysis using binary classification...
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Adaptive response of microbial communities to soluble microbial products.
PublikacjaBadano wpływ obecności ubocznych produktów mikroorganizmów na stężenie biomasy osadu czynnego oraz na efektywność obniżenia ładunku BZT5 i ChZT w ściekach syntetycznych. Doświadczenia prowadzono w obecności ubocznych produktów mikroorganizmów (Soluble Microbial Products) oraz w warunkach pozbawionych tych produktów.
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MicroscopicA75sNMR study of the effect of impurities on the first-order spin-density-wave transition inBaFe2As2
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Cyclodextrin polymers as efficient adsorbents for removing toxic non-biodegradable pimavanserin from pharmaceutical wastewaters
PublikacjaPresence of even small amount of active pharmaceutical ingredients in the environment carries risks tohuman and animal health, presenting an important issue. The paper presents issues related to the newdrug - pimavanserin (PMV). Biological treatment efficiency of pimavanserin (PMV) was evaluated usinglab-scale Sequencing Batch Reactor (SBR). It has been shown to have a negative effect on aquatic or-ganisms by classifying it as...
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Fermented vegetable products
PublikacjaRozdział opisuje wpływ różnych czynników na jakość fermentowanych produktów warzywnych, kiszonej kapusty, kiszonych ogórków, kimchi i oliwek.
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The Technological Advancement of New Products, Product Newness and Market Information
PublikacjaThe purpose of this study is to propose product newness and obtaining market information as mediators of the relationship between the technological advancement of a new product and its commercial success. So far, little is known about the mediators of this relationship but knowledge about the factors that strengthen or weaken it is valid, both for the theory and practice of new product management. On the one hand, product newness...
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EXCHANGE TRADED COMMODITIES AS A CATEGORY OF INNOVATIVE PRODUCTS ON EUROPEAN FINANCIAL MARKETS
PublikacjaThe article presents the main features of one category of innovative financial products – exchange traded commodities (ETCs) and results of the analysis of the European market for ETCs. ETCs are products listed and traded on the stock exchanges and they offer investors returns based on various assets (commodities or currencies). In contrast with the most widely recognized exchange traded funds (ETFs), ETCs are structured as debt...
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Exploration of the Solubility Hyperspace of Selected Active Pharmaceutical Ingredients in Choline- and Betaine-Based Deep Eutectic Solvents: Machine Learning Modeling and Experimental Validation
PublikacjaDeep eutectic solvents (DESs) are popular green media used for various industrial, pharmaceutical, and biomedical applications. However, the possible compositions of eutectic systems are so numerous that it is impossible to study all of them experimentally. To remedy this limitation, the solubility landscape of selected active pharmaceutical ingredients (APIs) in choline chloride- and betaine-based deep eutectic solvents was...
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Study of impurities in alpha-Al 2 O 3 powders and crystals using EPR spectroscopy
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Treatment innovation using solar/UV In book: The Treatment of Pharmaceutical Wastewater: Innovative Technologies and the Adaptation of Treatment Systems
PublikacjaSince ancient times, sunlight irradiation has been widely used for water purification. Apart from solar water disinfection techniques, UV irradiation is of particular interest when considering the photodegradation of various classes of emerging pollutants. Pharmaceutically active compounds are one of the largest classes of micropollutants. The main sources of these contaminants in wastewater and aqueous environments are households,...
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Detection of petroleum products using optical coherence tomography
PublikacjaIn this work, we present a novel method developed for the analysis of the properties of thin layers for detecting petroleum products on a water surface using a commercially available optical coherence tomography (OCT) system. The spectral density analysis of the signal from a spectroscopic OCT (S-OCT) enables us to perform the precision calculation of the thin layer thickness and other properties like homogeneity, and dispersion,...
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Deep eutectic solvent based method for analysis of Niclosamide in pharmaceutical and wastewater samples – A green analytical chemistry approach
PublikacjaThe paper presents a simple, but very effective and sensitive spectrophotometric method for trace analysis of Niclosamide based on liquid–liquid microextraction using deep eutectic solvents (DESs) prior to its quantification. Here, different DES systems, such as Choline chloride (ChCl) + Urea, ChCl + Citric acid, ChCl + Ethylene glycol and ChCl + Phenol, were synthesized and evaluated at different molar ratios, selecting ChCl + Phenol...
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Occurrence and seasonal variations of 25 pharmaceutical residues in wastewater and drinking water treatment plants
PublikacjaThousands of tons of pharmaceuticals are introduced into the aqueous environment due to their incomplete elimination during treatment process in wastewater treatment plants (WWTPs) and water treat- ment plants (WTPs). The presence of pharmacologically active compounds in the environment is of a great interest because of their potential to cause negative effects. Furthermore, drugs can undergo different pro- cesses leading to the...
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Topical delivery of pharmaceutical and cosmetic macromolecules using microemulsion systems
PublikacjaMicroemulsions are transparent, thermodynamically stable colloidal systems. Over the recent years, they have been increasingly investigated due to their potential as skin delivery vehicles for a wide range of drug molecules. The nanoscale particle size and the specificity of microemulsion components are the main features determining the skin permeation process. However, in order to effectively cross the skin barrier, the active...
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Recovery of ibuprofen from pharmaceutical wastes using ionic liquids
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Bioremediation of pharmaceutical effluent by food industry and agricultural waste biomass
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Bee Products and Essential Oils as Alternative Agents for Treatment of Infections Caused by S. aureus
PublikacjaBacteria of the genus Staphylococcus are important human and veterinary pathogens. A crucial characteristic for this group of bacteria is that they can easily acquire mechanisms of antibiotic resistance for a plethora of antibiotics currently in use for human and animal therapies. Therefore, there is a great need to find novel, non-antibiotic chemotherapeutics with marked antistaphylococcal activity. Promising but still underestimated...
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Cost Effective Corrosion and Fatigue Monitoring for Marine Transport Products
PublikacjaW artykule omówiono genezę i główne założenia projektu badawczego "Cost Effective Corrosion and Fatigue Monitoring for Transport Products'' o kryptonimie CORFAT, realizowanego w ramach VII Programu Ramowego Unii Europejskiej. Przedstawiono cele i metodykę badań, zalety nowej nowej metodyki monitorowania statków, zadania projektu, zalety i ograniczenia metody Emisji Akustycznej (EA), opis innych metod badań nieniszczących (NNDT)....
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Review of cigars and cigar-type products as potential sources of consumer exposure to heavy metals
PublikacjaThe popularity of cigars, growing since 1993, has not gone hand in hand with the increased interest of researchers in these products. Although the literature widely describes the harmfulness of tobacco and the content of toxic substances in tobacco products, the topic is often treated selectively as relating primarily to cigarettes and rarely extends to other products of the broadly defined tobacco industry. However, there is no...
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A modern solid waste management strategy – the generation of new by-products
PublikacjaTo benefit the environment and society, EU legislation has introduced a ‘zero waste’ strategy, in which waste material should be converted to resources. Such legislation is supported by the solid waste hierarchy concept, which is a set of priorities in waste management. Under this concept, municipal solid waste plants (MSWPs) should be equipped with sorting and recycling facilities, composting/incineration units and landfill prisms...
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Evaluation of the photoprotective effect of ˇ-cyclodextrin on the emission of volatile degradation products of ranitidine
PublikacjaThe process of the photo-excitation of ranitidine hydrochloride (RAN) in a solid state makes visible changes to its colour and generates an unpleasant odour. The purpose of the present study was to observe the protective effects of ˇ-cyclodextrin (CD) complexation as well as the effect of the mixture of two stoichiometries 1:1 and 1:2 (RAN:CD, IC) on the photostability of samples in a solid state. Sam- ples of inclusion complexes...
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Evaluation of the photoprotective effect of β-cyclodextrin on the emission of volatile degradation products of ranitidine
PublikacjaThe process of the photo-excitation of ranitidine hydrochloride (RAN) in a solid state makes visible changes to its colour and generates an unpleasant odour. The purpose of the present study was to observe the protective effects of ˇ-cyclodextrin (CD) complexation as well as the effect of the mixture of two stoichiometries 1:1 and 1:2 (RAN:CD, IC) on the photostability of samples in a solid state. Samples of inclusion complexes...
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Viability of fruit seed oil O/W emulsions in personal care products
PublikacjaThe use of fruit seed oils in personal care products is of significance to both their function and image. Poland is an important processor of fruit products within the EU, and thus has a large availability of seeds from domestic fruits, which are normally considered to be a waste material or feed for livestock. Unfortunately, current literature is scarce of the suitability of these oils for topical dermatological use in the form...
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Microscopic Imaging to Visualize the Distribution of Dietary Nucleic Acids in Food Products of Various Origins
PublikacjaDietary nucleic acids (dietNAs) are being increasingly recognized as important food components with nutritional value. However, the precise dietary recommendations for dietNAs are limited, because established methods for determining the quantity and nutritional role of dietNAs are still lacking. One of the tools to narrow this gap could be microscopic imaging, as a convenient approach to visualize the abundance and distribution...
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Receptor for advanced glycation end‐products: Biological significance and imaging applications
PublikacjaThe receptor for advanced glycation end-products (RAGE or AGER) is a transmembrane, immunoglobulin-like receptor that, due to its multiple isoform structures, binds to a diverse range of endo- and exogenous ligands. RAGE activation caused by the ligand binding initiates a cascade of complex pathways associated with producing free radicals, such as reactive nitric oxide and oxygen species, cell proliferation, and immunoinflammatory...
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Microscopic 75^As NMR study of the effect of impurities on the first-order spin-density-wave transition in BaFe2As2
PublikacjaOpisane są wyniki badań NMR na 75^As w monokryształach i próbkach polikrystalicznych BaFe2As2. Zanieczyszczenia cyną wpływają na niskoenergetyczne fluktuacje spinowe i obniżają temperaturę krytyczną ze 138K do 85K.
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Elimination of metal catalyst and carbon-like impurities from single-wall carbon nanotube raw material
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GOOD HEALTH PRODUCTS AND POLYMER COMPOSITES OBTAINED WITH THE USE OF NATURAL ORIGIN MICRO- AND NANOFIBERS
PublikacjaThe aim of this work was focused on good health products and polymer composites obtained with the use of natural origin micro- and nanofibers. Many different type of the natural plants are used in the production of good health products and polymer processing like curcuma, cellulose, microalgae and others. Often are used as a antioxidants and fillers. In this work the effect of algae and cellulose as a microfillers on the chosen...
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Investigating COVID-19 active pharmaceutical ingredients (APIs) degradation using Peroxydisulfate/FeMnOx binary metal oxide/Ultrasound System
PublikacjaDegradation of Favipiravir using a hybrid system of peroxydisulfate, FeMnOx binary metal oxide, and ultrasound irradiation was studied. A novel catalyst was synthesized with deep eutectic solvent (DES). The effects of DES type on catalytic performance was evaluated and the catalysts were characterized using XRD, SEM, BET, XPS, and EDS. DES-based catalysts exhibited higher efficiency due to structure change, surface area enhancement...
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Potential applications of by-products from the coffee industry in polymer technology – Current state and perspectives
PublikacjaCoffee is one of the most popular beverages in the world, and its popularity is continuously growing, which can be expressed by almost doubling production over the last three decades. Cultivation, processing, roasting, and brewing coffee are known for many years. These processes generate significant amounts of by-products since coffee bean stands for around 50% of the coffee cherry. Therefore, considering the current pro-ecological...
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Acceptance Testing of Software Products for Cloud-Based On-Line Delivery
PublikacjaSoftware products intended for on-line delivery by distributors serving an open community of subscribers are developed in a specific life-cycle model, in which roles of the major stakeholders are strongly separated, unlike in any other software development model known in software engineering. Its specificity underlines the fact that a distributor of the final product, responsible for its acceptance for publication and delivery...
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Educational resources as digital products
PublikacjaW artykule zaproponowano podejście do tworzenia i dystrybucji materiałów edukacyjnych oparte na znanych rozwiązaniach dotyczących produktów cyfrowych. Szczególnie skoncentrowano się na pracochłonności wykonania materiałów oraz wynikającego z niej kosztu zakupu i ceny materiałów. Zaproponowano miarę rozmiaru obiektów edukacyjnych, która wykazuje korelację z pracochłonnością wykonania obiektów. Zaproponowano także metody dotyczące...
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Lycopene in tomatoes and tomato products
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Sustainable Management of Food Wastes Through Cavitation-Assisted Conversion into Value-Added Products
PublikacjaMore than 30% of worldwide food consumption is thrown out as food wastes causing serious environmental, economic, and social problems. Therefore, it is required to develop sustainable food waste management methods leading to an enhancement in social and economic benefits and mitigation of environmental impacts. Anaerobic digestion can be regarded as one of those effective methods that can be employed for the conversion of food...
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The evolving structure of Polish exports (1994-2010) - diversification of products and trade partners.
PublikacjaThis paper presents empirical evidence on the diversification process concerning Polish exports (1994–2010), compared to European and global samples of countries. It analyzes both the commodity structure of Polish trade and the geographical diversification of Poland’s trading partners. The analysis draws on highly disaggregated data on exports (HS 6 digit) and combines descriptive analysis with non-parametric, semi-parametric and...
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Detection, identification and determination of chiral pharmaceutical residues in wastewater: Problems and challenges
PublikacjaChiral pharmaceuticals (CPs) are widely used in different areas of human life, thus they are frequentlydetected in different ecosystems. However, before CPs reach the environment, wastewater is subjected todifferent treatment processes in order to remove them. Nevertheless, such processes may affect thechirality of CPs, thus it is very important to monitor CP levels during the wastewater treatment.This review addresses the present...
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Chapter 13. Immunological determination of the pharmaceutical diclofenac in environmental and biological samples
PublikacjaOpracowano wysoce specyficzną i czułą metodę immunologiczną oznaczania przeciwzapalnego leku diklofenaku. Jest to jeden z najczęściej wykrywanych farmaceutyków w środowisku. Granicę wykrywalności oraz wartość IC50 określono na poziomie 6 ng/L oraz 60 ng/L dla wody wodociągowej, odpowiednio. W badaniu porównawczym, stosując test ELISA oraz GC-MS określono poziomy stężeń diklofenaku w wodach ściekowych z 21 oczyszczalni ścieków i...
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Trade differentiation and the characteristics of new imported and exported products - international panel data analysis
PublikacjaDrawing on o large panel of international economies we have shown how the set of imported and exported products evolves in economic growth process. Strong activity at the extensive margin, manifested through the rise in the number of active export and import lines, is typical for early stages of development. Trade diversification tendency, typical for a predominant mass of observations in our panel, is associated with changes in...
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Membrane technologies assisting plant-based and agro-food by-products processing: A comprehensive review
PublikacjaBackground Nowadays, membrane-based technologies (e.g. microfiltration, ultrafiltration, nanofiltration, membrane distillation, and pervaporation) have demonstrated to meet the requirements to be involved in different food and bioproduct processes. Scope and approach Several applications have been developed, including either separation, recovery or concentration of bioactive molecules from agro-food products and by-products,...
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Green products from herbal medicine wastes by subcritical water treatment
PublikacjaHerbal medicine wastes (HMWs) are byproducts of medicine factories, which are mainly landfilled for their environmental problems. Only bearing in mind the contamination and concerns caused by the COVID-19 pandemic and environmental emissions, the worth of herbal medicine wastes management and conversion to green products can be understood. In this work, subcritical water treatment was carried out batch-wise in a stainless tube...
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Efficiency and proportions of waste tyre pyrolysis products depending on the reactor type—A review
PublikacjaThis article discusses the current use of different pyrolytic reactors, their constructions and operating principles regarding the yields of main products of waste tyre pyrolytic recycling. Whether one makes a larger or smaller profit, or even a loss due to a surcharge being levied on waste tyre recycling, depends on the sale of the pyrolysis products (gas, char, oil), the proportions and market prices of which differ. The cheapest...
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Effect of cooking on the contents of glucosinolates and their degradation products in selected Brassica vegetables
PublikacjaChanges in the levels of glucosinolates and their degradation products in selected Brassica vegetables due to the cooking process were investigated. The purple cauliflower was found to be the best source of aliphatic and indole glucosinolates, and it was also abundant in compounds such as sinigrin, glucoraphanin and glucobrassicin. As a result of cooking rutabaga, green cauliflower and purple cauliflower, a significant decrease...
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More than just a beer—the potential applications of by-products from beer manufacturing in polymer technology
PublikacjaBeer is the most popular alcoholic beverage in the world, and its popularity is continuously growing. Currently, global beer production is estimated at around 2 billion hectoliters. Nevertheless, the increasing production capacity implicates the rising issue of generated by-products—brewers’ spent grain, spent hops, spent yeast, and wastewater. They are generated in massive amounts, so having in mind the current pro-ecological...
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Enhancing the bioconversion rate and end products of black soldier fly (BSF) treatment – A comprehensive review
PublikacjaFood security remains a pressing concern in the face of an increasing world population and environmental challenges. As climate change, biodiversity loss, and water scarcity continue to impact agricultural productivity, traditional livestock farming faces limitations in meeting the growing global demand for meat and dairy products. In this context, black soldier fly larvae (BSFL) have emerged as a promising alternative for sustainable...
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The potential of enhancing denitrification in the activated sludge process with by-products from the alcohol production
PublikacjaIn this study, by-products from the alcohol production were examined in terms of their potential application as external carbon sources for enhancing denitrification in biological nutrient removal systems. Three kinds of experimental assays were used to compare the effects of the by-products with other external carbon sources (ethanol and acetic acid) and the settled wastewater. Based on the results obtained, it appears that one...
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Behavior of microbial communities developed in the presence/reduced level of soluble microbial products.
PublikacjaBadano aktywność mikrobiologiczną organizmów osadu czynnego (adaptowanego i nieadaptowanego) poprzez monitorowanie zmian pH, rozpuszczonego tlenu, BZT5 oraz ChZT w ściekach syntetycznych. Obserwowano pojawianie się ubocznych produktów mikroorganizmów (Soluble Microbial Products) oraz ich wpływ na efekt oczyszczenia ścieków. Ilość obecnych ubocznych produktów mikroorganizmów w trakcie procesu zależała także od rodzaju rozkładanych...
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Assessment of cytotoxic and endocrine potential of selected xenobiotics commonly present in food products
PublikacjaMore and more increased intensity of anthropopressure processes can be observed, among other things, in the release of great quantities of synthetic substances into the environment, including the Endocrine Disrupting Compounds (EDC). A vast number of chemical substances is considered to belong to the this group, including substances which occur naturally in the environment, such as mycotoxins and phytoestrogens, and substances...
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Products of Photo- and Thermochemical Rearrangement of 19-Membered di-tert-Butyl-Azoxybenzocrown
PublikacjaThe preparation and characterization of products of the photochemical and thermochemical rearrangements of 19-membered azoxybenzocrowns with two, bulky, tert-butyl substituents in benzene rings in the para positions to oligooxyethylene fragments (meta positions to azoxy group, i.e., t-Bu-19-Azo-O have been presented. In photochemical rearrangement, two colored typical products were expected, i.e., 19-membered o-hydroxy-m,m′-di-tert-butyl-azobenzocrown...
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From polymer waste to potential main industrial products: Actual state of recycling and recovering
Publikacjalastics have become widely used materials in everyday life due to their special properties such as durability, easy processing, light-weight and low-cost of production. However, because of their stable and non-biodegradable nature, postconsumer plastics become an issue to the environment. The growing amounts of waste are generated, as plastic products are commonly used only once before disposal. The alternatives of practical techniques...
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iPP/HDPE blends compatibilized by a polyester: An unconventional concept to valuable products
PublikacjaPolyolefins are the most widely used plastics accounting for a large fraction of the polymer waste stream. Although reusing polyolefins seems to be a logical choice, their recycling level remains disappointingly low. This is mainly due to the lack of large-scale availability of efficient and inexpensive compatibilizers for mixed polyolefin waste, typically consisting of high-density polyethylene (HDPE) and isotactic polypropylene...