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Homogeneity study of candidate reference material (contaminated soil) based on determination of selected metals, PCBs and PAHs
PublikacjaReference materials (RMs) are an indispensable part of QA/QC system and have played a critical role in the continual expansion of analytical capabilities of the analytical laboratories. The homogeneity study of the candidate for reference material is essential for the quality of reference material (certified reference material) used in quality assurance activities. The homogeneity study of candidate for reference materials of contaminated...
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Three Editions of Inter-University Studies on Space and Satellite Technology. Candidate and/vs. Graduate, a Case Study
PublikacjaCurrently, there is a growing demand for most up-to-date academic courses that will fulfil the needs of modern society. Each candidate has to make choices and judgements carefully, in order to succeed on the market. This is particularly important when educating individuals with different backgrounds, especially on an inter-university course in the field of space sciences and technology. This paper describes a case study carried...
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Multilocus Analysis of Candidate Genes Involved in Neurogenic Inflammation in Pediatric Asthma and Related Phenotypes: A Case–Control Study
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l-ascorbic acid modified poly(ester urethane)s as a suitable candidates for soft tissue engineering applications
PublikacjaIn this paper we created novel poly(ester urethane)s (PESUs) designed specifically for tissue engineering. The PESUs were derived from oligomeric α,ω-dihydroxy(ethylene-butylene adipate) (dHEBA), 1,4-butanediol (BDO) and aliphatic 1,6-hexamethylene diisocyanate (HDI) and modified with l-ascorbic acid to improve their biocompatibility. In addition, we determined their mechanical properties (such as tensile strength, elongation at...
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In Silico Safety Assessment of Bacillus Isolated from Polish Bee Pollen and Bee Bread as Novel Probiotic Candidates
PublikacjaBacillus species isolated from Polish bee pollen (BP) and bee bread (BB) were characterized for in silico probiotic and safety attributes. A probiogenomics approach was used, and in-depth genomic analysis was performed using a wide array of bioinformatics tools to investigate the presence of virulence and antibiotic resistance properties, mobile genetic elements, and secondary metabolites. Functional annotation and Carbohydrate-Active...
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High Cu content LaNi1-xCuxO3-δ perovskites as candidate air electrode materials for Reversible Solid Oxide Cells
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Ruddlesden-Popper-type Nd2-xNi1-yCuyO4±δ layered oxides as candidate materials for MIEC-type ceramic membranes
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Identification and Analysis of Candidate Genes Associated with Yield Structure Traits and Maize Yield Using Next-Generation Sequencing Technology
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Development of a Peptide Derived from Platelet-Derived Growth Factor (PDGF-BB) into a Potential Drug Candidate for the Treatment of Wounds
PublikacjaObjective: This study evaluated the use of novel peptides derived from platelet-derived growth factor (PDGF-BB) as potential wound healing stimulants. One of the compounds (named PDGF2) was subjected for further research after cytotoxicity and proliferation assays on human skin cells. Further investigation included evaluation of: migration and chemotaxis of skin cells, immunological and allergic safety, the transcriptional analyses...
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In vitro studies of antimicrobial activity of Gly-His-Lys conjugates as potential and promising candidates for therapeutics in skin and tissue infections
PublikacjaWe presented in vitro studies of antimicrobial activity of Gly-His-Lys conjugates that are important point in preliminary biological evaluation of their potential application in skin and tissue therapy. The novel compounds include the conjugation of fatty acids with a modification of the amino acid sequence in the primary structure of Gly-His-Lys.
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Fatigue behaviour of SLM maraging steel under variable-amplitude loading
PublikacjaOne of the most challenging issues for additive manufactured materials is fatigue endurance. Engineering components often operate under complex, variable amplitude loadings, in which existing technological imperfections promote fatigue cracks growth and damage of elements eventually. In this study the effects of different variable-amplitude strain levels on fatigue life, 18Ni300 steel was tested. The work presents various behaviours...
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Strain sequence effect on fatigue life and fracture surface topography of 7075-T651 aluminium alloy
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Biocomposites from recycled resources as candidates for laboratory reference material to validate analytical tools used in organic compounds emissions investigation
PublikacjaA suitably chosen reference material should meet specific criteria like representing one of the compound classes most commonly occurring in indoor materials as well as having optimal long-term stability during storage and transport to its destination point and having a compact size. The described interdisciplinary pilot research was aimed to develop and characterize a polymer-based candidate for the laboratory reference material...
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Strain sequence effect on fatigue life and fracture surface topography of 7075-T651 aluminium alloy
PublikacjaThe paper studies the effect of strain-loading sequence on fatigue lifetime and fracture surface topographies in 7075-T651 aluminum alloy specimens. Fatigue tests were performed in two ways: (i) constant-amplitude loading and (ii) two series of variable amplitude loading with non-zero mean strain values. The topography of the fatigue fractures was measured over their entire surfaces with the help of an optical confocal measurement...
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A- and B-site doping effect on physicochemical properties of Sr2−xBaxMMoO6 (M = Mg, Mn, Fe) double perovskites — candidate anode materials for SOFCs
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Prediction of Overall In Vitro Microsomal Stability of Drug Candidates Based on Molecular Modeling and Support Vector Machines. Case Study of Novel Arylpiperazines Derivatives
PublikacjaOther than efficacy of interaction with the molecular target, metabolic stability is the primary factor responsible for the failure or success of a compound in the drug development pipeline. The ideal drug candidate should be stable enough to reach its therapeutic site of action. Despite many recent excellent achievements in the field of computational methods supporting drug metabolism studies, a well-recognized procedure to model...
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Diversity of Expression Patterns of Lr34, Lr67, and Candidate Genes towards Lr46 with Analysis of Associated miRNAs in Common Wheat Hybrids in Response to Puccinia triticina Fungus
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Expression patterns of candidate genes for the Lr46/Yr29 “slow rust” locus in common wheat (Triticum aestivum L.) and associated miRNAs inform of the gene conferring the Puccinia triticina resistance trait
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Quasistatic and fatigue behavior of an AISI H13 steel obtained by additive manufacturing and conventional method
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Quasistatic and fatigue behavior of an AISI H13 steel obtained by additive manufacturing and conventional method
PublikacjaThis work aims to compare the mechanical behavior of an AISI H13 steel obtained by additive manufacturing with that obtained by conventional manufacturing methods. The average values of the ultimate tensile strength (UTS) and ductility obtained for the specimens produced by the conventional method were equal to 658 MPa and 18%, respectively, which compares with 503 MPa and 0.75% registered for the selective laser melting (SLM)...
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A CRISPR/Cas9-Based Mutagenesis Protocol for Brachypodium distachyon and Its Allopolyploid Relative, Brachypodium hybridum
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Mechanical Properties of Additively Manufactured Polymeric Materials—PLA and PETG—For Biomechanical Applications
PublikacjaThe study presented herein concerns the mechanical properties of two common polymers for potential biomedical applications, PLA and PETG, processed through fused filament fabrication (FFF)—Material Extrusion (ME). For the uniaxial tension tests carried out, two printing orientations—XY (Horizontal, H) and YZ (Vertical, V)—were considered according to the general principles for part positioning, coordinates, and orientation typically...
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Synthesis, anticandidal activity of N3-(4-methoxyfumaroyl)-(S)-2,3-diaminopropanoic amide derivatives – Novel inhibitors of glucosamine-6-phosphate synthase
PublikacjaNovel FMDP amiders 4-6 have been synthesized and tested against Candida strains. The anticandidal activity has been confined only to Candida albicans. Anticandidal activity of the tested amides has correlated with their inhibitory activity of glucosamine-6-phosphate synthase in cell free extract from Candida albicans.
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Oxolane Ammonium Salts (Muscarine-Like)—Synthesis and Microbiological Activity
PublikacjaCommercially available 2-deoxy-D-ribose was used to synthesize the appropriate oxolane derivative—(2R,3S)-2-(hydroxymethyl)oxolan-3-ol—by reduction and dehydration/cyclization in an acidic aqueous solution. Its monotosyl derivative, as a result of the quaternization reaction, allowed us to obtain eight new muscarine-type derivatives containing a quaternary nitrogen atom and a hydroxyl group linked to the oxolane ring. Their structure...
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Application of electronic nose to effectiveness monitoring of air contaminated with toluene vapors biofiltration process
PublikacjaThe research presents the application of electronic nose (combined with MLR model) to on-line effectiveness monitoring of biofiltration of air contaminated with hydrophobic, odorous compound (toluene vapors). The research was conducted using two-section biotrickling filter inhabited by Candida environmental isolates. Gas chromatography was used as the comparative technique to obtain reliable quantification of toluene concentration...
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Hydrazinolysis Products of Selected Sugar Lactones—Crystal Structure and Microbiological Activity
PublikacjaCommercially available lactones, as well as those synthesized by us, turned out to be good substrates for the synthesis of sugar hydrazides. The exception was L-ascorbic acid, whose hydrazinolysis led to the formation of a hydrazinium salt, not the hydrazide as expected. The structure of all compounds was confirmed by NMR and X-ray analyses. The lower durability of hydrazinium L-ascorbate was additionally confirmed by thermogravimetric...
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Antifungal activity of thionated analogues of nva-fmdp and lys-nva-fmdp
Publikacjaotrzymano dwa peptydy w których wiązanie amidowe łączące aminokwasy zamieniono na tioamidowe w wyniku kilkunastoetapowej syntezy chemicznej. do reakcji tionowania zastosowano odczynnik lawessona. otrzymane związki poddano badaniom aktywności z wykorzystaniem pięciu szczepów candida , w tym szczepów opornych na flukonazol. stwierdzono, ze obecniość wiązania tioamidowego znacznie obniża aktywność przeciwgrzybową testowanych związków...
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Chapter 31. Preparation of silver doped titanium dioxide nanoparticles in microemulsion system
PublikacjaNanocząstki TiO2 domieszkowanego srebrem przygotowano w mikroemulsji woda-AOT-cykloheksan. Zbadano wpływ zawartości srebra (od 1,5 do 8,5% mol.) na aktywność fotokatalityczą oraz właściwości bakterio- i grzybobójcze. Stwierdzono, że TiO2 modyfikowany za 6,5% mol. Ag wykazuje najwyższą aktywność w reakcji degradacji fenolu oraz najwyższą aktywność mikrobiologiczną. Aktywność mikrobiologiczną wyznaczano jako minimalne stężenie hamujące...
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New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets
PublikacjaInfections of Candida spp. etiology are frequently treated with azole drugs. Among azoles, the most widely used in the clinical scenario remains fluconazole (FLC). Promising results in treatment of dangerous, systemic Candida infections demonstrate the advantages of combined therapies carried out with combinations of at least two different antifungal agents. Here, we report five conjugates composed of covalently linked FLC and...
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Synthesis, Antimicrobial and Mutagenic Activity of a New Class of d-Xylopyranosides
PublikacjaEight N-[2-(2′,3′,4′-tri-O-acetyl-α/β-d-xylopyranosyloxy)ethyl]ammonium bromides, a new class of d-xylopyranosides containing a quaternary ammonium aglycone, were obtained. Their complete structure was confirmed using NMR spectroscopy (1H, 13C, COSY and HSQC) and high-resolution mass spectrometry (HRMS). An antimicrobial activity against fungi (Candida albicans, Candida glabrata) and bacteria (Staphylococcus aureus, Escherichia...
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Isolation and Characterization of Phenol-Degrading Psychrotolerant Yeasts
PublikacjaIn this study, the potential of selected psychrotolerant yeast strains for phenol biodegradation was studied. From 39 strains isolated from soil and water samples from Rucianka peat bog, three psychrotolerant yeast strains: A011, B021 and L012 showed the ability to phenol degradation. The result shows that all three yeast strains could degrade phenol at 500 mg l-1 and 750 mg l-1 concentration, whereas strains A011 and L012 could...
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Anticandiadal properties of N-acylpeptides containing inhibitor of glucosamine-6-phosphate synthase
PublikacjaOtrzymano serię N-acylopeptydów zawierających inhibitor syntazy glukozamino-6-fosforanu i zbadano ich aktywność w stosunku do szczepów Candida albicans. Aktywność przeciwgrzybową skorelowano z właściwościami lipofilowymi otrzymanych peptydów. Peptydy zawierające resztę kwasu dekanowego wykazywały najwyższą aktywność przeciwgrzybową.
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Wpływ poliuretanów z syntetycznym polihydroksymaślanem na wzrost mikroorganizmów
PublikacjaW pracy przedstawiono wyniki badań oddziaływania nowych alifatycznych poliuretanów, otrzymanych z udziałem polihydroksymaślanu na wzrost Staphylococcus aureus, Escherichia coli i Candida albicans wokół próbek poliuretanowych. Najbardziej wrażliwym na działanie materiału poliuretanowego w warunkach prowadzenia doświadczenia był szczep Staphylococcus aureus.
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N-acylpeptides with glucosamine-6-phosphate synthase inhibitors - synthesisand antifungal activity
PublikacjaOpracowano syntezę kilku peptydów (di i tripeptydów) zawierających inhibitory syntazy glukozamino-6-fosforanu oraz przeprowadzono je w N-acylopochodne (acetylowe, heksanoilowe, dekanoilowe) oraz zbadano ich aktywność przeciwgrzybową w stosunku do szczepów Candida albicans z opornością wielolekową. Stwierdzono, że N-acylopeptydy wykazują aktywność przeciwgrzybową oraz określono wartości MIC.
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Wytyczne dotyczące diagnostyki inwazyjnych zakażeń grzybiczych u pacjentów hematologicznych i onkologicznych
PublikacjaInwazyjne zakażenia grzybicze (ang. invasive fungal diseases - IFD) są główną przyczyną zachorowań i śmiertelności, szczególnie u pacjentów z nowotworami hematologicznymi. Grzyby, które są najczęstszymi przyczynami schorzeń u tego typu pacjentów to Aspergillus spp. oraz Candida albicans. Gatunki Candida nie-albicans oraz rosnąca liczba innych grzybów (np. Zygomycetes, Trichosporon, Fusarium spp.) są także coraz częściej wykrywane....
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Synthesis of isomeric, oxathiolone fuded chalcones and comparison of their activity toward various microorganisms and human cancer cell lines
PublikacjaIzomeryczne oksationolowe sprzężone chalkony otrzymano w wyniku kondensacji odpowiedniego acetylobenzo[1,3]oksatiolo-2-onu z aldehydem benzoesowym w środowisku kwaśnym. Określono aktywność cytotoksyczną otrzymanych związków wobec komórek linii HeLa, przeciwbakteryjną wobec Micrococcus luteus, Staphylococcus aureus, Salmonella typhimurium, Escherichia coli i Proteus vulgaris, przeciwgrzybową wobec Candida albicans i tuberkulostatyczną...
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Photosensitive and pH-dependent activity of pyrazine-functionalized carbazole derivative as promising antifungal and imaging agent
PublikacjaCarbazole skeleton plays a significant role as a structural scaffold of many pharmacologically active compounds. Pyrazine-functionalized carbazole derivative was constructed by coupling 2-amino-5-bromo-3-methylaminepyrazine (ABMAP) into 3 and 6 positions of the carbazole ring. Multi-experimental methods were used, e.g., potentiometric, spectroscopic (ATR, UV, XRD powder,1H and13C NMR), electrochemical (cyclic voltammetry), and...
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Fatty acids as molecular carriers in cleavable antifungal conjugates
PublikacjaConjugates composed of C2-18 fatty acid (FA) residues as a molecular carrier and 5-fluorocytosine (5-FC) as an active agent, released upon the action of intracellular esterases on the ester bond between FA and “trimethyl lock” intramolecular linker, demonstrate good in vitro activity against human pathogenic yeasts of Candida spp. The minimal inhibitory concentrations (MIC) values for the most active conjugates containing caprylic...
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Izolacja i identyfikacja psychrotolerancyjnych szczepów drożdży z torfowiska Rucianka zdolnych do efektywnej biodegradacji fenolu w obecności tlenu oraz identyfikacja szlaku metabolicznego zaangażowanego w tym procesie w celu oceny potencjału biotechnologicznego badanych szczepów drożdży
PublikacjaFenole to grupa toksycznych węglowodorów aromatycznych, a do głównych źródeł ich emisji do środowiska można zaliczyć przemysł chemiczny, procesy przeróbki węgla kamiennego i przemysł tekstylny. Pośród nich, fenol stanowi główne zanieczyszczenie gleb i wód spowodowane związkami fenolowymi. W wyniku realizacji badań prowadzonych w ramach mojej rozprawy doktorskiej wykazałam, że torfowiska mogą stanowić miejsce izolacji mikroorganizmów...
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Development of biocompatible iron oxide-silicon oxide core-shell nanoparticles as subcellular delivery platform for glucosamine-6-phosphate synthase inhibitors
PublikacjaIn order to develop the preparation of iron oxide-silica coreshell nanoparticles (CSNPs), thesis deeply explores the cetyltrimethylammonium (CTA+) directed silica coating methods of the oleic-acid capped iron oxide nanoparticles (OA-IONPs) initialized under near-neutral pH conditions. It is demonstrated that the initial alkaline hydrolysis of ethyl acetate in the presence of CTA+ and OA-IONPs induces an unusual ligand exchange...
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Synthesis and biological activity of novel ester derivatives of N3-(4-metoxyfumaroyl)-(S)-2,3-diaminopropanoic acid containing amide and keto function as inhibitors of glucosamine-6-phosphate synthase
PublikacjaA short series of novel ester derivatives of N3-4-methoxyfumaroyl-(S)-2,3-diaminopropanoic acid (FMDP) containing amido or keto functions have been designed and synthesized. Their antifungal activity and inhibitory properties toward fungal glucosamine-6-phosphate synthase has also been evaluated. The obtained compounds 11-13 and 15-17 demonstrated good antifunga activity against Candida albicans. Compounds 11-13 displayed also...
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Investigations on the removal of hydrophobic odorous volatile organic compounds by biotrickling filtration monitored with electronic nose
PublikacjaThe presented paper presents the results of research on the removal of selected hydrophobic volatile organic compounds (VOCs) from their mixture with air by means of a trickled-bed biofiltration. The efficiency of the removal of toluene and α-pinene, as model VOCs, in a three-section biotrickling filter is evaluated using GCFID and additionally monitored with an electronic nose. The results show that the removal of the model mixture...
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The use of fungi in biofiltration to remove hydrophobic volatile organic compounds
PublikacjaThe growing importance placed on air quality by environmental regulations and public opinion necessitate the minimization and removal of volatile organic compound emissions (VOCs), including odours. The removal of hydrophobic VOCs from the air by biological methods remains a major technical challenge (despite its importance in the shift to green engineering). A potential solution to this challenge is the use of fungi in biofiltration....
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Novel Nystatin A1 derivatives exhibiting low host cell toxicity and antifungal activity in an in vitro model of oral candidosis
PublikacjaOpportunistic oral infections caused by Candida albicans are frequent problems in immunocompromised patients. Management of such infections is limited due to the low number of antifungal drugs available, their relatively high toxicity and the emergence of antifungal resistance. Given these issues, our investigations have focused on novel derivatives of the antifungal antibiotic Nystatin A1, generated by modifications at the amino...
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Antimicrobial, Cytotoxic and Mutagenic Activity of Gemini QAS Derivatives of 1,4:3,6-Dianhydro-l-iditol
PublikacjaA series of quaternary diammonium salts derivatives of 1,4:3,6-dianhydro-L-iditol were synthesized, using isommanide (1,4:3,6-dianhydro-D-mannitol) as a startingmaterial. Both aromatic (pyridine, 4-(N,N-dimethylamino)pyridine (DMAP), (3-carboxamide)pyridine; N-methylimidazole) and aliphatic (trimethylamine, N,N-dimethylhexylamine, N,N-dimethyloctylamine, N,N-dimethyldecylamine) amines were used, giving eight gemini quaternary ammonium...
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Synthesis and Characterization of Monometallic (Ag, Cu) and Bimetallic Ag-Cu Particles for Antibacterial and Antifungal Applications
PublikacjaIn this paper, the experimental studies are concerned with the effect of the synthesis parameters on the formation of monometallic Ag and Cu nanoparticles (NPs). We consider the synthesis strategies verification for the bimetallic core-shell and alloy particles preparation. It was successfully obtained by chemical reduction method. The obtained colloidal solution is characterized by the transmission electron microscopy (TEM) with...
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Efficient synthesis and antifungal investigation of nucleosides’ quaternary ammonium salt derivatives
PublikacjaQuaternary ammonium salts are a group of compounds with diverse biological properties, the most important of which are their antiviral, antibacterial, and antifungal activities. The quaternization reactions of 5'-O-tosyl derivatives of uridine and thymidine with triethylamine, trimethylamine, 4-(N ,N -dimethylamino)pyridine, 2-methylpyridine, and pyridine are described in this article. Two of the synthesized compounds are exceptional...
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Chemical reactivity and antimicrobial activity of N-substituted maleimides
PublikacjaZsyntezowano kilkanaście N-podstawionych maleimidów, zawierających w swojej strukturze podstawniki o różnej wielkości i polarności.Maleimidy o charakterze obojętnym wykazywały silny efekt przeciwgrzybowy; ich aktywność przeciwbakteryjna była zróżnicowana. Niską aktywność przeciwbakteryjną, ale wysoką aktywność cytostatyczną stwierdzono dla maleimidów o charakterze zasadowym. Reaktywność chemiczna i lipofilowość miały wpływ na aktywność...
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Antifungal Activity of Homoaconitate and Homoisocitrate Analogs
PublikacjaThirteen structural analogs of two initial intermediates of the L-alpha-aminoadipate pathway of L-lysine biosynthesis in fungi have been designed and synthesized, including fluoro- and epoxy-derivatives of homoaconitate and homoisocitrate. Some of the obtainedcompounds exhibited at milimolar range moderate enzyme inhibitory properties against homoaconitase and/or homoisocitrate dehydrogenase of Candida albicans. The structural...
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Antifungal dipeptides incorporating an inhibitor of homoserine dehydrogenase
PublikacjaThe antifungal activity of 5‐hydroxy‐4‐oxo‐L‐norvaline (HONV), exhibited under conditions mimicking human serum, may be improved upon incorporation of this amino acid into a dipeptide structure. Several HONV‐containing dipeptides inhibited growth of human pathogenic yeasts of the Candida genus in the RPMI‐1640 medium, with minimal inhibitory concentration values in the 32 to 64 μg mL−1 range. This activity was not affected by multidrug...