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Determination of trace levels of eleven bisphenol A analogues in human blood serum by high performance liquid chromatography–tandem mass spectrometry
PublikacjaChemicals showing structural or functional similarity to bisphenol A (BPA), commonly called BPA analogues, have recently drawn scientific attention due to their common industrial and commercial application as a substitute for BPA. In the European Union, the use of BPA has been severely restricted by law due to its endocrine disrupting properties. Unfortunately, it seems that all BPA analogues show comparable biological activity,...
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Development of chromatographic and mass spectrometry conditions for untargeted lipidomic analysis of human breast milk
PublikacjaHuman breast milk (HBM) is a complex biofluid containing components which are essential for the proper growth of the newborn (for example nutrients such as carbohydrates, proteins, lipids) and also bioactive substances. According to the literature, most of studies involving HBM nutrients investigations focused essentially on the determination of proteins. The molecular composition of lipids in HBM is not well known as the protein...
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A miniaturized solid-contact potentiometric multisensor platform for determination of ionic profiles in human saliva
PublikacjaThis paper describes a miniaturized multisensor platform (MP-ISES) consisting of electrodes: a reference one (RE) and ion-selective electrodes (ISEs) for monitoring Na+, K+, Ca2+, Mg2+, Cl−, and SCN− ions and pH in human saliva. Gold electrode surface was modified by deposition of two layers: electrosynthesized PEDOT:PSS forming an intermediate layer, and ion-selective membrane. The developed ISEs were characterized by a wide linear...
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Induction of G2/M phase arrest and apoptosis of human pancreatic cancer BxPC-3 cells by potenet antitumor 1-nitroacridine derivative C-1748
PublikacjaPancreatic ductal adenocarcinoma (PDA) is among the most lethal human cancers, in part because it is insensitive to many chemotherapeutic drugs. Gemcitabine still remains the best chemotherapeutic agent available for the treatment of advanced pancreatic cancer. However, gemcitabine treatment results in only a marginal survival advantage. Thus, there is a strong need for the continuous development of novel therapeutic agents...
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Tensile modulus of human orbital wall bones cut in sagittal and coronal planes
PublikacjaIn the current research, 68 specimens of orbital superior and/or medial walls taken from 33 human cadavers (12 females, 21 males) were subjected to uniaxial tension untill fracture. The samples were cut in the coronal (38 specimens) and sagittal (30 specimens) planes of the orbital wall. Apparent density (ρapp), tensile Young’s modulus (E-modulus) and ultimate tensile strength (UTS) were identified. Innovative test protocols were...
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α-Pinene, 3-carene and d-limonene in indoor air of Polish apartments: The impact on air quality and human exposure
PublikacjaMonoterpenes are among most ubiquitous volatile organic compounds (VOCs) to be detected in indoor air. Since the quality of indoor air is considered important for inhabitants' well-being, the present study aimed at investigating impact of human activity on levels of selected monoterpenes applying passive sampling technique followed by thermal desorption and gas chromatography coupled mass spectrometry. One of the objectives of...
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Tensile and flexural moduli for human orbital wall bones – comparative study
PublikacjaThe main aims of the current research were: (1) to analyze in detail the tensile modulus and ultimate tensile strength (UTS) of orbital wall bones separately for the left and right orbit of the same cadaver and (2) to compare the obtained results with a flexural modulus of the left and right orbit reported earlier by A. C. van Leeuwen et al. [14]. A set of 54 specimens of orbital superior and/or medial walls harvested from 16 human...
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Drill holes decrease cancellous bone strength: A comparative study of 33 paired osteoporotic human and 9 paired artificial bone samples
PublikacjaThis study was designed to compare compressive strength of cancellous bone retrieved from the femoral head in a specimen with and without guide wire hole, with comparison to synthetic bone samples. Femoral heads retrieved from 33 patients who sustained femoral neck fractures and underwent hip arthroplasty were cut into cuboids leaving two matching samples from the same femoral head. Similar samples were prepared from synthetic femurs....
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Classifying the transformation products (TPs) of emerging contaminants (ECs) for prioritizing research into their impact on the environment and human health
PublikacjaOne of the first books to cover transformation products, rather than primary compounds, Transformation Products of Emerging Contaminants in the Environment gathers, specifies, synthesizes, and advances existing knowledge of the most important transformation product (TPs) of the main groups of emerging contaminants with potential concern to human health and the environment. This two-volume set for researchers and professionals covers...
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Mechanism-based inactivation of human cytochrome P450 1A2 and 3A4 isoenzymes by antitumor triazoloacridinone C-1305.
Publikacja5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone, C-1305, is a promising antitumor therapeutic agent with high activity against several experimental tumors. It was determined to be a potent and selective inhibitor of liver microsomal and human recombinant cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1305 might modulate the effectiveness of other drugs used in multidrug therapy. The objective of this study was...
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Human hip joint lubrication for permeable cartilage
PublikacjaPraca przedstawia pewien model obliczeń wartości sił tarcia zapisany w ortogonalnych sferycznych i innych krzywoliniowych układach współrzędnych dla hydrodynamicznego, niesymetrycznego przepływu cieczy synowialnej o własnościach nienewtonowskich i zmiennej lepkości w szczelinie stawu biodrowego człowieka z uwzględnieniem zmian losowych. Według informacji autora tak przedstawiony model nie był do tej pory rozpatrywany w pracach...
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Statistical and fractal analysis of human heart dynamics.
PublikacjaPrzedstawiono sposób obliczania podstawowych i bardziej zaawansowanych (dyskrepancja) wielkości statystycznych do analizy dynamiki ludzkiego serca. Oprócz analizy statystycznej pokazano elementy analizy fraktalnej (wykresy Poincare). Przedstawiona analiza umożliwia wykrywanie patologicznych sytuacji i jest pomocna lekarzom w diagnostyce.
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A rapid assay of human thyroid peroxidase activity
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Unstability of 4-CMC in human serum specimen
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Rare-earth elements in human colostrum milk
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Human Preference Modelling in Usability of Graphical Interfaces
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Workload Assessment Predictability for Digital Human Models
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Identification of toxic metals in human embryonic tissues
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Edible Lepidoptera as human foods – a comprehensive review
PublikacjaAs the global population continues to grow, traditional protein sources like meat and fish are becoming increasingly unsustainable due to their environmental impact. Edible insects, on the other hand, are highly nutritious, require minimal resources to produce, and emit significantly fewer greenhouse gases than traditional livestock. Lepidoptera, one of the most diverse insect orders, contains some popular edible species that have...
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Effect of silver nanoparticles on human primary keratinocytes
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Analysis of human negotiations for e-business improvements
PublikacjaW artykule zaproponowano ogólny model negocjacji oraz oparty na nim uproszczony model jakości negocjacji. Zaproponowany model jakości negocjacji umożliwia zdefiniowanie wielu scenariuszy negocjacji i ich ocenę w kategoriach kompletności, efektywności, wydajności i satysfakcji. Przeanalizowano 150 eksperymentów (f2f i czat) w celu określenia wpływu osobowości negocjatorów i strategii negocjacyjnych na ich rezultat.
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Optical Investigation of Hematocrit Level in Human Blood
PublikacjaW artykule przedstawiono możliwości wykorzystania metod optoelektronicznych, takich jak: spektroskopia Ramana i interferometria niskokoherencyjna do pomiaru poziomu hematokrytu ludzkiej krwi.
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Model of human psychology for controlling autonomous robots
PublikacjaReferat przedstawia model umysłu, uzyskany w oparciu o wiedzę na temat ludzkiej psychologii, służący do sterowania systemami autonomicznych robotów. Systemy poznawczy i motywacyjny (emocje i potrzeby) stanowią jego główne części. System motywacyjny kontroluje reakcje robota w oparciu o zmienne stanu potrzeb. Z drugiej strony, emocje nadzorują i zmieniają/modyfikują zachowanie robota poprzez zmianę pewnych parametrów uwzględnianych...
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Human reliability analysis in the context of accident scenarios
PublikacjaArtykuł przedstawia problematykę analizy niezawodności człowieka (HRA) w kontekście zidentyfikowanych scenariuszy awaryjnych. Podkreślono potrzebę kontekstowej analizy postępowania człowieka-operatora ze szczególnym uwzględnieniem błędów i uszkodzeń zależnych w rozważanych scenariuszach awaryjnych. Analizę bezpieczeństwa funkcjonalnego z uwzględnieniem oceny niezawodności człowieka zilustrowano na przykładzie warstw zabezpieczeń...
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Complex human computer interface for las patient
PublikacjaW pracy zaprezentowano system umożliwiający komunikację osobie sparaliżowanej z komputerem przy pomocy wzroku.
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New Applications of Multimodal Human-Computer Interfaces
PublikacjaMultimodal computer interfaces and examples of their applications to education software and for the disabled people are presented. The proposed interfaces include the interactive electronic whiteboard based on video image analysis, application for controlling computers with gestures and the audio interface for speech stretching for hearing impaired and stuttering people. Application of the eye-gaze tracking system to awareness...
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Human Centric Lighting w miejscach pracy
PublikacjaWyniki badań wskazują na poszerzenie zakresu efektów odziaływania światła dziennego na człowieka od komfortu pracy wzrokowej po jakość snu, czujność, nastrój, wydajność i stan zdrowia [1]. Ta złożoność wiąże się z nakładami finansowymi ponoszonymi przez społeczeństwo na badania, ale również na tworzenie optymalnego środowiska oświetleniowego w miejscach pracy. HCL to termin, który wywołuje wiele dyskusji w branży oświetleniowej....
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The compositional space of exhaled breath condensate and its link to the human breath volatilome
PublikacjaBreath analysis is commonly understood to target gaseous or volatile organic compounds (VOCs) for the characterization of different pathologies. Targeted analysis is most effective if a working hypothesis can be based on a plethora of data. The recently published volatilome builds an optimal basis for organizing powerful target sets. However, the origin and pathways of biosynthesis of many VOCs are not known, which complicates...
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Concentrations of alfa- and gamma- tocopherols in human breast milk during the first months of lactation and in infant formulas
PublikacjaThe aim of this study was to determine the concentrations of alpha- and gamma-tocopherols in human breast milk samples from different periods of lactation and to compare them with tocopherol content in commercially available formulas for infants at corresponding ages. The study included 93 breast milk samples obtained on the 2nd (colostrum, n=17), 14th (n=30), 30th (n=27) and 90th day of lactation (n=19), along with 90 samples...
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New conjugates of tuftsin and muramyl dipeptide as stimulators of human monocytes-derived dendritic cells
PublikacjaMuramyl dipeptide (MDP) and tuftsin are known biologically active compound displaying a significant influence on various cell populations of innate immune response. MDP, as a fragment of bacterial cell wall, stimulates not only macrophages and monocytes, but also dendritic cells. In contrast, little is known about tuftsin influence on these cells. Therefore it seemed vital to access whether tuftsin or its derivatives conjugated...
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Multisine impedimetric probing of biocatalytic reactions for label-free detection of DEFB1 gene: How to verify that your dog is not human?
PublikacjaAlbert is a dog (Canis familiaris), but he does not realize this. Albert loves human food (and beer), watching movies on the internet, sleeping in bed, and more. But he should not do all these things. To convince him that, we have desinged a test procedure. The DEFB1 gene is unique to human species. Detecting its presence from saliva and in short periods may offer an advantage in the field of forensic medicine, and influence Albert’s...
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Development of Safirinium dyes for new applications: fluorescent staining of bacteria, human kidney cells, and the horny layer of the epidermis
PublikacjaLow-molecular synthetic fluorophores are convenient tools in bioimaging applications. Several derivatives of Safirinium dyes as well as their reactive N-hydroxysuccinimide (NHS) esters bearing diverse substituents were synthesized and evaluated experimentally in terms of their lipophilicity by means of reverse-phase and immobilized artificial membrane high-performance liquid chromatography. Subsequently, the selected compounds...
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Knowledge-based functional safety and security management in hazardous industrial plants with emphasis on human factors
PublikacjaExisting and emerging new hazards have significant potential to impact destructively operation of technical systems, hazardous plants, and systems / networks of critical infrastructure. The programmable control and protection systems play nowadays an important role in reducing and controlling risk in the process of hazardous plant operation. It is outlined how to deal with security related hazards concerning such systems to be...
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3-Monochloropropane-1,2-diol in Infant Foods and Human Breast Milk: Determination by GC-MS
Publikacja3-Monochloropropane-1,2-diol is one of the food borne contaminants called chloropropanols. Over the last decade plenty of analytical methods was developed in order to determine 3-monochloropropane-1,2-diol in its free and bound form in various foodstuffs with the use of GC-FID, GC-ECD, LC-TOFMS and finally GC-MS, which is now widely used in laboratories. The aim of this research was the determination of 3-monochloropropane--1,2-diol...
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Long‐time scale simulations of virus‐like particles from three human‐norovirus strains
PublikacjaThe dynamics of the virus like particles (VLPs) corresponding to the GII.4 Houston, GII.2 SMV, and GI.1 Norwalk strains of human noroviruses (HuNoV) that cause gastroenteritis was investigated by means of long-time (about 30 μs in the laboratory timescale) molecular dynamics simulations with the coarse-grained UNRES force field. The main motion of VLP units turned out to be the bending at the junction between the P1 subdomain (that...
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Increased time varying heart rate and cardiovascular risk in hypertension – Benefit of selective I(f)channel inhibitor?
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Investigation of sour substances by five-channel potentiometric taste sensor containing all-solid-state-electrodes ( ASSEs)
PublikacjaAn elaboration of taste sensor for discrimination of different food products is of great importance for food industry. Potentiometric taste sensor containing ion selective electrodes with lipid/polymer membranes has already been applied commercially in food industry. However, time-consuming and demanding preconditioning method of ions selective electrodes as well as maintenance of electrodes’ bodies are disadvantages of this taste...
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INVESTIGATION OF SOUR SUBSTANCES BY FIVE-CHANNEL POTENTIOMETRIC TASTE SENSOR CONTAINING ALL-SOLID-STATE- ELECTRODES (ASSEs)
PublikacjaAn elaboration of taste sensor for discrimination of different food products is of great importance for food industry. Potentiometric taste sensor containing ion selective electrodes with lipid/polymer membranes has already been applied commercially in food industry. However, time-consuming and demanding preconditioning method of ions selective electrodes as well as maintenance of electrodes’ bodies are disadvantages of this taste...
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Investigations on mixture preparation for two phase adiabatic pressure drop of R134a flowing in 5 mm diameter channel
PublikacjaThe article presents detailed two-phase adiabatic pressure drops data for refrigerant R134a. Study cases have been set for a mass flux varying from 200 to 400 kg/m2 s, at the saturation temperature of 19.4 ◦C. Obtained experimental data was compared with the available correlations from the literature for the frictional pressure drop during adiabatic flow. Influence of mixture preparation on pressure drop was investigated, for...
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Fluid structure interaction study of non-Newtonian Casson fluid in a bifurcated channel having stenosis with elastic walls
PublikacjaFluid–structure interaction (FSI) gained a huge attention of scientists and researchers due to its applications in biomedical and mechanical engineering. One of the most important applications of FSI is to study the elastic wall behavior of stenotic arteries. Blood is the suspension of various cells characterized by shear thinning, yield stress, and viscoelastic qualities that can be assessed by using non-Newtonian models. In this...
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Destruction of shell structures under the dynamic load on the human skull trauma basis
PublikacjaThe main aim of this work is to investigate patterns of potential orbital bone fractures due to mechanical injuries. The solution of the main problem is followed by analysis of several testing examples having straight correlation with civil engineering structures, in which materials of wide range of stiffness are applied. To solve the main problem, the three-dimensional finite element method (FEM) model of the orbital region has...
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The Effect of the Body Mass Indexes of Young Healthy Individuals on the Glyacemic Indexes of Traditional and Modified Vegetarian Meals
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Does caffeine ingestion affect the lower-body post-activation performance enhancement in female volleyball players?
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Impact of the “Sling Shot” Supportive Device on Upper-Body Neuromuscular Activity during the Bench Press Exercise
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Six Weeks of Calorie Restriction Improves Body Composition and Lipid Profile in Obese and Overweight Former Athletes
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Human breast milk concentration of neopterin at various stages of lactation and during a single feeding
PublikacjaThe aim of this work was to determine the physiological level of neopterin in human breast milk, and to study its variability depending on the duration of a single feeding and the lactation stage. Breast milk samples from 74 women were collected between 2 and 4 days after delivery, and at 15, 30, and 90 days after delivery. Additionally, breast milk samples from eight women were collected before and after 7 and 15 min of breastfeeding....
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Absorption spectroscopy setup for determination of whole human blood and blood–derived materials spectral characteristics
PublikacjaA dedicated absorption spectroscopy system was set up using tungsten-halogen broadband source, optical fibers, sample holder, and a commercial spectrometer with CCD array. Analysis of noise present in the setup was carried out. Data processing was applied to the absorption spectra to reduce spectral noise, and improve the quality of the spectra and to remove the baseline level. The absorption spectra were measured for whole blood...
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Social Capital, Human Capital, Tacit Knowledge, and Innovations: A Polish-US Cross-Country Study
PublikacjaThis study measures the relationship between human and social capital (internal and external) and tacit knowledge sharing's influence on innovativeness among knowledge workers employed in Polish (n=1050) and US (n=1118) organizations. The structural equation modeling method revealed that internal social capital matters more for organizational innovativeness in the US. In Poland, both external and internal were important. Specifically,...
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To donate or not to donate? Future healthcare professionals’ opinions on biobanking of human biological material for research purposes
PublikacjaBackground Over the last few decades biobanks have been recognised as institutions that may revolutionisebiomedical research and the development of personalised medicine. Poland, however, still lacks clear regulationsregarding the running of biobanks and the conducting of biomedical research. While the awareness of the generalpublic regarding biobanks is low, healthcare professions and medical students also...
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MEDIA ARCHITECTURE AND INTERACTIVE ART INSTALLATIONS STIMULATING HUMAN INVOLVEMENT AND ACTIVITIES IN PUBLIC SPACES
PublikacjaThis paper examines the potential for media architecture and interactive art installations to stimulate human involvement and activities in public spaces. On the basis of theoretical approaches, case studies and interdisciplinary surveys, the paper provides insight into how screens projecting media and interactive installations in city spaces can inspire people to become active on many levels. The research is focused, both on temporary...