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Wyniki wyszukiwania dla: Β-AMYLASE TREATMENT
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The Effects of Acute and Chronic Haloperidol Treatment on Dopamine Release Mediated by the Medial Forebrain Bundle in the Striatum and Nucleus Accumbens
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Do bacteria isolated from ICU patients ‘ESKAPE’ antibiotic treatment? In vitro susceptibility of the Enterobacteriaceae family to tigecycline
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New and Old Genes Associated with Primary and Established Responses to Cisplatin and Topotecan Treatment in Ovarian Cancer Cell Lines
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Morphological and cellular alternations of HepG2 cells overexpressing CYP3A4 after treatment with antitumor imidazoacridinone derivative C-1311
PublikacjaW pracy badano odpowiedź biologiczną komórek nowotworu wątroby HepG2 z nadekspresją izoenzymu CYP3A4 pod wpływem pochodnej imidazoakrydonu C-1311. Wyniki porównywano z odpowiedzią komórek HepG2 z tzw. wektorem zerowym.Izoeznym CYP3A4 jest jednym z izoenzymów cytochromu P450 odpowiedzialnych za przemiany metaboliczne pochodnej C-1311. Wykazano, że pochodna C-1311 indukuje w obu liniach komórkowych blok w fazie G2/M cyklu komórkowego,...
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Efficiency of landfill leachate treatment in a MBR/UF system combined with NF, with a special focus on phthalates and bisphenol A removal
PublikacjaIn this study, a pilot-scale membrane bioreactor (MBR) was operated at a municipal solid waste plant (MSWP) to treat a mixture of landfill leachates (LLs) obtained from modern (MP-LLs) and previous (PP-LLs) waste cells. The MBR unit combined anoxic and aerobic zones with external ultra- and nanofiltration (MBR/UF and MBR/UF/NF, respectively). In addition to the removal of macropollutants, special attention was given to phthalates...
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Autologous Stem Cells Transplants in the Treatment of Temporomandibular Joints Disorders: A Systematic Review and Meta-Analysis of Clinical Trials
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Response to Letter to the Editor re ‘Urinary tract infection in children: Diagnosis, treatment, imaging – Comparison of current guidelines’
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Updated principles of prevention, diagnosis and treatment of COVID-19 in children in Poland – recommendations for paediatricians and family medicine doctors
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Novel 2019 coronavirus structure, mechanism of action, antiviral drug promises and rule out against its treatment
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Analysis of the Degradation Process of Alginate-Based Hydrogels in Artificial Urine for Use as a Bioresorbable Material in the Treatment of Urethral Injuries
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918 The role of patients and doctors in making decisions about the choice of the kind of adjuvant treatment in early breast cancer
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260. The role of patients and doctors in making decisions about the choice of the kind of adjuvant treatment in early brest cancer
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Trace analyses of gaseous products formed during heat treatment of high stage H2SO4-GICs and expanded graphite
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Three-dimensional hierarchical porous carbon derived from natural resources for highly efficient treatment of polluted water
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Stathmin reduction and cytoskeleton rearrangement in rat nucleus accumbens in response to clozapine and risperidone treatment – Comparative proteomic study
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Impact of orthostatic hypotension and antihypertensive drug treatment on total and cardiovascular mortality in a very elderly community-dwelling population
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High mortality explained by mildly elevated blood pressure in Scandinavian adolescent conscripts – A plea for early drug treatment?
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Advantages of continuous Fenton reaction over the traditional batch process in wastewater treatment in a single and two-step mode
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Water treatment by H2O2 and/or UV affects carbon nanotube (CNT) properties and fate in water and tannic acid solution
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THE EVALUATION OF EFFICACY OF VALBAZEN (PFLIZER) IN THE TREATMENT OF GASTRO-INTESTINAL TRACT PARASITE INVASIONS IN BEEF CATTLE OF WEST POMERANIA
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Trastuzumab-Modified Gold Nanoparticles Labeled with 211At as a Prospective Tool for Local Treatment of HER2-Positive Breast Cancer
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Estimation of wastewater treatment plant state for model predictive control of N-P remowal at medium time scale.
PublikacjaPrzy ograniczonych możliwościach pomiarowych estymaty stanu są potrzebne w sterowaniu optymalizującym, opartym na sterowaniu predykcyjnym, sterującym usuwaniem azotu i fosforu, w biologicznej oczyszczalni ścieków. Optymalizator MPC do implementacji sprzężenia zwrotnego z obiektu potrzebuje tych estymat. Dodatkowo aktualizowane muszą być parametry modelu Gray-Box wykorzystywanego w module MPC. Wtedy estymaty stanu są używane przez...
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Influence of retrogression and reaging (RRA) heat treatment on microstructure, mechanical and chemical behaviour of an Al-Zn-Mg alloy
PublikacjaBadano metodą stałego wolnego rozciągania w wodzie morskiej wpływ czasu i temperatury nawrotu oraz powtórnego starzenia na czas do zniszczenia, energię zniszczenia, przewężenie i odkształcenie. Stwierdzono ogólnie niewielki wpływ, przy czym wzrostowi odporności na korozję naprężeniową towarzyszył spadek właściwości mechanicznych. Obserwowane zmiany właściwości przypisano zmianom struktury dyslokacyjnej i mikrostruktury.
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Zeolitic imidazolate framework (ZIF-8) modified cellulose acetate NF membranes for potential water treatment application
PublikacjaIn this study, cellulose acetate (CA)-based nanofiltration membranes, modified with zeolitic imidazole framework-8 (ZIF-8) particles, were prepared with various ZIF-8 contents (0, 0.1, 0.25, 0.5, 1 and 2 wt%), to obtain membranes with improved flux and filtration performance by combining advantages of CA polymer and ZIF-8 metal-organic frameworks. Removal efficiency studies were carried out with bovine serum albumin and two different...
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pH-Responsive Drug Delivery Nanoplatforms as Smart Carriers of Unsymmetrical Bisacridines for Targeted Cancer Therapy
PublikacjaSelective therapy and controlled drug release at an intracellular level remain key challenges for effective cancer treatment. Here, we employed folic acid (FA) as a self-navigating molecule in nanoconjugates containing quantum dots (QDs) and β-cyclodextrin (β-CD) for the delivery of antitumor unsymmetrical bisacridine compound (C-2028) to lung and prostate cancers as well as normal cells. The bisacridine derivative can form the...
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Review on Current Status of Echinocandins Use
PublikacjaFungal infections are rising all over the world every year. There are only five medical compound classes for treatment: triazoles, echinocandins, polyenes, flucytosine and allylamine. Currently, echinocandins are the most important compounds, because of their wide activity spectrum and much lower sides effects that may occur during therapy with other drugs. Echinocandins are secondary metabolites of fungi, which can inhibit the...
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Therapeutic biomaterials – application in neurology and cardiology
PublikacjaBiomaterials are of interest in most medical fields. It's hard to imagine life without them. And due to the ever-increasing demand, scientists are developing new materials. Diseases of the nervous and cardiovascular systems are still a big problem, which are associated with a limited ability to regenerate brain or heart tissues. Therefore, this review discusses the advancement in biomaterial engineering for the treatment of neurological...
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The Effect of Surface Treatment with Isocyanate and Aromatic Carbodiimide of Thermally Expanded Vermiculite Used as a Functional Filler for Polylactide-Based Composites
PublikacjaIn this work, thermally expanded vermiculite (TE-VMT) was surface modified and used as a filler for composites with a polylactide (PLA) matrix. Modification of vermiculite was realized by simultaneous ball milling with the presence of two PLA chain extenders, aromatic carbodiimide (KI), and 4,4’-methylenebis(phenyl isocyanate) (MDI). In addition to analyzing the particle size of the filler subjected to processing, the efficiency...
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Anti-fouling and permeable polyvinyl chloride nanofiltration membranes embedded by hydrophilic graphene quantum dots for dye wastewater treatment
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Alterations in the metabolism of tryptophan in patients with chronic hepatitis C six months after pegylated interferon-α 2a treatment
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Induction of secondary metabolite production in transformated callus of Ammi majus L. grown after electromagnetic treatment of culture medium
PublikacjaW pracy przedstawiono wyniki badań, których celem było zbadanie wpływu elicytacji przy użyciu ADR-4, na produkcję metabolitów wtórnych. Elicytacja ADR-4 zwiększyła 2-krotnie zawartość bergaptenu. Porównano również efektywność 3 technik ekstrakcyjnych stosowanych do izolacji feuranokumaryn, kumaryn i ich glikozydów z kalusa A.majus. Ekstrakcja przy użyciu techniki ASE okazała się najbardziej efektywna.
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High-Dose Testosterone Propionate Treatment Reverses the Effects of Endurance Training on Myocardial Antioxidant Defenses in Adolescent Male Rats
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Poor evidence for depolarization block but uncoupling of nigral from striatal dopamine metabolism after chronic haloperidol treatment in the rat
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Biofilm Growth Causes Damage to Silicone Voice Prostheses in Patients after Surgical Treatment of Locally Advanced Laryngeal Cancer
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Effect of culinary treatment on chnages in the contents of selected nutrients and non-nutrients in curly kale (Brassica oleracea var. acephala)
PublikacjaKale has a great nutritive value, very high antioxidant activity and pro-healthypotential. The level of phytochemicals and related bioactive compounds arestrongly dependent on pre and postharvest stages of production chain (domestic orindustrial). The study investigated changes in the levels of vitamin C, b-carotene,total polyphenols, antioxidant activity, degradation products of glucosinolates aswell as nitrates and nitrites in...
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Potential and limits of landfill leachate treatment in a multi-stage subsurface flow constructed wetland – evaluation of organics and nitrogen removal
PublikacjaConstructed wetlands have potential of treating wastewater of poor biodegradability. The performance of a multistage sub-surface flow wetland treating municipal landfill leachate was assessed during three years of operation. During the study three research periods with different operation conditions were established. The hydralic loads, operation mode of vertical flow beds and type of treated wastewater (raw leachate – leachate...
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To what extent can hyperelastic models make sense the effect of clay surface treatment on the mechanical properties of elastomeric nanocomposites?
PublikacjaThe poor knowledge about nonlinear mechanical behavior of elastomer nanocomposites arises from the incomplete information on the interface. Application of hyperelastic models provides more insights into the nature and the situation of interaction between the elastomeric matrix and nanofillers. The current work seeks to address the effect of interphase strength on tensile properties of the elastomer nanocomposites under large deformations....
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Predicting Outcome and Conservative Treatment Failure in Patients with Skull Fracture after Traumatic Brain Injury: A Retrospective Cohort Study
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Systematic review of the effect of D‑mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (Review)
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Protocol of the study: the effectiveness of pleuran in the treatment of acute gastroenteritis in children—a randomised, placebo-controlled, double-blind trial (EPTAGE)
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Empirical Versus Targeted Treatment of Helicobacter pylori Infections in Southern Poland According to the Results of Local Antimicrobial Resistance Monitoring
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Short‐term outcome following concurrent surgical treatment of ureteral ectopia and intrapelvic urinary bladder in nine neutered bitches
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Pharmacological treatment of a depressive episode and recurrent depressive disorder – guidelines of the Polish Psychiatric Association and the National Consultant for Adult Psychiatry
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Recommendations of the Polish Psychiatric Association regarding the treatment of affective disorders in women of childbearing age. Part II: Bipolar disorder
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Changes in subcellular localization of visfatin in human colorectal HCT-116 carcinoma cell line after cytochalasin B treatment
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Treatment strategies for comorbid conditions lower residual risk in patients with treated hypertension: FOURIER and other randomized outcome trials
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Editorial [Hot topic: Controversies in Hypertension Treatment (Guest Editors: Maciej Banach, Sverre E. Kjeldsen and Krzysztof Narkiewicz)]
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Non-stoichiometric magnetite as catalyst for the photocatalytic degradation of phenol and 2,6-dibromo-4-methylphenol – a new approach in water treatment
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Revisional operations among patients after surgical treatment of obesity: a multicenter Polish Revision Obesity Surgery Study (PROSS)
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Coincidental Detection of Gastrointestinal Stromal Tumors During Laparoscopic Bariatric Procedures—Data and Treatment Strategy of a German Reference Center
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Update on the molecular pathogenesis and clinical treatment of Mantle Cell Lymphoma (MCL): minutes of the 9th European MCL Network conference
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Future opportunities for products derived from black soldier fly (BSF) treatment as animal feed and fertilizer - A systematic review
PublikacjaThe pursuit of novel food products with good nutritional value for both direct and indirect human consumption is crucial. Given the nutritional benefits of insects and the sustainability of this sort of farming, using them as food for farmed animals is a promising alternative. In this regard, the black soldier fly (Hermetia illucens) is most capable of efficiently converting a wide variety of organic materials, from food waste...
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Enhancing nitrogen removal in the partial denitrification/anammox processes for SO4− - Rich wastewater treatment: Insights into autotrophic and mixotrophic strategies
PublikacjaThe investigation of partial denitrification/anammox (PD/anammox) processes was conducted under autotrophic (N–S cycle) and mixotrophic (N–S–C cycle) conditions over 180 days. Key findings revealed the remarkable capability of SO42--dependent systems to produce NO2− effectively, supporting anaerobic NH4+ oxidation. Additionally, SO42− served as an additional electron acceptor in sulfate reduction ammonium oxidation (SRAO). Increasing...
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Antimicrobial resistance of Pseudomonas spp. isolated from wastewater and wastewater-impacted marine coastal zone
PublikacjaIn this study, species distribution and antimicrobial susceptibility of cultivated Pseudomonas spp. were studied in influent (INF), effluent (EFF), and marine outfall (MOut) of wastewater treatment plant (WWTP). The susceptibility was tested against 8 antimicrobial classes, active against Pseudomonas spp.: aminoglycosides, carbapenems, broad-spectrum cephalosporins from the 3rd and 4th generation, extended-spectrum penicillins,...
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Investigation of MIEX® resin sedimentation in the aspect of particle sizes remaining in the supernatant
PublikacjaThe aim of the study was to evaluate the effectiveness of the MIEX® resin sedimentation process, both new and repeatedly used in hybrid water treatment MIEX®DOC + microfiltration (MF) or ultrafiltration (UF) processes (repeatedly regenerated). The tests consisted of performing 1 h sedimentation of the suspension resin in nonflow conditions and analysis of supernatant water at different process durations. The suspension weight analysis...
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Antiproliferative, Antiangiogenic, and Antimetastatic Therapy Response by Mangiferin in a Syngeneic Immunocompetent Colorectal Cancer Mouse Model Involves Changes in Mitochondrial Energy Metabolism
PublikacjaIn spite of the current advances and achievements in cancer treatments, colorectal cancer (CRC) persists as one of the most prevalent and deadly tumor types in both men and women worldwide. Drug resistance, adverse side effects and high rate of angiogenesis, metastasis and tumor relapse remain one of the greatest challenges in long-term management of CRC and urges need for new leads of anticancer drugs. We demonstrate that CRC...
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Effect of heat treatment on the diffusion intermixing and structure of the Cu thin film on Si (111) substrate: a molecular dynamics simulation study
PublikacjaThis work is devoted to the study of the diffusion process at the interface between copper films with a thickness of 2, 3, 4, 7 and 10 atomic monolayers and silicon substrate by molecular dynamics simulation method. For this purpose, the variation of the concentration of copper and silicon along the perpendicular direction to the interface was investigated. An analysis of the density profile along this direction made it possible...
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Scheelite-Type Wide-Bandgap ABO4 Compounds (A = Ca, Sr, and Ba; B = Mo and W) as Potential Photocatalysts for Water Treatment
PublikacjaIn the present study, alkaline-earth metal scheelite-type compounds ABO4 (A = Ca, Sr, Ba, B = Mo, W) synthesized by a hydrothermal method were systematically studied. The as-obtained photocatalysts were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller surface area analysis (BET), UV–Vis diffuse reflectance spectroscopy (DR/UV-Vis), photoluminescence, and thermoluminescence (TL)...
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Dynamics of hepatitis B virus quasispecies heterogeneity in association with nucleos(t)ide analogue treatment determined by MALDI-TOF MS
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Microwave plasma treatment of simulated biomass syngas: Interactions between the permanent syngas compounds and their influence on the model tar compound conversion
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Superoxide dismutase is upregulated in Staphylococcus aureus following protoporphyrin-mediated photodynamic inactivation and does not directly influence the response to photodynamic treatment
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Changes in oxidative stress in the rat brain during post-cardiac arrest reperfusion, and the effect of treatment with the free radical scavenger idebenone
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Zastosowanie ultrafiltracji do dezynfekcji i doczyszczania ścieków oczyszczonych = Ultrafiltration process in disinfection and advanced treatment of tertiary treated wastewater
PublikacjaW pracy przedstawiono wyniki badań nad ultrafiltracją komunalnych ścieków oczyszczonych. Ustalono, że ultrafiltracja jest skuteczną metodą dezynfekcji. W permeacie obserwowano jedynie pojedyncze komórki bakterii wskaźnikowych. Proces ultrafiltracji umożliwia dalszą poprawę parametrów fizyczno-chemicznych ścieków oczyszczonych. Najlepiej usuwane były mętność oraz fosfor ogólny, dobre efekty uzyskano w usuwaniu ChZT oraz BZT5, w...
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Improvement of the Treatment of Loop Structures in the UNRES Force Field by Inclusion of Coupling between Backbone- and Side-Chain-Local Conformational States
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Remediation of Polycyclic Aromatic Hydrocarbons Contaminated Soil Using Combined Ozonation and Peroxy-Acid Treatment in the Site of Abadan Oil Refinery
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The Use of Titanium 3D Mini-Plates in the Surgical Treatment of Fractures of the Mandibular Condyle: A Systematic Review and Meta-Analysis of Clinical Trials
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Polymeric micelle-mediated delivery of half-sandwich ruthenium(II) complexes with phosphanes derived from fluoroloquinolones for lung adenocarcinoma treatment
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Effects of seed treatment with mustard meal in control of Fusarium culmorum Sacc. and the growth of common wheat (Triticum aestivum ssp. vulgare)
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Capecitabine and temozolomide combination for treatment of high-grade, well-differentiated neuroendocrine tumour and poorly-differentiated neuroendocrine carcinoma — retrospective analysis
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Treatment of insomnia in older adults. Recommendations of the Polish Sleep Research Society, Polish Society of Family Medicine and the Polish Psychiatric Association
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Non-invasive hemodynamic monitoring as a guide to drug treatment of uncontrolled hypertensive patients: effects on home blood pressure in the BEAUTY study
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HOPE-3, SPRINT, VALUE and a meta-analysis of trials in patients with diabetes support treatment of hypertension to a target below 140 mmHg
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Ibrutinib as Treatment for Patients With Relapsed/Refractory Follicular Lymphoma: Results From the Open-Label, Multicenter, Phase II DAWN Study
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Gemcitabine-Based Treatment in Poor Prognosis Patients with Relapsed and Refractory Hodgkin Lymphoma and Non-Hodgkin Lymphoma – a Multicenter Polish Experience
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Development of potent and effective SARS-CoV-2 main protease inhibitors based on maleimide analogs for the potential treatment of COVID-19
PublikacjaIn the present work, we report a new series of potent SARS-CoV-2 Main Protease (Mpro) inhibitors based on maleimide derivatives. The inhibitory activities were tested in an enzymatic assay using recombinant Mpro (3CL Protease from coronavirus SARS-CoV-2). Within the set of new Mpro inhibitors, 6e demonstrated the highest activity in the enzymatic assay with an IC50 value of 8.52 ± 0.44 mM. The IC50 value for Nirmatrelvir (PF-07321332,...
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Usuwanie struwitu z rurociągów w oczyszczalni ścieków komunalnych = Struvite removal from pipelines in municipal wastewater treatment plant
PublikacjaStruwit MgNH4PO4 .6H2O jest minerałem występującym w przyrodzie. Minerał ten może powstawać również w organizmie człowieka oraz zwierząt jako kamień nerkowy. W wielu oczyszczalniach ścieków struwit wytrąca się m.in. podczas odprowadzania cieczy nadosadowej z komór fermentacyjnych. Powoduje to szybkie zmniejszanie się przekroju czynnego rurociągów i konieczność ich wymiany lub usuwania powstałego osadu. Ponadto, powstający osad...
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Human-associated bacteria and their mobile genetic elements - important minority in wastewater and wastewater impacted ecosystems
PublikacjaSince human-associated bacteria have been recognized as vectors in two - way gene transmission between the pathogenic and environmental populations, health hazard connected with wastewater discharge requires reevaluation. In this paper the particular attention was given to antimicrobial-resistance of Escherichia coli and enterococci isolated from wastewater and wastewater impacted environments. The obtained results showed that...
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Cloning and characterization of a novel cold-active glycoside hydrolase family 1 enzyme with beta-glucosidase, beta-fucosidase and beta-galactosidase activities.
PublikacjaBackground: Cold-active enzymes, sourced from cold-adapted organisms, are characterized by high catalytic efficiencies at low temperatures compared with their mesophilic counterparts, which have poor activity. This property makes them advantageous for biotechnology applications as it: (i) saves energy costs, (ii) shortens the times for processes operated at low temperatures, (iii) protects thermosensitive substrates or products...
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Isolation and characterization of stable nanofiber from turmeric spent using chemical treatment by acid hydrolysis and its potential as antimicrobial and antioxidant activities
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Koncepcja oczyszczania odcieków o wysokich stężeniach zanieczyszczeń metoda hydrofitową = Conception og highly contaminated wastewater treatment by hydrophytes method
PublikacjaJednym z bardzo istotnych problemów w gospodarce komunalnej jest oczyszczanie odcieków powstających na składowiskach odpadów oraz podczas odwadniania przefermentowanych osadów ściekowych w miejskich oczyszczalniach. Celem niniejszej pracy jest analiza możliwości zastosowania metody hydrofitowej do oczyszczania następujących ścieków charakteryzujących się wysokim ładunku zanieczyszczeń: odcieków ze składowisk (OS) oraz odcieków...
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The increased level of cytochrome P450 isoenzyme CYP3A4 affects the cellular response in CHO cells upon antitumor imidazoacridinone C-1311 treatment
PublikacjaPochodna C-1311 to potencjalny związek przeciwnowotworowy, który dotarł do II fazy badań klinicznych. Związek ten ulega metabolicznej transformacji pod wpływem szczurzych i ludzkich białek mikrosomalnych. Wykazano, że białka cytochromu P450 odpowiadają za przemiany metaboliczne C-1311 jedynie w niewielkim stopniu. Z drugiej strony wykazano, że pochodna C-1311 jest inhibitorem białek cytochromu P450, zwłaszcza izoenzymu CYP1A2...
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Functional Polymorphism in the Interleukin 6 (IL6) Gene with Respect to Depression Induced in the Course of Interferon-α and Ribavirin Treatment in Chronic Hepatitis Patients
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Efficacy of high-dose corticosteroid-based treatment for chronic lymphocytic leukemia patients with p53 abnormalities in the era of B-cell receptor inhibitors
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Antibiotic Resistance Carriage Causes a Lower Survivability Due to Stress Associated with High-Pressure Treatment among Strains from Starter Cultures
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Preparation and characterization of gold nanoparticles prepared with aqueous extracts of Lamiaceae plants and the effect of follow-up treatment with atmospheric pressure glow microdischarge
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Diverging frequency-modulated 50-kHz vocalization, locomotor activity and conditioned place preference effects in rats given repeated amphetamine treatment
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Validation of odor concentration from mechanical-biological treatment piles using static chamber and wind tunnel with different wind speed values
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Different expression level of CYP3A4 isoenzyme modulate cellular response of CHO cells following treatment with the CYP3A4 inhibitor, C-1311 compound
PublikacjaEfektywność terapii przeciwnowotworowej może być zmieniana przez różne czynniki. Jednym z ograniczeń jest odmienny u każdego pacjenta poziom enzymów metabolizujących odpowiedzialnych za aktywację i detoksykację leków, co może zmieniać jego odpowiedź na zastosowaną terapię. Co więcej, enzymy metabolizujące często są celem molekularnym wielu ksenobiotyków, co dodatkowo może zmieniać skuteczność terapii. Zatem zrozumienie oddziaływań...
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P.0253 Two-week lithium treatment modulates translocator protein expression in brain regions in the animal models of acute bipolar episodes
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Various neuromodulation methods including Deep Brain Stimulation of the medial forebrain bundle combined with psychopharmacotherapy of treatment-resistant depression—Case report
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Set-Bounded joined parameter and state estimation for model predictive control of integrated wastewater treatment plant systems at medium time scale.
PublikacjaW artykule opisano moduł łącznej estymacji w postaci zbiorów ograniczonych (ang. set-bounded) parametrów i stanu systemu dla potrzeb sterowania predykcyjnego zintegrowanym systemem ściekowym w średniej skali czasu. Jest to jeden ze składowych elementów Inteligentnej Hierarchicznej Struktury Sterowania opracowanej w celu pokonania następujących problemów, które występują w kontrolowanym systemie: różne skale czasowe procesów, silnie...
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Combined anticancer therapy with imidazoacridinone analogue C‐1305 and paclitaxel in human lung and colon cancer xenografts—Modulation of tumour angiogenesis
PublikacjaThe acridanone derivative 5-dimethylaminopropylamino- 8- hydroxytriazoloacridinone (C-1305) has been described as a potent inhibitor of cancer cell growth. Its mechanism of action in in vitro conditions was attributed, among others, to its ability to bind and stabilize the microtubule network and subsequently exhibit its tumour- suppressive effects in synergy with paclitaxel (PTX). Therefore, the objective of the present study...
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The cellular response of human colon carcinoma HCT116 cells to 4-methyl-1-nitroacridine derivative C-1748 treatment depending on p53 status
PublikacjaWykazano, że pochodna C-1748 indukuje apoptozę w komórkach linii ludzkich raków jelita grubego HCT116 p53+/+ i p53-/- w sposób zależny od czasu inkubacji i stężenia związku. Wskazują na to: pojawienie się frakcji komórek sub-G1, charakterystyczne zmiany w morfologii jąder komórkowych, zmiany w strukturze błony plazmatycznej. Ponadto, pod wpływem badanego związku komórki HCT116 p53+/+ wykazują większą podatność do ulegania apoptozie...
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The role of anthranilic acid in the increase of depressive symptoms and major depressive disorder during treatment for hepatitis C with pegylated interferon-α2a and oral ribavirin
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Successful Treatment of Persistent SARS-CoV-2 Infection in a B-Cell Depleted Patient with Activated Cytotoxic T and NK Cells: A Case Report
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Nanoemulsion Structural Design in Co-Encapsulation of Hybrid Multifunctional Agents: Influence of the Smart PLGA Polymers on the Nanosystem-Enhanced Delivery and Electro-Photodynamic Treatment
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The Influence of Long-Term Heat Treatment on Microstructure of Zr-Modified Aluminide Coating Deposited by CVD Method on MAR M200+Hf Nickel Superalloy
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Safety and efficacy of P2X3 receptor antagonist for the treatment of refractory or unexplained chronic cough: A systematic review and meta-analysis of 11 randomized controlled trials
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Liposomal cytarabine in the prophylaxis and treatment of CNS lymphoma: toxicity analysis in a retrospective case series study conducted at Polish Lymphoma Research Group Centers
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CYP3A4 overexpression enhances apoptosis induced by anticancer agent imidazoacridinone C-1311, but does not change the metabolism of C-1311 in CHO cells
PublikacjaWe examine whether CYP3A4 overexpression influences the rate and pattern of antitumor imidazoacridinone C-1311 metabolism, in relation to the impact of this overexpression on cell cycle progression and final cellular response of CHO cells following C-1311 treatment. Methods: Three CHO cell lines: CHO-WT, wild type, CHO-HR, overexpressing cytochrome P450 reductase (CPR) and CHO-HR-3A4, coexpressing CPR and CYP3A4 were applied....